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Wyszukujesz frazę "Sebastian, John M." wg kryterium: Autor


Tytuł:
Pressure drop of filtering facepiece respirators: How low should we go?
Autorzy:
Kim, Jung-Hyun
Roberge, Raymond J.
Powell, Jeffrey B.
Shaffer, Ronald E.
Ylitalo, Caroline M.
Sebastian, John M.
Tematy:
respirator
filter
oral breathing
nasal breathing
Pokaż więcej
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Powiązania:
https://bibliotekanauki.pl/articles/2177016.pdf  Link otwiera się w nowym oknie
Opis:
Introduction This study was undertaken to determine the mean peak filter resistance to airflow (R filter) encountered by subjects while wearing prototype filtering facepiece respirators (PRs) with low Rfilter during nasal and oral breathing at sedentary and low-moderate work rates. Material and methods In-line pressure transducer measurements of mean R filter across PRs with nominal R filter of 29.4 Pa, 58.8 Pa and 88.2 Pa (measured at 85 l/min constant airflow) were obtained during nasal and oral breathing at sedentary and low-moderate work rates for 10 subjects. Results The mean R filter for the 29.4 PR was significantly lower than the other 2 PRs (p < 0.000), but there were no significant differences in mean R filter between the PRs with 58.8 and 88.2 Pa filter resistance (p > 0.05). The mean R filter was greater for oral versus nasal breathing and for exercise compared to sedentary activity (p < 0.001). Conclusions Mean oral and nasal R filter for all 3 PRs was at, or below, the minimal threshold level for detection of inspiratory resistance (the 58.8–74.5 Pa/l×s⁻¹), which may account for the previously-reported lack of significant subjective or physiological differences when wearing PRs with these low R filter. Lowering filtering facepiece respirator R filter below 88.2 Pa (measured at 85 l/min constant airflow) may not result in additional subjective or physiological benefit to the wearer.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modelling Climate and Societal Resilience in the Eastern Mediterranean in the Last Millennium
Autorzy:
Xoplaki, Elena
Bozkurt, Deniz
Luterbacher, Jürg
Sargent, Abigail M.
Akçer-Ön, Sena
Zorita, Eduardo
Preiser-Kapeller, Johannes
Fleitmann, Dominik
White, Sam
Izdebski, Adam
Mordechai, Lee
Haldon, John F.
Wagner, Sebastian
Toreti, Andrea
Opis:
This article analyses high-quality hydroclimate proxy records and spatial reconstructions from the Central and Eastern Mediterranean and compares them with two Earth System Model simulations (CCSM4, MPI-ESM-P) for the Crusader period in the Levant (1095-1290 CE), the Mamluk regime in Transjordan (1260-1516 CE) and the Ottoman crisis and Celâlî Rebellion (1580-1610 CE). During the three time intervals, environmental and climatic stress tested the resilience of complex societies. We find that the multidecadal precipitation and drought variations in the Central and Eastern Mediterranean cannot be explained by external forcings (solar variations, tropical volcanism); rather they were driven by internal climate dynamics. Our research emphasises the challenges, opportunities and limitations of linking proxy records, palaeoreconstructions and model simulations to better understand how climate can affect human history.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Umbralisib, a Dual PI3Kδ/CK1ε Inhibitor in Patients With Relapsed or Refractory Indolent Lymphoma
Autorzy:
Cheah, Chan Y.
Chavez, Julio C.
Sharman, Jeff P.
Miskin, Hari P.
Hodson, Daniel J.
Leslie, Lori A.
Babu, Sunil
Cheson, Bruce D.
Oconnor, Owen A.
Weiss, Michael S.
Law, Jennie Y.
Samaniego, Felipe
Jurczak, Wojciech
Grosicki, Sebastian
Derenzini, Enrico
Reeves, James A.
Knopinśka-Posłuszny, Wanda
Phillips, Tycel
Lech-Maranda, Ewa
Ghosh, Nilanjan
Burke, John M.
Fonseca, Gustavo
Zinzani, Pier Luigi
Shao, Spencer H.
Pagel, John M.
Fowler, Nathan H.
Caimi, Paolo F.
Sportelli, Peter
Opis:
Purpose: Phosphatidylinositol-3-kinase (PI3K) inhibitors have shown activity in relapsed or refractory (R/R) indolent non-Hodgkin lymphoma (iNHL). PI3K inhibitors have been hampered by poor long-term tolerability and toxicity, which interfere with continuous use. Umbralisib, a dual inhibitor of PI3Kδ/casein kinase-1ε, exhibits improved selectivity for PI3Kδ compared with other PI3K inhibitors. This phase IIb trial was designed to evaluate the efficacy and safety of umbralisib in patients with R/R iNHL. Patients and Methods; In this multicohort, open-label, phase IIb study, 208 patients with R/R marginal zone, follicular, or small lymphocytic lymphoma (MZL, FL, or SLL) unresponsive to prior treatments (≥ 1 MZL; ≥ 2 FL/SLL), including ≥ 1 anti-CD20–based therapy, were administered umbralisib 800 mg orally once daily until disease progression, unacceptable toxicity, or study withdrawal. Primary end point is overall response rate; secondary end points include time to response, duration of response, progression-free survival, and safety. Results; The median follow-up is 27.7 months (efficacy) and 21.4 months (safety). The overall response rate was 47.1%, and tumor reduction occurred in 86.4% of patients. The median time to response was 2.7-4.6 months. The median duration of response was not reached for MZL, 11.1 months for FL, and 18.3 months for SLL. Median progression-free survival was not reached for MZL, 10.6 months for FL, and 20.9 months for SLL. At least one grade ≥ 3 treatment-emergent adverse event (TEAE) was reported in 53.4% of patients. TEAEs led to umbralisib discontinuation in 32 patients (15.4%). A total of 31 patients (14.9%) discontinued because of a treatment-related adverse event. Grade ≥ 3 TEAEs reported in ≥ 10% of patients: neutropenia (11.5%) and diarrhea (10.1%). Increased ALT/AST (grade ≥ 3) occurred in 6.7%/7.2% of patients. Conclusion; Umbralisib achieved meaningful clinical activity in heavily pretreated patients with iNHL. The safety profile was manageable, with a relatively low incidence of immune-mediated toxicities and adverse event–related discontinuations.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
A global survey of taxa-metabolic associations across mouse microbiome communities
Autorzy:
Garrett, Wendy S.
Wullaert, Andy
Grassi, Fabio
Le Gac, Constance
Baertschi, Isabel
Van Loo, Pascalle L.P.
Ohno, Hiroshi
Black, Caitlin
Pachnis, Vassilis
Small, Lewin
Silva-Santos, Bruno
Trajkovski, Mirko
Evans, Julian
Vicente, Ana Mafalda
Blank, Thomas
Kim, Kwan Soon
Ciftci, Pinar
Stelling, Jörg
Obata, Yuuki
Birchenough, George M.H.
Mossad, Omar
Cassano, Marco
Karacan, Ilker
Trono, Didier
Kariuki, Daniel
Kaser, Arthur
Denaxa, Myrto
Rescigno, Maria
Pettersson, Sven
Lopes, Patricia
Boatman, Bruce
Costa, Rui M.
Bae, Sena
Cerutti, Andrea
Sauer, Uwe
Jeney, Viktoria
Baines, John F.
Claudinot, Stephanie
Adnan, Ali
Gonçalves-Sousa, Natacha
Cowan, Peter J.
Powrie, Fiona
Yilmaz, Bahtiyar
Maffei, Sara
Martín, Pilar
Kotlinowski, Jerzy
Heikenwalder, Mathias
Lam, Lilian
Grasset, Emilie K.
Bozza, Marcelo T.
Fremond, Cecile
Li, Jiaqi
Lindholm, Anna K.
Macpherson, Andrew J.
Karaman, Sinem
Knowles, Sarah C.L.
Rigo, Dorothée
Holland, Lorraine M.
Weis, Sebastian
Prinz, Marco
Altıntaş, Ali
Jordi, Sebastian B.U.
Sullivan, Zuri
Im, Sin-Hyeog
Speksnijder, Ewoud N.
Gozzelino, Raffaella
Kanaya, Takashi
Offner, Sandra
Vereecke, Lars
Pearson, Claire
Hamza, Iqbal
Lamas, Sofia
König, Barbara
Hanski, Eveliina
Li, Hai
Nanou, Aikaterini
Meier, Karin H.U.
Vidal, Vinicius M.
Cardoso, Silvia
Lizier, Michela
Opis:
Host-microbiota mutualism is rooted in the exchange of dietary and metabolic molecules. Microbial diversity broadens the metabolite pool, with each taxon contributing distinct compounds in varying proportions. In the human microbiome, high variability in consortial composition is largely compensated by similar metabolic functions across different taxa. However, the extent of compensation in lower diversity mouse models, and whether vivaria are metabolically equivalent, is unknown. We provide a searchable resource of microbiome composition variability across 51 murine vivaria and 12 wild mouse colonies worldwide, with vivarium-specific variants mapped according to predicted 3D structures for each microbial species. Our matched metabolomics data show that realized metabolic potential has relatively low variability, providing functional evidence for metabolic compensation. Additionally, variability is related to taxonomic composition rather than vivarium, revealing taxa-metabolite associations that are potentially relevant to phenotypic differences between vivaria. Collectively, this resource offers tools to strengthen microbiome studies and collaborative science.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
GrassPlot v. 2.00 : first update on the database of multi-scale plant diversity in Palaearctic grasslands
Autorzy:
Molau, Ulf
Mašić, Ermin
Kącki, Zygmunt
Savchenko, Galina
Świerszcz, Sebastian
Dramstad, Wenche
Deák, Balázs
Demeter, László
Jiménez-Alfaro, Borja
Hájek, Michal
Burrascano, Sabina
Jeanneret, Philippe
Zlotnikova, Ekaterina
Aleffi, Michele
Dembicz, Iwona
Dřevojan, Pavel
Doležal, Jiří
Etzold, Jonathan
Berg, Christian
Essl, Franz
Dolnik, Christian
Wróbel, Anna
Bhatta, Kuber Prasad
Alatalo, Juha M.
Waldén, Emelie
Pellissier, Vincent
Kelemen, András
Meier, Eliane S.
Tölgyesi, Csaba
Moysiyenko, Ivan
Güler, Behlül
Wolfrum, Sebastian
Swacha, Grzegorz
Pielech, Remigiusz
Valkó, Orsolya
Meerbeek, Koenraad van
Garcia-Mijangos, Itziar
Stevens, Carly
Kuzemko, Anna
Hepenstrick, Daniel
Klichowska, Ewelina
Shyriaieva, Dariia
Babbi, Manuel
Grytnes, John-Arvid
Pedersen, Christian
Nobis, Marcin
Fjellstad, Wendy
Mirin, Denis
Magnes, Martin
Vashenyak, Iuliia
Campos, Juan Antonio
Boch, Steffen
Vetaas, Ole Reidar
Ceulemans, Tobias
Naqinezhad, Alireza
Ninot, Josep M.
Afif, Elias
Erschbamer, Brigitta
Belonovskaya, Elena
Deng, Lei
Widmer, Stefan
Dengler, Jürgen
Lomba, Angela
Mimet, Anne
Nowak, Arkadiusz
Palpurina, Salza
Jägerbrand, Annika K.
Kapfer, Jutta
Vynokurov, Denys
Honrado, João P.
Peters, Jan
Löbel, Swantje
Roleček, Jan
Filibeck, Goffredo
Lepš, Jan
Kirschner, Philipp
Hodgson, John G.
Kolomiiets, Ganna
Tsarevskaya, Nadezda
Ronkin, Vladimir
Janišová, Monika
Bergamini, Ariel
Bátori, Zoltán
Ecker, Klaus
Malicki, Marek
Manthey, Michael
Csergő, Anna Mária
Cancellieri, Laura
Mayrhofer, Helmut
Marcenò, Corrado
Pladevall-Izard, Eulàlia
Biurrun, Idoia
Pérez-Haase, Aaron
Sickel, Hanne
Mechelen, Carmen Van
Lindborg, Regina
Guarino, Riccardo
Wagner, Viktoria
Kozub, Łukasz
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł

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