- Tytuł:
- A global survey of taxa-metabolic associations across mouse microbiome communities
- Autorzy:
-
Garrett, Wendy S.
Wullaert, Andy
Grassi, Fabio
Le Gac, Constance
Baertschi, Isabel
Van Loo, Pascalle L.P.
Ohno, Hiroshi
Black, Caitlin
Pachnis, Vassilis
Small, Lewin
Silva-Santos, Bruno
Trajkovski, Mirko
Evans, Julian
Vicente, Ana Mafalda
Blank, Thomas
Kim, Kwan Soon
Ciftci, Pinar
Stelling, Jörg
Obata, Yuuki
Birchenough, George M.H.
Mossad, Omar
Cassano, Marco
Karacan, Ilker
Trono, Didier
Kariuki, Daniel
Kaser, Arthur
Denaxa, Myrto
Rescigno, Maria
Pettersson, Sven
Lopes, Patricia
Boatman, Bruce
Costa, Rui M.
Bae, Sena
Cerutti, Andrea
Sauer, Uwe
Jeney, Viktoria
Baines, John F.
Claudinot, Stephanie
Adnan, Ali
Gonçalves-Sousa, Natacha
Cowan, Peter J.
Powrie, Fiona
Yilmaz, Bahtiyar
Maffei, Sara
Martín, Pilar
Kotlinowski, Jerzy
Heikenwalder, Mathias
Lam, Lilian
Grasset, Emilie K.
Bozza, Marcelo T.
Fremond, Cecile
Li, Jiaqi
Lindholm, Anna K.
Macpherson, Andrew J.
Karaman, Sinem
Knowles, Sarah C.L.
Rigo, Dorothée
Holland, Lorraine M.
Weis, Sebastian
Prinz, Marco
Altıntaş, Ali
Jordi, Sebastian B.U.
Sullivan, Zuri
Im, Sin-Hyeog
Speksnijder, Ewoud N.
Gozzelino, Raffaella
Kanaya, Takashi
Offner, Sandra
Vereecke, Lars
Pearson, Claire
Hamza, Iqbal
Lamas, Sofia
König, Barbara
Hanski, Eveliina
Li, Hai
Nanou, Aikaterini
Meier, Karin H.U.
Vidal, Vinicius M.
Cardoso, Silvia
Lizier, Michela - Opis:
- Host-microbiota mutualism is rooted in the exchange of dietary and metabolic molecules. Microbial diversity broadens the metabolite pool, with each taxon contributing distinct compounds in varying proportions. In the human microbiome, high variability in consortial composition is largely compensated by similar metabolic functions across different taxa. However, the extent of compensation in lower diversity mouse models, and whether vivaria are metabolically equivalent, is unknown. We provide a searchable resource of microbiome composition variability across 51 murine vivaria and 12 wild mouse colonies worldwide, with vivarium-specific variants mapped according to predicted 3D structures for each microbial species. Our matched metabolomics data show that realized metabolic potential has relatively low variability, providing functional evidence for metabolic compensation. Additionally, variability is related to taxonomic composition rather than vivarium, revealing taxa-metabolite associations that are potentially relevant to phenotypic differences between vivaria. Collectively, this resource offers tools to strengthen microbiome studies and collaborative science.
- Dostawca treści:
- Repozytorium Uniwersytetu Jagiellońskiego
Artykuł