Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Pedagogiczna Biblioteka Wojewódzka im. Komisji Edukacji Narodowej w Lublinie Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaPedagogiczna Biblioteka Wojewódzka im. Komisji Edukacji Narodowej w Lublinie
Zmień bibliotekę

Wyszukujesz frazę "Przyborowski, Kamil" wg kryterium: Autor

  Lista filtrów
Wyrównaj
Wyświetlanie 1-10 z 30
Tytuł:
Natura 2000 w kontekście konkurencyjności i możliwości rozwojowych gmin w Polsce
Natura 2000 in the context of competitiveness and local development opportunities in Poland
Autorzy:
Dziemianowicz, Wojciech
Peszat, Klaudia
Przyborowski, Kamil
Tematy:
Natura 2000
środowisko naturalne
konkurencyjność
rozwój lokalny
environment
competitiveness
local development
Pokaż więcej
Wydawca:
Uniwersytet Warszawski. Instytut Ameryk i Europy. Centrum Europejskich Studiów Regionalnych i Lokalnych (EUROREG)
Powiązania:
https://bibliotekanauki.pl/articles/414681.pdf  Link otwiera się w nowym oknie
Opis:
W artykule zaprezentowane zostały wyniki badania konkurencyjności gmin objętych Europejską Siecią Ekologiczną Natura 2000. Na podstawie analiz korelacji udziału obszarów Natura 2000 w ogólnej powierzchni gminy i wskaźników charakteryzujących wymiary konkurencyjności i rozwoju, a także ankiet przeprowadzonych wśród samorządów gminnych w Polsce sformułowano wnioski dotyczące sytuacji społeczno-gospodarczej gmin tzw. naturowych oraz wpływu tej formy ochrony przyrody na rozwój lokalny. W artykule podjęto również próbę odpowiedzi na pytanie, czy sieć Natura 2000 faktycznie zapewnia zrównoważony rozwój, czy wymusza jedynie dbałość o interesy przyrody bez uwzględniania potrzeb społecznych i gospodarczych lokalnych społeczności.
The article discusses the results of empirical research on the competitiveness of municipalities covered by the Natura 2000 network. Authors conducted a correlation analysis of the share of the Natura 2000 sites in the general area of a municipality and the indicators characterizing dimensions of competitiveness and development. Questionnaire surveys were conducted among local governments in Poland. On this basis conclusions on the socio-economic situation of municipalities with a large share of Natura 2000 areas and the impact of this form of conservation for local development were formulated. The article is also an attempt to answer the question whether Natura 2000 actually delivers sustainable development, or simply forces environmental protection without taking into account social and economic needs of local communities.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Distinct Pharmacological Properties of Gaseous CO and CO-Releasing Molecule in Human Platelets
Autorzy:
Chłopicki, Stefan
Kaczara, Patrycja
Mohaissen, Tasnim
Przyborowski, Kamil
Opis:
Carbon monoxide (CO)-gaseous or released by CO-RMs-both possess antiplatelet properties; however, it remains uncertain whether the mechanisms involved are the same. Here, we characterise the involvement of soluble guanylate cyclase (sGC) in the effects of CO-delivered by gaseous CO-saturated buffer (COG) and generated by CORM-A1-on platelet aggregation and energy metabolism, as well as on vasodilatation in aorta, using light transmission aggregometry, Seahorse XFe technique, and wire myography, respectively. ODQ completely prevented the inhibitory effect of COG on platelet aggregation, but did not modify antiplatelet effect of CORM-A1. In turn, COG did not affect, whereas CORM-A1 substantially inhibited energy metabolism in platelets. Even though activation of sGC by BAY 41-2272 or BAY 58-2667 inhibited significantly platelet aggregation, their effects on energy metabolism in platelets were absent or weak and could not contribute to antiplatelet effects of sGC activation. In contrast, vasodilatation of murine aortic rings, induced either by COG or CORM-A1, was dependent on sGC. We conclude that the source (COG vs. CORM-A1) and kinetics (rapid vs. slow) of CO delivery represent key determinants of the mechanism of antiplatelet action of CO, involving either impairment of energy metabolism or activation of sGG.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
The endothelial barrier and cancer metastasis : does the protective facet of platelet function matter?
Autorzy:
Chłopicki, Stefan
Stojak, Marta
Przyborowski, Kamil
Smęda, Marta
Opis:
Overwhelming evidence suggests that platelets have a detrimental role in promoting cancer spread via platelet-cancer cell interactions linked to thrombotic mechanisms. On the other hand, a beneficial role of platelets in the preservation of the endothelial barrier in inflammatory conditions has been recently described, a phenomenon that could also operate in cancer-related inflammation. It is tempting to speculate that some antiplatelet strategies to combat cancer metastasis may impair the endogenous platelet-dependent mechanisms preserving endothelial barrier function. If the protective function of platelets is impaired, it may lead to increased endothelial permeability and more efficient cancer cell intravasation in the primary tumor and cancer cell extravasation at metastatic sites. In this commentary, we discuss current evidence that could support this hypothesis.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Effects of chronic nitric oxide synthase inhibition on $VO_{2max}$ and exercise capacity in mice
Autorzy:
Mateuszuk, Łukasz
Sitek, Barbara
Wojewoda, Marta
Zoladz, J. A.
Przyborowski, Kamil
Zakrzewska, Agnieszka
Chłopicki, Stefan
Opis:
Acute inhibition of NOS by L-NAME ($N^{\omega}$-nitro-L-arginine methyl ester) is known to decrease maximal oxygen consumption ($V'O_{2max}$) and impair maximal exercise capacity, whereas the effects of chronic L-NAME treatment on $V'O_{2max}$ and exercise performance have not been studied so far. In this study, we analysed the effect of L-NAME treatment, (LN2 and LN12, respectively) on $V'O_{2max}$ and exercise capacity (in maximal incremental running and prolonged sub-maximal incremental running tests), systemic NO bioavailability (plasma nitrite ($NO_{2}^{-}$) and nitrate ($NO_{3}^{-}$)) and prostacyclin ($PGI_{2}$) production in C57BL6/J mice. Mice treated with L-NAME for 2 weeks (LN2) displayed higher $V'O_{2max}$ and better running capacity than age-matched control mice. In LN2 mice, NO bioavailability was preserved, as evidenced by maintained $NO_{2}^{-}$ plasma concentration. $PGI_{2}$ production was activated (increased 6-keto-$PGF_{1\alpha}$ plasma concentration) and the number of circulating erythrocytes (RBC) and haemoglobin concentration were increased. In mice treated with L-NAME for 12 weeks (LN12), NO bioavailability was decreased (lower $NO_{2}^{-}$ plasma concentration), and 6-keto-$PGF_{1\alpha}$ plasma concentration and RBC number were not elevated compared to age-matched control mice. However, LN12 mice still performed better during the maximal incremental running test despite having lower $V'O_{2max}$. Interestingly, the LN12 mice showed poorer running capacity during the prolonged sub-maximal incremental running test. To conclude, short-term (2 weeks) but not long-term (12 weeks) treatment with L-NAME activated robust compensatory mechanisms involving preservation of NO2- plasma concentration, overproduction of $PGI_{2}$ and increased number of RBCs, which might explain the fully preserved exercise capacity despite the inhibition of NOS.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Simultaneous quantification of $PGI_{2}$ and $TXA_{2}$ metabolites in plasma and urine in NO-deficient mice by a novel UHPLC/MS/MS method
Autorzy:
Kij, Agnieszka
Przyborowski, Kamil
Walczak, Maria
Sitek, Barbara
Chłopicki, Stefan
Mateuszuk, Łukasz
Zakrzewska, Agnieszka
Wandzel, Krystyna
Opis:
The balance between vascular prostacyclin ($PGI_{2}$) generated mainly via cyclooxygenase-2 (COX-2) and its physiological antagonist platelet-derived thromboxane $A_{2}$ ($TXA_{2}$) formed by cyclooxygenase-1 (COX-1) determines cardiovascular homeostasis. In the present work, a novel bioanalytical method for simultaneous quantification of stable plasma and urinary metabolites of $PGI_{2}$ (6-keto-$PGF_{1\alpha}$, 2,3-dinor-6-keto-$PGF_{1\alpha}$) and $TXA_{2}$ ($TXB_{2}$, 2,3-dinor-$TXB_{2}$) using ultra high-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC/MS/MS) was developed. The method was validated using artificial plasma and urine and linearity range, intra- and inter-day precision and accuracy, recovery of analytes, relative and absolute matrix effect and stability of analytes were determined. The use of artificial biofluids improved the method sensitivity as it eliminated the contribution of endogenous metabolites present in mice plasma and urine to validation procedure. The newly developed and validated method allowed to quantify 6-keto-$PGF_{1\alpha}$ and $TXB_{2}$ in mice plasma as well as 2,3-dinor-6-keto-$PGF_{1\alpha}$ and 2,3-dinor-$TXB_{2}$ in urine samples with high sensitivity and accuracy. The calibration range was established from 0.1 to 100 ng/mL for all analytes using artificial biofluids and the recoveries were greater than 89.9%. All validated parameters met the criteria of acceptance specified in FDA and EMA guidance. This method was successfully employed for profiling of the changes in $PGI_{2}$ and $TXA_{2}$ generation in NO-deficient mice. This work demonstrated that NO-deficiency induced by L-NAME, evidenced by a fall in nitrite in plasma and urine, was associated with platelet activation, robust increase in $TXB_{2}$ and mild increase in 6-keto-$PGF_{1\alpha}$ concentration in plasma. Changes in 2,3-dinor-6-keto-$PGF_{1\alpha}$ and 2,3-dinor-$TXB_{2}$ concentration in urine were less evident suggesting that the measurements in plasma better reflect modest changes in $PGI_{2}/TXA_{2}$ homeostasis than measurements in urine.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Effects of 1-methylnicotinamide (MNA) on exercise capacity and endothelial response in diabetic mice
Autorzy:
Kij, Agnieszka
Przyborowski, Kamil
Sitek, Barbara
Zoladz, Jerzy Andrzej
Wojewoda, Marta
Chłopicki, Stefan
Zakrzewska, Agnieszka
Wandzel, Krystyna
Opis:
1-Methylnicotinamide (MNA), which was initially considered to be a biologically inactive endogenous metabolite of nicotinamide, has emerged as an anti-thrombotic and anti-inflammatory agent with the capacity to release prostacyclin (PGI2). In the present study, we characterized the effects of MNA on exercise capacity and the endothelial response to exercise in diabetic mice. Eight-week-old db/db mice were untreated or treated with MNA for 4 weeks (100 mg·kg-1), and their exercise capacity as well as NO- and PGI2-dependent response to endurance running were subsequently assessed. MNA treatment of db/db mice resulted in four-fold and three-fold elevation of urine concentrations of MNA and its metabolites (Met-2PY + Met-4PY), respectively (P<0.01), but did not affect HbA1c concentration, fasting glucose concentration or lipid profile. However, insulin sensitivity was improved (P<0.01). In MNA-treated db/db mice, the time to fatigue for endurance exercise was significantly prolonged (P<0.05). Post-exercise Δ6-keto-PGF1α (difference between mean concentration in the sedentary and exercised groups) tended to increase, and post-exercise leukocytosis was substantially reduced in MNA-treated animals. In turn, the post-exercise fall in plasma concentration of nitrate was not affected by MNA. In conclusion, we demonstrated for the first time that MNA improves endurance exercise capacity in mice with diabetes, and may also decrease the cardiovascular risk of exercise.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Wyświetlanie 1-10 z 30

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies