- Tytuł:
- Synthesis and characterization of novel 2-oxo-4-((4-(3-oxomorpholino)phenyl)amino)-2H-chromene-3-carbonitrile derivatives
- Autorzy:
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Jilariya, Krushnakumar J.
Chodvadiya, Vijay D.
Patel, P. K.
Babariya, Jayesh - Tematy:
-
3-cyano-4chlor coumarin
4-(4-aminophenyl)morpholin-3-one
antimicrobial activity - Pokaż więcej
- Wydawca:
- Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
- Powiązania:
- https://bibliotekanauki.pl/articles/1075711.pdf Link otwiera się w nowym oknie
- Opis:
- A highly functionalized heterocyclic library were synthesized, and characterized by common spectroscopic methods. This novel synthetic rout involves nucleophilic substitution reaction of 3-cyano-4chloro coumarin with 4-(4-aminophenyl)morpholin-3-one in the presence of base and methanol as a solvent in good yield and high purity. Key starting material 4-(4-aminophenyl)morpholin-3-one synthesized from aniline. The reaction of aniline with ethylene oxide gives INT-1 which on reaction with Chloroacetyl chloride yield INT-b. Nitration of INT-b gives INT-c, which on reduction with Sn/HCl gives int-D. Further INT-3 was synthesized from 4-hydroxy coumarin. The Vilsmeier-haack reaction of 4-hydroxy coumarin gives INT-01 which on reaction with hydroxylamine hydrochloride and sodium acetate furnished INT-03. All the synthesized compound of libraries characterized using 1H NMR, Mass, and IR spectroscopic technique.
- Dostawca treści:
- Biblioteka Nauki
Artykuł