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    Wyświetlanie 1-5 z 5
    Tytuł:
    Zanubrutinib versus ibrutinib in symptomatic Waldenström macroglobulinemia : final analysis from the randomized phase III ASPEN study
    Autorzy:
    Dimopoulos, Meletios A.
    McCarthy, Helen
    Trneny, Marek
    D'Sa, Shirley
    Cohen, Aileen
    Motta, Marina
    Mulligan, Stephen
    Wahlin, Bjorn E.
    Schneider, Jingjing
    Tam, Constantine S.
    Fernández de Larrea, Carlos
    Garcia-Sanz, Ramon
    Allewelt, Heather
    Buske, Christian
    Czyz, Jaroslaw
    Marlton, Paula
    Libby, Edward
    Tani, Monica
    Jurczak, Wojciech
    Opat, Stephen
    Siddiqi, Tanya
    Patel, Sheel
    Cull, Gavin
    Owen, Roger G.
    Leblond, Veronique
    Belada, David
    Castillo, Jorge J.
    Tedeschi, Alessandra
    Treon, Steven P.
    Trotman, Judith
    Chan, Wai Y.
    Lee, Hui-Peng
    Minnema, Monique C.
    Matous, Jeffrey
    Opis:
    The phase III ASPEN study demonstrated the comparable efficacy and improved safety of zanubrutinib versus ibrutinib in patients with Waldenström macroglobulinemia (WM). Here, we report long-term follow-up outcomes from ASPEN. The primary end point was the sum of very good partial response (VGPR) + complete response (CR) rates; secondary and exploratory end points were also reported. Cohort 1 comprised 201 patients (myeloid differentiation primary response 88–mutant WM: 102 receiving zanubrutinib; 99 receiving ibrutinib); cohort 2 comprised 28 patients (myeloid differentiation primary response 88 wild-type WM: 28 zanubrutinib; 26 efficacy evaluable). At 44.4-month median follow-up, VGPR + CR rates were 36.3% with zanubrutinib versus 25.3% with ibrutinib in cohort 1 and 30.8% with one CR in cohort 2. In patients with CXC motif chemokine receptor 4 mutation, VGPR + CR rates were 21.2% with zanubrutinib versus 10.0% with ibrutinib (cohort 1). Median progression-free survival and overall survival were not reached. Any-grade adverse events (AEs) of diarrhea (34.7% v 22.8%), muscle spasms (28.6% v 11.9%), hypertension (25.5% v 14.9%), atrial fibrillation/flutter (23.5% v 7.9%), and pneumonia (18.4% v 5.0%) were more common with ibrutinib versus zanubrutinib; neutropenia (20.4% v 34.7%) was less common with ibrutinib versus zanubrutinib (cohort 1). Zanubrutinib was associated with lower risk of AE-related treatment discontinuation. Overall, these findings confirm the long-term response quality and tolerability associated with zanubrutinib.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Autorzy:
    Pire, B.
    Tripathi, S.
    Antonioli, P.
    Flore, C.
    Hauenstein, F.
    Moiseev, V.
    Stewart, I.W.
    Jezo, T.
    Li, S.
    Bozzi, G.
    Santopinto, E.
    Bacchetta, A.
    Higinbotham, D.W.
    Širca, S.
    Dasgupta, S.S.
    Noferini, F.
    Bissolotti, C.
    Soto, O.
    Gay Ducati, M.B.
    Wei, S.Y.
    Xie, J.
    El Fassi, L.
    Moutarde, H.
    Evdokimov, O.
    Fernandez-Ramirez, C.
    Baker, M.D.
    Pasquini, B.
    Terry, J.
    Zhang, J.
    Bufalino, S.
    Tezgin, K.
    Seidl, R.
    Collins, J.L.
    Liu, X.
    Gao, H.
    Krelina, M.
    Fanelli, C.
    Paukkunen, H.
    Van Hulse, C.
    Kalantarians, N.
    Stutzman, M.L.
    Battaglieri, M.
    Wallon, S.
    Zheng, L.
    Lappi, T.
    Kumar, K.S.
    Goncalves, V.P.
    Klasen, M.
    Hohlmann, M.
    Cisbani, E.
    Olness, F.
    Poblaguev, A.A.
    Ringer, F.
    Mkrtchyan, H.
    Mondal, M.M.
    Mehtar-Tani, Y.
    Surrow, B.
    Sato, N.
    Chudakov, E.
    Dumitru, A.
    Tu, Z.
    Gonella, L.
    Ullrich, T.
    Kalicy, G.
    Morreale, A.
    Woody, C.
    Lunghi, E.
    Mkrtchyan, A.
    Sherrill, N.
    Kumar, L.
    Tuvè, C.
    Dalla Torre, S.
    Keppel, C.E.
    Hen, O.
    Kiselev, A.
    Cosyn, W.
    Durham, J.M.
    Contin, G.
    Preghenella, R.
    Kim, J.
    Schweitzer, P.
    Chatterjee, C.
    Pegg, I.L.
    Brei, N.
    Kutak, K.
    Torales Acosta, F.
    Furletov, S.
    Dilks, C.
    Wang, X.
    Celentano, A.
    Romanov, D.
    Ethier, J.J.
    Schnell, G.
    Detmold, W.
    Brooks, W.K.
    Kotko, P.
    Liyanage, N.
    Bhattacharya, S.
    Barion, L.
    Fitzgerald, D.
    Petti, R.
    Schenke, B.
    Janoska, Z.
    Murray, M.J.
    Purschke, M.L.
    Bazilevsky, A.
    Jadhav, M.
    Pecar, C.
    Colella, D.
    Fazio, S.
    Rossi, P.
    Abdul Khalek, R.
    Posik, M.
    Song, Y.
    Boglione, M.
    Zhang, Z.
    Singh, B.K.
    Chen, K.
    Wikramanayake, A.
    Da Silva, C.
    Lee, K.
    Reimer, P.E.
    Brandenburg, J.D.
    Mantry, S.
    Lai, Y.S.
    Glazier, D.I.
    Adamiak, D.
    Delcarro, F.
    Schmookler, B.
    Eyser, K.O.
    Pitonyak, D.
    Peng, C.
    Nam, J.
    Valentini, A.
    Liuti, S.
    Gonzalez Hernandez, J.O.
    Bukhari, M.H.S.
    Musico, P.
    Sterman, G.
    Sichtermann, E.
    Volpe, G.
    Kuleshov, S.
    Potekhin, M.
    Muñoz Camacho, C.
    Scopetta, S.
    Rinaldi, M.
    Greiner, L.C.
    Hyde, C.E.
    Liu, H.
    Wang, Q.
    Lukow, N.S.
    Sassot, R.
    Slifer, K.
    Hiller Blin, A.N.
    Kang, Z.B.
    Dehmelt, K.
    Szymanowski, L.
    Vitev, I.
    Słomiński, Wojciech
    Kauder, K.
    Petriello, F.
    Cicala, G.
    Zurita, P.
    Mäntysaari, H.
    Mirazita, M.
    Chien, Y.-T.
    Xu, Q.H.
    Rajput-Ghoshal, R.
    Gericke, M.
    Kay, S.J.D.
    Mastroserio, A.
    Crafts, J.
    Aune, S.
    Kostina, A.
    Xiao, B.W.
    Behera, N.K.
    Joosten, S.
    Signori, A.
    Stepanov, P.
    Celiberto, F.G.
    Pilloni, A.
    Lawrence, D.
    Klest, H.T.
    Tassielli, G.F.
    Borsa, I.
    Mendez, L.
    Xing, H.
    Finger, M.
    Lu, Z.
    Gil Da Silveira, G.
    Voutier, E.
    Osborn, J.D.
    Sekula, S.
    Li, H.
    Bossù, F.
    Nguyen, D.
    Weiss, C.
    Vossen, A.
    Jacak, B.V.
    Guzey, V.
    Cuevas, R.C.
    Lalwani, K.
    Pinkenburg, C.
    Camsonne, A.
    Al-bataineh, A.
    Mandjavidze, I.
    Akers, W.
    Li, W.
    Gnanvo, K.
    Dixit, D.U.
    Frederico, T.
    Echevarria, M.G.
    Bondì, M.
    Cocuzza, C.
    Lucero, G.
    Rojo, J.
    Chiarusi, T.
    Sznajder, P.
    Prokudin, A.
    Dulat, S.
    Klein, S.
    Wenaus, T.
    Constantinou, M.
    Ameli, F.
    Vladimirov, A.
    Cloet, I.C.
    Okorokov, V.A.
    Stevens, J.R.
    Page, B.S.
    Schmidke, W.B.
    Barish, K.N.
    Radici, M.
    Szczepaniak, A.
    Hattawy, M.
    Hemmick, T.K.
    Strikman, M.
    Esha, R.
    Tsai, O.D.
    Gaskell, D.
    Chang, W.
    Cruz-Torres, R.
    Defurne, M.
    Del Dotto, A.
    Horn, T.
    Tribedy, P.
    Mochalov, V.
    Tapia Takaki, J.D.
    Tadepalli, A.S.
    Rodini, S.
    Mihovilovič, M.
    Li, X.
    Asai, M.
    Perrino, R.
    Korchak, O.
    Melnitchouk, W.
    Schmidt, A.
    Ayerbe Gayoso, C.
    Metz, A.
    Liu, M.X.
    Azmoun, B.
    Murgia, F.
    Jacobs, P.M.
    Armesto, N.
    Boer, D.
    Deconinck, W.
    Lee, C.
    He, X.
    Kovchegov, Y.V.
    Parker, A.
    Albaladejo, M.
    Makris, Y.
    Spiesberger, H.
    Segovia, J.
    Huang, Q.
    Lavinsky, M.
    Nocera, E.R.
    Nunes, A.S.
    Meziani, Z.-E.
    Roberts, C.D.
    Contalbrigo, M.
    Sarsour, M.
    Paschke, K.
    Mezrag, C.
    Friščić, I.
    Gates, K.
    Majka, R.
    Marhauser, F.
    Sullivan, M.
    Pujahari, P.
    Chu, X.
    Guryn, W.
    Schwiening, J.
    Buttimore, N.H.
    Semenov-Tian-Shanskiy, K.
    Ilieva, Y.
    Pybus, J.R.
    Girod, F.-X.
    Triloki,
    Winney, D.
    Varner, G.
    Avagyan, H.
    Vancura, P.
    Xia, L.
    Zhao, Z.W.
    Lauret, J.
    Jentsch, A.
    Joo, K.
    Noto, F.
    Gal, C.
    Cole, P.L.
    Adam, J.
    Berdnikov, V.V.
    Wickramaarachchi, N.
    Courtoy, A.
    Bertone, V.
    Strakovsky, I.
    Zhao, Y.X.
    Furletova, Y.
    Kumar, R.
    Vandenbroucke, M.
    Bernauer, J.C.
    Heyes, G.
    Szumila-Vance, H.
    Pisano, C.
    Kang, D.
    Morrison, D.
    Li, W.B.
    Chiosso, M.
    Ent, R.
    Goto, Y.
    Sturm, M.
    Milner, R.
    Tessarotto, F.
    Barry, P.C.
    Polakovic, T.
    Arratia, M.
    Hobbs, T.J.
    Bressan, A.
    Kumano, S.
    Barbosa, F.
    Gamberg, L.
    Boora, P.
    Scimemi, I.
    Accardi, A.
    Hou, T.-J.
    Preins, S.
    Wagner, J.
    Asaturyan, A.
    Marsicano, L.
    Sondheim, W.E.
    Neyret, D.
    Wang, H.
    Shao, D.Y.
    Nadolsky, P.M.
    Fatemi, R.
    Trotta, R.L.
    Nadel-Turonski, P.
    Alexeev, M.G.
    Lorcé, C.
    Syritsyn, S.
    Schmidt, I.
    Pentchev, L.
    Svihra, P.
    Kumerički, K.
    Venugopalan, R.
    Jing, X.
    Ungaro, M.
    Wong, C.P.
    Sokhan, D.
    Tomasek, L.
    Burkert, V.
    Das, D.
    Motyka, Leszek
    Benmokhtar, F.
    Markowitz, P.
    Arrington, J.
    Pellegrino, C.
    Huang, J.
    Deshpande, A.
    Chetry, T.
    Elia, D.
    Aschenauer, E.C.
    Levorato, S.
    Huber, G.M.
    Park, S.
    Lednicky, D.
    Paul, S.
    De Vita, R.
    Jones, P.G.
    Hatta, Y.
    Iakovidis, G.
    DeGraw, W.
    Corliss, R.
    Garg, P.
    Lee, S.H.
    Tricoli, A.
    Ligonzo, T.
    Kafka, V.
    Armstrong, W.R.
    Siddikov, M.
    Mathieu, V.
    Kusina, A.
    Grancagnolo, F.
    Fucini, S.
    Dupré, R.
    Zhang, S.
    Urciuoli, G.M.
    D'Alesio, U.
    Stasto, A.M.
    Diefenthaler, M.
    Newman, P.R.
    Zhou, Y.
    Wennlöf, H.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Hot QCD white paper
    Autorzy:
    Perepelitsa, D. V.
    O'Brien, E.
    Zajc, W. A.
    Niida, T.
    Yee, H. -U.
    Wang, F.
    Ratti, C.
    Shi, Z.
    Bock, F.
    Schäfer, T.
    Narde, A.
    Koch, V.
    Finger Jr., M.
    Putschke, J.
    Berdnikov, Y.
    Ramasubramanian, N. V.
    Bossi, H.
    Drees, A.
    Salur, S.
    Voloshin, S. A.
    Ye, Z.
    Schenke, B.
    Lajoie, J. G.
    Morrison, D. P.
    Judd, E. G.
    Yao, X.
    Shen, C.
    Hong, B.
    Caines, H.
    Jacak, B. V.
    Praszałowicz, Michał
    Kotov, D.
    Odyniec, G.
    Evdokimov, O.
    Timmins, A. R.
    Bautista, I.
    Jheng, H. R.
    Karpenko, I.
    Song, H.
    Knospe, A. G.
    Jahan, J.
    Blair, J. T.
    Tribedy, P.
    Yang, Y.
    Luo, X.
    Teaney, D.
    Videbæk, F.
    Durham, J. M.
    Boimska, B.
    Liu, M. X.
    Khachatryan, V.
    Dexheimer, V.
    Lim, S. H.
    Okorokov, V. A.
    Schmidt, N. V.
    Loizides, C.
    Csanád, M.
    Osborn, J. D.
    Reed, R.
    Kharzeev, D. E.
    Thomas, D.
    Ruan, L.
    Jeon, S.
    Majumder, A.
    Seger, J.
    Gonzalez, V.
    Soudi, I.
    Chen, Y.
    Minafra, N.
    Menon, A. S.
    Xie, W.
    Nagle, J. L.
    Kimelman, B.
    Dash, A. P.
    Schmier, A.
    Bielcik, J.
    Becattini, F.
    Rueda, O. V.
    Stephanov, M.
    Luzum, M.
    Tapia Takaki, D.
    Venugopalan, R.
    Nouicer, R.
    Royon, C.
    Steinberg, P.
    Hachiya, T.
    Dehmelt, K.
    Mueller, B.
    Dong, X.
    Ma, R.
    Mehtar-Tani, Y.
    Petreczky, P.
    Greene, S. V.
    Frawley, A. D.
    Geurts, F.
    Chien, Y. -T.
    He, X.
    Sumbera, M.
    Klein, S. R.
    Rosati, M.
    Tu, Z.
    Heinz, U.
    Klay, J. L.
    Strickland, M.
    Weyhmiller, S.
    Stahl Leiton, A. G.
    Noronha-Hostler, J.
    Krintiras, G. K.
    Rinn, T.
    Read, K. F.
    Tang, A. H.
    Mak, S.
    Novitzky, N.
    Gale, C.
    Ivanishchev, D.
    Ehlers, R. J.
    Likmeta, I.
    Mignerey, A. C.
    Arslandok, M.
    Noronha, J.
    Sakaguchi, T.
    Frantz, J.
    Grau, N.
    Singh, M.
    Smith, K. L.
    Sarsour, M.
    Bellwied, R.
    Seto, R
    Smirnov, N.
    Park, S.
    Vovchenko, V.
    Humanic, T. J.
    Liao, J.
    Elfner, H.
    Sickles, A. M.
    Singh, B. K.
    Bass, S. A.
    Beattie, C.
    Kim, M.
    Kuo, C. M.
    Grossberndt, S. K.
    Baty, A. A.
    Wang, X. -N.
    Kapusta, J. I.
    Berdnikov, A.
    Nattrass, C. E.
    Vujanovic, G.
    Shulga, E.
    Velkovska, J.
    Chiu, M.
    Finger, M.
    Sunar Cerci, D.
    Connors, M. E.
    Rebello Teles, P.
    Jia, J.
    Wang, X.
    David, G.
    Paquet, J. -F.
    Rapp, R.
    Tuo, S.
    Du, L.
    Kunnawalkam Elayavalli, R.
    Lee, Y. -J.
    Longo, R.
    Xu, N.
    Markert, C.
    Pruneau, C.
    Parotto, P.
    Pinkenburg, C.
    Sheibani, Oveis
    Tachibana, Y.
    da Silva, C. L.
    Li, W.
    Roland, G.
    Opis:
    Hot QCD physics studies the nuclear strong force under extreme temperature and densities. Experimentally these conditions are achieved via high-energy collisions of heavy ions at the Relativistic Heavy Ion Collider (RHIC) and the Large Hadron Collider (LHC). In the past decade, a unique and substantial suite of data was collected at RHIC and the LHC, probing hydrodynamics at the nucleon scale, the temperature dependence of the transport properties of quark-gluon plasma, the phase diagram of nuclear matter, the interaction of quarks and gluons at different scales and much more. This document, as part of the 2023 nuclear science long range planning process, was written to review the progress in hot QCD since the 2015 Long Range Plan for Nuclear Science, as well as highlight the realization of previous recommendations, and present opportunities for the next decade, building on the accomplishments and investments made in theoretical developments and the construction of new detectors. Furthermore, this document provides additional context to support the recommendations voted on at the Joint Hot and Cold QCD Town Hall Meeting, which are reported in a separate document.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    The case for an EIC theory alliance : theoretical challenges of the EIC
    Autorzy:
    Hobbs, Timothy
    Constantinou, Martha
    Srednyak, Stanislav
    Fox, Geofrey
    Schnell, Gunar
    Szczepaniak, Adam
    Eichmann, Gernot
    Signori, Andrea
    Sznajder, Pawel
    Boughezal, Radja
    Lee, Kyle
    Vogt, Ramona
    Lebed, Richard
    Boglione, M.
    de Florian, Daniel
    Shao, Ding-Yu
    Gil da Silveira, Gustavo
    Li, Hai Tao
    Dumitru, Adrian
    Shanahan, Phiala
    Zurita, Pia
    Vujanovic, Gojko
    Sargsian, Misak
    Khachatryan, Vladimir
    Ringer, Felix
    Karki, Bishnu
    Chien, Yang-Ting
    Engelhardt, Michael
    Pitonyak, Daniel
    Vittoria Garzelli, Maria
    Song, Qin-Tao
    Terry, John
    Abir, Raktim
    Praszałowicz, Michał
    Yao, Xiaojun
    Döring, Michael
    Xiao, Bo-Wen
    Bertulani, Carlos A.
    Michel, Johannes K. L.
    Mukherjee, Swagato
    Petriello, Frank
    Pasquini, Barbara
    Swanson, Eric
    Braaten, Eric
    Radici, Marco
    Bacchetta, Alessandro
    Segovia, Jorge
    Lorcé, Cédric
    Mereghetti, Emanuele
    Rodas, Arkaitz
    Waalewijn, Wouter
    Gupta, Rajan
    Nocera, E.
    Hiller Blin, Astrid
    Korepin, Vladimir
    Kovchegov, Yuri
    Hentschinski, Martin
    Rittenhouse West, Jennifer
    Wang, Xiang-Peng
    Gamberg, Leonard
    Kriesten, Brandon
    Venugopalan, Raju
    Boer, Daniël
    Kumano, Shunzo
    Mathur, Nilmani
    Glazier, Derek
    Salazar, Farid
    Schindler, Stella
    Lai, Wai Kin
    Prokudin, Alexei
    Vladimirov, Alexey
    Zhao, Yong
    de Melo, J. P. B. C.
    Kang, Zhong-Bo
    Sabbir Sufian, Raza
    Akushevich, Igor
    Detmold, William
    Miller, Gerald
    Mukherjee, Asmita
    Yang, Yi-Bo
    Raya, Khépani
    Czajka, Alexander
    Danilkin, Igor
    Kharzeev, Dmitri
    Santopinto, Elena
    Barata, Joao
    Petreczky, Peter
    Jalilian-Marian, Jamal
    Delgado, Andrea
    Scimemi, Ignazio
    Liuti, Simonetta
    Balantekin, Baha
    Sievert, Matt
    Echevarria, Miguel G.
    Beuf, Guillaume
    Skokov, Vladi
    Xing, Hongxi
    Machado, Magno V. T.
    Singh, Rajeev
    Altinoluk, Tolga
    Lee, Christopher
    Klein, Spencer R.
    Guo, Feng-Kun
    Grossberndt, Silas
    Nadolsky, P. M.
    Olness, Fredrick
    Okorokov, Vitalii
    Mehtar-Tani, Yacine
    Brambilla, Nora
    Semenov-Tian-Shansky, Kirill
    Syritsyn, Sergey
    Stewart, Iain W.
    Freese, Adam
    Ilyichev, Alexander
    Cloët, Ian C.
    Vitev, Ivan
    Qiu, Jianwei
    Nemchik, Jan
    Schenke, Bjoern
    Courtoy, Aurore
    Cosyn, Wim
    Braun, Vladimir
    Aslan, Fatma P.
    Pisano, Cristian
    Goncalves, Victor P.
    Mantysaari, Heikki
    Mkrtchyan, Hamlet
    Jia, Shuo
    Mulders, Piet
    Munier, Stéphane
    Pire, Bernard
    Giacosa, Francesco
    Mathieu, Vincent
    Bozzi, Giuseppe
    Sato, Nobuo
    Tawfik, A.
    Fischer, Christian
    Metz, Andreas
    Anderle, Daniele Paolo
    Tawabutr, Yossathorn
    Twagirayezu, Fidele
    Schweitzer, Peter
    Tandogan, Asli
    Rojo, Juan
    Ji, Chueng-Ryong
    Vogelsang, Werner
    Murgia, Francesco
    Byer, Duane
    Celiberto, Francesco Giovanni
    Lin, Huey-Wen
    Rodini, Simone
    Toll, Tobias
    Das, Debasish
    Hatta, Yoshitaka
    Battaglieri, Marco
    Yuan, Feng
    Tomalak, Oleksandr
    Negele, John W
    Ke, Weiyao
    Liao, Jifeng
    Fernandez-Ramirez, Cesar
    Liu, Keh-Fei
    El-Bennich, Bruno
    Edwards, Robert
    Melnitchouk, Wally
    Neill, Duff
    Bissolotti, Chiara
    Pilloni, Alessandro
    Peng, Chao
    D'Alesio, Umberto
    Opis:
    We outline the physics opportunities provided by the Electron Ion Collider (EIC). These include the study of the parton structure of the nucleon and nuclei, the onset of gluon saturation, the production of jets and heavy flavor, hadron spectroscopy and tests of fundamental symmetries. We review the present status and future challenges in EIC theory that have to be addressed in order to realize this ambitious and impactful physics program, including how to engage a diverse and inclusive workforce. In order to address these many-fold challenges, we propose a coordinated effort involving theory groups with differing expertise is needed. We discuss the scientific goals and scope of such an EIC Theory Alliance.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
      Wyświetlanie 1-5 z 5

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