- Tytuł:
- Intracranial aneurysm classifier using phenotypic factors : an international pooled analysis
- Autorzy:
-
Millwood, Iona Y.
Woo, Daniel
Desal, Hubert
Hirsch, Sven
Słowik, Agnieszka
Consortium Isgc, International Stroke Genetics
Ko, Nerissa U.
Alg, Varinder S.
Kulcsar, Zolt
Dauvillier, Jerome
Kivisaari, Riku
Caroff, Jildaz
Rüfenacht, Daniel
Rinkel, Gabriel J.E.
Jiménez-Conde, Jordi
Karakachoff, Matilde
Jahromi, Behnam Rezai
Worrall, Bradford B.
Werring, David J.
Meling, Torstein R.
Pera, Joanna
Laakso, Aki
Morel, Sandrine
Redon, Richard
Soriano-Tárraga, Carolina
von Und Zu Fraunberg, Mikael
Hostettler, Isabel C.
Jaaskelainen, Juha E.
Schaller, Karl
Niemelä, Mika
Moomaw, Charles J.
Machi, Paolo
Foroud, Tatiana
Martin, Olivier
Mendes Pereira, Vitor
Kim, Helen
Constant-Dits-Beaufils, Pacôme
Lai, Dongbing
Gaal-Paavola, Emilia I.
Cuadrado-Godia, Elisa
Houlden, Henry
Lindgren, Antti
Subarachnoid Haemorrhage Gosh Study Investigators, Genetics And Observational
Tulamo, Riikka
Rouchaud, Aymeric
Friedrich, Christoph M.
Isidor, Nathalie
Lövblad, Karl O.
Vant Hof, Femke
Walters, Robin G.
Broderick, Joseph P.
Bijlenga, Philippe
Rouleau, Guy A.
Kaukovalta, Hanna
Schilling, Sabine
Ruigrok, Ynte M.
Rimbert, Antoine
Bakker, Mark K.
Spinner, Georg R.
Bourcier, Romain - Opis:
- Intracranial aneurysms (IAs) are usually asymptomatic with a low risk of rupture, but consequences of aneurysmal subarachnoid hemorrhage (aSAH) are severe. Identifying IAs at risk of rupture has important clinical and socio-economic consequences. The goal of this study was to assess the effect of patient and IA characteristics on the likelihood of IA being diagnosed incidentally versus ruptured. Patients were recruited at 21 international centers. Seven phenotypic patient characteristics and three IA characteristics were recorded. The analyzed cohort included 7992 patients. Multivariate analysis demonstrated that: (1) IA location is the strongest factor associated with IA rupture status at diagnosis; (2) Risk factor awareness (hypertension, smoking) increases the likelihood of being diagnosed with unruptured IA; (3) Patients with ruptured IAs in high-risk locations tend to be older, and their IAs are smaller; (4) Smokers with ruptured IAs tend to be younger, and their IAs are larger; (5) Female patients with ruptured IAs tend to be older, and their IAs are smaller; (6) IA size and age at rupture correlate. The assessment of associations regarding patient and IA characteristics with IA rupture allows us to refine IA disease models and provide data to develop risk instruments for clinicians to support personalized decision-making.
- Dostawca treści:
- Repozytorium Uniwersytetu Jagiellońskiego
Artykuł