Autor: Simon, Rolf - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Element changes occurring in brain point at the white matter abnormalities in rats exposed to the ketogenic diet during prenatal life
Autorzy:: Setkowicz-Janeczko, Zuzanna
Chwiej, Joanna
Rugieł, Marzena
Baumbach, Tilo
Simon, Rolf
Czyzycki, Mateusz
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 2.

Tytuł:: Elemental changes in the hippocampal formation following two different formulas of ketogenic diet : an X-ray fluorescence microscopy study
Autorzy:: Patulska, Agnieszka
Janeczko, Krzysztof
Kaczyńska, Małgorzata
Skoczeń, Agnieszka
Simon, Rolf
Setkowicz-Janeczko, Zuzanna
Chwiej, Joanna
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 3.

Tytuł:: The applicability of Fourier transform infrared microspectroscopy for correction against matrix effects in X-ray fluorescence microimaging of tissues
Autorzy:: Stec, Patryk
Czyzycki, Mateusz
Ziomber-Lisiak, Agata
Szczerbowska-Boruchowska, Magdalena
Simon, Rolf
Szczerbowski, Zbigniew
Baumbach, Tilo
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 4.

Tytuł:: Progress of elemental anomalies of hippocampal formation in the pilocarpine model of temporal lobe epilepsy-an X-ray fluorescence microscopy study
Autorzy:: Setkowicz-Janeczko, Zuzanna
Gzieło, Kinga
Chwiej, Joanna
Janeczko, Krzysztof
Uram, Łukasz
Simon, Rolf
Kutorasińska, Justyna
Appel, Karen
Opis:: In the present paper, X-ray fluorescence microscopy was applied to follow the processes occurring in rat hippocampal formation during the post-seizure period. In the study, one of the status epilepticus animal models of epilepsy was used, namely the model of temporal lobe epilepsy with pilocarpine-induced seizures. In order to analyze the dynamics of seizure-induced elemental changes, the samples taken from seizure-experiencing animals 3 h and 1, 4, and 7 days after proconvulsive agent administration were analyzed. The obtained results confirmed the utility of X-ray fluorescence microscopy in the research of mechanisms involved in the pathogenesis and progress of epilepsy. The topographic and quantitative elemental analysis of hippocampal formations from different periods of epileptogenesis showed that excitotoxicity, mossy fibers sprouting, and iron-induced oxidative stress may be the processes responsible for seizure-induced neurodegenerative changes and spontaneous recurrent seizures occurring in the chronic phase of the pilocarpine model. The analysis of correlations between the recorded elemental anomalies and quantitative parameters describing animal behavior in the acute period of pilocarpine-induced status epilepticus showed that the areal densities of selected elements measured in the latent period strongly depend on the progress of the acute phase. Especially important seem to be the observations done for Ca and Zn levels which suggest that the intensity of the pathological processes such as excitotoxicity and mossy fibers sprouting depend on the total time of seizure activity. These results as well as dependencies found between the levels of S, K, and Cu and the intensity of maximal seizures clearly confirm how important it is to control the duration and intensity of seizures in clinical practice.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 5.

Tytuł:: The influence of the ketogenic diet on the elemental and biochemical compositions of the hippocampal formation
Autorzy:: Simon, Rolf
Setkowicz-Janeczko, Zuzanna
Sandt, Christophe
Skoczeń, Agnieszka
Chwiej, Joanna
Matusiak, Katarzyna
Patulska, Agnieszka
Janeczko, Krzysztof
Kaczyńska, Małgorzata
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 6.

Tytuł:: Altered elemental distribution in male rat brain tissue as a predictor of glioblastoma multiforme growth : studies using SR-XRF microscopy
Autorzy:: Planeta, Karolina
Simon, Rolf
Setkowicz-Janeczko, Zuzanna
Baumbach, Tilo
Ryszawy, Damian
Chwiej, Joanna
Janik-Olchawa, Natalia
Janeczko, Krzysztof
Czyzycki, Mateusz
Opis:: Glioblastoma multiforme (GBM) is a particularly malignant primary brain tumor. Despite enormous advances in the surgical treatment of cancer, radio- and chemotherapy, the average survival of patients suffering from this cancer does not usually exceed several months. For obvious ethical reasons, the search and testing of the new drugs and therapies of GBM cannot be carried out on humans, and for this purpose, animal models of the disease are most often used. However, to assess the efficacy and safety of the therapy basing on these models, a deep knowledge of the pathological changes associated with tumor development in the animal brain is necessary. Therefore, as part of our study, the synchrotron radiation-based X-ray fluorescence microscopy was applied for multi-elemental micro-imaging of the rat brain in which glioblastoma develops. Elemental changes occurring in animals after the implantation of two human glioma cell lines as well as the cells taken directly from a patient suffering from GBM were compared. Both the extent and intensity of elemental changes strongly correlated with the regions of glioma growth. The obtained results showed that the observation of elemental anomalies accompanying tumor development within an animal's brain might facilitate our understanding of the pathogenesis and progress of GBM and also determine potential biomarkers of its extension. The tumors appearing in a rat's brain were characterized by an increased accumulation of Fe and Se, whilst the tissue directly surrounding the tumor presented a higher accumulation of Cu. Furthermore, the results of the study allow us to consider Se as a potential elemental marker of GBM progression.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego