- Tytuł:
- Evolutionary and functional history of the Escherichia coli K1 capsule
- Autorzy:
-
Samuelsen, Ørjan
Horner, Carolyne
Blundell-Hunter, George
Ares, Miguel A.
Loraine, Jessica
Corander, Jukka
Penadés, José R.
Fu, Zuyi
Gladstone, Rebecca A.
McNally, Alan
Arredondo-Alonso, Sergio
Johnsen, Pål J.
Klein, Nigel
Fillol-Salom, Alfred
Reis, Joice N.
McCarthy, Allan
Thomson, Nicholas R.
Belleville-Taylor, Pauline
Pöntinen, Anna K.
Chmielarczyk, Agnieszka
Cléon, François
Chavez-Bueno, Susana
Vongsouvath, Manivanh
Cloutman-Green, Elaine
De la Cruz, Miguel A. - Opis:
- Escherichia coli is a leading cause of invasive bacterial infections in humans. Capsule polysaccharide has an important role in bacterial pathogenesis, and the K1 capsule has been firmly established as one of the most potent capsule types in E. coli through its association with severe infections. However, little is known about its distribution, evolution and functions across the E. coli phylogeny, which is fundamental to elucidating its role in the expansion of successful lineages. Using systematic surveys of invasive E. coli isolates, we show that the K1-cps locus is present in a quarter of bloodstream infection isolates and has emerged in at least four different extraintestinal pathogenic E. coli (ExPEC) phylogroups independently in the last 500 years. Phenotypic assessment demonstrates that K1 capsule synthesis enhances E. coli survival in human serum independent of genetic background, and that therapeutic targeting of the K1 capsule re-sensitizes E. coli from distinct genetic backgrounds to human serum. Our study highlights that assessing the evolutionary and functional properties of bacterial virulence factors at population levels is important to better monitor and predict the emergence of virulent clones, and to also inform therapies and preventive medicine to effectively control bacterial infections whilst significantly lowering antibiotic usage.
- Dostawca treści:
- Repozytorium Uniwersytetu Jagiellońskiego
Artykuł