Autor: Stolarz, A. - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Endorsing titanium–scandium radionuclide generator for PET and positronium imaging
Autorzy:: Choiński, J.
Kadenko, I.
Moskal, Paweł
Majkowska-Pilip, A.
Walczak, R.
Jones, P.
Stolarz, A.
Stępień, Ewa
Palit, R.
Khreptak, Aleksander
Opis:: The development of positron emission tomography and positronium imaging techniques is strictly related to the availability of suitable radionuclides and robust radiochemistry platforms. Among the emerging candidates, $^{44}$Sc has attracted significant interest due to its favourable physical properties, including a half-life of ~4 h, a pure β$^{+}$ emission profile, and the additional prompt γ-emission that enables advanced triple-photon detection schemes. These characteristics make $^{44}$Sc particularly promising for high-resolution imaging and novel quantitative methodologies. However, routine clinical and preclinical implementation requires a practical, sustainable, and cost-efficient production route. In this context, we propose a titanium–scandium radionuclide generator as an optimal solution. This study focuses on optimising the synthesis of the long-lived parent isotope, $^{44}$Ti (T$^{1/2}$ = 59.1 years), from which $^{44}$Sc can be selectively eluted in a chemically pure form when needed. An analysis of various production pathways was conducted, including proton and deuteron reactions on scandium, as well as α-particle and lithium-induced reactions on calcium, to determine the most efficient reaction parameters, target design, and expected yield. Furthermore, we identify some existing cyclotron facilities suitable for implementing this technology. Results indicate that efficient $^{44}$Ti production is achievable using proton beams in the 20–30 MeV range under extended irradiation conditions. The proposed generator system would enable routine and decentralised $^{44}$Sc supply. Its integration with the novel Jagiellonian positron emission tomography scanner may significantly reduce diagnostic costs and improve access to advanced positron emission tomography imaging in regions with limited medical imaging infrastructure.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 2.

Tytuł:: Warsaw cyclotron: present status and plans of development
Autorzy:: Choiński, J.
Czosnyka, T.
Dworski, J.
Jastrzębski, J.
Kownacki, J.
Kulczycka, E.
Kurzyński, J.
Miszczak, J.
Stolarz, A.
Sudlitz, K.
Sura, J.
Zemło, L.
Tematy:: accelerators physics
cyclotrons
application of cyclotron in nuclear
atomic and solid state physics; Pokaż więcej
Wydawca:: Instytut Chemii i Techniki Jądrowej
Powiązania:: https://bibliotekanauki.pl/articles/148689.pdf Link otwiera się w nowym oknie
Opis:: The operation of the Warsaw heavy ion cyclotron is presented. Technical solutions adopted were intended to accommodate the needs of different groups of users requiring a wide scope of beam species and energies. The accelerating structure of the machine, with two 45 degree dees, allows for the operation in the harmonics modes from 2 to 6 (first harmonic mode is also possible, although the acceleration of protons and deuterons is currently not within the scope of interest). Available energies range from 2 to about 10 MeV/amu due to the wide range of the stripping extraction system. Development of the multiturn stripping extraction technique was necessary to achieve the flexibility in energy variation, otherwise not reachable due to the highly saturated iron structure, which makes impossible the change of magnetic field and radio-frequency within the desirable limits. At present, the cyclotron, equipped with the ECR ion source, is capable of delivering ion beams from gaseous media up to Ar. Available ion beam species, their energies and intensities obtained up-to-date are shown. An overview of the experiments performed on the Warsaw cyclotron, including basic nuclear physics research, solid state physics and materials science, is intended to demonstrate the potential of the facility. The efficiency of the cyclotron and the ion beam line optics is discussed, as well as the plans for the future upgrade of the cyclotron and its infrastructure.
Dostawca treści:: Biblioteka Nauki

Artykuł

na półce

Skocz do pozycji: 3.

Tytuł:: Medical Radioisotopes Produced Using the Alpha Particle Beam from the Warsaw Heavy Ion Cyclotron
Autorzy:: Szkliniarz, K.
Jastrzębski, J.
Bilewicz, A.
Chajduk, E.
Choiński, J.
Jakubowski, A.
Janiszewska, Ł.
Leszczuk, E.
Łyczko, M.
Sitarz, M.
Stolarz, A.
Trzcińska, A.
Wąs, B.
Zipper, W.
Tematy:: 87.57.un
87.57.-s; Pokaż więcej
Wydawca:: Polska Akademia Nauk. Instytut Fizyki PAN
Powiązania:: https://bibliotekanauki.pl/articles/1402612.pdf Link otwiera się w nowym oknie
Opis:: The internal alpha particle beam of the heavy ion cyclotron operated by the Heavy Ion Laboratory (HIL) of the University of Warsaw has a maximum energy of 32 MeV and currently an intensity of up to 1 pμA. This beam is used by the HIL-University of Silesia collaboration for the production of research quantities of $\text{}^{211}At,$ $\text{}^{72}Se//\text{}^{72}As$ and $\text{}^{43,44}Sc$ radioisotopes. The produced activities are transported to the Institute of Nuclear Chemistry and Technology in Warsaw where research on therapeutic and imaging radiopharmaceuticals based on these radioisotopes is pursued.
Dostawca treści:: Biblioteka Nauki