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Wyświetlanie 1-10 z 202
Tytuł:
Comparative phytochemistry, antioxidant, antidiabetic, and anti-inflammatory activities of traditionally used Ocimum basilicum L. Ocimum gratissimum L., and Ocimum tenuiflorum L.
Autorzy:
Sharma, Arun Dev
Kaur, Inderjeet
Angish, Sooraj
Thakur, Alisha
Sania, Sania
Singh, Amritpal
Tematy:
antioxidants
anti-inflammatory
antidiabetic
Ocimum
Pokaż więcej
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Powiązania:
https://bibliotekanauki.pl/articles/16648104.pdf  Link otwiera się w nowym oknie
Opis:
Ocimum spp. are the widely studied herbal plants because of their diverse biological activities. The present study aimed at comparative extraction of secondary metabolites and evaluation of their biological activities in different solvents such as acetone, ethanol, methanol, and water. Three Ocimum species, namely Ocimum basilicum L. (Green tulsi), Ocimum gratissimum L. (Jungli tulsi), and Ocimum tenuiflorum (Black tulsi), were selected for this study. Leaf extracts from dried powder of these species were prepared in different solvents. The contents of total phenolics, flavonoids, and total condensed tannins were estimated using standard assays. Fingerprint analysis using UV, Fourier transform infrared (FT-IR), and fluorescent spectroscopy was also conducted. Total antioxidant, antidiabetic, and anti-inflammatory activities of the extracts were evaluated. Fingerprint analysis indicated the presence of a sufficient level of polyphenolics in all the solvent extracts. Among all the solvents, acetone provided a higher yield of phenolics, flavonoids, and tannins in all Ocimum species. Black Ocimum showed the maximum level of antioxidants. All Ocimum extracts exhibited a sufficient level of antidiabetic and anti-inflammatory activities. The results indicated that by using appropriate solvents, bioactive compounds from Ocimum species can be extracted and used as therapeutic agents with potential biological activities.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Grzyby nadrewnowe z rodzaju Ganoderma źródłem biologicznie aktywnych triterpenów
Wood Decay Mushrooms of The Genus Ganoderma as A Source of Biologically Active Triterpenes
Autorzy:
Sułkowska-Ziaja, Katarzyna
Piechaczek, Małgorzata
Pacławska, Aneta
Muszyńska, Bożena
Tematy:
Ganoderma sp.
anti-inflammatory
antitumor
terpenoids
Pokaż więcej
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Powiązania:
https://bibliotekanauki.pl/articles/1033575.pdf  Link otwiera się w nowym oknie
Opis:
Species of the genus Ganoderma are an example of some of the most thoroughly studied representatives of Basidiomycota both in terms of chemical composition and biological activity. Among the compounds found in this kind, the therapeutic effect is primarily associated with the polysaccharides that are heteroglycans or β-D-glucans and terpenoids represented mainly by triterpenes. Triterpene compounds have a structure composed of 30 carbon atoms, usually forming a system of five six-membered rings. Characteristic of these structures are functional groups (hydroxyl, carboxyl or ketone) and double bonds. Mycochemical studies have led to the isolation of numerous triterpenes of the lanostane type (ganoderic acids, aldehydes, alcohols, esters), lucidenic acids and others from various species of the Ganoderma genus. The broad spectrum of biological activity determined by triterpene compounds includes anti- tumor, anti-inflammatory, antioxidant, hepatoprotective, antidiabetic, and antiviral effects. This work describes biologically active triterpenes in selected species of the genus Ganoderma: Ganoderma lucidum, Ganoderma applanatum, Ganoderma adspersum, Ganoderma pfeifferi, Ganoderma colossum and others. These species are sources of natural compounds valued for thousands of years in the traditional medicine of the Far East, while ongoing research has confirmed their medicinal properties nowadays.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and Biological Evaluation of Some New Hydrazone Derivatives Bearing Pyrimidine Ring as Analgesic and Anti-Inflammatory Agents
Autorzy:
Akdağ, Kadriye
Ünal, Gökhan
Tok, Fatih
Arıcıoğlu, Feyza
Temel, Halide E.
Kaymakcıoğlu-Koçyiğit, Bedia
Tematy:
anti-inflammatory activity
hydrazones
analgesic activity
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Wydawca:
Polskie Towarzystwo Farmaceutyczne
Powiązania:
https://bibliotekanauki.pl/articles/895455.pdf  Link otwiera się w nowym oknie
Opis:
New hydrazone derivatives were synthesized from 4-chloro-2-(methylthio)pyrimidine-5-carbohydrazide. Synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, mass spectral data and elemental analysis. All compounds were investigated for analgesic and anti-inflammatory activity with hot plate test and biochemical assay, respectively. The results of anti-inflammatory activity showed that compound 2t had maximal Lipoxygenase (LOX) inhibition (66.30%) whereas inhibitions of 2a, 2c, 2i, 2k, 2l, 2m, 2p, 2s and 2u were observed between approximately 45-15 %. Our results also indicated that 15 compounds of 21 had analgesic effect in hot plate test. Analgesic effect of 2l, 2s, 2t began earlier than others while effect of 2i began at latest time. According to the activity results, compound 2t have significant analgesic and anti-inflammatory effects.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
New thiopyridine complexes: design, electrochemical preparation and biological assessment
Autorzy:
El-Sabbagh, Osama I.
Yamany B., Yamany
Eldeab, Hany A.
Tematy:
Thiopyridine
complexes
electrochemical
antimicrobial
anti-inflammatory
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Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Powiązania:
https://bibliotekanauki.pl/articles/778283.pdf  Link otwiera się w nowym oknie
Opis:
Novel complexes of Ru (III), Cu (II) and Au (III) (2–4) were prepared using 6-phenyl-2-thioxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (HL, 1) adopting either electrochemical or traditional chemical methods. The electrochemical method is preferred in the synthesis of the complexes than the chemical one because it affords pure products with higher yields in shorter reaction time. The novel thiopyridine complexes were characterized by elemental analyses, IR, 1H, 19F-NMR, TGA and DTA measurements. The antimicrobial activity evaluation revealed that the complex bearing copper metal 3 has nearly the same activity as the reference drug ciprofloxacin. Anti-inflammatory activity evaluation showed that complex 4 containing gold displayed anti-inflammatory activity higher than the reference drug celecoxib upon using carrageenan rat hind paw edema method.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Can edible sprouts be the element of effective chemopreventive strategy? - a systematic review of in vitro and in vivo study
Autorzy:
Galanty, Agnieszka
Paśko, Paweł
Grudzińska, Marta
Opis:
Background: Cancer is a disease that seriously and increasingly threatens human health and life, affecting various organs such as: breast, lung, colon and rectum, prostate or stomach. Because of that it is so important to find appropriate chemopreventive agents that can prevent the development of cancer in humans. One of such methods may be a healthy diet rich in vegetables and fruits, including sprouts, which have recently gained popularity due to their health-promoting properties and easy process of cultivation. Scope and approach: The purpose of the following systematic review is to collect the results of all so far published studies on the chemopreventive potential of sprouts of various edible plants, in order to elect the most promising species for further research. This paper focused on the impact of sprouts extracts on cancer cells in vitro, as determined by the inhibition of tumor cell proliferation, growth and viability, or apoptosis stimulation, with special interest put on the results of the in vivo and human studies. The influence of different cultivation conditions and biofortification with selenium and probiotics on the activity of sprouts was assessed. Attempts were also made to indicate the main compounds responsible for sprouts' biological activity. Key findings and conclusions: Most of the results suggest that the sprouts may play a role in chemoprevention, as a part of the daily diet, with especially encouraging effects observed for broccoli sprouts. However, further research on cultivation conditions, safety profile, the impact of Se-enrichment or pharmacokinetic studies are necessary to assess the effectiveness of sprouts as chemopreventive agents in humans.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Autorzy:
Woessner, Katharine
Sanak, Marek
Kowalski, Marek L.
Opis:
Nonsteroidal anti-inflammatory drug (NSAID)–induced urticarial and angioedema reactions are among the most commonly encountered drug hypersensitivity reactions in clinical practice. Three major clinical phenotypes of NSAIDinduced acute skin reactions manifesting with angioedema, urticaria, or both have been distinguished: NSAIDexacerbated cutaneous disease, nonsteroidal anti-inflammatory drug–induced urticaria/angioedema (NIUA), and single NSAID–induced urticaria and angioedema. In some patients clinical history alone might be sufficient to establish the diagnosis of a specific type of NSAID hypersensitivity, whereas in other cases oral provocation challenges are necessary to confirm the diagnosis. Moreover, classification of the type of cutaneous reaction is critical for proper management. For example, in patients with single NSAID– induced reactions, chemically nonrelated COX-1 inhibitors can be safely used. However, there is cross-reactivity between the NSAIDs in patients with NSAID-exacerbated cutaneous disease and NIUA, and thus only use of selective COX-2 inhibitors can replace the culprit drug if the chronic treatment is necessary, although aspirin desensitization will allow for chronic treatment with NSAIDs in some patients with NIUA. In this review we present a practical clinical approach to the patient with NSAID-induced urticaria and angioedema.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
ANTI-INFLAMMATORY ACTIVITY AND CYTOTOXICITY OF DIOSGENIN ON LIPOPOLYSACCHARIDES INDUCED RAW 264.7 CELLS
Autorzy:
ning, jing
chang, yu
wang, ruxia
lan, zhiwei
ru, qing
liu, mingchun
tian, chunlian
Tematy:
Diosgenin
Anti-inflammatory
lipopolysaccharides
cytotoxicity
phagocytosis ability  
Pokaż więcej
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Powiązania:
https://bibliotekanauki.pl/articles/895615.pdf  Link otwiera się w nowym oknie
Opis:
Diosgenin is a steroidal sapogenin compound, and possesses multiple biological activities including anti-inflammatory, anticancer, immunological regulation, and anti-aging. The current study focused on its anti-inflammatory activities and cytotoxicity by analysis of NO production, phagocytosis activity, secretion of TNF-α and IL-6 and cell viability in LPS-induced RAW 264.7 cells. An IC50 value of diosgenin of 2.8 μM was calculated for diosgenin by regression of cell viability from concentrations ranging from 0.01 to 25 μM; this indicated that 0.01, 0.02, 0.04 μM diosgenin could reduce phagocytic activity very significantly (p<0.01) in a dose-dependent manner with no cytotoxic effect on the LPS-induced RAW 264.7 cells. However, there was no significant effect on NO content and secretion of TNF-α and IL-6 after diosgenin treatment. The research revealed that low concentrations diosgenin can directly inhibit cells phagocytosis, with no effect on the release of inflammatory mediators and cytokines. This lays a foundation for screening for a safe dose in research and developent of derivatives and new formulation of diosgenin for its anti-inflammatory effect.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The impact of ginger and curcumin on diabetic nephropathy induced by streptozotocin in rats
Autorzy:
Taha, Alaa
Ashour, Hanaa
Reffat, Manar
Elkhawaga, Omali Yousef
Wydawca:
Medical University of Gdańsk
Cytata wydawnicza:
Taha A, Ashour H, Reffat M, Elkhawaga OY. Impact of ginger and curcumin on diabetic nephropathy induced by streptozotocin in rats. Eur J Transl Clin Med. 2023;6(2):51-65.
Opis:
Background: Diabetes mellitus is a global health concern affecting 173 million adults annually that requires effective treatment. Medicinal plants such as ginger and curcumin, rich in bioactive compounds, have therapeutic potential. The aim of this study was to evaluate the therapeutic potential of ginger and curcumin extracts in diabetic nephropathy in the rat model. Material and methods: High-performance liquid chromatography was used to examine ginger and curcumin extracts. Fifty male Sprague Dawley rats were divided into five groups: control, untreated diabetic, ginger-treated diabetic, curcumin-treated diabetic, and a ginger + curcumin combination group. Diabetes was induced with a single intraperitoneal dose of streptozotocin. Rats received daily oral doses of ginger, curcumin or the combination of both. After sixteen weeks, rats were anesthetized and various tests were conducted to evaluate treatment outcomes. Results: The rats treated with combined ginger and curcumin extracts had superior outcome in terms of more antioxidant activity, better glycemia management and less DN-related kidney damage (reduced albuminuria and less histological changes). Conclusions: Our findings indicate that ginger and curcumin extracts have therapeutic potential in mitigating functional and structural alterations in the kidneys of diabetic rats, possibly due to their anti-diabetic and anti-inflammatory properties.
Dostawca treści:
Repozytorium Centrum Otwartej Nauki
Artykuł
Wyświetlanie 1-10 z 202

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