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    Wyświetlanie 1-6 z 6
    Tytuł:
    Association of Factor V Leiden With Subsequent Atherothrombotic Events : a GENIUS-CHD Study of Individual Participant Data
    Autorzy:
    Delgado, Graciela
    Pilbrow, Anna
    Wallentin, Lars
    Lang, Chim
    Nikus, Kjell
    Patel, Riyaz
    Simon, Tabassome
    Gong, Yan
    Pare, Guillaume
    Deloukas, Panos
    James, Stefan
    Laurikka, Jari
    Szczeklik, Wojciech
    Holmes, Michael
    Muehlschlegel, Jochen
    Stewart, Alexandre
    Hartiala, Jaana
    Hovingh, G.
    Dudbridge, Frank
    Richards, A.
    Baranova, Ekaterina
    Scholz, Markus
    Cresci, Sharon
    Gijsberts, Crystel
    McPherson, Ruth
    Tang, W.H.
    Danchin, Nicolas
    Burkhardt, Ralph
    McCubrey, Raymond
    Mahmoodi, Bakhtawar
    Pepine, Carl
    Grobbee, Diederick
    Kleber, Marcus
    Direk, Kenan
    ten Berg, Jurriën
    Johnson, Julie
    Levin, Daniel
    Bots, Michiel
    Kaczor, Marcin
    Doughty, Robert
    Schmidt, Amand
    van Setten, Jessica
    Sanak, Marek
    Lenzini, Petra
    Klungel, Olaf
    Cooper-DeHoff, Rhonda
    Body, Simon
    Hingorani, Aroon
    van der Laan, Sander
    Tragante, Vinicius
    Nelson, Christopher
    Deanfield, John
    Spertus, John
    Held, Claes
    Kähönen, Mika
    Sattar, Naveed
    Lehtimäki, Terho
    Visseren, Frank
    Teren, Andrej
    Allayee, Hooman
    Waltenberger, Johannes
    Hoefer, Imo
    Maitland-van der Zee, Anke
    Akerblom, Axel
    Kraaijeveld, Adriaan
    Palmer, Colin
    Kuukasjarvi, Pekka
    Eriksson, Niclas
    Mordi, Ify
    Hazen, Stanley
    Heydarpour, Mahyar
    Pasterkamp, Gerard
    März, Winfried
    Hagström, Emil
    Asselbergs, Folkert
    Bergmeijer, Thomas
    Cameron, Vicky
    Lyytikäinen, Leo-Pekka
    Thiery, Joachim
    Braund, Peter
    Samani, Nilesh
    Vilmundarson, Ragnar
    Howe, Laurence
    Kotti, Salma
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease : a molecular and genetic association study
    Autorzy:
    Hoefer, Imo E.
    Delgado, Graciela
    Lee, Vei-Vei
    Lenzini, Petra A.
    Kofink, Daniel
    Wallentin, Lars
    Schnabel, Renate B.
    Gong, Yan
    Mons, Ute
    Szczeklik, Wojciech
    Braund, Peter S.
    Kleber, Marcus E.
    Smit, Roelof A.J.
    Quyyumi, Arshed A.
    Blankenberg, Stefan
    Waldeyer, Christoph
    Jennings, Richard T.
    Asselbergs, Folkert W.
    Scholz, Markus
    Labos, Christopher
    Laufs, Ulrich
    Cresci, Sharon
    Smith, J. Gustav
    McPherson, Ruth
    Fliser, Danilo
    Drexel, Heinz
    Klug, Mira
    Hartiala, Jaana A.
    Svingen, Gard Frodahl Tveitevag
    Vilmundarson, Ragnar O.
    Nelson, Christopher P.
    Pilote, Louise
    Karp, Igor
    Richards, A. Mark
    Direk, Kenan
    Sinning, Christoph
    Scharnagl, Hubert
    Petrakis, Ioannis
    Girelli, Domenico
    Doughty, Robert N.
    Leiherer, Andreas
    Saely, Christoph H.
    Johnson, Julie
    Ko, Yi-An
    Bogaty, Peter
    Virani, Salim S.
    Kaczor, Marcin
    Spertus, John A.
    Tang, W.H. Wilson
    Schmidt, Amand F.
    Kramer, Bernhard K.
    Sinisalo, Juha
    Siegbahn, Agneta
    Ringdal Pedersen, Eva
    Beutner, Frank
    Horne, Benjamin D.
    Tell, Grethe S.
    Marz, Winfried
    Trompet, Stella
    Ballantyne, Christie M.
    Mundlein, Axel
    Nygard, Ottar
    Hagstrom, Emil
    Sanak, Marek
    Cooper-DeHoff, Rhonda
    Cameron, Vicky A.
    Hingorani, Aroon
    Tragante, Vinicius
    Laaksonen, Reijo
    Speer, Thimoteus
    Held, Claes
    Patel, Riyaz S.
    Breitling, Lutz P.
    Sattar, Naveed
    Werner, Christian
    Filips, Alexandra
    Allayee, Hooman
    Holmes, Michael V.
    Akerblom, Axel
    Brenner, Herrmann
    Martinelli, Nicola I.
    Thanassoulis, George
    Eriksson, Niclas
    Nieminen, Markku S.
    Stojakovic, Tatjana
    Koenig, Wolfgang
    Boerwinkle, Eric
    Pilbrow, Anna P.
    Samani, Nilesh J.
    Pasterkamp, Gerard
    Brophy, James M.
    Stewart, Alexandre F. R.
    Vlachopoulou, Efthymia
    Engert, James C.
    Rothenbacher, Dietrich
    Zewinger, Stephen
    Jukema, J. Wouter
    Thiery, Joachim
    McCubrey, Raymond O.
    Hazen, Stanley L.
    Groesdonk, Heinrich V.
    Olivieri, Oliviero
    Triem, Sarah
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Subsequent event risk in individuals with established coronary heart disease : design and rationale of the GENIUS-CHD consortium
    Autorzy:
    Sun, Yan
    Delgado, Graciela
    Carpeggiani, Clara
    Pilbrow, Anna
    Lee, Vei-Vei
    Kofink, Daniel
    Wallentin, Lars
    Fox, Keith
    Lang, Chim
    Nikus, Kjell
    Patel, Riyaz
    Mahmoodi, B.
    Simon, Tabassome
    Gong, Yan
    Pare, Guillaume
    Al Ali, Lawien
    Deloukas, Panos
    Mons, Ute
    James, Stefan
    Laurikka, Jari
    Szczeklik, Wojciech
    ten Berg, Jurrien
    Holmes, Michael
    Kaminski, Karol
    van der Graaf, Yolanda
    Quyyumi, Arshed
    Muehlschlegel, Jochen
    Stender, Steen
    Dube, Marie-Pierre
    Stewart, Alexandre
    Brenner, Hermann
    Hartiala, Jaana
    Hovingh, G.
    Brugts, Jasper
    Jukema, J.
    Dudbridge, Frank
    Richards, A.
    Baranova, Ekaterina
    Van de Werf, Frans
    Scholz, Markus
    Fitzpatrick, Natalie
    Cresci, Sharon
    Gijsberts, Crystel
    Niemcunowicz-Janica, Anna
    McPherson, Ruth
    Lotufo, Paulo
    Tang, W.H.
    Drexel, Heinz
    Alver, Maris
    Danchin, Nicolas
    Burkhardt, Ralph
    Wilde, Arthur
    Anderson, Jeffrey
    McCubrey, Raymond
    Marziliano, Nicola
    Pereira, Alexandre
    Pepine, Carl
    Pilote, Louise
    Saely, Christoph
    Carlquist, John
    Grobbee, Diederick
    Kleber, Marcus
    Direk, Kenan
    Lindholm, Daniel
    Martinelli, Nicola
    Sandesara, Pratik
    Ardissino, Diego
    Girelli, Domenico
    Leiherer, Andreas
    Johnson, Julie
    Bogaty, Peter
    Lagerqvist, Bo
    Lehtimaki, Terho
    Arsenault, Benoit
    Levin, Daniel
    Bots, Michiel
    Kaczor, Marcin
    Doughty, Robert
    Virani, Salim
    Sinisalo, Juha
    Siegbahn, Agneta
    Boersma, Eric
    Wauters, Els
    Algra, Ale
    Duarte, Nubia
    Lokki, Marja-Liisa
    Engert, James
    Smith, J.
    Schmidt, Amand
    Trompet, Stella
    Marz, Winfried
    Kettner, Jiri
    van Setten, Jessica
    Hagstrom, Emil
    Sanak, Marek
    Boeckx, Bram
    Lenzini, Petra
    Klungel, Olaf
    Cooper-DeHoff, Rhonda
    Body, Simon
    Kahonen, Mika
    Hingorani, Aroon
    Breitling, Lutz
    van der Laan, Sander
    Tragante, Vinicius
    Pitha, Jan
    Samman-Tahhan, Ayman
    Szpakowicz, Anna
    Nelson, Christopher
    Tanck, Michael
    Deanfield, John
    Spertus, John
    Held, Claes
    Tfelt-Hansen, Jacob
    Condorelli, Gianluigi
    Horne, Benjamin
    Ballantyne, Christie
    Sattar, Naveed
    Melander, Olle
    Metspalu, Andres
    Tardif, Jean-Claude
    Visseren, Frank
    Ford, Ian
    Teren, Andrej
    Allayee, Hooman
    Waltenberger, Johannes
    Foco, Luisa
    Hoefer, Imo
    Maitland-van der Zee, Anke
    Jabbari, Reza
    Muhlestein, Joseph
    Akerblom, Axel
    Kuukasjarvi, Pekka
    Palmer, Colin
    Stott, David
    Engstrom, Thomas
    Thanassoulis, George
    Eriksson, Niclas
    de Faire, Ulf
    Hubacek, Jaroslav
    Lambrechts, Diether
    Hazen, Stanley
    Boerwinkle, Eric
    Glinge, Charlotte
    Heydarpour, Mahyar
    Pasterkamp, Gerard
    Dufresne, Line
    Bezzina, Connie
    Newton-Cheh, Christopher
    Behlouli, Hassan
    Anselmi, Chiara
    Casu, Gavino
    Lyytikainen, Leo-Pekka
    Leander, Karin
    Vlachopoulou, Efthymia
    Gigante, Bruna
    Andreassi, Maria
    Bergmeijer, Thomas
    Cameron, Vicky
    Asselbergs, Folkert
    Kiliszek, Marek
    Carruthers, Kathryn
    Thiery, Joachim
    Brophy, James
    Braund, Peter
    Fox, Kim
    Almgren, Peter
    Hemingway, Harry
    Briguori, Carlo
    Timmis, Adam
    van der Harst, Pim
    Opolski, Grzegorz
    Samani, Nilesh
    Vilmundarson, Ragnar
    Howe, Laurence
    Ploski, Rafal
    Torp-Pedersen, Christian
    Olivieri, Oliviero
    Kotti, Salma
    Opis:
    BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events. RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%–91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints. CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Association of chromosome 9p21 with subsequent coronary heart disease events : a GENIUS-CHD study of individual participant data
    Autorzy:
    Kaminski, Karol A.
    Allayee, Hooman
    Boeckx, Bram
    Kuukasjarvi, Pekka
    Gijsberts, Crystel M.
    Carlquist, John F.
    Dube, Marie-Pierre
    Leander, Karin
    Hemingway, Harry
    Hoefer, Imo E.
    Stewart, Alexandre F.R.
    Thanassoulis, George
    Saely, Christoph H.
    Held, Claes
    Olivieri, Oliviero
    Nelson, Christopher P.
    Cresci, Sharon
    Lee, Vei-Vei
    Cooper-DeHoff, Rhonda M.
    Kaczor, Marcin
    Briguori, Carlo
    Thiery, Joachim
    Anderson, Jeffrey L.
    Kleber, Marcus
    Smith, J. Gustav
    Burkhardt, Ralph
    de Faire, Ulf
    Leiherer, Andreas
    Nikus, Kjell
    Ford, Ian
    Vlachopoulou, Efthymia
    Almgren, Peter
    Pilbrow, Anna P.
    Body, Simon C.
    Lang, Chim C.
    Gigante, Bruna
    ten Berg, Jurrien M.
    Algra, Ale
    Pitha, Jan
    James, Stefan
    Hartiala, Jaana
    Eriksson, Niclas
    Howe, Laurence J.
    Direk, Kenan
    Drexel, Heinz
    Szpakowicz, Anna
    Pare, Guillaume
    Akerblom, Axel
    Schmidt, Amand F.
    Hubacek, Jaroslav A.
    Sanak, Marek
    Virani, Salim S.
    Vilmundarson, Ragnar O.
    Wilde, Arthur A.M.
    Van de Werf, Frans J.
    Pepinski, Witold
    Waltenberger, Johannes
    Arsenault, Benoit J.
    Maitland-van der Zee, Anke H.
    McPherson, Ruth
    McCubrey, Raymond O.
    Stott, David J.
    Sattar, Naveed
    Breitling, Lutz P.
    Ploski, Rafal
    Wauters, Els
    Boerwinkle, Eric
    Hazen, Stanley L.
    Muhlestein, Joseph B.
    Johnson, Julie A.
    Kofink, Daniel
    Spertus, John A.
    Wallentin, Lars
    Cheh, Chris Newton
    Pereira, Alexandre C.
    Lotufo, Paulo A.
    Pilote, Louise
    Gong, Yan
    Bezzina, Connie R.
    Melander, Olle
    Condorelli, Gianluigi
    Hovingh, G. Kees
    Carpeggiani, Clara
    Horne, Benjamin D.
    Casu, Gavino
    Hingorani, Aroon D.
    Patel, Riyaz S.
    Deloukas, Panos
    Samman-Tahhan, Ayman
    Dufresne, Line
    Lyytikainen, Leo-Pekka
    Ardissino, Diego
    Brenner, Hermann
    Ballantyne, Christie M.
    Mordi, Ify R.
    Sinisalo, Juha
    Alver, Maris
    Pasterkamp, Gerard
    Holmes, Michael V.
    Heydarpour, Mahyar
    Opolski, Grzegorz
    Carruthers, Kathryn F.
    Laurikka, Jari O.
    Siegbahn, Agneta
    Girelli, Domenico
    Mahmoodi, Bakhtawar K.
    Marziliano, Nicola
    Marz, Winfried
    Behlouli, Hassan
    Duarte, Nubia E.
    Foco, Luisa
    Fox, Keith A.A.
    Trompet, Stella
    van der Graaf, Yolanda
    Visseren, Frank L.J.
    Lagerqvist, Bo
    Metspalu, Andres
    Scholz, Markus
    van der Harst, Pim
    Cameron, Vicky A.
    Wilson Tang, W.H.
    de Borst, Gert J.
    Mons, Ute
    Tragante, Vinicius
    Quyyumi, Arshed A.
    Samani, Nilesh J.
    Bergmeijer, Thomas O.
    Palmer, Colin N.
    Braund, Peter S.
    Asselbergs, Folkert W.
    Fitzpatrick, Natalie
    Tardif, Jean-Claude
    Pepine, Carl J.
    Levin, Daniel
    Richards, A. Mark
    Doughty, Robert N.
    Tanck, Michael W.T.
    Lindholm, Daniel
    de Jong, Pim A.
    Brophy, James M.
    Lambrechts, Diether
    van der Laan, Sander W.
    Anselmi, Chiara Viviani
    Lenzini, Petra A.
    Timmis, Adam
    Muehlschlegel, Jochen D.
    Jukema, J. Wouter
    Hagstrom, Emil
    van Setten, Jessica
    Dudbridge, Frank
    Baranova, Ekaterina V.
    Lokki, Marja-Liisa
    Sandesara, Pratik B.
    Bogaty, Peter
    Andreassi, Maria G.
    Teren, Andrej
    Deanfield, John
    Martinelli, Nicola
    Engert, James C.
    Kahonen, Mika
    Klungel, Olaf H.
    Kiliszek, Marek
    Delgado, Graciela
    Kettner, Jiri
    Lehtimaki, Terho
    Szczeklik, Wojciech
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
      Wyświetlanie 1-6 z 6

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