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    Wyświetlanie 1-9 z 9
    Tytuł:
    Inflammatory syndromes including PIMS-TS in children hospitalised in the Malopolska region of Poland in the first wave of the COVID-19 pandemic
    Autorzy:
    Kwinta, Przemko
    Stopyra, Lidia
    Kania, Urszula
    Opis:
    Introduction: To describe cases meeting the criteria of Kawasaki disease (KD), with particular consideration of the first 2 cases of paediatric inflammatory multisystem syndrome temporarily associated with SARS-CoV-2 infection (PIMS-TS) in patients in the Malopolska region in the first wave of the disease caused by SARS-CoV-2 infection (COVID-19) pandemic. Material and methods: From 4 March to 15 July 2020 a total of 11 children meeting KD criteria were hospitalised in the Department of Infectious Diseases and Paediatrics, S. Żeromski Specialist Hospital in Krakow and the Clinic of Children’s Diseases, Department of Paediatrics, Jagiellonian University Medical College in Krakow. This paper analyses the data collected and describes in detail the disease in 2 children with PIMS-TS. Results: None of the 11 children who met the criteria of KD had a positive SARS-CoV-2 PCR test on admission. SARS-CoV-2 IgG test results were positive in 2 patients. All children presented with fever, rash, and conjunctivitis; 9 with swollen hands and feet; 8 with mucous membrane changes; 5 with abdominal symptoms; 5 with respiratory symptoms; and 1 with neurological signs. As regards laboratory tests, C-reactive protein (CRP), procalcitonin, lymphocytes, platelets, All were assessed in all patients, albumin in 10/11, lactate dehydrogenase (LDH), fibrinogen in 9/11, troponin and ferritin in 6/11, pro-BNP, D-dimers in 8/11. Echocardiography was performed in all patients and showed coronary artery abnormalities in 4 children. In PIMS-TS significant elevation of procalcitonin, CRP, D-dimers, N-terminal prohormone of brain natriuretic peptide (NT-pro-BNP), and thrombocytopaenia were observed. Conclusions1. Because of the asymptomatic course of SARS-CoV-2 infection in children who subsequently developed PIMS-TS and the absence of any viral genetic material in a sample collected from the upper airways upon PIMS-TS diagnosis, a detailed epidemiological interview and a reliable serology testing for SARS-CoV-2 infection are necessary in each case meeting KD or PIMS-TS criteria. 2. There is a need to look for new factors differentiating PIMS-TS and KD, other than polymerase chain reaction (PCR) and serology tests.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    The age-related course of COVID-19 in pediatric patients-1405 cases in a single center
    Autorzy:
    Majchrzak, Ida
    Kwinta, Przemko
    Szebla, Justyna
    Jakosz, Mateusz
    Kowalik, Aleksandra
    Stala, Justyna
    Stopyra, Lidia
    Opis:
    Since the beginning of the pandemic, many reports have pointed to age as the most important risk factor for severe COVID-19 in adults, but this relationship is less clear in children. Between March 2020 and April 2022, 1405 pediatric COVID-19 patients were included in our prospective study, which aimed to analyze the disease’s characteristics in three age groups: infants, toddlers (1–5 years), and children (5–18 years). We observed male prevalence of the disease in infants and toddlers compared to female prevalence in children. Comorbidities appeared most often in children. In the first pandemic wave, the vast majority of pediatric patients were children, but later, the percentage of infant and toddler patients increased significantly. A total of 74% of hospitalized children were younger than five years. Upper respiratory tract symptoms were most common in infants and toddlers, and lower respiratory tract symptoms and gastroenterocolitis were more common in children. Neurological symptoms appeared similarly in all age groups. The activities of ALT, CK, and LDH were the most elevated in infants, along with D-dimers. The median length of hospitalization fluctuated between three and four days and was highest in infants. Severe courses were more common in adolescents.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Characteristics of hospitalized pediatric patients in the first five waves of the COVID-19 pandemic in a single center in Poland - 1407 cases
    Autorzy:
    Majchrzak, Ida
    Grzywaczewska, Karolina
    Szebla, Justyna
    Jakosz, Mateusz
    Kowalik, Aleksandra
    Kwinta, Przemko
    Stopyra, Lidia
    Stala, Justyna
    Opis:
    This is a single-center, prospective study that compared the clinical presentation and laboratory findings of hospitalized children during the first five waves of the COVID-19 pandemic. Data were collected, according to a standardized questionnaire, from 1407 children from 23 March 2020 to 30 April 2022. Significant differences in clinical courses were found among the five waves probably due to different SARS-CoV-2 variants. The median age was 95.8 months in the first wave versus 14.6–23 months in the others. The number of patients with upper respiratory infection was the highest in the fifth wave (74.4% versus 43.8–56.9% in the others) and for lower respiratory infection in the first wave (50.0% versus 16.4–32.5%). Gastroenterocolitis was more common in the fifth wave (24.4% versus 8.9–16.5%); neurological diagnoses appeared more frequently in the fourth wave (16.6% versus 0.6–9.9%), while anosmia and ageusia were higher in the fifth wave (13% versus 1.5–4%). Life-threatening courses were relatively rare. However, children with pneumonia, dehydration from high fever, gastrointestinal symptoms, loss of smell and taste, and neurological symptoms required hospitalization.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
      Wyświetlanie 1-9 z 9

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