Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Wyszukujesz frazę "Wells, R. P." wg kryterium: Autor


Wyświetlanie 1-7 z 7
Tytuł:
Did You Have an Impact? A Theory-Based Method for Planning and Evaluating Knowledge-Transfer and Exchange Activities in Occupational Health and Safety
Autorzy:
Kramer, D. M.
Wells, R. P.
Carlan, N.
Aversa, T.
Bigelow, P. P.
Dixon, S. M.
McMillan, K.
Tematy:
knowledge transfer and exchange
evaluation
workplace-based research
musculoskeletal disorders
choroby narządów ruchu
ewakuacja
transfer wiedzy bhp
planowanie
badania naukowe
Pokaż więcej
Wydawca:
Centralny Instytut Ochrony Pracy
Powiązania:
https://bibliotekanauki.pl/articles/90884.pdf  Link otwiera się w nowym oknie
Opis:
Few evaluation tools are available to assess knowledge-transfer and exchange interventions. The objective of this paper is to develop and demonstrate a theory-based knowledge-transfer and exchange method of evaluation (KEME) that synthesizes 3 theoretical frameworks: the promoting action on research implementation of health services (PARiHS) model, the transtheoretical model of change, and a model of knowledge use. It proposes a new term, keme, to mean a unit of evidence-based transferable knowledge. The usefulness of the evaluation method is demonstrated with 4 occupational health and safety knowledge transfer and exchange (KTE) implementation case studies that are based upon the analysis of over 50 pre-existing interviews. The usefulness of the evaluation model has enabled us to better understand stakeholder feedback, frame our interpretation, and perform a more comprehensive evaluation of the knowledge use outcomes of our KTE efforts.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Host-derived protease promotes aggregation of Staphylococcus aureus by cleaving the surface protein SasG
Autorzy:
Crosby, Heidi A.
LaRivière, Wells B.
Langouët-Astrié, Christophe J.
Horswill, Alexander R.
Kwieciński, Jakub
Schmidt, Eric P.
Oshima, Kaori
Keim, Klara
Opis:
Staphylococcus aureus is one of the leading causes of hospital-acquired infections, many of which begin following attachment and accumulation on indwelling medical devices or diseased tissue. These infections are often linked to the establishment of biofilms, but another often overlooked key characteristic allowing S. aureus to establish persistent infection is the formation of planktonic aggregates. Such aggregates are physiologically similar to biofilms and protect pathogens from innate immune clearance and increase antibiotic tolerance. The cell-wall-associated protein SasG has been implicated in biofilm formation via mechanisms of intercellular aggregation but the mechanism in the context of disease is largely unknown. We have previously shown that the expression of cell-wall-anchored proteins involved in biofilm formation is controlled by the ArlRS-MgrA regulatory cascade. In this work, we demonstrate that the ArlRS two-component system controls aggregation, by repressing the expression of sasG by activation of the global regulator MgrA. We also demonstrate that SasG must be proteolytically processed by a non-staphylococcal protease to induce aggregation and that strains expressing functional full-length sasG aggregate significantly upon proteolysis by a mucosal-derived host protease found in human saliva. We used fractionation and N-terminal sequencing to demonstrate that human trypsin within saliva cleaves within the A domain of SasG to expose the B domain and induce aggregation. Finally, we demonstrated that SasG is involved in virulence during mouse lung infection. Together, our data point to SasG, its processing by host proteases, and SasG-driven aggregation as important elements of S. aureus adaptation to the host environment.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Bacterial pneumonia-induced shedding of epithelial heparan sulfate inhibits the bactericidal activity of cathelicidin in a murine model
Autorzy:
McCollister, Bruce D.
Erzen, Christopher L.
Oshima, Kaori
Horswill, Alexander R.
Langouet-Astrie, Christophe J.
Zhang, Fuming
Kwieciński, Jakub
Rizzo, Alicia N.
Colbert, James F.
Bastarache, Julie A.
Shi, Deling
Windham, Samuel L.
Schmidt, Eric P.
LaRiviere, Wells B.
Zehr, Evan P.
Opis:
Bacterial pneumonia is a common clinical syndrome leading to significant morbidity and mortality worldwide. In the current study, we investigate a novel, multidirectional relationship between the pulmonary epithelial glycocalyx and antimicrobial peptides in the setting of methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. Using an in vivo pneumonia model, we demonstrate that highly sulfated heparan sulfate (HS) oligosaccharides are shed into the airspaces in response to MRSA pneumonia. In vitro, these HS oligosaccharides do not directly alter MRSA growth or gene transcription. However, in the presence of an antimicrobial peptide (cathelicidin), increasing concentrations of HS inhibit the bactericidal activity of cathelicidin against MRSA as well as other nosocomial pneumonia pathogens (Klebsiella pneumoniae and Pseudomonas aeruginosa) in a dose-dependent manner. Surface plasmon resonance shows avid binding between HS and cathelicidin with a dissociation constant of 0.13 μM. These findings highlight a complex relationship in which shedding of airspace HS may hamper host defenses against nosocomial infection via neutralization of antimicrobial peptides. These findings may inform future investigation into novel therapeutic targets designed to restore local innate immune function in patients suffering from primary bacterial pneumonia. NEW & NOTEWORTHY Primary Staphylococcus aureus pneumonia causes pulmonary epithelial heparan sulfate (HS) shedding into the airspace. These highly sulfated HS fragments do not alter bacterial growth or transcription, but directly bind with host antimicrobial peptides and inhibit the bactericidal activity of these cationic polypeptides. These findings highlight a complex local interaction between the pulmonary epithelial glycocalyx and antimicrobial peptides in the setting of bacterial pneumonia.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
The influenza-injured lung microenvironment promotes MRSA virulence, contributing to severe secondary bacterial pneumonia
Autorzy:
Horswill, Alexander R.
Langouët-Astrié, Christophe
Kwieciński, Jakub
Shi, Deling
McMurtry, Sarah A.
Perelman, Sofya S.
Liu, Jian
Schmidt, Eric P.
Zhang, Fuming
Oshima, Kaori
Zakharevich, Igor
Kavanaugh, Jeffrey S.
Yang, Yimu
Boguslawski, Kristina M.
LaRivière, Wells B.
Su, Gouwei
Torres, Victor J.
Hansen, Kirk C.
Opis:
Influenza infection is substantially worsened by the onset of secondary pneumonia caused by bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). The bidirectional interaction between the influenza-injured lung microenvironment and MRSA is poorly understood. By conditioning MRSA ex vivo in bronchoalveolar lavage fluid collected from mice at various time points of influenza infection, we found that the influenza-injured lung microenvironment dynamically induces MRSA to increase cytotoxin expression while decreasing metabolic pathways. LukAB, a SaeRS two-component system-dependent cytotoxin, is particularly important to the severity of post-influenza MRSA pneumonia. LukAB’s activity is likely shaped by the post-influenza lung microenvironment, as LukAB binds to (and is activated by) heparan sulfate (HS) oligosaccharide sequences shed from the epithelial glycocalyx after influenza. Our findings indicate that post-influenza MRSA pneumonia is shaped by bidirectional host-pathogen interactions: host injury triggers changes in bacterial expression of toxins, the activity of which may be shaped by host-derived HS fragments.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Nuclear astrophysics with radioactive ions at FAIR
Autorzy:
Trautmann, W.
Csatlós, M.
Dupont, E.
Litvinov, Y.
Neumann-Cosel, P. von
Labiche, M.
Spieker, M.
Rigollet, C.
Wagner, A.
Déchery, F.
Pandit, S.
Morcelle, V.
Reifarth, R.
Sohler, D.
Dueñas, J.
Ornelas, A.
Kulessa, Reinhard
Endres, J.
Körner, G.
Zerguerras, T.
Fernandez-Dominguez, B.
Uvarov, L.
Borge, M. G.
Naqvi, F.
Heftrich, T.
Lederer, C.
Savran, D.
Timar, J.
Jonson, B.
Schmitt, C.
Zgura, M.
Al-Khalili, J.
Zartova, I.
Uesaka, T.
Bertulani, C.
Körper, D.
Grigorenko, L.
Mahata, K.
Kratz, J.
Nikolski, E.
Stuhl, L.
Weick, H.
Pietri, S.
Ignatyuk, A.
Sümmerer, K.
Cherciu, M.
Herzberg, R.
Nociforo, C.
Jakobsson, B.
Gulyas, J.
Söderström, P.
Iwasa, N.
Nacher, E.
Casarejos, E.
Streicher, B.
Wieland, O.
Lazarus, I.
Bagchi, S.
Trivedi, T.
Cederkall, J.
Brambilla, S.
Catford, W.
Tengblad, O.
Pietralla, N.
Detistov, P.
Stan, E.
Taylor, J.
Tostevin, J.
Benlliure, J.
Kröll, T.
Petrache, C.
Boutachkov, P.
Fernandez, P. Diaz
Langanke, K.
Monago, J. Briz
Hammache, F.
Alkhomashi, N.
Heil, M.
Cresswell, J.
Johansson, H.
Davids, B.
Thornhill, J.
Khan, E.
Rauscher, T.
Panin, V.
Pivovarov, Y.
Derya, V.
Stevenson, P.
Rosado, J. Sánchez
Kuzmin, E.
Pawłowski, P.
Thoennessen, M.
Beceiro, S.
Maev, E.
Liberati, V.
Tornyi, T.
Parkar, V.
Schrock, P.
Gasparic, I.
Avdeichikov, V.
Gastineau, B.
Volknandt, M.
Elekes, Z.
Lemmon, R.
Jurado, B.
Romig, C.
Cederwall, B.
Zhukov, M.
Sanchez, J.
Terashima, S.
Aksouh, F.
Alvarez-Rodriguez, R.
Rastrepina, G.
Thungstrom, G.
Taieb, J.
Ilieva, S.
Shrivastava, A.
Schwengner, R.
Kelic-Heil, A.
Koloczek, A.
Woods, P.
Ritter, C.
Egelhof, P.
Togano, Y.
Saez, del Rio
Wimmer, C.
Sauerwein, A.
Dmitry, S.
Townsley, C.
Ershova, O.
Aumann, T.
Stanoiu, M.
Schmid, M. von
Bertini, D.
Gilbert, M.
Davinson, T.
Wells, D.
Udias, J.
Mengoni, D.
Paradela, C.
Bleis, T. Le
Boztosun, I.
Kogimtzis, M.
Yakorev, D.
Redondo, D. Galaviz
Garg, U.
Kräckmann, S.
Egorova, I.
Sakuta, S.
Belier, G.
Palit, R.
Scheit, H.
Roussel-Chomaz, P.
Röder, M.
Chartier, M.
Geissel, H.
Coleman-Smith, P.
Suda, T.
Velho, P.
Machado, J.
Stepantsov, S.
Najafi, M.
Mancusi, D.
Sidorchuk, S.
Ricciardi, M.
Heine, M.
Cardona, J. Zamora
Ershov, S.
Fiori, E.
Haiduc, M.
Gernhäuser, R.
Gannon, S.
Holl, M.
Salsac, M.
Tomohiro, U.
Junghans, A.
Nyman, G.
Movsesyan, A.
Doré, D.
Andreev, V.
Pereira, J.
Perea, A.
Tanihata, I.
Frutos, T. Rodriguez
Bishop, S.
Slobodan, D.
Pohl, M.
Schnorrenberger, L.
Münzenberg, G.
Camera, F.
Pickstone, S.
Singh, P.
Winfield, J. S.
Andrei, B.
Atar, L.
Fomichev, A.
Chatillon, A.
Typel, S.
Weigand, M.
Kurz, N.
Ivanov, M.
Gorshkov, A.
Paschalis, S.
Crespi, F.
Kalantar, N.
Kanungo, R.
Sampson, J.
Fetisov, A.
Barbieri, C.
Bendel, M.
Gourishetty, A.
Wimmer, K.
Ghosh, T.
Kiselev, O.
Berjillos, R.
Blumenfeld, Y.
Nilsson, T.
AlGhamdi, S.
Krupko, S.
Marganiec, J.
Bracco, A.
Enders, J.
Vikhrov, V.
Altstadt, S.
Nolan, P.
Sarriguren, P.
Ignatov, A.
Thomas, T.
Lemasson, A.
Marusov, V.
Langer, C.
Cortina-Gil, D.
Schmidt, S.
Boretzky, K.
Simpson, E.
Teubig, P.
Joshi, P.
Kumar, S.
Ribeiro, G.
Sonnabend, K.
Khanzadeev, A.
Simon, H.
Glorius, J.
Krücken, R.
Bonaccorso, A.
Sanjari, S.
Zuber, K.
Fonseca, M.
Gasques, L.
Friese, J.
Riisager, K.
Adachi, T.
Seddon, D.
Scheidenberger, C.
Silva, J.
Richter, A.
Wyss, R.
Strieder, F.
Perez, M. Martinez
Wiescher, M.
Chulkov, L.
Fraile, L.
Hass, M.
Vignote, J. Rodriguez
Vajta, Z.
Westerberg, L.
Stach, D.
Potlog, P.
AlGarawi, M.
Moreno, O.
Ter-Akopian, G.
Volkov, V.
Henriques, A.
Crespo, R.
Sherrill, B.
Herraiz, J. Lopez
Nakamura, T.
Uberseder, E.
Rout, P.
Krings, T.
Sarkar, M. Saha
Bloch, T.
Blasi, N.
Zieblinski, M.
Zilges, A.
Alkhazov, G.
Roy, S.
Botvina, A.
Winkel, M.
Bemmerer, D.
Hennig, A.
Million, B.
Löher, B.
Kresan, D.
Harakeh, M.
Bacri, C.
Beinrucker, C.
Petri, M.
Freer, M.
Alvarez-Pol, H.
Prokofiev, A.
Krumbholz, A.
Plag, R.
Benzoni, G.
Caesar, C.
Göbel, K.
Golubev, P.
Yavor, M.
Beck, C.
Zhdanov, A.
Caamano, M.
Wamers, F.
Novatsky, B.
Thies, R.
Boudard, A.
Rossi, D.
Rios, A.
Krasznahorkay, A.
DiJulio, D.
Takechi, M.
Kezzar, K.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Inne
Tytuł:
Multi-ethnic genome-wide association study for atrial fibrillation
Autorzy:
Woo, Daniel
Cole, John W.
Aeschbacher, Stefanie
Delgado, Graciela
Yang, Pil-Sung
Roden, Dan M.
Schurman, Claudia
Cook, James
Gudnason, Vilmundur
Bloom, Heather L.
Morris, Andrew P.
Mahajan, Anubha
Low, Siew-Kee
Nikus, Kjell
Chung, Mina K.
Schnabel, Renate B.
London, Barry
Smith, Albert V.
Benjamin, Emelia J.
Nazarian, Saman
Launer, Lenore J.
Shaffer, Christian
Lin, Honghuang
Daniels, Brian R.
Risch, Lorenz
Lubitz, Steven A.
Lunetta, Kathryn L.
Anderson, Christopher D.
Sun, Han
Margolin, Lauren
Campbell, Archie
Laurikka, Jari
Rosand, Jonathan
Mohanty, Sanghamitra
Margulies, Kenneth B.
Shalaby, Alaa A.
Tanriverdi, Kahraman
Lindgren, Cecilia M.
Kleber, Marcus E.
Rader, Daniel J.
Stricker, Bruno H.
Dichgans, Martin
Guo, Xiuqing
Ingelsson, Erik
Uitterlinden, Andre G.
Esko, Tonu
Rienstra, Michiel
Krieger, Jose E.
Conen, David
Johnson, Renee
Tucker, Nathan R.
Sun, Albert
Wells, Quinn S.
Yao, Jie
Zeng, Lingyao
Wang, Biqi
Harris, Tamara B.
Cutler, Michael J.
Cappola, Thomas P.
Felix, Stephan B.
Orho-Melander, Marju
Kaab, Stefan
Rost, Natalia
Smith, J. Gustav
Ipek, Esra Gucuk
Loos, Ruth J.F.
Smith, Jonathan D.
Taylor, Kent D.
Weijs, Bob
Worrall, Bradford B.
Yoneda, Zachary T.
Weiss, Raul
Pereira, Alexandre
Tanaka, Toshihiro
Niemeijer, Maartje N.
Gutmann, Rebecca
Schramm, Katharina
Choi, Eue-Keun
Magnusson, Patrik K.
Tveit, Arnljot
Chen, Lin Y.
Seppala, Ilkka
Carlquist, John
Pak, Hui-Nam
Bartz, Traci M.
Thériault, Sébastien
Dorr, Marcus
Hocking, Lynne J.
Crijns, Harry J.
Paré, Guillaume
Neumann, Benjamin
Padmanabhan, Sandosh
Kirchhof, Paulus
Scott, Stuart A.
Saba, Samir
Lehtimaki, Terho
Leineweber, Kirsten
Montgomery, Jay A.
Refsgaard, Lena
Shah, Svati
Katschnig-Winter, Petra
Chasman, Daniel I.
Ito, Kaoru
Smith, Blair H.
Grewal, Raji P.
Fatkin, Diane
Knight, Stacey
Sinisalo, Juha
Weiss, Stefan
Huang, Jie
Gustafsson, Stefan
Alonso, Alvaro
Bottinger, Erwin B.
Smith, Nicholas L.
Kane, John P.
Kietselaer, Bas L.
Huang, Paul L.
Zeller, Tanja
Geelhoed, Bastiaan
Lokki, Marja-Liisa
Marz, Winfried
Trompet, Stella
Ahlberg, Gustav
Lu, Yingchang
Ridker, Paul M.
Kamatani, Yoichiro
Kahonen, Mika
Jimenez-Conde, Jordi
Aragam, Krishna G.
Olesen, Morten S.
Pera, Joanna
Huffman, Jennifer
Psaty, Bruce M.
Noordam, Raymond
Van Wagoner, David R.
Brody, Jennifer A.
Weeke, Peter E.
Damrauer, Scott M.
Weng, Lu-Chen
Lim, Hong Euy
Denny, Joshua C.
Pulit, Sara L.
Choi, Seung Hoan
Albert, Christine M.
McManus, David D.
Melander, Olle
Siland, Joylene E.
Chaffin, Mark D.
Barnard, John
Dudley, Samuel C.
Ford, Ian
Pullinger, Clive R.
Lind, Lars
Lemaitre, Rozenn N.
Pedersen, Nancy L.
Natale, Andrea
Ribasés, Marta
Hayward, Caroline
Christophersen, Ingrid E.
Teder-Laving, Maris
Volker, Uwe
Bis, Joshua C.
Li, Man
Shim, Jaemin
Rotter, Jerome I.
Verweij, Niek
Kastrati, Adnan
Shoemaker, M. Benjamin
Nilsson, Peter
Kathiresan, Sekar
Dudink, Elton A.
Horimoto, Andrea R.V.R.
Słowik, Agnieszka
Schunkert, Heribert
Wiggins, Kerri L.
Kubo, Michiaki
Boerwinkle, Eric
Malik, Rainer
Oellers, Heidi
Hofman, Albert
Hamsten, Anders
Teumer, Alexander
Newton-Cheh, Christopher
Muller-Nurasyid, Martina
Soliman, Elsayed Z.
Kavousi, Maryam
Sotoodehnia, Nona
Roselli, Carolina
Chen, Yii-Der Ida
Calkins, Hugh
Heckbert, Susan R.
Mansur, Alfredo J.
Morley, Michael P.
Lyytikainen, Leo-Pekka
Svendsen, Jesper H.
Vlachopoulou, Efthymia
Porteous, David
Ellinor, Patrick T.
Esa, Nada
Van Gelder, Isabelle C.
Darbar, Dawood
Hernesniemi, Jussi
Kessler, Thorsten
Jukema, J. Wouter
Wong, Jorge A.
Gupta, Namrata
Lin, Henry J.
Arking, Dan E.
Marcus, Gregory M.
Bihlmeyer, Nathan A.
Sandhu, Roopinder K.
Almgren, Peter
Eskola, Markku
Macfarlane, Peter W.
van der Harst, Pim
Rosenberg, Michael A.
Sinner, Moritz F.
Franco, Oscar H.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Apophis planetary defense campaign
Autorzy:
Sonbas, Eda
Bressi, Terry H.
Farnocchia, Davide
Falco, Carmelo
Morate, David
Weryk, Robert
Yim, Hong-Suh
Chastel, Serge
Marsset, Michael
Larsen, Jeffrey A.
Mastaler, Ron A.
Licandro, Javier
Taylor, Patrick A.
Pérez-Toledo, Fabricio
Warner, Elizabeth
Heinze, Aren N.
Cantillo, David
Kamiński, Krzysztof
Weiland, Henry J.
Kokina, Tatiana
Kaplan, Murat
Perminov, Alexander
Reddy, Vishnu
Kim, Myung-Jin
Chingis, Omarov
Kelley, Michael S.
Brozovic, Marina
Kamińska, Monika K.
Lees, Robert C.
Micheli, Marco
Bauer, James
Mathias, Donovan L.
Satpathy, Akash
Michel, Patrick
Moon, Hong-Kyu
Alarcon, Miguel R.
Serebryanskiy, Aleksander
de León, Julia
Elenin, Leonid
Kim, Dong-Heun
Ogłoza, Waldemar
Choi, Young-Jun
Kaiser, Galina
Mainzer, Amy
Szakáts, Robert
Christensen, Eric
Janse van Rensburg, Petro
Nastasi, Alessandro
Scotti, James V.
Cennamo, Ramona
Jacques, Cristovao
Glamazda, Dmitry
Ivanov, Alexander
McMillan, Robert S.
Lee, Hee-Jae
Serra-Ricart, Miquel
Novichonok, Artem
Pál, András
Marciniak, Anna
Buzzi, Luca
Popescu, Marcel
Tubbiolo, Andrew F.
Brucker, Melissa J.
Graziani, Filippo
Medeiros, Hissa
Schmalz, Sergei
Kuznetsov, Eduard
Dróżdż, Marek
Holman, Matthew J.
Kiss, Csaba
Read, Mike T.
Mokhnatkin, Artem
Zoła, Stanisław
Bell, David
Zhornichenko, Anastasiya
Faggioli, Laura
Roh, Dong-Goo
Veres, Peter
Reva, Inna
Erasmus, Nicolas
Polishook, David
Naidu, Shantanu P.
Benner, Lance A. M.
Wiebe, Yulia
Wheeler, Lorien F.
Petrescu, Elisabeta
Tonry, John L.
Masiero, Joseph
Rumpf, Clemens
Erece, Orhan
Reichart, Daniel E.
Barnardi, Fabrizio
Denneau, Larry
Balam, David
Żejmo, Michał
Cano, Juan
Wells, Guy
Dotson, Jessie
Wainscoat, Richard
Bamberger, Daniel
Opis:
We describe results of a planetary defense exercise conducted during the close approach to Earth by the near-Earth asteroid (99942) Apophis during 2020 December–2021 March. The planetary defense community has been conducting observational campaigns since 2017 to test the operational readiness of the global planetary defense capabilities. These community-led global exercises were carried out with the support of NASA's Planetary Defense Coordination Office and the International Asteroid Warning Network. The Apophis campaign is the third in our series of planetary defense exercises. The goal of this campaign was to recover, track, and characterize Apophis as a potential impactor to exercise the planetary defense system including observations, hypothetical risk assessment and risk prediction, and hazard communication. Based on the campaign results, we present lessons learned about our ability to observe and model a potential impactor. Data products derived from astrometric observations were available for inclusion in our risk assessment model almost immediately, allowing real-time updates to the impact probability calculation and possible impact locations. An early NEOWISE diameter measurement provided a significant improvement in the uncertainty on the range of hypothetical impact outcomes. The availability of different characterization methods such as photometry, spectroscopy, and radar provided robustness to our ability to assess the potential impact risk.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
    Wyświetlanie 1-7 z 7

    Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies