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Wyświetlanie 1-10 z 55
Tytuł:
Interplay between different cytotoxic parameters in Galleria mellonella (Lepidoptera, Pyralidae) larvae fed with polypropylene
Autorzy:
Homa, Joanna
Wilczek, G.
Chajec, Ł.
Siwek, D.
Rost-Roszkowska, M.
Wrońska, A. K.
Student, S.
Mermer, P.
Krpec, K.
Magiera, K.
Opis:
Plastic waste, which pollutes water and soil and negatively impacts organisms, is currently a major ecological problem. Therefore, methods for its degradation are being sought, including biodegradation using various organisms to dispose of plastics. One invertebrate animal suspected of being used in plastic biodegradation is Galleria mellonella (Insecta, Lepidoptera). However, there is no data on whether plastics ingested by this insect’s larvae will induce cytotoxic effects in cells, tissues, or organs, which would exclude this species from biodegradation. The aim of this study was to determine whether G. mellonella larvae, after consuming a popular plastic, polypropylene (PP), activate specific cytotoxic parameters. Larvae of the studied species were fed PP bags for 24 and 48 h. Control (G0-C) and starved (G0-S) individuals were also analyzed to determine whether cytotoxic effects could be attributed to factors such as a lack of normal food. Confocal microscopy and flow cytometry were changes, employed to investigate cell death processes, caspase and Bcl-2 protein activation, and mitochondrial alterations. The results of our studies suggest that G. mellonella may be considered as a potential candidate used in the biodegradation of PP.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Migraine-associated common genetic variants confer greater risk of posterior vs. anterior circulation ischemic stroke
Autorzy:
Dalca, A.V.
Thijs, V.
Ryan, K.
Frid, P.
Meschia, J.F.
Schmidt, R.
Słowik, Agnieszka
Kissela, B.M.
Holmegaard, L.
Golland, P.
Broderick, J.P.
Worrall, B.B.
Wu, O.
Rundek, T.
Giralt-Steinhauer, E.
Drake, M.
Mcardle, P.F.
Woo, D.
Mocking, S.J.T.
Bouts, M.J.R.J.
Lemmens, R.
Sharma, P.
Xu, H.
Jood, K.
Cole, J.W.
Lindgren, A.
Irie, R.
Kleindorfer, D.O.
Rost, N.S.
Schirmer, M.
Roquer, J.
Kittner, S.J.
Donahue, K.L.
Gaynor, B.
Mitchell, B.D.
Sacco, R.L.
Jern, C.
Giese, A.K.
Wasselius, J.
Rosand, J.
Mcintosh, E.C.
Jimenez-Conde, J.
Petersson, J.
Opis:
Objective: To examine potential genetic relationships between migraine and the two distinct phenotypes posterior circulation ischemic stroke (PCiS) and anterior circulation ischemic stroke (ACiS), we generated migraine polygenic risk scores (PRSs) and compared these between PCiS and ACiS, and separately vs. non-stroke control subjects. Methods: Acute ischemic stroke cases were classified as PCiS or ACiS based on lesion location on diffusion-weighted MRI. Exclusion criteria were lesions in both vascular territories or uncertain territory; supratentorial PCiS with ipsilateral fetal posterior cerebral artery; and cases with atrial fibrillation. We generated migraine PRS for three migraine phenotypes (any migraine; migraine without aura; migraine with aura) using publicly available GWAS data and compared mean PRSs separately for PCiS and ACiS vs. non-stroke control subjects, and between each stroke phenotype. Results:Our primary analyses included 464 PCiS and 1079 ACiS patients with genetic European ancestry. Compared to non-stroke control subjects (n=15396), PRSs of any migraine were associated with increased risk of PCiS (p=0.01–0.03) and decreased risk of ACiS (p=0.010–0.039). Migraine without aura PRSs were significantly associated with PCiS (p=0.008–0.028), but not with ACiS. When comparing PCiS vs. ACiS directly, migraine PRSs were higher in PCiS vs. ACiS for any migraine (p=0.001–0.010) and migraine without aura (p=0.032–0.048). Migraine with aura PRS did not show a differential association in our analyses. Conclusions: Our results suggest a stronger genetic overlap between unspecified migraine and migraine without aura with PCiS compared to ACiS. Possible shared mechanisms include dysregulation of cerebral vessel endothelial function.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Wyświetlanie 1-10 z 55

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