Autor: Tutka, Piotr - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Strategia leczenia farmakologicznego w stabilnym okresie przewlekłej obturacyjnej choroby płuc
Autorzy:: Mosiewicz, Jerzy
Tutka, Piotr
Tematy:: przewlekła obturacyjna choroba płuc (POChP)
leczenie farmakologiczne; Pokaż więcej
Wydawca:: Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Powiązania:: https://bibliotekanauki.pl/articles/551901.pdf Link otwiera się w nowym oknie
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Investigation of pharmaceuticals by nuclear magnetic resonance imaging and spectroscopy
Autorzy:: Bober, Zuzanna
Aebisher, David
Tabarkiewicz, Jacek
Guz, Wiesław
Tutka, Piotr
Bartusik-Aebisher, Dorota
Tematy:: drug delivery systems
drug forms
magnetic resonance imaging pharmaceuticals; Pokaż więcej
Wydawca:: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Powiązania:: https://bibliotekanauki.pl/articles/454783.pdf Link otwiera się w nowym oknie
Opis:: Currently, new and easier ways of analyzing pharmaceutical drug forms and drug delivery mechanisms are being sought. Magnetic resonance imaging (MRI) is a non-invasive imaging technique that images drug forms such as tablets, liquids and topicals and drug form behavior in living organisms on both the tissue and cellular scale. The advantages of MRI include noninvasiveness, variable sample capacity and ease of transfer of phantom results to in vitro and in vivo studies. This review concerns the usefulness of clinical MRI that cannot be understated as this technique provides non-invasive and non-destructive insight into the properties of drug delivery systems. The research discussed here concerns the use of magnetic resonance, spectroscopy and chromatography to investigate selected pharmaceuticals and covers work of selecting drugs and antibodies for modification by synthesis for evaluation by MRI. Modifications have been aimed at improving therapeutic efficacy, delivery, and MRI. Modification conditions such as (pH, concentration, temperature, and the influence of other components present in the solutions) will be discussed to understand drug delivery system improvements and the reliability and repeatability of the results obtained. We hope to explore and expand the scope of pharmaceutical imaging with MRI for application in clinical medicine.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: 19F MRI As a tool for imaging drug delivery to tissue and individual cells
Autorzy:: Bober, Zuzanna
Aebisher, David
Ożóg, Łukasz
Tabarkiewicz, Jacek
Tutka, Piotr
Bartusik-Aebisher, Dorota
Tematy:: drug delivery
drug tracking
fluorine
magnetic resonance imaging; Pokaż więcej
Wydawca:: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Powiązania:: https://bibliotekanauki.pl/articles/454941.pdf Link otwiera się w nowym oknie
Opis:: Over the past few decades, magnetic resonance imaging (MRI) has proven to be extremely successful in medical applications. More recently, the biomedical applications of MRI have been gaining more use in the field of clinical pharmacy. In 1977, perfluorocarbon compounds (PFC), which form emulsions that can carry drugs, were analyzed by 19F MRI and emulsified PFC compounds have been investigated as potential blood substitutes since the early 1960s and now a wide variety of PFC compounds are currently available as 19F MRI biomarkers. Molecules with 19F substituents are particularly attractive for use in drug tracking by 19F MRI due to 100% 19F abundance, high 19F MRI sensitivity (0.83 relative to 1H MRI) and an impressively large chemical shift range (400 ppm). Another benefit in the use of 19F MRI is a zero background signal in biological samples due to lack of endogenous fluorine. Therefore, drugs containing fluorine atom have potential for 19F MRI imaging drug delivery to tissue. This article will review recent developments in the use of 19F MRI in imaging drug delivery to tissue and individual cells.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Applications of cytisine extraction and detection in biological materials for clinical medicine
Autorzy:: Bartusik-Aebisher, Dorota
Aebisher, David
Courtney, Ryan
Sobczak, Andrzej
Bober, Zuzanna
Podgórski, Rafał
Kołodziejczyk, Patrycjusz
Tutka, Piotr
Tematy:: smoking cessation
chromatography
Biomedicine
cytisine extraction
biopharmacy; Pokaż więcej
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Powiązania:: https://bibliotekanauki.pl/articles/895314.pdf Link otwiera się w nowym oknie
Opis:: Tobacco use is a leading cause of preventable mortality worldwide. New cost-effective smoking cessation treatments are needed especially in some low-to-middle income countries where smoking rates are rising, and current pharmacotherapy treatments remain cost-prohibitive. Since the 1960’s, cytisine has been used as an effective nicotine substitution agent to aid in smoking cessation albeit limited to a selected few Eastern/Central Europe and Central Asian countries. Cytisine is a biologically active alkaloid of plant origin and is known to be a ligand of nicotinic acetylcholinergic receptors (nAChRs). For several decades, the properties of cytisine have been investigated and reported in the biomedical and pharmaceutical literature. Due to the beneficial impact of cytisine on smoking cessation and its costly multistep synthesis, there is a growing interest in extraction from natural sources as well as in analytical identification and quantification for clinical medicine and forensic toxicology. In this paper, we present several current analytical approaches to cytisine extraction and identification from biological samples of plant and human origin. The development of extraction techniques will allow for the widespread use of the drug in experimental and clinical pharmacology, toxicology and forensic medicine.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Cytisine parameters measured in the 1.5 Tesla magnetic field
Autorzy:: Bober, Zuzanna
Galiniak, Sabina
Leksa, Dawid
Dynarowicz, Klaudia
Aebisher, David
Ostańska, Elżbieta
Czmil, Anna
Bar, Piotr
Bartusik-Aebisher, Dorota
Tutka, Piotr
Tematy:: cytisine
desmoxan
magnetic resonance imagin
tabex; Pokaż więcej
Wydawca:: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Powiązania:: https://bibliotekanauki.pl/articles/454807.pdf Link otwiera się w nowym oknie
Opis:: Introduction. Cytisine, Cytisinum (C11H14N2O), is an organic chemical compound. Cytisine is heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. Aim. The aim of the study is to measure the influence of water on the form of drug in the magnetic field 1.5 Tesla. Material and methods. For this purpose, magnetic resonance imaging tests were performed to check the solubility of pure cytisine, Desmoxan tablets and Tabex capsules. Results. From a pharmacological point of view, both Desmoxan tablets and Tabex capsules should exert the same effect on the human body, this is due to the identical content of the active substance, in this case cytisine (1.5 mg). Conclusion. The differences in the results obtained may be related to additional excipients that contain medications, but it is believed that they should not have a negative impact on the action of the active substances.
Dostawca treści:: Biblioteka Nauki

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