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Wyszukujesz frazę "Moniche, Francisco" wg kryterium: Autor


Wyświetlanie 1-4 z 4
Tytuł:
RP11-362K2.2:RP11-767I20.1 genetic variation is associated with post-reperfusion therapy parenchymal hematoma. A GWAS meta-analysis
Autorzy:
Martínez-Domeńo, Alejandro
Gallego-Fabrega, Cristina
Fernández-Cadenas, Israel
Ibańez, Laura
Lledós, Miquel
del Mar Freijo-Guerrero, Maria
Tur, Silvia
Krupinsky, Jerzy
Strbian, Daniel
Arenillas, Juan F.
Thijs, Vincent
Pera, Joanna
Obach, Victor
Cruchaga, Carlos
Martí-Fŕbregas, Joan
Delgado-Mederos, Raquel
Guasch, Marina
Muińo, Elena
Lee, Jin-Moo
Camps-Renom, Pol
Montaner, Joan
Millán, Mňnica
Campos, Francisco
Bustamante, Alejandro
Prats-Sánchez, Luis
Cabezas, Juan Antonio
Sobrino, Tomás
Muńoz-Narbona, Lucía
Lemmens, Robin
Cullell, Natalia
Rodríguez-Castro, Emilio
Castellanos, Mar
Słowik, Agnieszka
Roquer, Jaume
Dhar, Rajat
Castillo, José
Jiménez-Conde, Jordi
Lluciŕ-Carol, Laia
Soriano-Tárraga, Carolina
Tatlisumak, Turgut
Segura, Tomás
Guisado, Daniel
Cárcel-Márquez, Jara
López-Cancio, Elena
Ribó, Marc
Álvarez-Sabín, José
Giralt-Steinhauer, Eva
Vives-Bauza, Cristófol
Díaz Navarro, Rosa
Marin, Rebeca
Serrano-Heras, Gemma
Heitsch, Laura
Moniche, Francisco
Carrera, Caty
Opis:
Stroke is one of the most common causes of death and disability. Reperfusion therapies are the only treatment available during the acute phase of stroke. Due to recent clinical trials, these therapies may increase their frequency of use by extending the time-window administration, which may lead to an increase in complications such as hemorrhagic transformation, with parenchymal hematoma (PH) being the more severe subtype, associated with higher mortality and disability rates. Our aim was to find genetic risk factors associated with PH, as that could provide molecular targets/pathways for their prevention/treatment and study its genetic correlations to find traits sharing genetic background. We performed a GWAS and meta-analysis, following standard quality controls and association analysis (fastGWAS), adjusting age, NIHSS, and principal components. FUMA was used to annotate, prioritize, visualize, and interpret the meta-analysis results. The total number of patients in the meta-analysis was 2034 (216 cases and 1818 controls). We found rs79770152 having a genome-wide significant association (beta 0.09, p-value 3.90 × 10−8) located in the RP11-362K2.2:RP11-767I20.1 gene and a suggestive variant (rs13297983: beta 0.07, p-value 6.10 × 10−8) located in PCSK5 associated with PH occurrence. The genetic correlation showed a shared genetic background of PH with Alzheimer’s disease and white matter hyperintensities. In addition, genes containing the ten most significant associations have been related to aggregated amyloid-β, tau protein, white matter microstructure, inflammation, and matrix metalloproteinases.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
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    Wyświetlanie 1-4 z 4

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