Autor: Lyon, I. - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Triple F—a comet nucleus sample return mission
Autorzy:: Blum, J.
Meierhenrich, U.
Fulle, M.
Palumbo, P.
Altwegg, K.
Hviid, S. F.
Aronica, A.
Mottola, S.
Zarnecki, J. C.
Barbieri, C.
Charnley, S.
Lomakin, I.
Sierks, H.
Bar-Nun, A.
Bredehöft, J.-H.
Epifani, E. M.
Korablev, O.
Goesmann, F.
Hilchenbach, M.
Kossacki, K.
Akim, E.
Yung, K. L.
Zolensky, M.
Szutowicz, S.
Ng, T. C.
Stroud, R. M.
Mennella, V.
Ehrenfreund, P.
Colangeli, L.
Cremonese, G.
Weiss, P.
Waniak, Wacław
Kührt, E.
Licandro, J.
Rickman, H.
Li, Z.-Y.
Biele, J.
Magni, G.
Pätzold, M.
Hartogh, P.
Markiewicz, W.
Basilevsky, A.
Schönbächler, M.
Zakharov, A.
Martynov, M.
Rodriguez, J.
Nazarov, M.
Bertrand, R.
Botta, O.
Gortsas, N.
Krüger, H.
Weissman, P.
Gerasimov, M.
Groussin, O.
Krause, C.
Ulamec, S.
Biver, N.
Rathke, A.
Lyon, I.
Capaccioni, F.
Kömle, N. I.
Srama, R.
Mall, U.
Wallis, M.
Benkhoff, J.
Bockelée-Morvan, D.
Henkel, T.
Busemann, H.
Capria, M. T.
Cloutis, E.
Ip, W.-H.
Lowry, S. C.
Tornow, C.
Ferri, F.
Keller, H. U.
Knollenberg, J.
Cottin, H.
Prialnik, D.
Grün, E.
Maurette, M.
Zelenyi, L.
Marov, M.
Esposito, F.
Jäckel, A.
Gutiérrez, P. J.
Korth, A.
Küppers, Michael
Wieler, R.
Crowther, S. A.
Horneck, G.
Kallenbach, R.
Mann, I.
Sandford, S.
Galimov, E.
Martins, Z.
Jessberger, E.
Kargl, G.
A’Hearn, M. F.
Ho, T.-M.
Roll, R.
Rengel, M.
Davidsson, B.
Wurz, P.
Nittler, L. R.
Ferrari, A. C.
Rost, D.
Crovisier, J.
Ball, A. J.
Lopez-Moreno, J. J.
Rotundi, A.
Green, S. F.
Gilmour, J.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 2.

Autorzy:: Sverdlov, A.L.
Zamorano, P.
Aktaa, S.
Tocchetti, C. G.
Parrini, I.
Pudil, R.
Farmakis, D.
Badimon, L.
Szmit, S.
Barac, A.
Garrido Lopez, P.
Curigliano, G.
Lee, G.A.
Cohen-Solal, A.
Gulati, G.
Jurczak, Wojciech
Abdin, A.
Stephens, R.
Lyon, A.R
Yaseen, Israa F.
Gale, C.P.
Kirby, A.M.
Blaes, A.H.
Asteggiano, R.
Lopez-Fernandez, T.
Iakobishvili, Z.
Opis:: Aims: To develop quality indicators (QIs) for the evaluation of the prevention and management of cancer therapy-related cardiovascular toxicity. Methods and results: We followed the European Society of Cardiology (ESC) methodology for QI development which comprises (i) identifying the key domains of care for the prevention and management of cancer therapy-related cardiovascular toxicity in patients on cancer treatment, (ii) performing a systematic review of the literature to develop candidate QIs, and (iii) selecting of the final set of QIs using a modified Delphi process. Work was undertaken in parallel with the writing of the 2022 ESC Guidelines on Cardio-Oncology and in collaboration with the European Haematology Association, the European Society for Therapeutic Radiology and Oncology and the International Cardio-Oncology Society. In total, 5 main and 9 secondary QIs were selected across five domains of care: (i) Structural framework, (ii) Baseline cardiovascular risk assessment, (iii) Cancer therapy related cardiovascular toxicity, (iv) Predictors of outcomes, and (v) Monitoring of cardiovascular complications during cancer therapy. Conclusion: We present the ESC Cardio-Oncology QIs with their development process and provide an overview of the scientific rationale for their selection. These indicators are aimed at quantifying and improving the adherence to guideline-recommended clinical practice and improving patient outcomes.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 3.

Tytuł:: Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations
Autorzy:: Palczewski, Krzysztof
Chen, Paul Z.
Kiser, Philip D.
Risalit,i Eleonora
Rodrigues Menezes, Carolline
Hołubowicz, Rafał
Smidak, Roman
Griffo Alessandra
Caprettini Valeria
Felgner, Philip L.
Dong, Zhiqian
Liu, David R.
Almeida Filipe
Lyon, David C.
Cheifet Barbara
Salom, David
Felgner, Jiin
Choi, Elliot H.
Palczewska, Grazyna
Bassetto, Marco
Du, Samuel W.
Haskell Jennifer
Gao, Fangyuan
Medani, Omar
Yan, Alexander L.
Hołubowicz, Maria W.
Newby, Gregory A.
Foik, Andrzej T.
Workman, J. Noah
Współwytwórcy:: Caprettini Valeria
Almeida Filipe
Cheifet Barbara
Griffo Alessandra
Haskell Jennifer
Wydawca:: Nature Portfolio
Cytata wydawnicza:: Hołubowicz, R., Du, S.W., Felgner, J. et al. Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations. Nat. Biomed. Eng 9, 57–78 (2025). https://doi.org/10.1038/s41551-024-01296-2
Opis:: Delivering ribonucleoproteins (RNPs) for in vivo genome editing is safer than using viruses encoding for Cas9 and its respective guide RNA. However, transient RNP activity does not typically lead to optimal editing outcomes. Here we show that the efficiency of delivering RNPs can be enhanced by cell-penetrating peptides (covalently fused to the protein or as excipients) and that lipid nanoparticles (LNPs) encapsulating RNPs can be optimized for enhanced RNP stability, delivery efficiency and editing potency. Specifically, after screening for suitable ionizable cationic lipids and by optimizing the concentration of the synthetic lipid DMG-PEG 2000, we show that the encapsulation, via microfluidic mixing, of adenine base editor and prime editor RNPs within LNPs using the ionizable lipid SM102 can result in in vivo editing-efficiency enhancements larger than 300-fold (with respect to the delivery of the naked RNP) without detectable off-target edits. We believe that chemically defined LNP formulations optimized for RNP-encapsulation stability and delivery efficiency will lead to safer genome editing.
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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Skocz do pozycji: 4.

Tytuł:: Multiplicity and net-electric charge fluctuations in central Ar+Sc interactions at 13A, 19A, 30A, 40A, 75A, and 150A GeV/c beam momenta measured by NA61/SHINE at the CERN SPS
Autorzy:: Rozpłochowski, Ł..
Bryliński, W.
Koshio, Y.
Paolone, V.
Shukla, A.
Świderski, Ł..
Golubeva, M.
Turko, L.
Amin, N.
Dalmazzone, C.
Kuchowicz, M.
Friend, M.
Maksiak, B.
Grebieszkow, K.
Buryakov, M.
Krasnoperov, A.
Hurh, P. G.
Seyboth, P.
Kiełbowicz, M.
Wyszyński, O.
Bhosale, S.
Malakhov, A. I.
Bajda, Mateusz
Mik, Ł..
Ivashkin, A.
Tsenov, R.
Dumarchez, J.
Matveev, V.
Witek, K.
Golovatyuk, V.
Olivier, A.
Nagai, Y.
Maćkowiak-Pawłowska, M.
Popov, B. A.
Rybczynski, M.
Balkova, Y.
Bondar, Y.
Allison, K. K.
Melkumov, G. L.
Andronov, E. V.
Gaździcki, M.
Dominik, W.
Ilieva, S.
Płaneta, Roman
Rustamov, A.
Słodkowski, M.
Rumyantsev, M.
Szukiewicz, R.
Röhrich, D.
Csanád, M.
Bogomilov, M.
Kolesnikov, R.
Tefelski, D.
Kuich, M.
Ortiz, V. Z. Reyna
Adhikary, H.
Golosov, O.
Engel, R.
Podlaski, P.
Dmitriev, A.
Marino, A. D.
Nishimori, S.
Panova, O.
Fodor, Z.
Kozłowski, B.
Tefelska, A.
Guber, F.
Bazgir, A.
Bielewicz, M.
Battaglia, D.
Chandak, Y. D.
Cybowska, J.
Marcinek, A.
Zviagina, A.
Wickremasinghe, A.
Schmidt, K.
Szewiński, J.
Gollwitzer, K. E.
Stepaniak, J.
Urbaniak, M.
Kireyeu, V. A.
Kucewicz, W.
Mathes, H.-J.
Tereshchenko, V.
Pszczel, D.
Czopowicz, T.
Tveter, T. S.
Adrich, P.
Veberič, D.
László, A.
Prokhorova, D. S.
Zimmerman, E. D.
Davis, N.
Ćirković, M.
Wójcik, K.
Kowalski, S.
Feofilov, G. A.
Ozvenchuk, V.
Ren, L.
Fields, L.
Zaitsev, A.
Stefanek, G.
Merzlaya, A.
Pórfy, B.
Arsene, I.-C.
Rybka, D.
Puławski, S.
Rybicki, A.
Karpushkin, N.
Kolev, D.
Doetinchem, P. von
Sakashita, K.
Roth, M.
Vitiuk, O.
Taranenko, A.
Zherebtsova, E.
Camino, A. F.
Shah, U. A.
Nakadaira, T.
Staszel, Paweł
Unger, M.
Lyubushkin, V. V.
Matulewicz, T.
Lyon, J. R.
Brzychczyk, Janusz
Morozov, S.
Lykasov, G.
Pidhurskyi, I.
Shiraishi, Y.
Lewicki, M.
Blondel, A.
Opis:: This paper presents results on multiplicity fluctuations of positively and negatively charged hadrons as well as net-electric charge fluctuations measured in central Ar+Sc interactions at beam momenta 13A, 19A, 30A, 40A, 75A, and 150A GeV/c. The fluctuation analysis is one of the tools to search for the predicted critical point of strongly interacting matter. Results are corrected for the experimental biases and quantified using cumulant ratios. In most instances, multiplicity and net-charge distributions appear narrower than the corresponding Poisson or Skellam distributions. Cumulant ratios are compared with the Epos1.99 model predictions, which provide a qualitative description that aligns with observations for positively and negatively charged particles. The obtained results are also compared to earlier NA61/SHINE results from inelastic p+p interactions in the same analysis acceptance.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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