Autor: Zheng, Jason - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Exome analysis links kidney malformations to developmental disorders and reveals causal genes
Autorzy:: Montini, Giovanni
Lin, Fangming
Shril, Shirlee
Vena, Natalie
Szmigielska, Agnieszka
Lugani, Francesca
Eerde, Albertien M.
Mane, Shrikant
Harnof, Ofek
Appel, Gerald B.
Guarino, Stefano
Gliwińska, Aleksandra
Tasic, Velibor
Groopman, Emily E.
Sanna-Cherchi, Simone
Mu, Xueru
Krzemien, Grażyna
Gesualdo, Loreto
Caliskan, Yasar
Yang, Sandy
Bradbury, Drew
Zamboli, Pasquale
Negrisolo, Susanna
Saraga, Marijan
Piva, Stacy
Masnata, Giuseppe
Jin, Gina
Cohen, David Jonathan
Biancone, Luigi
Miklaszewska, Monika
Martino, Jeremiah
Elefant, Naama
Lim, Tze Y.
Rao, Maya K.
Lozanovski, Vladimir J.
Amoroso, Antonio
Ghavami, Iman
Scolari, Francesco
Coughlin, Arielle C.
Marasa, Maddalena
Lifton, Richard P.
Lekkerkerker, Iris
Westland, Rik
Izzi, Claudia
Zaniew, Marcin
Milo Rasouly, Hila
Bheda, Shiraz
Mehl, Karla
Verbitsky, Miguel
Szczepanska, Maria
Kiryluk, Krzysztof
Stevens, Kelsey O.
Uy, Natalie S.
Ke, Juntao
Canetta, Pietro A.
Bomback, Andrew S.
La Scola, Claudio
Khan, Atlas
Hays, Thomas
Bodria, Monica
Reingold, Rachel
Hildebrandt, Friedhelm
Bjanid, Omar
Jamry-Dziurla, Anna
Latos-Bielenska, Anna
Krishna Murthy, Sarath Babu
Alam, Shumyle
Radhakrishnan, Jai
Meneghesso, Davide
Chatterjee, Debanjana
Morban, Maria
Badenski, Andrzej
Borszewska-Kornacka, Maria K.
Fasel, David
Kolupaeva, Victoria
Ghiggeri, Gian Marco
Crew, Russell J.
Tondolo, Francesco
Drożdż, Dorota
Wongboonsin, Janewit
Zhang, Jun Y.
Capone, Valentina
Gharavi, Ali G.
Ionita-Laza, Iuliana
Zaza, Gianluigi
Grandinetti, Valeria
Reytan-Miron, Sivan
Baraldi, Olga
Zheng, Jason
Zachwieja, Katarzyna
Kil, Byum Hee
Ranghino, Andrea
Beenken, Andrew
Goldstein, David
Esposito, Pasquale
Marzuillo, Pierluigi
Mizerska-Wasiak, Malgorzata
Mittrori, Adele
La Manna, Gaetano
Santoro, Domenico
Materna-Kiryluk, Anna
Fiaccadori, Enrico
Pisani, Isabella
Tkaczyk, Marcin
Povysil, Gundula
Sikora, Przemyslaw
Tomar, Nikita
Kisselev, Sergey
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 2.

Tytuł:: Robotic vs. minimally invasive mitral valve repair : a 5-year comparison of surgical outcomes
Autorzy:: Daly, Richard C.
Arghami, Arman
Mazur, Piotr
Dearani, Joseph A.
Zheng, Clark R.
Crestanello, Juan A.
Viehman, Jason K.
Rowse, Phillip G.
Bagameri, Gabor
Jahanian, Sepideh
King, Katherine S.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 3.

Tytuł:: Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure
Autorzy:: Mattson, David L.
Lund, Hayley
Momotani, Ko
Ge, Zhi-Dong
Zhang, David X.
Somlyo, Avril V.
Zheng, Xiaodong
Lakshmikanthan, Sribalaji
Maas, Jason E.
Auchampach, John A.
Zięba, Bartosz J.
Artamonov, Mykhaylo V.
Chrzanowska-Wodnicka, Magdalena
Szabo, Aniko
Opis:: Objective—Small GTPase Ras-related protein 1 (Rap1b) controls several basic cellular phenomena, and its deletion in mice leads to several cardiovascular defects, including impaired adhesion of blood cells and defective angiogenesis. We found that Rap1b−/− mice develop cardiac hypertrophy and hypertension. Therefore, we examined the function of Rap1b in regulation of blood pressure. Approach and Results—Rap1b−/− mice developed cardiac hypertrophy and elevated blood pressure, but maintained a normal heart rate. Correcting elevated blood pressure with losartan, an angiotensin II type 1 receptor antagonist, alleviated cardiac hypertrophy in Rap1b−/− mice, suggesting a possibility that cardiac hypertrophy develops secondary to hypertension. The indices of renal function and plasma renin activity were normal in Rap1b−/− mice. Ex vivo, we examined whether the effect of Rap1b deletion on smooth muscle–mediated vessel contraction and endothelium-dependent vessel dilation, 2 major mechanisms controlling basal vascular tone, was the basis for the hypertension. We found increased contractility on stimulation with a thromboxane analog or angiotensin II or phenylephrine along with increased inhibitory phosphorylation of myosin phosphatase under basal conditions consistent with elevated basal tone and the observed hypertension. Cyclic adenosine monophosphate–dependent relaxation in response to Rap1 activator, Epac, was decreased in vessels from Rap1b−/− mice. Defective endothelial release of dilatory nitric oxide in response to elevated blood flow leads to hypertension. We found that nitric oxide–dependent vasodilation was significantly inhibited in Rap1b-deficient vessels. Conclusions—This is the first report to indicate that Rap1b in both smooth muscle and endothelium plays a key role in maintaining blood pressure by controlling normal vascular tone.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego