Autor: Meler, Jan - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Działalność drużyn egzekucyjnych w Polsce Ludowej
Operation of execution squads in the People’s Republic of Poland
Autorzy:: Meler, Jan
Tematy:: execution teams
administration of death penalty
executioners
death penalty instruction
drużyny egzekucyjne
wykonywanie kary śmierci
kaci
instrukcja wykonywania kary śmierci; Pokaż więcej
Wydawca:: Krakowska Akademia im. Andrzeja Frycza Modrzewskiego
Powiązania:: https://bibliotekanauki.pl/articles/533072.pdf Link otwiera się w nowym oknie
Opis:: The article is devoted to an analysis of the organisation and operation of the system of death penalty execution in post-second-world-war Poland, and the dependence of the solutions applied by the NKVD. The investigation moves from the questions of legal grounds, via the organisation of execution squads, their equipment and uniforms, to the technical questions of the actual administration of death penalty.
Artykuł poświecony jest analizie organizacji i funkcjonowania systemu egzekucji kary śmierci w Polsce po II wojnie światowej i ich zależności od rozwiązań stosowanych przez NKWD. Przedmiotem analizy są kolejno kwestie podstawy prawnej, organizacji drużyn egzekucyjnych, ich uposażeniu i ubiorowi, oraz zagadnienia techniczne wykonywania kary śmierci
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Application of chitosan in the formulation of hydrogels applied on skin
Autorzy:: Meler, Jan
Tematy:: chitosan
hydrocortisone
hydrogels
pharmaceutical availability; Pokaż więcej
Wydawca:: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Powiązania:: https://bibliotekanauki.pl/articles/1035198.pdf Link otwiera się w nowym oknie
Opis:: These studies concerned the effect of composition on the substrate physicochemical parameters of hydrogels for use on skin. Hydrogels containing 1% of hydrocortisone and 1% of chitosan addition was made on the basis of methylcellulose, sodium carboxymethylcellulose and Carbopol 934 P. The release proceeds according to first-order kinetics. Depending on the type and composition of the polymer gels were obtained with various pharmaceutical availability of hydrocortisone. Addition of 1% chitosan affects the acceleration of the release in any given case.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: The influence of different kinds of chitosan on bioavailability of anti-inflammatory drugs
Autorzy:: Meler, Jan
Tematy:: naproxen sodium salt
ketoprofen
chitosan
absorption; Pokaż więcej
Wydawca:: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Powiązania:: https://bibliotekanauki.pl/articles/1035484.pdf Link otwiera się w nowym oknie
Opis:: Chitosan as a dietary supplement has been used in the treatment of obesity due to its capability of binding bioactive compounds. A molecule of a cationic polymer, such as chitosan, may bind acid drugs. The aim of the study was to determine the binding capability of Ketoprofen and Naproxen sodium salt by chitosans contained in weight-loss supplements. The drug absorption was investigated by means of a dynamic method in a biopharmaceutical model imitating in vitro conditions including the required level of nutrients. Mean absorption of drugs by chitosan ranged from 92% to 96% depending on the environmental pH. The highest absorption rate was observed at above pH 7. Concluding, the studies confirmed that the investigated drugs interact with chitosan, what leads to decrease in their amount and affects the bioavailability of the drugs.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Studies of gentamycin adsorption on chitosan
Autorzy:: Meler, Jan
Grimling, Bożena
Pluta, Janusz
Tematy:: Gentamycin
adsorption
chitosan; Pokaż więcej
Wydawca:: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Powiązania:: https://bibliotekanauki.pl/articles/1035211.pdf Link otwiera się w nowym oknie
Opis:: Chitosan as a dietary supplement has been used in the treatment of obesity due to its capability of binding bioactive compounds. A molecule of a cationic polymer, such as chitosan, may bind gentamycin. The aim of the study was to determine the binding capability of Gentamycin by chitosan’s contained in weight-loss supplements. The Gentamycin absorption was investigated by means of a dynamic method in a biopharmaceutical model imitating in vitro conditions including the required level of nutrients. Mean absorption of gentamycin by chitosan ranged from 2,1% to 34,1% depending on the environmental pH. The highest absorption rate was observed at above pH 6,8. Concluding, the studies confirmed that the investigated gentamycin interact with chitosan, what leads to decrease in their amount and affects the bioavailability of the drugs.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Studies of norfloxacin adsorption on chitosan
Autorzy:: Meler, Jan
Grimling, Bożena
Pluta, Janusz
Tematy:: adsorption
chitosan
norfloxacin; Pokaż więcej
Wydawca:: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Powiązania:: https://bibliotekanauki.pl/articles/1035394.pdf Link otwiera się w nowym oknie
Opis:: In clinical practice a lot of natural macromolecular compounds which operation is based on assisting weight loss are used in the obesity treatment. These measures swell in the digestive tract and form the polymer gel system, which has the ability to adsorb up to 5 times more lipids relative to its own weight. When using dietary supplements containing chitosan, sometimes it comes to illness and in the therapy other agents such as chemotherapeutics are used. The aim of our study was to determine the binding capacity of chemotherapeutic norfloxacin present in the digestive tract model by chitosans found in slimming medicines, depending on variable physico-chemical factors. Phenomenon of norrfloxacin adsorption was studied by a dynamic pharmaceutical model simulating in vitro conditions. The amount of adsorbed chemotherapeutic agent by chitosan was calculated by the difference in concentrations of study drug before and after sorption. The results of measurements of quantities bounded norfloxacin were used to calculate the average percentage of adsorbed dose. The results show that norfloxacin is adsorbed by the chitosans in the applicable pH ranges, and the binding capacity depends on the pH, viscosity and concentration of chemotherapeutics, as well as the type of chitosan and additional substances in the gastrointestinal tract. The average amount of chemotherapeutic adsorption in the system chitosan-nutrients, depending on the pH ranged from 80 to 98%. The highest number of adsorption points above pH 7. In conclusion, the addition of dietary supplement such as chitosan reduces the amount of administered uniformly chemotherapeutic and simultaneously has a large impact on the bioavailability. The observed dependence may require changes in therapeutic process.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Evaluation of preparations pharmaceutical salazosulfapiridin depending used food supplements containing chitosan in model “in vitro”
Autorzy:: Meler, Jan
Grimling, Bożena
Pluta, Janusz
Wydawca:: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Powiązania:: https://bibliotekanauki.pl/articles/1035432.pdf Link otwiera się w nowym oknie
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Studies on adsorption tiamfenicol on chitosans degraded radiation in pharmaceutical in vitro model
Autorzy:: Meler, Jan
Grimling, Bożena
Pluta, Janusz
Tematy:: chitosan; absorption
tiamphenicol; Pokaż więcej
Wydawca:: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Powiązania:: https://bibliotekanauki.pl/articles/1035368.pdf Link otwiera się w nowym oknie
Opis:: Connections of polymers and biopolymers with biologically active compounds are recently the subject of intensive research. Low molecular weight active ingredient combined with a polymer has, in many cases, the modified action. On the other hand, the use of inappropriate polymers can result in incompatibilities drug-polymer. The phenomenon of adsorption of the antibiotic has been studied by the static method in the concentration range generally taken single dose using a pharmaceutical gastrointestinal tract model. The results of measurements bounded drug quantity were used to determine the average percentage of adsorbed dose. The results show that antibiotic tiamphenicol is adsorbed on chitosan in used pH ranges, and the binding ability depends on the variety of chitosan and directly from the environment reaction. It was observed that the average sorption depending on the type of chitosan was within the limit from 82% to 97%.The fact of the lowest adsorption value at pH 6.4 can be explained by chemical properties of chitosan, which shows the load until the pH > 6.7 and the electrostatic adsorption may be exhibit in relation to weak acid medicinal substance. Thus, the specific polymer surface area and its sorption capacity is increased. Based on the above considerations can be stated that between study drug and the polymer an antagonistic interaction exist by involving the adsorption of drugs from this group on chitosan.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Investigation of fenofibrate solubility in the presence of chitosan
Autorzy:: Grimling, Bożena
Meler, Jan
Pluta, Janusz
Tematy:: chitosan
dissolution
fenofibrate
solid state; Pokaż więcej
Wydawca:: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Powiązania:: https://bibliotekanauki.pl/articles/1035391.pdf Link otwiera się w nowym oknie
Opis:: Fenofibrate is an active substance which is well absorbed from the gastrointestinal tract, but it is characterized by limited solubility. Due to a wide spectrum of its pharmacological activity, it would be beneficial to improve its solubility, and thus increase the drug absorption capability. The aim of the study was to investigate the effect of chitosan on the solubility of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions at the drug to polymer ratio of 3:7,5:5,7:3. The solubility investigation was performed by means of a dynamic method in a dissolution apparatus; mean amount of dissolved fenofibrate and the drug to polymer quantitative ratio in which the solid dispersion possessed the most beneficial properties improving the drug solubility were calculated. The study revealed a multi-fold increase (from 33 to 50 times) in fenofibrat solubility in the presence of chitosan, which increased with duration of the study and with increasing percentage of the polymer in formulations. The obtained results may help develop new technologies for fenofibrate preparations with chitosan, with better solubility characteristics, and thus increased bioavailability of the drug.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: THE STUDY OF ADSORPTION AND DESORPTION OF ANTIBIOTICS ON THE SURFACE OF NANOPARTICLES
Autorzy:: Biernat, Paweł
Borak, Beata
Meler, Jan
Karolewicz, Bożena
Tematy:: silica
antibiotics
nanoparticles
adsorption
drug
carrier; Pokaż więcej
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Powiązania:: https://bibliotekanauki.pl/articles/895282.pdf Link otwiera się w nowym oknie
Opis:: Nanotechnology is a field that is gaining more and more importance in the modern world. It uses a particle size of between a few dozen to a few hundred nanometers, or 10-9 meters. It is noted that the use of nanospheres (balls with a diameter of from several to several hundred nm) as carriers of drugs gives an opportunity for their controlled and sustained release. (1,2) Nanospheres as a potential drug carrier for sustained release may enhance the effectiveness of antibiotics. In order to examine the effects of antibiotics with nanospheres an attempt was made to deposit on them three drugs differing in chemical structure. These were chloramphenicol, gentamicin and ceftazidime. The aim of this study was to determine the degree of adsorption of the drug on the surface of nanospheres and to examine the process of desorption from the surface of silica nanoparticles. The results of the study indicate that in the case of chloramphenicol it is essentially a process of chemisorption, and for gentamicin and ceftazidime both physical and chemical adsorption, without there being any clearly defined relationship between this two processes. The purpose of the nanospheres as drug carriers is to obtain controlled and prolonged exposure to the drug. The amount of adsorbed substance depends primarily on its structure. Ceftazidime, as the compound with the highest number of double bonds, and a large number of groups to form hydrogen bonds (carbonyl groups, amino groups), adsorbed to the greatest extent.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Application of chitosan in the formulation of dermatological hydrogels prepared on the basis of macromolecular compounds
Autorzy:: Szcześniak, Maria
Grimling, Bożena
Meler, Jan
Karolewicz, Bożena
Tematy:: chitosan
hydrogels
rheological parameters; Pokaż więcej
Wydawca:: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Powiązania:: https://bibliotekanauki.pl/articles/1034450.pdf Link otwiera się w nowym oknie
Opis:: The effect of chitosan concentration on the properties of dermatological preparations prepared with 2% methylcellulose and 10% polyvinylpyrrolidone was studied. As the levels of chitosan, propylene glycol-1,2 and glycerol increased, the hardness, consistency and cohesiveness of the hydrophilic gels increased, while the dissipation capacity decreased. Gels based on methylcellulose and chitosan, compared to formulations containing polyvinylpyrrolidone, have a higher rate of loss of volatile compounds, higher pH values for 1,2-propylene glycol formulation and higher texture parameters. The tested hydrogels have good rheological properties, allowing extrusion from the tube and spreading on the skin.
Dostawca treści:: Biblioteka Nauki

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