Autor: Palmer, Colin - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Association of Factor V Leiden With Subsequent Atherothrombotic Events : a GENIUS-CHD Study of Individual Participant Data
Autorzy:: Delgado, Graciela
Pilbrow, Anna
Wallentin, Lars
Lang, Chim
Nikus, Kjell
Patel, Riyaz
Simon, Tabassome
Gong, Yan
Pare, Guillaume
Deloukas, Panos
James, Stefan
Laurikka, Jari
Szczeklik, Wojciech
Holmes, Michael
Muehlschlegel, Jochen
Stewart, Alexandre
Hartiala, Jaana
Hovingh, G.
Dudbridge, Frank
Richards, A.
Baranova, Ekaterina
Scholz, Markus
Cresci, Sharon
Gijsberts, Crystel
McPherson, Ruth
Tang, W.H.
Danchin, Nicolas
Burkhardt, Ralph
McCubrey, Raymond
Mahmoodi, Bakhtawar
Pepine, Carl
Grobbee, Diederick
Kleber, Marcus
Direk, Kenan
ten Berg, Jurriën
Johnson, Julie
Levin, Daniel
Bots, Michiel
Kaczor, Marcin
Doughty, Robert
Schmidt, Amand
van Setten, Jessica
Sanak, Marek
Lenzini, Petra
Klungel, Olaf
Cooper-DeHoff, Rhonda
Body, Simon
Hingorani, Aroon
van der Laan, Sander
Tragante, Vinicius
Nelson, Christopher
Deanfield, John
Spertus, John
Held, Claes
Kähönen, Mika
Sattar, Naveed
Lehtimäki, Terho
Visseren, Frank
Teren, Andrej
Allayee, Hooman
Waltenberger, Johannes
Hoefer, Imo
Maitland-van der Zee, Anke
Akerblom, Axel
Kraaijeveld, Adriaan
Palmer, Colin
Kuukasjarvi, Pekka
Eriksson, Niclas
Mordi, Ify
Hazen, Stanley
Heydarpour, Mahyar
Pasterkamp, Gerard
März, Winfried
Hagström, Emil
Asselbergs, Folkert
Bergmeijer, Thomas
Cameron, Vicky
Lyytikäinen, Leo-Pekka
Thiery, Joachim
Braund, Peter
Samani, Nilesh
Vilmundarson, Ragnar
Howe, Laurence
Kotti, Salma
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 2.

Tytuł:: Subsequent event risk in individuals with established coronary heart disease : design and rationale of the GENIUS-CHD consortium
Autorzy:: Sun, Yan
Delgado, Graciela
Carpeggiani, Clara
Pilbrow, Anna
Lee, Vei-Vei
Kofink, Daniel
Wallentin, Lars
Fox, Keith
Lang, Chim
Nikus, Kjell
Patel, Riyaz
Mahmoodi, B.
Simon, Tabassome
Gong, Yan
Pare, Guillaume
Al Ali, Lawien
Deloukas, Panos
Mons, Ute
James, Stefan
Laurikka, Jari
Szczeklik, Wojciech
ten Berg, Jurrien
Holmes, Michael
Kaminski, Karol
van der Graaf, Yolanda
Quyyumi, Arshed
Muehlschlegel, Jochen
Stender, Steen
Dube, Marie-Pierre
Stewart, Alexandre
Brenner, Hermann
Hartiala, Jaana
Hovingh, G.
Brugts, Jasper
Jukema, J.
Dudbridge, Frank
Richards, A.
Baranova, Ekaterina
Van de Werf, Frans
Scholz, Markus
Fitzpatrick, Natalie
Cresci, Sharon
Gijsberts, Crystel
Niemcunowicz-Janica, Anna
McPherson, Ruth
Lotufo, Paulo
Tang, W.H.
Drexel, Heinz
Alver, Maris
Danchin, Nicolas
Burkhardt, Ralph
Wilde, Arthur
Anderson, Jeffrey
McCubrey, Raymond
Marziliano, Nicola
Pereira, Alexandre
Pepine, Carl
Pilote, Louise
Saely, Christoph
Carlquist, John
Grobbee, Diederick
Kleber, Marcus
Direk, Kenan
Lindholm, Daniel
Martinelli, Nicola
Sandesara, Pratik
Ardissino, Diego
Girelli, Domenico
Leiherer, Andreas
Johnson, Julie
Bogaty, Peter
Lagerqvist, Bo
Lehtimaki, Terho
Arsenault, Benoit
Levin, Daniel
Bots, Michiel
Kaczor, Marcin
Doughty, Robert
Virani, Salim
Sinisalo, Juha
Siegbahn, Agneta
Boersma, Eric
Wauters, Els
Algra, Ale
Duarte, Nubia
Lokki, Marja-Liisa
Engert, James
Smith, J.
Schmidt, Amand
Trompet, Stella
Marz, Winfried
Kettner, Jiri
van Setten, Jessica
Hagstrom, Emil
Sanak, Marek
Boeckx, Bram
Lenzini, Petra
Klungel, Olaf
Cooper-DeHoff, Rhonda
Body, Simon
Kahonen, Mika
Hingorani, Aroon
Breitling, Lutz
van der Laan, Sander
Tragante, Vinicius
Pitha, Jan
Samman-Tahhan, Ayman
Szpakowicz, Anna
Nelson, Christopher
Tanck, Michael
Deanfield, John
Spertus, John
Held, Claes
Tfelt-Hansen, Jacob
Condorelli, Gianluigi
Horne, Benjamin
Ballantyne, Christie
Sattar, Naveed
Melander, Olle
Metspalu, Andres
Tardif, Jean-Claude
Visseren, Frank
Ford, Ian
Teren, Andrej
Allayee, Hooman
Waltenberger, Johannes
Foco, Luisa
Hoefer, Imo
Maitland-van der Zee, Anke
Jabbari, Reza
Muhlestein, Joseph
Akerblom, Axel
Kuukasjarvi, Pekka
Palmer, Colin
Stott, David
Engstrom, Thomas
Thanassoulis, George
Eriksson, Niclas
de Faire, Ulf
Hubacek, Jaroslav
Lambrechts, Diether
Hazen, Stanley
Boerwinkle, Eric
Glinge, Charlotte
Heydarpour, Mahyar
Pasterkamp, Gerard
Dufresne, Line
Bezzina, Connie
Newton-Cheh, Christopher
Behlouli, Hassan
Anselmi, Chiara
Casu, Gavino
Lyytikainen, Leo-Pekka
Leander, Karin
Vlachopoulou, Efthymia
Gigante, Bruna
Andreassi, Maria
Bergmeijer, Thomas
Cameron, Vicky
Asselbergs, Folkert
Kiliszek, Marek
Carruthers, Kathryn
Thiery, Joachim
Brophy, James
Braund, Peter
Fox, Kim
Almgren, Peter
Hemingway, Harry
Briguori, Carlo
Timmis, Adam
van der Harst, Pim
Opolski, Grzegorz
Samani, Nilesh
Vilmundarson, Ragnar
Howe, Laurence
Ploski, Rafal
Torp-Pedersen, Christian
Olivieri, Oliviero
Kotti, Salma
Opis:: BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events. RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%–91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints. CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 3.

Tytuł:: Association of chromosome 9p21 with subsequent coronary heart disease events : a GENIUS-CHD study of individual participant data
Autorzy:: Kaminski, Karol A.
Allayee, Hooman
Boeckx, Bram
Kuukasjarvi, Pekka
Gijsberts, Crystel M.
Carlquist, John F.
Dube, Marie-Pierre
Leander, Karin
Hemingway, Harry
Hoefer, Imo E.
Stewart, Alexandre F.R.
Thanassoulis, George
Saely, Christoph H.
Held, Claes
Olivieri, Oliviero
Nelson, Christopher P.
Cresci, Sharon
Lee, Vei-Vei
Cooper-DeHoff, Rhonda M.
Kaczor, Marcin
Briguori, Carlo
Thiery, Joachim
Anderson, Jeffrey L.
Kleber, Marcus
Smith, J. Gustav
Burkhardt, Ralph
de Faire, Ulf
Leiherer, Andreas
Nikus, Kjell
Ford, Ian
Vlachopoulou, Efthymia
Almgren, Peter
Pilbrow, Anna P.
Body, Simon C.
Lang, Chim C.
Gigante, Bruna
ten Berg, Jurrien M.
Algra, Ale
Pitha, Jan
James, Stefan
Hartiala, Jaana
Eriksson, Niclas
Howe, Laurence J.
Direk, Kenan
Drexel, Heinz
Szpakowicz, Anna
Pare, Guillaume
Akerblom, Axel
Schmidt, Amand F.
Hubacek, Jaroslav A.
Sanak, Marek
Virani, Salim S.
Vilmundarson, Ragnar O.
Wilde, Arthur A.M.
Van de Werf, Frans J.
Pepinski, Witold
Waltenberger, Johannes
Arsenault, Benoit J.
Maitland-van der Zee, Anke H.
McPherson, Ruth
McCubrey, Raymond O.
Stott, David J.
Sattar, Naveed
Breitling, Lutz P.
Ploski, Rafal
Wauters, Els
Boerwinkle, Eric
Hazen, Stanley L.
Muhlestein, Joseph B.
Johnson, Julie A.
Kofink, Daniel
Spertus, John A.
Wallentin, Lars
Cheh, Chris Newton
Pereira, Alexandre C.
Lotufo, Paulo A.
Pilote, Louise
Gong, Yan
Bezzina, Connie R.
Melander, Olle
Condorelli, Gianluigi
Hovingh, G. Kees
Carpeggiani, Clara
Horne, Benjamin D.
Casu, Gavino
Hingorani, Aroon D.
Patel, Riyaz S.
Deloukas, Panos
Samman-Tahhan, Ayman
Dufresne, Line
Lyytikainen, Leo-Pekka
Ardissino, Diego
Brenner, Hermann
Ballantyne, Christie M.
Mordi, Ify R.
Sinisalo, Juha
Alver, Maris
Pasterkamp, Gerard
Holmes, Michael V.
Heydarpour, Mahyar
Opolski, Grzegorz
Carruthers, Kathryn F.
Laurikka, Jari O.
Siegbahn, Agneta
Girelli, Domenico
Mahmoodi, Bakhtawar K.
Marziliano, Nicola
Marz, Winfried
Behlouli, Hassan
Duarte, Nubia E.
Foco, Luisa
Fox, Keith A.A.
Trompet, Stella
van der Graaf, Yolanda
Visseren, Frank L.J.
Lagerqvist, Bo
Metspalu, Andres
Scholz, Markus
van der Harst, Pim
Cameron, Vicky A.
Wilson Tang, W.H.
de Borst, Gert J.
Mons, Ute
Tragante, Vinicius
Quyyumi, Arshed A.
Samani, Nilesh J.
Bergmeijer, Thomas O.
Palmer, Colin N.
Braund, Peter S.
Asselbergs, Folkert W.
Fitzpatrick, Natalie
Tardif, Jean-Claude
Pepine, Carl J.
Levin, Daniel
Richards, A. Mark
Doughty, Robert N.
Tanck, Michael W.T.
Lindholm, Daniel
de Jong, Pim A.
Brophy, James M.
Lambrechts, Diether
van der Laan, Sander W.
Anselmi, Chiara Viviani
Lenzini, Petra A.
Timmis, Adam
Muehlschlegel, Jochen D.
Jukema, J. Wouter
Hagstrom, Emil
van Setten, Jessica
Dudbridge, Frank
Baranova, Ekaterina V.
Lokki, Marja-Liisa
Sandesara, Pratik B.
Bogaty, Peter
Andreassi, Maria G.
Teren, Andrej
Deanfield, John
Martinelli, Nicola
Engert, James C.
Kahonen, Mika
Klungel, Olaf H.
Kiliszek, Marek
Delgado, Graciela
Kettner, Jiri
Lehtimaki, Terho
Szczeklik, Wojciech
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 4.

Tytuł:: Genetic insights into resting heart rate and its role in cardiovascular disease
Autorzy:: Newton-Cheh, Christopher H.
Strachan, David P.
Assimes, Themistocles
Gudnason, Vilmundur
Stolarz-Skrzypek, Katarzyna
Lorentzon, Mattias
Morris, Andrew P.
Hicks , Andrew A.
Nikus, Kjell
Linneberg, Allan
Ntalla, Ioanna
Smith, Albert V.
Perola, Markus
Lecoeur, Cecile
Launer, Lenore J.
Riese, Harriette
van de Vegte, Yordi J.
Ulivi, Sheila
Campbell, Archie
Zhao, Wei
Arnar, David O.
Rizzi, Federica
Sabanayagam, Charumathi
Eppinga, Ruben N.
Bielak, Lawrence F.
Sever, Peter
Ormel, Johan
Pina Concas, Maria
Lindgren, Cecilia M.
Kleber, Marcus E.
Smith, Jennifer A.
Wareham, Nicholas J.
Guo, Xiuqing
Gudbjartsson, Daniel F.
Ohlsson, Claes
O’Donnell, Christopher J.
Silva, Claudia T.
Sinagra, Gianfranco
Sundstrom, Johan
Balkau, Beverley
Shah, Nabi
Bottinger , Erwin P.
Delgado, Graciela E.
de Mutsert, Renée
Meitinger , Thomas
Hansen, Torben
Morrison , Alanna C.
Tanaka, Toshiko
Froguel, Philippe
Yao, Jie
Rankinen, Tuomo
Tham, Yih-Chung
Lange, Leslie A.
Felix, Stephan B.
Wong, Tien-Yin
Taylor, Kent D.
Kaab, Stefan
Smith, J. Gustav
Lakatta, Edward L.M.
Salfati, Elias
Appel, Emil V.
Girotto, Giorgia
de Geus, Eco J. C.
Cocca, Massimiliano
Rao, Dabeeru C.
Tarasov, Kirill V.
Schraut, Katharina E.
Schurmann, Claudia
van Duijn, Cornelia M.
Mononen, Nina
Ring, Susan M.
Milaneschi, Yuri
Burgess, Stephen
Dorr, Marcus
Wilson, James F.
Padmanabhan, Sandosh
Franke, Andre
Tan, Nicholas
Vollenweider, Peter
Kooner, Jaspal S.
Lahti , Jari
Lehtimaki, Terho
Snieder, Harold
Wang , Lihua
Kardia, Sharon L. R.
Robino, Antonietta
Palmer, Colin N. A.
Nolte, Ilja M.
Boehnke, Michael
Gyllensten, Ulf
Weiss, Stefan
Stefansson, Kari
Li, Hengtong L.
Ferrucci, Luigi
Oldehinkel, Albertine J.
Marz, Winfried
Trompet, Stella
Pavani, Francesca
Kahonen, Mika
Porteous, David J.
Luan, Jian’an
van der Ende, M. Yldau
Hwang, ShihJen
Kraft, Peter
Psaty, Bruce M.
Raitakari, Olli T.
Noordam, Raymond
Mohlke, Karen L.
Brody, Jennifer A.
Witte, Daniel R.
den Hoed, Marcel
Chambers, John C.
Qi, Lu
Galesloot, Tessel E.
Pistis, Giorgio
Kiemeney, Lambertus A. L. M.
Melander, Olle
Auro, Kirsi
Pechlivanis, Sonali
de Vries, Paul S.
Holm, Hilma
Iribarren, Carlos
Lind, Lars
Zeng, Linyao
van der Most, Peter J.
Foco, Luisa
Hayward, Caroline
Timpson, Nicholas J.
Peters, Annette
Feitosa, Mary F.
Quek, Debra Q.
Strauch, Konstantin
Zhao, Jing
Rotter, Jerome I.
Degenhardt, Frauke
Verweij, Niek
Groop, Leif
Ingelsson, Martin
Schunkert, Heribert
Bouchard, Claude
Hagemeijer, Yanick P.
Joshi, Peter K.
Moebus, Susanne
Bandinelli, Stefania
Tai, E. Shyong
Mahendran, Yuvaraj
Erdmann, Jeanette
Jackson, Anne U.
Muller-Nurasyid, Martina
Zhang, Weihua
Eriksson, Johan G.
Tan, Vanessa Y.
Sim, Xueling S.
Sveinbjornsson, Gardar
van den Berg, Marten E.
Sotoodehnia, Nona
Mook-Kanamori, Dennis O.
Roselli, Carolina
Heckbert, Susan R.
Cornelis, Marilyn C.
Penninx, Brenda W. J. H.
Lieb, Wolfgang
Lyytikainen, Leo-Pekka
Cheng, Ching-Yu
Ladenvall, Claes
Correa, Adolfo
Eijgelsheim, Mark
Kolcic, Ivana
Waldenberger, Melanie
Isaacs, Aaron
Grarup, Niels
Jukema, J. Wouter
Faul, Jessica D.
Munroe, Patricia B.
Lin, Henry J.
de Graaf, Jacqueline
Loos, Ruth J. F.
Polasek, Ozren
Johansson, Åsa
Macfarlane, Peter W.
van der Harst, Pim
Salo, Perttu
Rueedi, Rico
Nethander, Maria
Cusi, Daniele
Sinner, Moritz F.
Weir, David R.
Peyser, Patricia A.
Arking, Dan E.
Said, M. Abdullah
Opis:: Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals 493 independent genetic variants in 352 loci, including 68 genetic variants outside previously identified resting heart rate associated loci. We prioritize 670 genes and in silico annotations point to their enrichment in cardiomyocytes and provide insights in their ECG signature. Two-sample Mendelian randomization analyses indicate that higher genetically predicted resting heart rate increases risk of dilated cardiomyopathy, but decreases risk of developing atrial fibrillation, ischemic stroke, and cardio-embolic stroke. We do not find evidence for a linear or non-linear genetic association between resting heart rate and all-cause mortality in contrast to our previous Mendelian randomization study. Systematic alteration of key differences between the current and previous Mendelian randomization study indicates that the most likely cause of the discrepancy between these studies arises from false positive findings in previous one-sample MR analyses caused by weak-instrument bias at lower P-value thresholds. The results extend our understanding of resting heart rate biology and give additional insights in its role in cardiovascular disease development.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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