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    Wyświetlanie 1-6 z 6
    Tytuł:
    Associations of parental air pollution and greenness exposures with offspring asthma outcomes
    Autorzy:
    Brandt, Jørgen
    Holm, Mathias
    Orru, Hans
    Oudin, Anna
    Geels, Camilla
    Markevych, Iana
    Johannessen, Ane
    Malinovschi, Andrei
    Svanes, Cecilie
    Marcon, Alessandro
    Bertelsen, Randi J.
    Real, Francisco Gomez
    Gislason, Thorarinn
    Frohn, Lise M.
    Janson, Christer
    Accordini, Simone
    Sinsamala, Robin M.
    Sigsgaard, Torben
    Skulstad, Svein M.
    Opis:
    Background: Air pollution and greenness impact respiratory health, but intergenerational effects remain unclear. We investigated whether pre-conception parental residential exposure to air pollution and greenness at age 20-44 years is associated with offspring asthma outcomes in the Lifespan and inter-generational respiratory effects of exposures to greenness and air pollution (Life-GAP) project. Methods: We analyzed data on 3684 RHINESSA study participants born after the year 1990 (mean age 19, standard deviation 4), offspring of 2689 RHINE study participants. Modelled annual concentrations of particulate matter (PM2.5, PM10), nitrogen dioxide (NO2), elemental carbon (EC), and ozone (O3), and greenness (Normalized Difference Vegetation Index, NDVI) were assigned to parental residential addresses in 1990, corresponding to 1–18 years prior to birth (mean: 6 years, SD: 5). We analyzed associations using generalized structural equation modelling (GSEM), with cluster-robust standard errors allowing for intra-family correlation, while adjusting for potential confounders. Results: Among offspring participants, 18% reported lifetime asthma, 9% active asthma, 8% asthma medication, 5% asthma attacks, and 37% any asthma symptom. An interquartile range (IQR) increase in parental residential NDVI exposure was associated with less lifetime asthma (OR = 0.79, 95%CI: 0.64, 0.98 per 0.3 units). Similar associations were observed for active asthma and asthma medication use. Associations of air pollution with asthma outcomes were inconclusive. Conclusion: Parental exposure to residential green spaces before conception was associated with lower asthma risk in offspring. Urban planning policies prioritizing green spaces may be a key public health intervention for future cities.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Lifelong exposure to air pollution and greenness in relation to asthma, rhinitis and lung function in adulthood
    Autorzy:
    Hertel, Ole
    Christensen, Jesper Heile
    de Hoogh, Kees
    Svanes, Cecilie
    Sigsgaard, Torben
    Johannessen, Ane
    Forsberg, Bertil
    Malinovschi, Andrei
    Bråbäck, Lennart
    Bertelsen, Randi J
    Nilsen, Roy Miodini
    Heinrich, Joachim
    Holm, Mathias
    Accordini, Simone
    Halvorsen, Thomas
    Hoek, Gerard
    Markevych, Iana
    Marcon, Alessandro
    Nordeide Kuiper, Ingrid
    Janson, Christer
    Opis:
    Objectives: to investigate if air pollution and greenness exposure from birth till adulthood affects adult asthma, rhinitis and lung function. Methods: We analysed data from 3428 participants (mean age 28) in the RHINESSA study in Norway and Sweden. Individual mean annual residential exposures to nitrogen dioxide (NO2), particulate matter (PM10 and PM2.5), black carbon (BC), ozone (O3) and greenness (normalized difference vegetation index (NDVI)) were averaged across susceptibility windows (0-10 years, 10-18 years, lifetime, adulthood (year before study participation)) and analysed in relation to physician diagnosed asthma (ever/allergic/non-allergic), asthma attack last 12 months, current rhinitis and low lung function (lower limit of normal (LLN), z-scores of forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and FEV1/FVC below 1.64). We performed logistic regression for asthma attack, rhinitis and LLN lung function (clustered with family and study centre), and conditional logistic regression with a matched case-control design for ever/allergic/non-allergic asthma. Multivariable models were adjusted for parental asthma and education. Results: Childhood, adolescence and adult exposure to NO2, PM10 and O3 were associated with an increased risk of asthma attacks (ORs between 1.29 and 2.25), but not with physician diagnosed asthma. For rhinitis, adulthood exposures seemed to be most important. Childhood and adolescence exposures to PM2.5 and O3 were associated with lower lung function, in particular FEV1 (range ORs 2.65 to 4.21). No associations between NDVI and asthma or rhinitis were revealed, but increased NDVI was associated with lower FEV1 and FVC in all susceptibility windows (range ORs 1.39 to 1.74). Conclusions: Air pollution exposures in childhood, adolescence and adulthood were associated with increased risk of asthma attacks, rhinitis and low lung function in adulthood. Greenness was not associated with asthma or rhinitis, but was a risk factor for low lung function.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Associations of preconception exposure to air pollution and greenness with offspring asthma and hay fever
    Autorzy:
    Bertil, Forsberg
    Gerard, Hoek
    Lennart, Bråbäck
    Ane, Johannessen
    Christer, Janson
    Randi, J. Bertelsen
    Mathias, Holm
    Torben, Sigsgaard
    Alessandro, Marcon
    Accordini, Simone
    Jesper, Heile Christensen
    Ole, Hertel
    Markevych, Iana
    Andrei, Malinovschi
    Nordeide Kuiper, Ingrid
    Cecilie, Svanes
    Joachim, Heinrich
    Kees, de Hoogh
    Thomas, Halvorsen
    Opis:
    We investigated if greenness and air pollution exposure in parents’ childhood affect offspring asthma and hay fever, and if effects were mediated through parental asthma, pregnancy greenness/pollution exposure, and offspring exposure. We analysed 1106 parents with 1949 offspring (mean age 35 and 6) from the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study. Mean particulate matter (PM2.5 and PM10), nitrogen dioxide (NO2), black carbon (BC), ozone (O3) (µg/m3) and greenness (normalized difference vegetation index (NDVI)) were calculated for parents 0-18 years old and offspring 0-10 years old, and were categorised in tertiles. We performed logistic regression and mediation analyses for two-pollutant models (clustered by family and centre, stratified by parental lines, and adjusted for grandparental asthma and education). Maternal medium PM2.5 and PM10 exposure was associated with higher offspring asthma risk (odds ratio (OR) 2.23, 95%CI 1.32-3.78, OR 2.27, 95%CI 1.36-3.80), and paternal high BC exposure with lower asthma risk (OR 0.31, 95%CI 0.11-0.87). Hay fever risk increased for offspring of fathers with medium O3 exposure (OR 4.15, 95%CI 1.28-13.50) and mothers with high PM10 exposure (OR 2.66, 95%CI 1.19-5.91). The effect of maternal PM10 exposure on offspring asthma was direct, while for hay fever, it was mediated through exposures in pregnancy and offspring’s own exposures. Paternal O3 exposure had a direct effect on offspring hay fever. To conclude, parental exposure to air pollution appears to influence the risk of asthma and allergies in future offspring.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
      Wyświetlanie 1-6 z 6

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