Autor: Schaefer, Andreas - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Light-cone distribution amplitudes of octet baryons from lattice QCD
Autorzy:: Wein, Philipp
Bali, Gunnar S.
Bürger, Simon
Hutzler, Fabian
Göckeler, Meinulf
Gruber, Michael
Söldner, Wolfgang
Braun, Vladimir M.
Schaefer, Andreas
Sternbeck, André
Korcyl, Piotr
Collins, Sara
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Tytuł:: Single donor infusion of S-nitroso-human-serum-albumin attenuates cardiac isograft fibrosis and preserves myocardial micro-RNA-126-3p in a murine heterotopic heart transplant model
Autorzy:: Nagel, Felix
Kiss, Attila
Hackl, Matthias
Aliabadi-Zuckermann, Arezu
Zuckermann, Andreas
Podesser, Bruno K.
Jakubowski, Andrzej
Schaefer, Anne-Kristin
Kain, Renate
Hallstrom, Seth
Acar, Eylem
Ferdinandy, Peter
Oszwald, André
Opis:: Objectives: Cold ischemia and subsequent reperfusion injury are non-immunologic cornerstones in the development of graft injury after heart transplantation. The nitric oxide donor S-nitroso-human-serum-albumin (S-NO-HSA) is known to attenuate myocardial ischemia-reperfusion (I/R)-injury. We assessed whether donor preservation with S-NO-HSA affects isograft injury and myocardial expression of GATA2 as well as miR-126-3p, which are considered protective against vascular and endothelial injury. Methods: Donor C57BL/6 mice received intravenous (0.1 μmol/kg/h) S-NO-HSA (n = 12), or 0.9% saline (control, n = 11) for 20 min. Donor hearts were stored in cold histidine-tryptophan-α-ketoglutarate-N solution for 12 h and underwent heterotopic, isogenic transplantation, except 5 hearts of each group, which were analysed immediately after preservation. Fibrosis was quantified and expression of GATA2 and miR-126-3p assessed by RT-qPCR after 60 days or immediately after preservation. Results: Fibrosis was significantly reduced in the S-NO-HSA group (6.47% ± 1.76 vs. 11.52% ± 2.16; p = 0.0023; 12 h-S-NO-HSA-hHTX vs. 12 h-control-hHTX). Expression of miR-126-3p was downregulated in all hearts after ischemia compared to native myocardium, but the effect was significantly attenuated when donors received S-NO-HSA (1 ± 0.27 vs. 0.33 ± 0.31; p = 0.0187; 12 h-S-NO-HSA-hHTX vs. 12 h-control-hHTX; normalized expression to U6 snRNA). Conclusion: Donor pre-treatment with S-NO-HSA lead to reduced fibrosis and preservation of myocardial miR-126-3p and GATA2 levels in murine cardiac isografts 60 days after transplantation.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Tytuł:: #EEGManyLabs : investigating the replicability of influential EEG experiments
Autorzy:: Mudrik, Liad
Muthuraman, Muthuraman
Zakharov, Ilya
Arvaneh, Mahnaz
Kalenkovich, Evgenii
Vloeberghs, Robin
Bradford, Daniel E.
Welke, Dominik
Hinojosa, Jose A.
Pavlov, Yuri G.
Ehinger, Benedikt
Liesefeld, Heinrich R.
Nilsonne, Gustav
Busch, Niko A.
Ganis, Giorgio
Bland, Amy R.
Bublatzky, Florian
Senderecka, Magdalena
Ladouceur, Cecile D.
Dumas, Guillaume
Johannesson, Magnus
Langer, Nicolas
Beste, Christian
Clayson, Peter E.
Niso, Guiomar
Tognoli, Emmanuelle
Huber-Huber, Christoph
Wessel, Jan R.
Sass, Sarah M.
Adamian, Nika
Appelhoff, Stefan
Dreber, Anna
Karimi-Rouzbahani, Hamid
Pourtois, Gilles
Ruzzoli, Manuela
Oostenveld, Robert
Ocklenburg, Sebastian
Snyder, Joel S.
Verona, Edelyn
MacNamara, Annmarie
van Vugt, Marieke K.
Pernet, Cyril R.
Kulke, Louisa
Neal, Lauren B.
Cruse, Damian
Benwell, Christopher S.Y.
He, Xun
Keil, Andreas
Schaefer, Alexandre
Jack, Bradley N.
Jones, Rhiannon
Tamnes, Christian K.
Czeszumski, Artur
Inzlicht, Michael
Mushtaq, Faisal
Kaltwasser, Laura
Konig, Peter
Luque, David
Kouara, Layla
Opis:: There is growing awareness across the neuroscience community that the replicability offindings about the relationship between brain activity and cognitive phenomena can beimproved by conducting studies with high statistical power that adhere to well-defined and standardised analysis pipelines. Inspired by recent efforts from the psychological sciences,and with the desire to examine some of the foundational findings using electroencephalog-raphy (EEG), we have launched #EEGManyLabs, a large-scale international collaborativereplication effort. Since its discovery in the early 20th century, EEG has had a profound in-fluence on our understanding of human cognition, but there is limited evidence on thereplicability of some of the most highly cited discoveries. After a systematic search and selection process, we have identified 27 of the most influential and continually cited studies inthe field. We plan to directly test the replicability of key findings from 20 of these studies inteams of at least three independent laboratories. The design and protocol of each replicationeffort will be submitted as a Registered Report and peer-reviewed prior to data collection.Prediction markets, open to all EEG researchers, will be used as a forecasting tool to examinewhich findings the community expects to replicate. This project will update our confidence insome of the most influential EEG findings and generate a large open access database that canbe used to inform future research practices. Finally, through this international effort, we hopeto create a cultural shift towards inclusive, high-powered multi-laboratory collaborations.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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