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Tytuł:
How does age affect outcomes after left ventricular assist device implantation : results from the PCHF-VAD registry
Autorzy:
Brugts, Jasper J.
Wierzbicki, Karol
Planinc, Ivo
Veenis, Jesse F.
Cikes, Maja
Gkouziouta, Aggeliki
van Craenenbroeck, Emeline M.
Biocina, Bojan
Jakus, Nina
D'Amario, Domenico
Droogne, Walter
Radhoe, Sumant P.
Flammer, Andreas J.
Timmermans, Philippe
Gasparovic, Hrvoje
Holcman, Katarzyna
Gaizauskas, Edvinas
Rubiś, Paweł
Meyns, Bart
Samardzic, Jure
Paolillo, Stefania
Barge-Caballero, Eduardo
Grundmann, Sebastian
Braun, Oscar O.
Pouleur, Anne-Catherine
Milicic, Davor
Lund, Lars H.
Ruschitzka, Frank
Opis:
Aims: Use of left ventricular assist devices (LVADs) in older patients has increased, and assessing outcomes in older LVAD recipients is important. Therefore, this study aimed to investigate associations between age and outcomes after continuous-flow LVAD (cf-LVAD) implantation. Methods and results: Cf-LVAD patients from the multicentre European PCHF-VAD registry were included and categorized into those <50, 50–64, and ≥65 years old. The primary endpoint was all-cause mortality. Among secondary outcomes were heart failure (HF) hospitalizations, right ventricular (RV) failure, haemocompatibility score, bleeding events, non-fatal thromboembolic events, and device-related infections. Of 562 patients, 184 (32.7%) were <50, 305 (54.3%) were aged 50–64, whereas 73 (13.0%) were ≥65 years old. Median follow-up was 1.1 years. Patients in the oldest age group were significantly more often designated as destination therapy (DT) candidates (61%). A 10 year increase in age was associated with a significantly higher risk of mortality (hazard ratio [HR] 1.34, 95% confidence interval [CI] [1.15–1.57]), intracranial bleeding (HR 1.49, 95% CI [1.10–2.02]), and non-intracranial bleeding (HR 1.30, 95% CI [1.09–1.56]), which was confirmed by a higher mean haemocompatibility score (1.37 vs. 0.77, oldest vs. youngest groups, respectively, P = 0.033). Older patients suffered from less device-related infections requiring systemic antibiotics. No age-related differences were observed in HF-related hospitalizations, ventricular arrhythmias, pump thrombosis, non-fatal thromboembolic events, or RV failure. Conclusions: In the PCHF-VAD registry, higher age was associated with increased risk of mortality, and especially with increased risk of major bleeding, which is particularly relevant for the DT population. The risks of HF hospitalizations, pump thrombosis, ventricular arrhythmia, or RV failure were comparable. Strikingly, older patients had less device-related infections.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Sex-related differences in left ventricular assist device utilization and outcomes : results from the PCHF-VAD registry
Autorzy:
D'Amario, Domenico
Ruschitzka, Frank
Grundmann, Sebastian
Planinc, Ivo
Lund, Lars H.
Rubiś, Paweł
Milicic, Davor
Gaizauskas, Edvinas
Droogne, Walter
Gasparovic, Hrvoje
Cikes, Maja
Jakus, Nina
Holcman, Katarzyna
Wierzbicki, Karol
Flammer, Andreas J.
Pouleur, Anne-Catherine
Timmermans, Philippe
Paolillo, Stefania
Barge-Caballero, Eduardo
Braun, Oscar O.
Gkouziouta, Aggeliki
van Craenenbroeck, Emeline M.
Veenis, Jesse F.
Macek, Jana Ljubas
Biocina, Bojan
Meyns, Bart
Radhoe, Sumant P.
Brugts, Jasper J.
Opis:
Aims: Data on sex and left ventricular assist device (LVAD) utilization and outcomes have been conflicting and mostly confined to US studies incorporating older devices. This study aimed to investigate sex-related differences in LVAD utilization and outcomes in a contemporary European LVAD cohort. Methods and results: This analysis is part of the multicentre PCHF-VAD registry studying continuous-flow LVAD patients. The primary outcome was all-cause mortality. Secondary outcomes included ventricular arrhythmias, right ventricular failure, bleeding, thromboembolism, and the haemocompatibility score. Multivariable Cox regression models were used to assess associations between sex and outcomes. Overall, 457 men (81%) and 105 women (19%) were analysed. At LVAD implant, women were more often in Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profile 1 or 2 (55% vs. 41%, P = 0.009) and more often required temporary mechanical circulatory support (39% vs. 23%, P = 0.001). Mean age was comparable (52.1 vs. 53.4 years, P = 0.33), and median follow-up duration was 344 [range 147–823] days for women and 435 [range 190–816] days for men (P = 0.40). No significant sex-related differences were found in all-cause mortality (hazard ratio [HR] 0.79 for female vs. male sex, 95% confidence interval [CI] [0.50–1.27]). Female LVAD patients had a lower risk of ventricular arrhythmias (HR 0.56, 95% CI [0.33–0.95]) but more often experienced right ventricular failure. No significant sex-related differences were found in other outcomes. Conclusions: In this contemporary European cohort of LVAD patients, far fewer women than men underwent LVAD implantation despite similar clinical outcomes. This is important as the proportion of female LVAD patients (19%) was lower than the proportion of females with advanced HF as reported in previous studies, suggesting underutilization. Also, female patients were remarkably more often in INTERMACS profile 1 or 2, suggesting later referral for LVAD therapy. Additional research in female patients is warranted.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Wyświetlanie 1-10 z 12

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