- Tytuł:
- Evaluation of ursolic acid as the main component isolated from Catharanthus roseus against hyperglycemia
- Autorzy:
-
Thanh Tam, N.
Thien, D.D.
Sung, T.V.
Thi Hoang Anh, N.
Thuy, T.T.
Trung, K.H.
Xuan, T.D.
Khanh, T.D. - Wydawca:
- Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
- Powiązania:
- https://bibliotekanauki.pl/articles/10779.pdf Link otwiera się w nowym oknie
- Opis:
- Ursolic acid with large amount (0.67% of dried plant weight) along with 7 compounds, namely as spatozoate (1), kaurenoic acid (2), ursonic acid (3), 3-hydroxy-11-ursen-28,13-olide (4), ursolic acid (5), vindoline (6) and mixture of β-sitosterol and stigmasterol were isolated from dichloromethane and ethyl acetate extracts which have shown anti-glucosidase activity of the whole plant of C.roseus. Some isolated compounds and their derivatives were also tested for anti-glucosidase and cytotoxicity.Ursolic acid was examined for hypoglycemic activity in alloxan-induced diabetic mice with dose of 200 and 300 mg/kg/day, respectively. The results have shown that the blood glucose level were reduced by 45.75% and 51.31% to compare with the control group. This study has confirmed that the main component of Vietnamese C. roseus has had significant anti-hyperglycemia activity.
- Dostawca treści:
- Biblioteka Nauki
Artykuł