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Wyszukujesz frazę "Roger, D." wg kryterium: Autor


Tytuł:
Magnetic characterization of the nickel layer protecting the copper wires in harsh applications
Autorzy:
Roger, D.
Duchesne, S.
Iosif, V.
Tematy:
high temperature motor winding
nickel diffusion barrier
temperature dependent magnetic properties
Pokaż więcej
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Powiązania:
https://bibliotekanauki.pl/articles/140802.pdf  Link otwiera się w nowym oknie
Opis:
High Temperature (HT°) motor coils open new perspectives for extending the applications of electrical motors or generators to very harsh environments or for designing very high power density machines working with high internal temperature gradients. Over a temperature of 300E°, the classic enameled wire cannot work permanently, the turn-to-turn insulation must be inorganic and made with high temperature textiles or vitro-ceramic compounds. For both cases, a diffusion barrier must protect the copper wire against oxidation. The usual solution consists of adding a nickel layer that yields an excellent chemical protection. Unfortunately, the nickel has ferromagnetic properties that change a lot the skin effect in the HT wire at high frequencies. For many applications such as aeronautics, electrical machines are always associated with PWM inverters for their control. The windings must resist to high voltage short spikes caused by the fast fronted pulses imposed by the feeding inverter. The nickel protection layer of the HTE inorganic wire has a large influence on the high frequency behavior of coils and, consequently, on the magnitude of the voltage spikes. A good knowledge of the non-linear magnetic characteristics of this nickel layer is helpful for designing reliable HT inorganic coils. The paper presents a method able to characterize non-linear electromagnetic properties of this nickel layer up to 500E°.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pooled safety analysis of zanubrutinib monotherapy in patients with B-cell malignancies
Autorzy:
Dimopoulos, Meletios A.
Ji, Meng
D'Sa, Shirley
Cohen, Aileen
Xu, Wei
Tam, Constantine S
Huang, Jane
Garcia-Sanz, Ramon
Roberts, Andrew W
Zhu, Jun
Li, Jianyong
Marlton, Paula
Guo, Haiyi
Song, Yuqin
Jurczak, Wojciech
Gottlieb, David J
Zhou, Lei
Munoz, Javier
Du, Chenmu
Phillips, Tycel
Novotny, William
Cull, Gavin
Owen, Roger G.
Zhu, Hongjie
Tedeschi, Alessandra
Trotman, Judith
Chan, Wai Y.
Qiu, Lugui
Opat, Stephen
Opis:
Zanubrutinib is a selective Bruton tyrosine kinase (BTK) inhibitor evaluated in multiple B-cell malignancy studies. We constructed a pooled safety analysis to better understand zanubrutinib-associated treatment-emergent adverse events (TEAEs) and identify treatment-limiting toxicities. Data were pooled from 6 studies (N=779). Assessments included type, incidence, severity, and outcome of TEAEs. Median age was 65 years; 20% were ≥75 years old. Most patients had Waldenström macroglobulinemia (33%), chronic lymphocytic leukemia/small lymphocytic lymphoma (29%), or mantle-cell lymphoma (19%). Median treatment duration was 26 months (range: 0.1-65); 16% of patients were treated for ≥3 years. Common nonhematologic TEAEs were upper respiratory tract infection (URI, 39%), rash (27%), bruising (25%), musculoskeletal pain (24%), diarrhea (23%), cough, pneumonia (21% each), urinary tract infection (UTI), fatigue (15% each). Most common grade ≥3 TEAEs were pneumonia (11%), hypertension (5%), URI, UTI, sepsis, diarrhea, and musculoskeletal pain (2% each). Atrial fibrillation and major hemorrhage occurred in 3% and 4% of patients, respectively. Atrial fibrillation, hypertension and diarrhea occurred at lower rates than those reported historically for ibrutinib. Grade ≥3 AEs included neutropenia (23%), thrombocytopenia (8%), and anemia (8%). Serious TEAEs included pneumonia (11%), sepsis (2%), and pyrexia (2%). Treatment discontinuations and dose reductions for AEs occurred in 10% and 8% of patients, respectively. Thirty-nine patients (4%) had fatal TEAEs, including pneumonia (n=9), sepsis (n=4), unspecified cause (n=4), and multiple organ dysfunction syndrome (n=5). This analysis demonstrates that zanubrutinib is generally well tolerated with a safety profile consistent with known BTK inhibitor toxicities; these were manageable and mostly reversible.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Autorzy:
Dimopoulos, Meletios A.
Drandi, Daniela
D'Sa, Shirley
Kersten, Marie Jose
Fend, Falko
Varettoni, Marzia
Owen, Roger
Garcia-Sanz, Ramon
Ferrero, Simone
Buske, Christian
Gilestro, Milena
Willenbacher, Wolfgang
Morel, Pierre
Bagratuni, Tina
Poulain, Stephanie
Kyriakou, Charalampia
Jurczak, Wojciech
Vos, Josephine M.I.
Leblond, Veronique
Puig, Noemi
Jimenez, Cristina
Garcia-Alvarez, Maria
Perez, Jose
Roccaro, Aldo M.
Ferrante, Martina
Tedeschi, Alessandra
Dogliotti, Irene
Kascak, Michal
Kastritis, Efstathios
Talaulikar, Dipti
Opis:
The diagnosis of Waldenström’s macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease presentation. Furthermore, in recent years, WM has witnessed remarkable progress on the diagnostic front, as well as a deeper understanding of the disease biology, which has affected clinical practice. This, together with the increasing variety of tools and techniques available, makes it necessary to have a practical guidance for clinicians to perform the initial evaluation of patients with WM. In this paper, we present the consensus recommendations and laboratory requirements for the diagnosis of WM developed by the European Consortium of Waldenström’s Macroglobulinemia (ECWM), for both clinical practice as well as the research/academical setting. We provide the procedures for multiparametric flow cytometry, fluorescence in situ hybridization and molecular tests, and with this offer guidance for a standardized diagnostic work-up and methodological workflow of patients with IgM monoclonal gammopathy of uncertain significance, asymptomatic and symptomatic WM.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł

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