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Wyświetlanie 1-10 z 231
Tytuł:
Investigation of the fuel cell temperature distribution on the current density and electric potential fields
Autorzy:
Schmidt, P.
Kurgan, E.
Tematy:
zaawansowane systemy medyczne
źródła energii przyjazne dla środowiska
symulacja metod numerycznych
ogniwa paliwowe
advanced medical systems
environmentally friendly energy sources
numerical simulation methods
fuel cells
Pokaż więcej
Wydawca:
Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Powiązania:
https://bibliotekanauki.pl/articles/333742.pdf  Link otwiera się w nowym oknie
Opis:
In many medical systems a reliable energy sources play an important role. In the case of failure of external energy system, the local electrical supply has to be activated. Such electrical sources should be environmentally friendly, infallible and easy in usage. The fuel cells using hydrogen as an energy source fulfil these conditions. Numerical modelling of such electrical sources is the primary aim of this publication. Influence of the distribution of temperature on the current density and electric potential fields in electrode of the PEM fuel cell is thoroughly considered. The problem is stated as coupled field problem, where partial differential equations describing mass transport are coupled with Laplace equations describing electric potential and temperature distribution. At the end some illustrative example is given
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Układ do pomiaru wielkości elektrycznych i mechanicznych w "stacji wielkich mocy"
System for measuring electrical and mechanical values in the high-power laboratory
Autorzy:
Babiuch, M.
Schmidt, P.
Sołek, M.
Tematy:
pomiary wielkości elektrycznych
układ pomiarowy
oprogramowanie
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Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Elektrotechniki
Powiązania:
https://bibliotekanauki.pl/articles/159269.pdf  Link otwiera się w nowym oknie
Opis:
Omówiono wdrożony w Laboratorium Badawczym Aparatury Rozdzielczej w IEL Warszawa złożony układ pomiaru wielkości elektrycznych i mechanicznych, wraz z oprogramowaniem wspomagającym rejestrację i analizę danych. Układ współpracuje z klasycznymi przetwornikami: prądu jak boczniki, przekładniki prądowe, napięcia jak dzielniki przekładniki napięciowe, czujnikami ruchu, przetwornikami ciśnienia, czujnikami naprężeń. Sygnały pomiarowe są separowane za pomocą układów optoelektronicznych i rejestrowane rejestratorem (transient-recorder) ADAM firmy Rene Maurer AG Electronic Instrument. Układ poprzez interfejs HPiB współpracuje z komputerem gdzie dane są obrabiane i analizowane za pomocą programu "WinAdam".
Complex measuring system for measuring electrical and mechanical values, implemented in the Short Circuit Laboratory of Switchgear Apparatus in Electrotechnical Institute, Warsaw, is discussed along with hardware assisting data recording and analysis. The circuit cooperates with classical converters: shunts and current transformers, voltage transformers, motion-sensors, pressure-sensors, stress-sensors. The measuring signals are separated by opto-electronic system and recorded by transient-recorder ADAM, made by Rene Maurer Electronic Instruments. The circuit is cooperating with computer by interface HPiB where data are treated and analyzed by means of program WinAdam.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oscillating ultra-cold neutron spectrometer
Autorzy:
Zsigmond, G.
Schmidt-Wellenburg, P.
Rozpędzik, Dagmara
Ries, D.
Bodek, Kazimierz
Lauss, B.
Opis:
The energy spectrum of ultra-cold neutrons (UCN) is very often a key point to determine the systematic effects in precision measurements utilizing UCN. The proposed novel method allows the in-situ measurements of the UCN velocity distribution and its time evolution. In addition, the proposed UCN spectrometer can be a handy diagnostic tool for monitoring the UCN spectrum in critical places in the transport system connecting an UCN source with experiments. In this paper, we present the preliminary results from measurements and simulations using the oscillating UCN spectrometer at the PSI UCN source.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Inne
Tytuł:
An analytical expression for the D.I.P.–P.I.P. flexion interdependence in human fingers
Autorzy:
Van-Zwieten, K. J.
Schmidt, K. P.
Bex, G. J.
Lippens, P. L.
Duyvendak, W.
Tematy:
model
palec
kinematyka
koordynacja
finger
kinematical
interphalangeal
flexion
coordination
Pokaż więcej
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Powiązania:
https://bibliotekanauki.pl/articles/306688.pdf  Link otwiera się w nowym oknie
Opis:
Empirical evidence shows that a strong correlation exists between the flexion angles of the distal and proximal interphalangeal (D.I.P., P.I.P.) joints of the human finger. Several authors measured this functional dependence, stating that the interdependence of D.I.P. and P.I.P. flexion is different for healthy individuals and patients displaying pathologies. The purpose of our study is to find an analytical expression for this correlation. Methods: Following closely the anatomical in situ relations, we developed a two-dimensional kinematical model which expresses analytically the D.I.P.–P.I.P. angle correlation. Numerical values for the model were extracted from one healthy and one pathological case data set. Results: The analytical form of the model allows for any P.I.P. angle not only to calculate the corresponding D.I.P. angle, but after first order differentiation with respect to the P.I.P. angle, it also shows the rate of change of the D.I.P. flexion. The model reproduces well the differences in the angular correlation of D.I.P. flexion of the two healthy-pathological data sets. Displaying the rate of change of D.I.P. flexion versus P.I.P. flexion provides an additional, clear-cut discriminatory tool between normal and pathological states. Conclusions: Information on differences between normal and pathological flexion of fingers is more pronounced and easier accessible from the derivatives of the D.I.P.–P.I.P. flexion behaviour than from direct angular correlation data. The analytical form of our model allows one to establish the rate of change of the D.I.P. angles, resulting in a better analysis of the situations at hand.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Host-derived protease promotes aggregation of Staphylococcus aureus by cleaving the surface protein SasG
Autorzy:
Crosby, Heidi A.
LaRivière, Wells B.
Langouët-Astrié, Christophe J.
Horswill, Alexander R.
Kwieciński, Jakub
Schmidt, Eric P.
Oshima, Kaori
Keim, Klara
Opis:
Staphylococcus aureus is one of the leading causes of hospital-acquired infections, many of which begin following attachment and accumulation on indwelling medical devices or diseased tissue. These infections are often linked to the establishment of biofilms, but another often overlooked key characteristic allowing S. aureus to establish persistent infection is the formation of planktonic aggregates. Such aggregates are physiologically similar to biofilms and protect pathogens from innate immune clearance and increase antibiotic tolerance. The cell-wall-associated protein SasG has been implicated in biofilm formation via mechanisms of intercellular aggregation but the mechanism in the context of disease is largely unknown. We have previously shown that the expression of cell-wall-anchored proteins involved in biofilm formation is controlled by the ArlRS-MgrA regulatory cascade. In this work, we demonstrate that the ArlRS two-component system controls aggregation, by repressing the expression of sasG by activation of the global regulator MgrA. We also demonstrate that SasG must be proteolytically processed by a non-staphylococcal protease to induce aggregation and that strains expressing functional full-length sasG aggregate significantly upon proteolysis by a mucosal-derived host protease found in human saliva. We used fractionation and N-terminal sequencing to demonstrate that human trypsin within saliva cleaves within the A domain of SasG to expose the B domain and induce aggregation. Finally, we demonstrated that SasG is involved in virulence during mouse lung infection. Together, our data point to SasG, its processing by host proteases, and SasG-driven aggregation as important elements of S. aureus adaptation to the host environment.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Bacterial pneumonia-induced shedding of epithelial heparan sulfate inhibits the bactericidal activity of cathelicidin in a murine model
Autorzy:
McCollister, Bruce D.
Erzen, Christopher L.
Oshima, Kaori
Horswill, Alexander R.
Langouet-Astrie, Christophe J.
Zhang, Fuming
Kwieciński, Jakub
Rizzo, Alicia N.
Colbert, James F.
Bastarache, Julie A.
Shi, Deling
Windham, Samuel L.
Schmidt, Eric P.
LaRiviere, Wells B.
Zehr, Evan P.
Opis:
Bacterial pneumonia is a common clinical syndrome leading to significant morbidity and mortality worldwide. In the current study, we investigate a novel, multidirectional relationship between the pulmonary epithelial glycocalyx and antimicrobial peptides in the setting of methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. Using an in vivo pneumonia model, we demonstrate that highly sulfated heparan sulfate (HS) oligosaccharides are shed into the airspaces in response to MRSA pneumonia. In vitro, these HS oligosaccharides do not directly alter MRSA growth or gene transcription. However, in the presence of an antimicrobial peptide (cathelicidin), increasing concentrations of HS inhibit the bactericidal activity of cathelicidin against MRSA as well as other nosocomial pneumonia pathogens (Klebsiella pneumoniae and Pseudomonas aeruginosa) in a dose-dependent manner. Surface plasmon resonance shows avid binding between HS and cathelicidin with a dissociation constant of 0.13 μM. These findings highlight a complex relationship in which shedding of airspace HS may hamper host defenses against nosocomial infection via neutralization of antimicrobial peptides. These findings may inform future investigation into novel therapeutic targets designed to restore local innate immune function in patients suffering from primary bacterial pneumonia. NEW & NOTEWORTHY Primary Staphylococcus aureus pneumonia causes pulmonary epithelial heparan sulfate (HS) shedding into the airspace. These highly sulfated HS fragments do not alter bacterial growth or transcription, but directly bind with host antimicrobial peptides and inhibit the bactericidal activity of these cationic polypeptides. These findings highlight a complex local interaction between the pulmonary epithelial glycocalyx and antimicrobial peptides in the setting of bacterial pneumonia.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Wyświetlanie 1-10 z 231

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