- Tytuł:
- Genetic insights into resting heart rate and its role in cardiovascular disease
- Autorzy:
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Newton-Cheh, Christopher H.
Strachan, David P.
Assimes, Themistocles
Gudnason, Vilmundur
Stolarz-Skrzypek, Katarzyna
Lorentzon, Mattias
Morris, Andrew P.
Hicks , Andrew A.
Nikus, Kjell
Linneberg, Allan
Ntalla, Ioanna
Smith, Albert V.
Perola, Markus
Lecoeur, Cecile
Launer, Lenore J.
Riese, Harriette
van de Vegte, Yordi J.
Ulivi, Sheila
Campbell, Archie
Zhao, Wei
Arnar, David O.
Rizzi, Federica
Sabanayagam, Charumathi
Eppinga, Ruben N.
Bielak, Lawrence F.
Sever, Peter
Ormel, Johan
Pina Concas, Maria
Lindgren, Cecilia M.
Kleber, Marcus E.
Smith, Jennifer A.
Wareham, Nicholas J.
Guo, Xiuqing
Gudbjartsson, Daniel F.
Ohlsson, Claes
O’Donnell, Christopher J.
Silva, Claudia T.
Sinagra, Gianfranco
Sundstrom, Johan
Balkau, Beverley
Shah, Nabi
Bottinger , Erwin P.
Delgado, Graciela E.
de Mutsert, Renée
Meitinger , Thomas
Hansen, Torben
Morrison , Alanna C.
Tanaka, Toshiko
Froguel, Philippe
Yao, Jie
Rankinen, Tuomo
Tham, Yih-Chung
Lange, Leslie A.
Felix, Stephan B.
Wong, Tien-Yin
Taylor, Kent D.
Kaab, Stefan
Smith, J. Gustav
Lakatta, Edward L.M.
Salfati, Elias
Appel, Emil V.
Girotto, Giorgia
de Geus, Eco J. C.
Cocca, Massimiliano
Rao, Dabeeru C.
Tarasov, Kirill V.
Schraut, Katharina E.
Schurmann, Claudia
van Duijn, Cornelia M.
Mononen, Nina
Ring, Susan M.
Milaneschi, Yuri
Burgess, Stephen
Dorr, Marcus
Wilson, James F.
Padmanabhan, Sandosh
Franke, Andre
Tan, Nicholas
Vollenweider, Peter
Kooner, Jaspal S.
Lahti , Jari
Lehtimaki, Terho
Snieder, Harold
Wang , Lihua
Kardia, Sharon L. R.
Robino, Antonietta
Palmer, Colin N. A.
Nolte, Ilja M.
Boehnke, Michael
Gyllensten, Ulf
Weiss, Stefan
Stefansson, Kari
Li, Hengtong L.
Ferrucci, Luigi
Oldehinkel, Albertine J.
Marz, Winfried
Trompet, Stella
Pavani, Francesca
Kahonen, Mika
Porteous, David J.
Luan, Jian’an
van der Ende, M. Yldau
Hwang, ShihJen
Kraft, Peter
Psaty, Bruce M.
Raitakari, Olli T.
Noordam, Raymond
Mohlke, Karen L.
Brody, Jennifer A.
Witte, Daniel R.
den Hoed, Marcel
Chambers, John C.
Qi, Lu
Galesloot, Tessel E.
Pistis, Giorgio
Kiemeney, Lambertus A. L. M.
Melander, Olle
Auro, Kirsi
Pechlivanis, Sonali
de Vries, Paul S.
Holm, Hilma
Iribarren, Carlos
Lind, Lars
Zeng, Linyao
van der Most, Peter J.
Foco, Luisa
Hayward, Caroline
Timpson, Nicholas J.
Peters, Annette
Feitosa, Mary F.
Quek, Debra Q.
Strauch, Konstantin
Zhao, Jing
Rotter, Jerome I.
Degenhardt, Frauke
Verweij, Niek
Groop, Leif
Ingelsson, Martin
Schunkert, Heribert
Bouchard, Claude
Hagemeijer, Yanick P.
Joshi, Peter K.
Moebus, Susanne
Bandinelli, Stefania
Tai, E. Shyong
Mahendran, Yuvaraj
Erdmann, Jeanette
Jackson, Anne U.
Muller-Nurasyid, Martina
Zhang, Weihua
Eriksson, Johan G.
Tan, Vanessa Y.
Sim, Xueling S.
Sveinbjornsson, Gardar
van den Berg, Marten E.
Sotoodehnia, Nona
Mook-Kanamori, Dennis O.
Roselli, Carolina
Heckbert, Susan R.
Cornelis, Marilyn C.
Penninx, Brenda W. J. H.
Lieb, Wolfgang
Lyytikainen, Leo-Pekka
Cheng, Ching-Yu
Ladenvall, Claes
Correa, Adolfo
Eijgelsheim, Mark
Kolcic, Ivana
Waldenberger, Melanie
Isaacs, Aaron
Grarup, Niels
Jukema, J. Wouter
Faul, Jessica D.
Munroe, Patricia B.
Lin, Henry J.
de Graaf, Jacqueline
Loos, Ruth J. F.
Polasek, Ozren
Johansson, Åsa
Macfarlane, Peter W.
van der Harst, Pim
Salo, Perttu
Rueedi, Rico
Nethander, Maria
Cusi, Daniele
Sinner, Moritz F.
Weir, David R.
Peyser, Patricia A.
Arking, Dan E.
Said, M. Abdullah - Opis:
- Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals 493 independent genetic variants in 352 loci, including 68 genetic variants outside previously identified resting heart rate associated loci. We prioritize 670 genes and in silico annotations point to their enrichment in cardiomyocytes and provide insights in their ECG signature. Two-sample Mendelian randomization analyses indicate that higher genetically predicted resting heart rate increases risk of dilated cardiomyopathy, but decreases risk of developing atrial fibrillation, ischemic stroke, and cardio-embolic stroke. We do not find evidence for a linear or non-linear genetic association between resting heart rate and all-cause mortality in contrast to our previous Mendelian randomization study. Systematic alteration of key differences between the current and previous Mendelian randomization study indicates that the most likely cause of the discrepancy between these studies arises from false positive findings in previous one-sample MR analyses caused by weak-instrument bias at lower P-value thresholds. The results extend our understanding of resting heart rate biology and give additional insights in its role in cardiovascular disease development.
- Dostawca treści:
- Repozytorium Uniwersytetu Jagiellońskiego
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