Autor: Schofield, Peter R.

Skocz do pozycji: 1.

Tytuł:: Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting
Autorzy:: Sharma, Pankaj
Woo, Daniel
Wong, Tien Y.
Beecham, Ashley H.
Cole, John W.
Thijs, Vincent
Griswold, Michael E.
Gudnason, Vilmundur
Montine, Thomas J.
Liewald, David
Maillard, Pauline
McWhirter, Rebekah
Kittner, Steven J.
Launer, Lenore J.
Hernández, Maria del C. Valdés
Aggarwal, Neelum T.
Wardlaw, Joanna M.
Rosand, Jonathan
van der Graaf, Yolanda
Brodaty, Henry
Adams, Hieab H.H.
Rexrode, Kathy
Thomson, Russell
Deary, Ian J.
Romero, Jose R.
Wittfeld, Katharina
Dichgans, Martin
Hofer, Edith
Tzourio, Christophe
Schmidt, Helena
Hopewell, Jemma C.
Schellenberg, Gerard D.
Satizabal, Claudia L.
International Stroke Genetics Consortium,
Rice, Kenneth
Longstreth, W.T.
Asselbergs, Folkert W.
Knopman, David S.
DeStefano, Anita L.
Srikanth, Velandai
Sachdev, Perminder S.
Beekman, Marian
Wright, Clinton B.
Starr, John M.
Armstrong, Nicola J.
Chouraki, Vincent
Jern, Christina
Schofield, Peter R.
van der Lee, Sven J.
Uh, Hae-Won
Saba, Yasaman
Worrall, Bradford B.
Hosten, Norbert
Benavente, Oscar R.
Callisaya, Michele
Schilling, Sabrina
Stott, David J.
van Duijn, Cornelia M.
Kjartansson, Olafur
Yamaguchi, Shuhei
Zhu, Yi-Cheng
Slagboom, Eline
Kaffashian, Sara
Rothwell, Peter M.
Amouyel, Philippe
DeCarli, Charles
Nabika, Toru
Uitterlinden, André G.
Kato, Norihiro
Amin, Najaf
Grewal, Raji P.
Chauhan, Ganesh
Rich, Stephen S.
McArdle, Patrick F.
Johnson, Julie A.
Trompet, Stella
van der Grond, Jeroen
Mitchell, Braxton D.
Gottesman, Rebecca F.
Sargurupremraj, Muralidharan
Phan, Thanh
Mather, Karen A.
Ames, David
Rajan, Kumar B.
Grabe, Hans J.
Jimenez-Conde, Jordi
Pera, Joanna
Meschia, James F.
Sacco, Ralph L.
Blanton, Susan H.
Beva, Steve
Wen, Wei
Kwok, John B.
Psaty, Bruce M.
von Sarnowski, Bettina
Seshadri, Sudha
Ikram, Mohammad K.
Liao, Jiemin
Pulit, Sara L.
de Bakker, Paul I.W.
Windham, B. Gwen
Stroke Genetics Network,
Moran, Chris
Wong, Quenna
Smith, Albert Vernon
Melander, Olle
Luciano, Michelle
Aparicio, Hugo J.
Bastin, Mark E.
Ford, Ian
Traylor, Matthew
Muñoz Maniega, Susana
Vernooij, Meike W.
Jukem, J. Wouter
Fornage, Myriam
Bis, Joshua C.
Thalamuthu, Anbupalam
Levi, Christopher
Geerlings, Mirjam I.
Rotter, Jerome I.
Arnett, Donna K.
Wasssertheil-Smoller, Sylvia
Markus, Hugh S.
Chen, Christopher
Słowik, Agnieszka
Mazoyer, Bernard
Beecham, Gary W.
Evans, Denis A.
Ikram, Mohammad A.
Völker, Uwe
Debette, Stéphanie
Rundek, Tatjana
Malik, Rainer
Hofman, Albert
Lopez, Oscar L.
Teumer, Alexander
Deelen, Joris
Lemmens, Robin
Lee, Jin-Moo
Chong, Elizabeth
De Jager, Philip L.
Schmidt, Reinhold
Cheng, Ching-Yu
Lindgren, Arne
Sudlow, Cathie L.M.
Rutten-Jacob, Loes C.A.
van der Lugt, Aad
Boncoraglio, Giorgio B.
Takeuchi, Fumihiko
Mosley, Thomas H.
METASTROKE,
Wright, Margaret J.
Hilal, Saima
Jian, Xueqiu
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 2.

Tytuł:: The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts
Autorzy:: Fan Chung, Kian
Sanak, Marek
Caruso, Massimo
Cheng, Xiaojing
Dahlen, Sven-Erik
Adcock, Ian M.
Sterk, Peter J.
Sousa, Ana R.
De Meulder, Bertrand
Krug, Norbert
Montuschi, Paolo
Dahlen, Barbro
Hou, Ruihua
Fowler, Stephen J.
Skipp, Paul J.
Bakke, Per S.
Sandström, Thomas
Horváth, Ildikó
Djukanovic, Ratko
Ye, Gang
Howarth, Peter H.
Schofield, James P.R.
Auffray, Charles
Shaw, Dominic E.
Opis:: Background: Growing evidence indicates high comorbid anxiety and depression in patients with asthma. However, the mechanisms underlying this comorbid condition remain unclear. The aim of this study was to investigate the role of inflammation in comorbid anxiety and depression in three asthma patient cohorts of the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) project. Methods: U-BIOPRED was conducted by a European Union consortium of 16 academic institutions in 11 European countries. A subset dataset from subjects with valid anxiety and depression measures and a large blood biomarker dataset were analysed, including 198 non-smoking patients with severe asthma (SAn), 65 smoking patients with severe asthma (SAs), 61 non-smoking patients with mild-to-moderate asthma (MMA), and 20 healthy non-smokers (HC). The Hospital Anxiety and Depression Scale was used to measure anxiety and depression and a series of inflammatory markers were analysed by the SomaScan v3 platform (SomaLogic, Boulder, Colo). ANOVA and the Kruskal-Wallis test were used for multiple-group comparisons as appropriate. Results: There were significant group effects on anxiety and depression among the four cohort groups (p < 0.05). Anxiety and depression of SAn and SAs groups were significantly higher than that of MMA and HC groups (p < 0.05. There were significant differences in serum IL6, MCP1, CCL18, CCL17, IL8, and Eotaxin among the four groups (p < 0.05). Depression was significantly associated with IL6, MCP1, CCL18 level, and CCL17; whereas anxiety was associated with CCL17 only (p < 0.05). Conclusions: The current study suggests that severe asthma patients are associated with higher levels of anxiety and depression, and inflammatory responses may underlie this comorbid condition.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 3.

Tytuł:: IL-17high asthma with features of a psoriasis immunophenotype
Autorzy:: Pandis, Ioannis
Sousa, Ana R.
Sanak, Marek
Howarth, Peter
Horvath, Ildiko
Krug, Norbert
Montuschi, Paolo
Sandstrom, Thomas
Bakke, Per S.
Djukanovic, Ratko
Bigler, Jeanette
Auffray, Charles
Östling, Jörgen
Sterk, Peter J.
Guo, Yike
Schofield, James P. R.
Fowler, Stephen J.
Shaw, Dominick E.
Jevnikar, Zala
Sun, Kai
Dahlen, Sven-Erik
Caruso, Massimo
Vaarala, Outi
Lutter, Rene
Ward, Jonathan
van Geest, Marleen
Wilson, Susan
Skipp, Paul J.
Chung, Kian Fan
Adcock, Ian M.
Opis:: Background: The role of IL-17 immunity is well established in patients with inflammatory diseases, such as psoriasis and inflammatory bowel disease, but not in asthmatic patients, in whom further study is required. Objective: We sought to undertake a deep phenotyping study of asthmatic patients with upregulated IL-17 immunity. Methods: Whole-genome transcriptomic analysis was performed by using epithelial brushings, bronchial biopsy specimens (91 asthmatic patients and 46 healthy control subjects), and whole blood samples (n 5 498) from the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) cohort. Gene signatures induced in vitro by IL-17 and IL-13 in bronchial epithelial cells were used to identify patients with IL-17–high and IL-13–high asthma phenotypes. Results: Twenty-two of 91 patients were identified with IL-17, and 9 patients were identified with IL-13 gene signatures. The patients with IL-17–high asthma were characterized by risk of frequent exacerbations, airway (sputum and mucosal) neutrophilia, decreased lung microbiota diversity, and urinary biomarker evidence of activation of the thromboxane B2 pathway. In pathway analysis the differentially expressed genes in patients with IL-17-high asthma were shared with those reported as altered in psoriasis lesions and included genes regulating epithelial barrier function and defense mechanisms, such as IL1B, IL6, IL8, and b-defensin. Conclusion: The IL-17–high asthma phenotype, characterized by bronchial epithelial dysfunction and upregulated antimicrobial and inflammatory response, resembles the immunophenotype of psoriasis, including activation of the thromboxane B2 pathway, which should be considered a biomarker for this phenotype in further studies, including clinical trials targeting IL-17.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 4.

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Skocz do pozycji: 5.

Tytuł:: Stratification of asthma phenotypes by airway proteomic signatures
Autorzy:: Nicholas, Ben
Lefaudeux, Diane
Horvath, Ildiko
Riley, John
Dahlen, Sven-Erik
Sun, Kai
Sandstrom, Thomas
Bakke, Per S.
Bansal, Aruna T.
Djukanovic, Ratko
Sousa, Ana R.
Montuschi, Paolo
Sanak, Marek
Chung, Kian Fan
Lutter, Rene
Krug, Norbert
Auffray, Charles
Caruso, Massimo
Xian, Yang
Staykova, Doroteya
Shaw, Dominick E.
Pandis, Ioannis
Corfield, Julie
De Meulder, Bertrand
Folisi, Caterina
Howarth, Peter
Adcock, Ian M.
Rowe, Anthony
Sterk, Peter J.
Wilson, Susan
Guo, Yike
Burg, Dominic
Skipp, Paul J.
Strazzeri, Fabio
Ward, Jonathan
Brandsma, Joost
Schofield, James P.R.
Fowler, Stephen J.
Opis:: neutrophils
proteomics
biomarkers
asthma
Background: Stratification by eosinophil and neutrophil counts increases our understanding of asthma and helps target therapy, but there is room for improvement in our accuracy in prediction of treatment responses and a need for better understanding of the underlying mechanisms. Objective: We sought to identify molecular subphenotypes of asthma defined by proteomic signatures for improved stratification. Methods: Unbiased label-free quantitative mass spectrometry and topological data analysis were used to analyze the proteomes of sputum supernatants from 246 participants (206 asthmatic patients) as a novel means of asthma stratification. Microarray analysis of sputum cells provided transcriptomics data additionally to inform on underlying mechanisms. Results: Analysis of the sputum proteome resulted in 10 clusters (ie, proteotypes) based on similarity in proteomic features, representing discrete molecular subphenotypes of asthma. Overlaying granulocyte counts onto the 10 clusters as metadata further defined 3 of these as highly eosinophilic, 3 as highly neutrophilic, and 2 as highly atopic with relatively low granulocytic inflammation. For each of these 3 phenotypes, logistic regression analysis identified candidate protein biomarkers, and matched transcriptomic data pointed to differentially activated underlying mechanisms. Conclusion: This study provides further stratification of asthma currently classified based on quantification of granulocytic inflammation and provided additional insight into their underlying mechanisms, which could become targets for novel therapies.
eosinophils
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 6.

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Skocz do pozycji: 7.

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Skocz do pozycji: 8.

Tytuł:: Treatable traits in the European U-BIOPRED adult asthma cohorts
Autorzy:: Wagers, Scott S.
Manta, A.
Krug, N.
Chung, Kian Fan
Seibold, W.
Fleming, L.J.
Sousa, Ana R.
Mazein, A.
Vestbo, J.
Hedlin, G.
van Geest, M.
Frey, U.
Horvath, Ildiko
James, A.J.
Bates, S.
Boedigheimer, M.J.
Djukanovic, Ratko
Burg, D.
Bonnelykke, K.
Postle, A.
Ahmed, H.
Simpson, Andrew J.
Miralpeix, M.
Baribaud, F.
Fitch, N.
Haughney, J.
Corfield, J.
Gahlemann, M.
Higenbottam, T.
Loza, M.J.
Masefield, S.
Dahlen, Sven-Erik
Bigler, J.
Sterk, P.J.
Sun, K.
Bisgaard, H.
Erpenbeck, V.J.
Guo, Y.
Bansal, A.T.
Adock, Ian M.
Chaiboonchoe, A.
Hohlfeld, J.M.
Mores, N.
Erzen, D.
Caruso, M.
Howarth, P.
De Meulder, B.
Pandis, Ioannis
Lutter, R.
Sigmund, R.
Montuschi, P.
Weiszhart, Z.
Rowe, A.
Rao, N.
Powel, P.
Geiser, T.
Bush, A.
Skipp, P.J.
Wagers, S.S.
Roberts, Graham
Compton, C.H.
Shaw, Dominick E.
Shaw, D.E.
Singer, Florian
Formaggio, E.
Pahus, L.
Sandstrom, Thomas
Hashimoto, S.
Knowles, R.
Montuschi, Paolo
Dahlen, Barbro
Matthews, J.G.
Wagener, A.H.
Musiał, Jacek
Fowler, Stephen J.
Hekking, P.W.
Vissing, N.H.
Bakke, Per S.
Knox, A.J.
Krung, Norbert
van Aalderen, W.
Riley, John H.
D'Amico, A.
Hekking, Pieter-Paul
Meiser, A.
Puig Valls, M.
Middelveld, R.J.M.
Auffray, C.
Caruso, Massimo
Roberts, A.
Sun, Kai
Bansal, Aruna T.
Goss, V.
Chanez, P.
Murray, C.S.
Sterk, Peter J.
Schofield, J.P.R.
Wheelock, C.E.
Brinkman, P.
Wilson, S.J.
Bel, E.H.
Pavlidis, S.
Brandsma, J.
Bucchioni, E.
Bates, Stewart
Selby, A.
Fleming, Louise J.
Lefaudeux, D.
Fichtner, K.
Singer, F.
Myles, D.
Pratico, G.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 9.

Tytuł:: Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
Autorzy:: Denaxas, Spiros
Lester, Kirchner H.
Bondy, Melissa
Casas, Juan P.
Kitchner, Terrie
Fiorito, Giovanni
Roden, Dan M.
Hovingh, Kees
Swerdlow, Daniel I.
Hemminki, Kari
Nicolaides, Andrew
Mahajan, Anubha
Linneberg, Allan
Lill, Christina M.
Pazoki, Raha
Wright, John
Morris, Richard
Pare, Guillaume
Law, Philip
Price, Jackie F.
Welch, Catherine
Hakonarson, Hakon
Campbell, Archie
Panayiotou, Andrie G.
Eppinga, Ruben N.
Uitterlinden, Andre
Wareham, Nicholas J.
Cooper, Jackie
Malyutina, Sofia
Valentine, Dennis
Fairhurst-Hunter, Zammy
Christen, Tim
Ingelsson, Erik
Hopewell, Jemma C.
Lerch, Markus M.
Franco, Oscar
Costa, Rui Providencia E.
Sanchez-Galvez, Adelaida
Guarrera, Simonetta
Kiechl, Stefan
Asselbergs, Folkert W.
Hancock, Stephen
Speedy, Helen
Scott, Robert A.
Hansen, Torben
Goldschmidt, Hartmut
Meade, Tom
Froguel, Philippe
Brilliant, Murray
Lange, Leslie A.
Demuth, Ilja
McLachlan, Stela
Faraway, Rupert
Grobbee, Diederick E.
Bao, Yanchun
Engert, Andreas
Mason, Dan
ODonnell, Martin
Bertram, Lars
Roussel, Ronan
Luan, Jianan
Crosslin, David R.
Ward, Joey
Hansson, Markus
Hartwig, Fernando Pires
Chong, Michael
Dorr, Marcus
Ritchie, Marylyn D.
Pikhart, Hynek
Holliday, Elizabeth
Li, Ni
Padmanabhan, Sandosh
Houlston, Richard
McCarty, Catherine A.
Moldovan, Max
Langenberg, Claudia
Smart, Melissa
Snieder, Harold
Kinnersley, Ben
Cornish, Alex J.
Chasman, Daniel I.
van Iperen, Erik
Pell, Jill P.
Schmidt, Amand F.
Willeit, Johann
Morgan, Gareth
Humphries, Steve E.
Young, Robin
Whincup, Peter
Bonnefond, Amelie
Labreche, Karim
Volzke, Henry
Finan, Chris
Ridker, Paul M.
Wanamethee, Goya
Dale, Caroline
Went, Molly
Attia, John
Ben-Shlomo, Yoav
Hingorani, Aroon D.
Tamosiunas, Abdonas
van der Schouw, Yvonne T.
Seshadri, Sudha
Kumari, Meena
Carrell, David S.
Denny, Joshua C.
Maitland-van der Zee, Anke H.
Matullo, Giuseppe
Patel, Riyaz S.
Sacerdote, Carlotta
Sattar, Naveed
Norman, Kristina
Power, Christine
Ford, Ian
Pająk, Andrzej
Lind, Lars
Schofield, Peter
Yusuf6, Salim
Holmes, Michael V.
Baumeister, Sebastian
Volker, Uwe
Christophersen, Ingrid E.
Scott, Rodney
Onland-Moret, N. Charlotte
Allan, James
Weinhold, Niels
Nilsson, Bjorn
Steinhagen-Thiessen, Elisabeth
Preiss, David
Verweij, Niek
Coassin, Stefan
Cariou, Bertrand
Bobak, Martin
Sanson, Marc
Jess, Tine
Baranova, Ekaterina V.
Bots, Michiel L.
Kivimaki, Mika
Willeit, Karin
Thuillier, Dorothee
Sonneveld, Pieter
Hofman, Albert
Teumer, Alexander
Hypponen, Elina
Simon, Matthias
Sud, Amit
de Andrade, Mariza
Larson, Eric B.
Carty, Cara
Grarup, Niels
Reiner, Alex P.
Said, M. Abdullah
Marques-Vidal, Pedro
Demuth, Juri
Fatemifar, Ghazaleh
Keating, Brendan J.
Hemingway, Harry
van der Harst, Pim
Mook-Kanamori, D. O.
Dobbins, Sara E.
Kubinova, Ruzena
Horta, Bernardo Lessa
Dehghan, Abbas
Pedersen, Oluf
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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