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Przejdź do strony domowej biblioteki Pedagogiczna Biblioteka Wojewódzka im. Komisji Edukacji Narodowej w Lublinie Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaPedagogiczna Biblioteka Wojewódzka im. Komisji Edukacji Narodowej w Lublinie
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    Wyświetlanie 1-7 z 7
    Tytuł:
    Charakterystyka aktywności fizycznej żołnierzy zawodowych podejmowana w czasie wolnym na przykładzie wybranych Jednostek Wojskowych Sił Powietrznych
    Characteristics of physical activity of professional soldiers in leisure time in chosen air force units
    Autorzy:
    Jaroszuk, J.
    Topolska, A.
    Popowicz, L.
    Miladowski, A.
    Budny, R.
    Wydawca:
    Uniwersytet Szczeciński
    Powiązania:
    https://bibliotekanauki.pl/articles/12831.pdf  Link otwiera się w nowym oknie
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Structure of the stapled p53 peptide bound to Mdm2
    Autorzy:
    Kutchukian, Peter S.
    Baek, Sohee
    Popowicz, Grzegorz M.
    Verdine, Gregory L.
    Huber, Robert
    Holak, Tadeusz
    Lee, Ki Won
    Opis:
    Mdm2 is a major negative regulator of the tumor suppressor p53 protein, a protein that plays a crucial role in maintaining genome integrity. Inactivation of p53 is the most prevalent defect in human cancers. Inhibitors of the Mdm2 − p53 interaction that restore the functional p53 constitute potential nongenotoxic anticancer agents with a novel mode of action. We present here a 2.0 Å resolution structure of the Mdm2 protein with a bound stapled p53 peptide. Such peptides, which are conformationally and proteolytically stabilized with all-hydrocarbon staples, are an emerging class of biologics that are capable of disrupting protein − protein interactions and thus have broad therapeutic potential. The structure represents the first crystal structure of an i , i + 7 stapled peptide bound to its target and reveals that rather than acting solely as a passive conformational brace, a staple can intimately interact with the surface of a protein and augment the binding interface.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Constraining lens masses in moderately to highly magnified microlensing events from Gaia
    Autorzy:
    Carrasco, J. M.
    Tsapras, Y.
    Rybicki, K. A.
    Pylypenko, U.
    Burgaz, U.
    Gurgul, A.
    Bachelet, E.
    Kvernadze, T.
    Mikołajczyk, P. J.
    Simon, A.
    Cassan, A.
    Joachimczyk, B.
    Popowicz, A.
    Qvam, J. K. T.
    Zieliński, P.
    Wyrzykowski, Ł.
    Awiphan, S.
    Stojanovic, M.
    Kaczmarek, Z.
    Ilyin, I.
    Pakstiene, E.
    Cusano, F.
    Jelinek, M.
    Tasuya, O.
    Wicker, M.
    Jabłońska, M.
    Sonbas, E.
    Garofalo, A.
    Hundertmark, M.
    Figuera Jaimes, R.
    Żejmo, M.
    Kurowski, Sebastian
    Ratajczak, M.
    Zdanavicius, J.
    Esenoglu, H. H.
    Damljanovic, G.
    Wambsganss, J.
    Kruszyńska, K.
    Hofbauer, P.
    Dominik, M.
    Bozza, V.
    Udalski, A.
    Güver, T.
    Galdies, C.
    Kotysz, K.
    Davidson, J. W.
    Godunova, V.
    Bąkowska, K.
    Howil, K.
    Rivet, J. P.
    Rota, P.
    Zoła, Stanisław
    Jovanovic, M. D.
    Brincat, S. M.
    Kvaratskhelia, O.
    Reichart, D. E.
    Street, R. A.
    Ihanec, N.
    Fukui, A.
    Sitek, M.
    Opis:
    Context. Microlensing events provide a unique way to detect and measure the masses of isolated, non-luminous objects, particularly dark stellar remnants. Under certain conditions, it is possible to measure the mass of these objects using photometry alone, specifically when a microlensing light curve displays a finite source (FS) effect. This effect generally occurs in highly magnified light curves, i.e. when the source and the lens are very well aligned. Aims. In this study, we analyse Gaia Alerts and Gaia Data Release 3 datasets, identifying four moderate-to-high-magnification microlensing events without a discernible FS effect. The absence of this effect suggests a large Einstein radius, implying substantial lens masses. Methods. In each event, we constrained the FS effect, and therefore established lower limits for the angular Einstein radius and lens mass. Additionally, we used the DarkLensCode software to obtain the mass, distance, and brightness distribution for the lens based on the Galactic model. Results. Our analysis established lower mass limits of ∼0.7 M$_{⊙}$ for one lens and ∼0.3 − 0.5 M$_{⊙}$ for two others. A DarkLensCode analysis supports these findings, estimating lens masses in the range of ∼0.42 − 1.70 M$_{⊙}$ and dark lens probabilities exceeding 80%. These results strongly indicate that the lenses are stellar remnants, such as white dwarfs or neutron stars. Conclusions. While further investigations are required to confirm the nature of these lenses, we demonstrate a straightforward yet effective approach to identifying stellar remnant candidates.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Asteroid sizes determined with thermophysical model and stellar occultations
    Autorzy:
    Libert, M.
    Andersson, S.
    Kulczak, P.
    Horbowicz, J.
    De Groot, H.
    Schreurs, O.
    Ellington, C.
    Nosworthy, P.
    Duffard, R.
    Ferrais, M.
    Carlson, N.
    Oszkiewicz, D.
    Takács, N.
    Yamamura, H.
    Geier, S.
    Hirsch, R.
    Csörnyei, G.
    Murawiecka, M.
    Ďurech, J.
    Wünsche, N.
    Collins, M.
    Eleftheriou, M.
    Pilcher, F.
    Manna, A.
    Lyzenga, G.
    Rottenborn, M.
    Frits, M.
    Kretlow, M.
    Ignácz, B.
    Sonbas, E.
    Liu, Y.
    Dequinze, R.
    Liu, R.
    Polakis, T.
    Błażewicz, D.
    Filipek, M.
    Skrzypek, J.
    Ortiz-Ochoa, A. M.
    Kankiewicz, P.
    Monteiro, F.
    Licandro, J.
    Rutkowski, A.
    Perig, V.
    Żejmo, M.
    Haymes, T.
    Sobkowiak, K.
    Agnetti, D.
    Reddy, V.
    Nadolny, J.
    Hanna, W.
    Zelený, P.
    Sposetti, S.
    Kaplan, M.
    Nosal, P.
    Mizutani, M.
    Polák, J.
    Swift, T.
    Boninsegna, R.
    Poláček, M.
    Nikitin, V.
    Nemoto, T.
    Kudak, V.
    Kamińska, M. K.
    Tychoniec, Ł.
    Szyszka, K.
    Grice, J.
    Marciniak, A.
    Vida, K.
    Bacci, R.
    Eisfeldt, D.
    Michniewicz, O.
    Żukowski, K.
    Lecossois, M.
    Zawilski, M.
    Higgins, D.
    Bacci, P.
    Messner, S.
    Sárneczky, K.
    Urakawa, S.
    Skiff, B.
    Bredner, E.
    Gault, D.
    Dogramatzidis, M.
    Choukroun, A.
    Baruffetti, P.
    Dróżdż, M.
    Kidd, S.
    Rives, J.-J.
    Pawłowski, M.
    Stewart, C.
    Golonka, J.
    Smith, D.
    Ogłoza, W.
    Kubánek, J.
    Saci, K.
    Kim, M.-J.
    Jehin, E.
    Cseh, B.
    Pál, A.
    Antuszewicz, D.
    Kalup, Cs.
    Oey, J.
    Petrescu, E.
    Kirpluk, B.
    Podlewska-Gaca, E.
    Broughton, J.
    Szakáts, R.
    Beisker, W.
    Stewart, W.
    Horti-Dávid, Á.
    Grazzini, L.
    Anderson, C.
    Konstanciak, I.
    Jones, A.
    Weber, C.
    Dunham, D.
    Miftah, M. A.
    Jones, R.
    Casalnuovo, G.
    Harman, M.
    Herald, D.
    Delincak, P.
    Gährken, B.
    Hasubick, W.
    Fini, P.
    Maley, P.
    Molnár, L.
    Kattentidt, B.
    Malagon, C.
    Morales, N.
    O’Connell, M.
    Santana-Ros, T.
    Galli, G.
    Bora, Zs.
    Denyer, P.
    Choi, Y.-J.
    Szkudlarek, M.
    Ossola, A.
    Guhl, K.
    Leiva, R.
    Borkowski, M.
    Kamiński, K.
    Cikota, S.
    Pakštienė, E.
    Fauvaud, M.
    Maestripieri, M.
    Yoshihara, H.
    Popowicz, A.
    Krannich, G.
    Butkiewicz-Bąk, M.
    Uno, M.
    Gimple, B.
    Polińska, M.
    Sempronio, V.
    Bertini, M.
    Ruocco, N.
    Lindner, P.
    Casarramona, F.
    Karagiannidis, A.
    Newman, J.
    Mieczkowska, I.
    Kim, D.-H.
    Benedyktowicz, L.
    Fauvaud, S.
    Zoła, Stanisław
    Perła, J.
    Arcoverde, P.
    Aubry, R.-L.
    Opis:
    Context. The sizes of many asteroids, especially slowly rotating, low-amplitude targets, remain poorly constrained due to selection effects. These biases limit the availability of high-quality data, leaving size estimates reliant on spherical shape assumptions. Such approximations introduce significant uncertainties propagating, for example, into density determinations or thermophysical and compositional studies, affecting our understanding of asteroid properties. Aims. This work targets poorly studied main-belt asteroids, for most of which no shape models were previously available. Using only high-quality, dense light curves, thermal infrared observations (systematically including WISE data), and stellar occultations, we aimed to produce reliable shape models and scale them using two independent techniques, allowing for size comparison at the end. We conducted two observing campaigns to achieve this: one to obtain dense photometric light curves and another to acquire multi-chord stellar occultations by these objects. Methods. Shape and spin models were reconstructed using light curve inversion techniques. Sizes were determined via two methods: (1) advanced thermophysical modelling using the convex inversion thermophysical model (CITPM), which optimises spin and shape models to light curve data in the visible range together with infrared data, and (2) scaling the shape models with stellar occultations. Results. We obtained precise sizes and shape models for 15 asteroids. CITPM and occultation-derived sizes agree within 5% for most cases, demonstrating the reliability of the modelling approach. Larger discrepancies are usually linked to incomplete occultation chord coverage. The study also provides insights into surface properties, including albedo, surface roughness and thermal inertia. Conclusions. The use of high-quality data, coupled with an advanced TPM that uses both thermal and visible data while allowing the shape model to be adjusted according to both types of data, enabled us to determine sizes with precision comparable to those derived from multichord stellar occultations. We resolved substantial inconsistencies in previous size determinations for target asteroids, providing good input for future studies on asteroid densities and surface properties.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
      Wyświetlanie 1-7 z 7

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