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Wyświetlanie 1-10 z 61
Tytuł:
Unified approach to contextuality, non-locality, and temporal correlations
Autorzy:
Lee, S.-Y.
Kurzyński, P.
Kaszlikowski, D.
Thompson, J.
Markiewicz, Marcin
Soeda, A.
Paterek, T.
Opis:
We highlight the existence of a joint probability distribution as the common underpinning assumption behind Bell-type, contextuality, and Leggett-Garg-type tests. We then present a procedure to translate contextual scenarios into temporal Leggett-Garg-type and spatial Bell-type ones. To demonstrate the generality of this approach we construct a family of spatial Bell-type inequalities. We show that in the Leggett-Garg scenario a necessary condition for contextuality in time is given by a violation of consistency conditions in the consistent histories approach to quantum mechanics.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Analysis of susceptibility loci for juvenile idiopathic arthritis in the extended MHC region using high resolution SNP and HLA allele typing
Autorzy:
Biesiada, J.
Sudman, M.
Wagner, M.
Rupert, A.
Hollenbach, J.
Haas, J. P.
Meller, J.
Thompson, S. D.
Tematy:
HLA
MHC region
autoimmunology
Juvenile Idiopathic Arthritis
HLA independent association
SNP genotyping
HLA alleles
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Wydawca:
Politechnika Gdańska
Powiązania:
https://bibliotekanauki.pl/articles/1935824.pdf  Link otwiera się w nowym oknie
Opis:
Juvenile idiopathic arthritis ( JIA ) spans several pediatric arthropathies that involve autoimmune responses. Primary genetic risk factors for JIA have been mapped to Major Histocompatibility Complex ( MHC ) class I and class II genes. Recent genome-wide association studies using SNP arrays have shown that the nonHLA genetic component of JIA involves multiple low-risk loci, reinforcing the notion that JIA is a complex genetic trait with a strong HLA component. In this work, with the goal of detailed mapping and analysis of lin kage disequilibrium ( LD ) patterns and associations with JIA in the extended MHC (x MHC ) region, we combined SNP data from Affymetrix SNP Array 6.0 and Immunochip ( IC ) platforms with high resolution typing of 8 classical HLA genes. A cohort of about 800 affected individuals and about 500 ethnically matched controls from the Cincinnati region, as well as secondary validation cohorts of affected individuals and matched controls from Germany were used to perform the analysis, and to assess reproducibility of the results across different platforms and p opulations. Accurate high resolution maps of linkage with classical HLA genes and association with individual HLA alleles were generated. High concordance of results obtained using Affymetrix SNP Array 6.0 and IC was observed, with an additional resolution and improved mapping of associat ions provided by the latter in some regions. Several new peaks of statistically signific ant and reproducible association with JIA outside the regions of strong LD with classical HLA genes were observed, including one peak in the class III region, and one in the telomeric end of x MHC . Conditional analysis provided further evidence that these associations appear to be independent of classical HLA genes studied here. The results and observed association patterns are further discussed in the context of other recent studies on autoimmune diseases, including the role of HLA DRB 1 in adult Rheumatoid Arthritis.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Extreme blazars studied with Fermi-LAT and Suzaku : 1ES 0347–121 and blazar candidate HESS J1943+213
Autorzy:
Finke, J.
Wagner, S. J.
Dubus, G.
Fukazawa, Y.
Stawarz, Łukasz
DeNaurois, M.
Cheung, C. C.
Tanaka, Y. T.
Dermer, C. D.
Bamba, A.
Kataoka, J.
Thompson, D. J.
Opis:
We report on our study of high-energy properties of two peculiar TeV emitters: the "extreme blazar" 1ES 0347–121 and the "extreme blazar candidate" HESS J1943+213 located near the Galactic plane. Both objects are characterized by quiescent synchrotron emission with flat spectra extending up to the hard X-ray range, and both were reported to be missing GeV counterparts in the Fermi Large Area Telescope (LAT) two-year Source Catalog. We analyze a 4.5 yr accumulation of the Fermi -LAT data, resulting in the detection of 1ES 0347–121 in the GeV band, as well as in improved upper limits for HESS J1943+213. We also present the analysis results of newly acquired Suzaku data for HESS J1943+213. The X-ray spectrum is well represented by a single power law extending up to 25 keV with photon index 2.00 $\pm$ 0.02 and a moderate absorption in excess of the Galactic value, which is in agreement with previous X-ray observations. No short-term X-ray variability was found over the 80 ks duration of the Suzaku exposure. Under the blazar hypothesis, we modeled the spectral energy distributions of 1ES 0347–121 and HESS J1943+213, and we derived constraints on the intergalactic magnetic field strength and source energetics. We conclude that although the classification of HESS J1943+213 has not yet been determined, the blazar hypothesis remains the most plausible option since, in particular, the broadband spectra of the two analyzed sources along with the source model parameters closely resemble each other, and the newly available Wide-field Infrared Survey Explorer and UKIRT Infrared Deep Sky Survey data for HESS J1943+213 are consistent with the presence of an elliptical host at the distance of approximately ~600 Mpc.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Wyświetlanie 1-10 z 61

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