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Tytuł:
Management of patient with immune thrombocytopenia with antiphospholipid syndrome and monoclonal gammopathy of undetermined significance
Autorzy:
Ryżewska, Wiktoria
Zarzycka, Malwina
Witkowski, Michał
Witkowska, Magdalena
Robak, Tadeusz
Tematy:
immune thrombocytopenia
monoclonal gammopathy of undetermined significance
antiphospholipid syndrome
Pokaż więcej
Wydawca:
Medical Education
Powiązania:
https://bibliotekanauki.pl/articles/2047812.pdf  Link otwiera się w nowym oknie
Opis:
Immune thrombocytopenia with antiphospholipid syndrome and monoclonal gammopathy of undetermined significance poses therapeutic dilemmas – whether we should modify the immune thrombocytopenia treatment in antiphospholipid syndrome, what is the influence of monoclonal gammopathy of undetermined significance on the course of immune thrombocytopenia and whether we should and how to prevent the progression of monoclonal gammopathy of undetermined significance to multiple myeloma.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
B-cell chronic lymphocytic leukemia-associated nuclear antigens
Autorzy:
Rogalińska, Małgorzata
Błoński, Jerzy Z
Robak, Tadeusz
Kiliańska, Zofia M
Tematy:
B-CLL specific antigens
electrophoresis
immunoblotting
Pokaż więcej
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Powiązania:
https://bibliotekanauki.pl/articles/764933.pdf  Link otwiera się w nowym oknie
Opis:
One- and two-dimensional polyacrylamide gel electrophoresis were used to compare the composition of nuclear polypeptides from normal and В-cell chronic lymphocytic leukemia mononuclear cells. Against two electrophoretically-specific nuclear proteins with molecular weight of 38/39 and 44/46 kD a from leukemic cells rabbit sera were obtained. As it was analyzed by Western blot technique the available antisera recognized the 38/39 kDa antigen in 53 of the 56 (94.6%), while the 44/46 kDa in 46 of the 49 (93.9%) of examined В-CLL nuclear fraction preparations, but not in normal ones. The pi values of described leukaemia-specific antigens were determined; p38/39 had pi in the range of pH 6.55 -7.00 and p44/46 - in the range of pH 6.2-6.4.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dealing with hypodysfibrinogenemia during pregnancy with a successful outcome
Autorzy:
Faflik, Zuzanna
Witkowski, Michał
Witkowska, Magdalena
Smolewski, Piotr
Robak, Tadeusz
Tematy:
hypodysfibrinogenemia
pregnancy
fibrynogen
substitution
Pokaż więcej
Wydawca:
Medical Education
Powiązania:
https://bibliotekanauki.pl/articles/2047810.pdf  Link otwiera się w nowym oknie
Opis:
Background: Fibrinogen is a protein playing pleiotropic role in human body. It is engaged in maintaining hemostasis. Congenital fibrinogen disorders comprise quantitative and qualitative fibrinogen anomalies. The symptoms range from bleeding, thrombosis to asymptomatic at all what is the most common case. Hypodysfibrinogenemia with lower level of fibrinogen of reduced activity, is the least common of all congenital fibrinogen disorders. Case report: A 31-year-old woman was reported at the 21 weeks of gestation, suffered from genital tract bleeding and there was a history of stillbirth. Clinical examination with no pathology, however laboratory tests revealed coagulation abnormalities due to prolonged thrombin test, decreased protein S and lower fibrinogen level (70 mg/dl). Autoimmune diseases were excluded and the diagnosis was widened with rotational thromboelastometry and genetic test for hypodysfibrinogenemia. The patient was treated with fibrinogen substitution and prophylactic dose of heparin throughout pregnancy and 2 weeks following labour. At 39 week of gestation Caesarean section was done, with no complications. Results: Genetic test revealed heterozygous mutation in fibrinogen gamma gene confirming hypodysfibrinogenemia. Due to bleeding manifestation in this patient of congenital fibrinogen disorders, fibrinogen substitution was implemented with heparin as a paranticoagulant prophylaxis, what turned out to be successful and enabled the patient to maintain the pregnancy. Conclusions: As hypodysfibrinogenemia symptoms are diverse the management is difficult and each patient’s therapy should be planned separately. Pregnancy may be the first time when congenital fibrinogen disorders reveal and it is especially challenging to prevent from obstetrical complications.
Dostawca treści:
Biblioteka Nauki
Artykuł

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