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Wyszukujesz frazę "Szade, Piotr" wg kryterium: Autor


Wyświetlanie 1-4 z 4
Tytuł:
Fatigue life of compacted wire ropes for applications in deep mining
Autorzy:
Kubiś, Bogusław
Olszyna, Grzegorz
Szade, Piotr
Tytko, Andrzej
Tematy:
steel wire rope
fatigue tests
compacted ropes
fatigue durability
Pokaż więcej
Wydawca:
STE GROUP
Powiązania:
https://bibliotekanauki.pl/articles/27315587.pdf  Link otwiera się w nowym oknie
Opis:
Recent months have highlighted the progressing energy crisis across Europe in connection with the severe sanctions imposed on the import of hydrocarbons and coal from Russia. This is particularly visible in Poland, where over 40% of electricity is generated from coal, while in individual households it is the primary source of heat. This situation puts the already enigmatic plans of shutting down coal mining in Poland into question. Therefore, work aimed at increasing the extraction capacity of existing shafts while maintaining the highest level of operational safety is still valid. This article concerns the issues of the fatigue life of compacted ropes used as hoist ropes in mine shafts. The discussion regarding the use of these ropes among shaft hoist users has been going on for several years. This paper presents the unique results of compacted rope fatigue tests carried out at the Central Mining Institute in Katowice. In the authors’ view, these results and their interpretation should serve to clarify several important aspects that arouse the interest of users.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Diosmetin alleviates TNFα-induced liver inflammation by improving liver sinusoidal endothelial cell dysfunction
Autorzy:
Pośpiech, Ewelina
Jura, Jolanta
Pydyn, Natalia
Kotlinowski, Jerzy
Radkowiak, Dorota
Szade, Krzysztof
Trzos, Katarzyna
Żurawek, Dariusz
Kuś, Edyta
Małczak, Piotr
Budzyński, Andrzej
Chłopicki, Stefan
Major, Piotr
Opis:
Sterile inflammation contributes to the development of many liver diseases including non-alcoholic fatty liver disease. Tumor necrosis factor alpha ($TNF\alpha$) is a key cytokine driving liver inflammation primarily through pro-inflammatory activation of liver sinusoidal endothelial cells (LSEC). The knowledge of whether modulating LSEC activation can alleviate liver inflammation is scarce. This study aims to establish and validate an animal model mimicking LSEC dysfunction observed in obese patients with elevated plasma levels of $TNF\alpha$, and explore whether vasoactive flavonoid diosmetin could serve as a therapeutic agent for liver inflammation by modulation of LSEC dysfunction. Obese patients with elevated plasma levels of $TNF\alpha$, LSEC dysfunction and liver inflammation had also reduced Mcpip1 expression in peripheral blood mononuclear cells. Mcpip1 is a protein that negatively regulates the levels of pro-inflammatory cytokines. To model this, we generated mice with Mcpip1 knock-out in myeloid cells ($Mcpip1^{fl/fl}LysM^{Cre}$), which displayed systemic and liver inflammation like that observed in patients. Diosmetin treatment efficiently reduced $TNF\alpha$-dependent LSEC activation in vitro and in vivo, and reduced liver inflammation in $Mcpip1^{fl/fl}LysM^{Cre}$ mice without affecting systemic inflammation. Diosmetin's effects may stem from inhibiting NF-κB pathway in $TNF\alpha$-activated endothelial cells. Our findings demonstrate that the $Mcpip1^{fl/fl}LysM^{Cre}$ mouse model is useful for studying new anti-inflammatory therapies for the liver. We show that diosmetin, a vasoactive flavonoid used in the clinic to treat chronic venous insufficiency, also has strong anti-inflammatory properties in the liver. These results indicate that diosmetin has the potential to be further investigated as a supportive therapy for liver inflammation in humans.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
SOLARIS National Synchrotron Radiation Centre in Krakow, Poland
Autorzy:
Mandziak, Anna
Panaś, Roman
Ciochoń, Piotr
Lichtenberg, Henning
Marendziak, Andrzej
Ślęzak, Tomasz
Stępień, Joanna
Wróbel, Tomasz
Błachucki, Wojciech
Kołodziej, Jacek
Rawski, Michał
Ważny, Grzegorz
Guła, Krzysztof
Gazdowicz, Grzegorz
Piszak, Marcel
Kołodziej, Tomasz
Ślęzak, Michał
Wiechecki, Jarosław
Korecki, Józef
Indyka, Paulina
Prange, Alexander
Freindl, Kinga
Hormes, Josef
Kosiorowski, Filip
Matlak, Krzysztof
Kwiatek, Wojciech
Kosowska, Karolina
Szlachetko, Jakub
Liberda-Matyja, Danuta
Madej, Ewa
Partyka-Jankowska, Ewa
Sikora, Marcin
Sowa, Katarzyna
Tyliszczak, Tolek
Korecki, Paweł
Olszowska, Natalia
Sobol, Tomasz
Klonecka, Agnieszka
Dumas, Paul
Maximenko, Alexey
Sławek, Joanna
Wróbel, Paweł
Rosmus, Marcin
Wolanin, Barbara
Wawrzyniak, Adriana
Szczepanik, Magdalena
Kowalski, Grzegorz
Roman, Maciej
Glatt, Sebastian
Zając, Marcin
Stankiewicz, Marek
Kozioł, Paulina
Wilgocka-Ślęzak, Dorota
Szade, Jacek
Beyer, Edyta
Spiridis, Nika
Nita, Paweł
Kozak, Maciej
Opis:
The SOLARIS synchrotron located in Krakow, Poland, is a third-generation light source operating at medium electron energy. The first synchrotron light was observed in 2015, and the consequent development of infrastructure lead to the first users’ experiments at soft X-ray energies in 2018. Presently, SOLARIS expands its operation towards hard X-rays with continuous developments of the beamlines and concurrent infrastructure. In the following, we will summarize the SOLARIS synchrotron design, and describe the beamlines and research infrastructure together with the main performance parameters, upgrade, and development plans.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
    Wyświetlanie 1-4 z 4

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