Autor: Patel, D. A. - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Sustain release Formulation and Evaluation of Ofloxacin floating delivery system
Autorzy:: Patel, A. J.
Naik, D. R.
Raval, J. R.
Tematy:: ofloxacin
ethyl cellulose
xanthum gum
floating drug delivery System
controlled release; Pokaż więcej
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Powiązania:: https://bibliotekanauki.pl/articles/412207.pdf Link otwiera się w nowym oknie
Opis:: Floating tablets has been accepted as a process to achieve controlled drug delivery by prolonging the residence time of the dosage form at the site of absorption, thereby improving and enhancing the bioavailability of drug. The objective of present study outlines the development and characterization the floating drug delivery system of Ofloxacin to enhance its bioavailability and therapeutic efficacy, using different grades of polymer along with effervescent agent sodium bicarbonate and citric acid. Ofloxacin is a synthetic chemotherapeutic second-generation antibiotic of the fluoroquinolone class. Different tablet formulations were formulated by wet granulation technique and were evaluated for physical parameters like Tablet Thickness, Hardness, % Friability, Weight variation, Content uniformity, In vitro buoyancy, Swelling index, In vitro dissolution study and drug release mechanisms. As the concentration of the polymer in the formulations increased the release of drug decreased. Hence it was considered as suitable candidate for formulation as floating drug delivery system. Different kinetic models were applied to drug release data in order to evaluate release mechanisms and kinetics. The optimized formula F4 showed better sustained drug release with good floating properties and fitted best to be Korsmeyer-Peppas model with R2 value of 0.9575. As the n value for the Korsmeyer- Peppas model was found be more than 0.5 it follows Non-Fickian diffusion mechanism. FTIR result showed that there is no drug excipients interaction.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Supernova model discrimination with Hyper-Kamiokande
Autorzy:: Mineev, O.
Minakata, H.
Nakayoshi, K.
Gialanella, L.
Zaldivar, B.
Kato, A.
Kim, S. Y.
Ashida, Y.
Wilkes, R. J.
Garode, S.
Feng, J.
Vilela, C.
Pac, M. Y.
Karlen, D.
Suganuma, T.
Kajita, T.
Paganini, P.
Lu, X.
Gramegna, F.
Nakadaira, T.
Yano, T.
Ostrowski, Michał
Vivolo, D.
Matusiak, M.
Fiorillo, G.
Mazzucato, E.
Finch, A.
Hiraide, K.
Navarro-Garcia, B.
Mondal, T.
Ikeda, M.
Insler, J.
Kudenko, Y.
Sato, K.
Kumita, T.
Malinský, M.
Lamers James, M.
Nascimento Machado, L.
Wronka, S.
Ohta, K.
Iijima, T.
Gornea, R.
Maret, L.
Jeon, S. H.
Lim, I. T.
Fiorentini, A.
Matsumoto, R.
O'Connor, E.
Coleman, J.
Harada, M.
Kikawa, T.
Danilov, M.
Kearns, E.
Yamaguchi, Y.
Magaletti, L.
Cartwright, S. L.
Nishimura, Y.
Jang, J. S.
Radicioni, E.
Vasseur, G.
Barr, G.
Porwit, K.
Nakagiri, K.
La Commara, M.
Learned, J. G.
Hirota, S.
Marchi, T.
Mollo, C. M.
Di Palma, I.
Sakashita, K.
Izmaylov, A.
El Hedri, S.
Tsukamoto, T.
Ochoa-Ricoux, J. P.
Takemoto, Y.
Medhi, A.
Bonavera, L.
Hartz, M.
Pozimski, J.
Zakrzewski, T.
Chabera, M.
Kinoshita, T.
Stankevich, K. L.
Payne, D.
Renner, J.
Doyle, T. A.
Sashima, I.
Matsuno, S.
Takenaka, A.
Loverre, P.
Wachala, T.
Gumplinger, P.
Booth, N.
Onishchuk, Y.
Ichikawa, A. K.
Ovsiannikova, T.
Suzuki, A. T.
Kameda, J.
Sano, S.
Yoo, J.
Nakai, S.
Hartfiel, B.
Jiang, M.
Moon, C. S.
Pari, M.
Jamieson, B.
Hoshina, K.
Nakajima, Y.
Feusels, T.
Ruggles, C.
Drapier, O.
Prouse, N. W.
Kurjata, R.
Mefodiev, A.
Sekiguchi, T.
Aushev, V.
Labarga, L.
Blanchet, A.
Uchida, Y.
Berardi, V.
Yokoyama, M.
Evangelisti, A.
Kormos, L. L.
Yeum, D. N.
Wendell, R. A.
Iacob, F.
Ogawa, N.
O'Sullivan, E.
Yamamoto, K.
Itow, Y.
Boyd, S. B.
Pasternak, J.
Ruggeri, A. C.
Ozaki, H.
Boiano, A.
Smy, M. B.
Roth, S.
Kim, S. B.
Ferrazzi, B.
Xie, Z.
Xin, T.
Stellacci, S. M.
Fukuda, Y.
Kouzakov, K. A.
Kim, J. H.
Sobczyk, J.
Drakopoulou, E.
Miki, S.
De la Fuente, E.
Munteanu, L.
Yu, M.
Hernando-Morata, J. A.
Longhin, A.
Orozco-Luna, F.
Zarnecki, G.
Korzenev, A.
Spina, R.
Lamoureux, M.
Mongelli, M.
Tzanov, M.
Ioannisian, A.
Cafagna, F. S.
Mermod, P.
González-Nuevo, J.
Carroll, A.
Garde, C.
Grella, G.
Bernardini, E.
Palladino, V.
Kravchuk, L.
Boschi, T.
Playfer, S.
Tanaka, M.
Suvorov, S.
Rountree, S. D.
Aihara, H.
Buchowicz, A.
Ameli, F.
Akutsu, R.
Hassani, S.
Mahn, K.
Fernández-Martinez, E.
Cicerchia, M.
Barker, G. J.
Martin, D.
Idrissi Ibnsalih, W.
Anghel, I.
Fernandez, P.
Jonsson, P.
Cook, L.
Ishida, T.
Wark, D.
Martin, J. F.
Borjabad, S.
Checchia, C.
Seo, J. W.
Lindner, T.
Pavin, M.
Mora, F. J.
Miura, M.
Mellet, L.
Russo, S.
Sobel, H. W.
Taketa, A.
Ziembicki, M.
Khotjantsev, A.
Nakahata, M.
Di Meo, P.
Fujii, Y.
Daz Lopez, G.
Riccio, C.
Wilson, J. R.
Ito, S.
Marinelli, A.
Jang, H. I.
Shimizu, I.
Collazuol, G.
Finley, C.
Niewczas, K.
Gorin, A.
Berns, L.
Antonova, M.
Guigue, M.
Densham, C. J.
Sarmah, P.
Poutissou, J. -M.
Bozza, C.
McGrew, C.
Calabria, N. F.
Ito, H.
Bhadra, S.
Peña-Garay, C.
Shiozawa, M.
Skwarczynski, K.
Mariani, C.
Kakuno, H.
Magar, K.
Konaka, A.
Galinski, G.
Ludovici, L.
Taani, M.
Yen, S.
Friend, M.
Shaykina, A.
Cuen-Rochin, S.
Soler, F. J. P.
Jakkapu, M.
Mezzetto, M.
Murase, K.
Pointon, B. W.
Miller, E. W.
Marti, Ll.
Shin, C. D.
Dumarchez, J.
Kryukov, A. P.
Kasperek, J.
Ishidoshiro, K.
Nakamura, KI.
Pastore, C.
Inomoto, M.
Gomez-Cadenas, J. J.
Suárez Gómez, S. L.
Kisiel, J.
Lee, J.
Popov, A.
Patel, D. A.
Vijayvargi, A.
Ellis, J.
Joo, K. K.
Khabibullin, M.
Suzuki, Y.
Grassi, M.
Minamino, A.
Svoboda, R.
Malek, M.
Walker, J.
Zalipska, J.
Menjo, H.
Rubbia, A.
Fitton, M.
Rajda, P. J.
Shinoki, M.
Valentino, V.
Tada, M.
Santucci, G.
Horiuchi, S.
Giganti, C.
Mehta, P.
Seo, S. H.
Kotsar, Y.
Vyalkov, M. M.
Holin, A.
Choubey, S.
Studenikin, A. I.
Quiroga, A. A.
Esmaili, A.
Ishino, H.
Bronner, C.
Kobayashi, T.
Bravo-Berguño, D.
Okumura, K.
Radics, B.
Koshio, Y.
Cao, S.
Ishitsuka, M.
Long, K. R.
Sgalaberna, D.
Makida, Y.
Vagins, M. R.
Monrabal, F.
Di Lodovico, F.
Bolognesi, S.
Bose, D.
Kazarian, N.
Kalaczynski, P.
Pinzon Guerra, E.
Esteve, R.
Kataoka, Y.
Ogitsu, T.
Takeuchi, Y.
Stopa, K.
Kano, Y.
Parsa, S.
Asaoka, Y.
Deshmukh, N.
Blaszczyk, F. d. M.
Hastings, N. C.
Quilain, B.
Suzuki, S. Y.
Koga, M.
Litchfield, R. P.
Richards, B.
Feely, M.
Laveder, M.
McCarthy, M.
Tortone, G.
Rondio, E.
Migliozzi, P.
Kwak, K.
Inoue, K.
Przewlocki, P.
Abe, K.
Naseby, C. E. R.
Nakaya, T.
Pronost, G.
Takhistov, V.
Metelko, C.
Bellato, M.
Popov, B.
Rychter, A.
de Perio, P.
Sonoda, Y.
Nakamura, H.
Frankiewicz, K.
Bian, J.
Batkiewicz-Kwasniak, M.
Hill, J.
Nicholls, T.
Yershov, N.
Nakayama, S.
Lagoda, J.
Santos, J. D.
Spisso, B.
Pidcott, C.
Roskovec, B.
Bubak, A.
Tomatani-Sánchez, A. K.
Zsoldos, S.
Izumi, N.
Sinnis, G.
Moharana, R.
Sánchez, M. L.
Bravar, A.
Dunne, P.
Ferrario, P.
Scott, M.
Obrebski, W.
Retiere, F.
Kikec, M.
Dergacheva, A.
Alekseev, I.
Gonin, M.
Gao, J.
Bandac, I.
Hadley, D. R.
Samani, S.
Anthony, L. H. V.
Rott, C.
O'Keeffe, H. M.
Noah, E.
Skrobova, N.
Migenda, J.
Hayato, Y.
Araya, A.
Nakamura, K.
Eklund, L.
Suwa, Y.
Tanaka, H. I.
Leitner, R.
Fedotov, S.
Ryu, D.
Garfagnini, A.
Kowalik, K. L.
De Rosa, G.
King, S.
Xia, J.
Blondel, A.
Kutter, T.
Spradlin, P.
Bernard, L.
Chakraborty, S.
Emery, S.
Ospina, N.
Pastuszak, G.
Bergevin, M.
Catanesi, M. G.
Koch, L.
Kolev, N.
Ziętara, Krzysztof
Jo, H. S.
Nagao, Y.
Lawe, M.
Okamoto, K.
Ballester, F.
Maekawa, Y.
Iwamoto, K.
Cebriàn, S.
Ricciardi, G.
Zaremba, K.
Mueller, Th. A.
Rescigno, M.
Moon, D. H.
Matsubara, T.
Dziewiecki, M.
Herrero, V.
Oyama, Y.
Zito, M.
Cowan, G.
Tanaka, H.
Dealtry, T.
Koerich, L.
Stawarz, Łukasz
Yu, I.
Jenkins, S. J.
Yonenaga, M.
Lavitola, L.
Needham, M.
Calvo-Mozota, J. M.
Buizza Avanzini, M.
Ali, A.
Moriyama, S.
Sanchez, M. C.
Adrich, P.
Thiesse, M.
Tsui, K. M.
Vinning, W. G. S.
Yanagisawa, C.
Kuze, M.
Brown, L.
Sánchez, F.
Wilking, M. J.
Klekotko, A.
Gousy-Leblanc, V.
Lezaun, V.
McElwee, J.
Choi, J. H.
O'Sullivan, L.
Mitra, A.
Takeda, A.
Thompson, L. F.
Tanaka, H. A.
Mijakowski, P.
Kim, J. Y.
Paolone, V.
Sekiya, H.
Nova, F.
Seiya, Y.
Mine, S.
Shan, Z.
Nakano, Y.
Katori, T.
Barbi, M.
Marzec, J.
Rose, H. J.
Posiadala-Zezula, M.
McCauley, N.
Wascko, M. O.
Oshlianskyi, A.
Nugent, J. C.
Martens, K.
Nunokawa, H.
Svirida, D.
Hultqvist, K.
Shaikhiev, A.
Devi, M. M.
Vladisavljevic, T.
Tashiro, T.
Toledo, J.
Vogelaar, R. B.
Izumiyama, S.
Valder, S.
Opis:: Core-collapse supernovae are among the most magnificent events in the observable universe. They produce many of the chemical elements necessary for life to exist and their remnants—neutron stars and black holes—are interesting astrophysical objects in their own right. However, despite millennia of observations and almost a century of astrophysical study, the explosion mechanism of core-collapse supernovae is not yet well understood. Hyper-Kamiokande is a next-generation neutrino detector that will be able to observe the neutrino flux from the next galactic core-collapse supernova in unprecedented detail. We focus on the first 500 ms of the neutrino burst, corresponding to the accretion phase, and use a newly-developed, high-precision supernova event generator to simulate Hyper-Kamiokande's response to five different supernova models. We show that Hyper-Kamiokande will be able to distinguish between these models with high accuracy for a supernova at a distance of up to 100 kpc. Once the next galactic supernova happens, this ability will be a powerful tool for guiding simulations toward a precise reproduction of the explosion mechanism observed in nature.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 3.

Tytuł:: Congestive myelopathy due to intradural spinal AVM supplied by artery of Adamkiewicz : case report with brief literature review and analysis of the Foix-Alajouanine syndrome definition
Autorzy:: Mistry, Kewal A.
Garg, Swati
Patel, Ankitkumar
Chadha, Veenal
Sood, Dinesh
Patel, Dhruv G.
Khatri, Garvit D.
Suthar, Pokhraj P.
Opis:: BACKGROUND: Spinal arteriovenous malformations (AVMs) can lead to development of congestive myelopathy (Foix-Alajouanine syndrome). Spinal AVMs are rare and so is this syndrome. Diagnosis is often missed due to its rarity and confusing definitions of the Foix-Alajouanine syndrome. CASE REPORT: We report a case of a 47-year-old male patient suffering from this rare syndrome with an AVM arising from the artery of Adamkiewicz, which is another rarity. Our patient was treated by embolization of the lesion with 20% glue, after which he showed mild improvement of symptoms. We also present a brief review of literature on spinal AVMs and elucidate the evolution of the term Foix-Alajouanine syndrome. CONCLUSIONS: Use of the term "Foix-Alajouanine syndrome" should be restricted to patients with progressive subacute to chronic neurological symptoms due to congestive myelopathy caused by intradural spinal AVMs. CT angiography should supplement DSA as preliminary Imaging modality. Patients may be treated with surgery or endovascular procedures.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 4.

Tytuł:: Membranous IVC obstruction presenting with antegrade/retrograde respiratory flow in the intrahepatic segment in Doppler imaging and prostatic and urethral congestion
Autorzy:: Sharma, Sarthak
Patel, Dhruv G.
Mistry, Kewal A.
Morey, Parikshit D.
Chadha, Veenal
Suthar, Pokhraj P.
Sood, Dinesh
Opis:: BACKGROUND: Obstruction of the inferior vena cava (IVC) is infrequent, membranous obstruction of the IVC (MOIVC) being one of its rare causes. Early diagnosis is important, as it can lead to hepatic congestion, cirrhosis and Budd-Chiari syndrome (BCS) and can predispose to development of hepatocellular carcinoma (HCC) in severe cases. CASE REPORT: We report a case of membranous IVC obstruction at the junction of hepatic and suprahepatic segments in a young male with extensive collateralization and venous aneurysms. Unique findings involved antegrade and retrograde flow during respiration in the upper part of intrahepatic IVC proximal to a large collateral vein as well as prostatic and urethral congestion leading to intermittent urinary hesitancy, which have not yet been described in such cases. CONCLUSIONS: MOIVC is a rare cause of IVC obstruction with typical radiological features. Early diagnosis and management is required due to risk of cirrhosis and HCC. Antegrade and retrograde flow may be seen in incomplete MOIVC above the level of a large collateral vein and it may lead to prostatic and urethral congestion.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 5.

Tytuł:: Association of hand grip strength with psychological stress, exercise habits and body composition amongst medical students: a cross-sectional study
Autorzy:: Barre, Samira
Inyingi, Laura
Orrego Castellanos, Julianna
Patel, Agastya
Ruckemann-Dziurdzinska, Katarzyna A.
Bryl, Ewa D.
Witkowski, Jacek M.
Tematy:: exercise
psychological stress
medical students
Hand grip strength; Pokaż więcej
Wydawca:: Gdański Uniwersytet Medyczny
Powiązania:: https://bibliotekanauki.pl/articles/33897312.pdf Link otwiera się w nowym oknie
Opis:: Background The aim of this study was to assess the effectiveness of hand grip strength (HGS) test in identifying highly stressed individuals and to examine the effect of exercise and lifestyle on HGS and stress measures. Material and methods It is cross-sectional study. Students of the Medical University of Gdańsk, Poland were asked to fill out a questionnaire, undergo body composition analysis, perform HGS test and provide a saliva sample for cortisol measurement. Results Self-rated stress (SRS) was significantly higher in pre-clinical years (PCY) compared to clinical years (CY). HGS was significantly lower in PCY males than CY males. Participants who performed some form of exercise had significantly higher HGS compared with those who did not exercise. A positive correlation between HGS and BMI was noted. Students with low HGS were found to have lower levels of salivary cortisol (SC). However, there was no significant difference in SC levels between PCY and CY students. Conclusions HGS may be a reliable method of identifying stressed individuals and promoting healthy lifestyle behaviors. HGS testing is a safe, cheap and easy to perform method for a large number of participants while being time economical.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Synthesis and Characterization of N-Methyl Indole Derivatives via Desulfitative Displacement by Various Amines and Its Antimicrobial Activity
Autorzy:: Chodvadiya, Vijay D.
Pambhar, Kaushik D.
Parmar, Nilesh D.
Dhamsaniya, Ashish P.
Safi, Shahrukh khan A.
Chhatbar, Pratiksha V.
Ram, Hemal N.
Khunt, Ranjan C.
Patel, P. K.
Tematy:: Anti-microbial agents
Desulfitative displacement
N-methyl indole
S-methyl; Pokaż więcej
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Powiązania:: https://bibliotekanauki.pl/articles/1065130.pdf Link otwiera się w nowym oknie
Opis:: A modular three step synthetic approach of N-methyl indole derivatives has been carried out by the condensation of N-methyl indole with cyanoacetic acid using acetic anhydride as solvent to yield 3-cyanoacetyl N-methyl indole, which further reacts with carbon disulphide and methyl iodide in basic condition to obtain 2-(1-methyl-1H-indole-3-carbonyl)-3,3-bis(methylthio)acrylonitrile as a scaffold. Subsequent, the scaffold when reacts with substituted various amine derivatives via desulfitative displacement forms new derivatives of 3-((substitutedphenyl)amino)-2-(1-methyl-1H-indole-3-carbonyl)-3-(methylthio)acrylonitrile in moderate to good yields. All the novel compounds were evaluated for their antimicrobial activity against Gram+ve and Gram-ve bacteria and different fungal species which demonstrated well to moderate antimicrobial activity.
Dostawca treści:: Biblioteka Nauki