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Tytuł:
C-Reactive Protein as a Marker of Postoperative Septic Complications
Autorzy:
Witczak, Andrzej
Jurałowicz, Piotr
Modzelewski, Bogdan
Gawlik, Małgorzata
Tematy:
C-reactive protein
postoperative septic complications
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Wydawca:
Index Copernicus International
Powiązania:
https://bibliotekanauki.pl/articles/1396704.pdf  Link otwiera się w nowym oknie
Opis:
The aim of the study was to answer the question whether or not determination of C-reactive protein in patients after serious abdominal surgeries can be prognostic of septic complications.Material and methods. 36 patients who underwent elective surgeries were included in the study. The patients were included either in the group where no postoperative SIRS developed or in the group where postoperative SIRS did occur. In the seven-day period after the surgery, in 26 patients SIRS was found, and in 10 - sepsis was suspected (according to the ACCP/SCCM definitions). In patients who underwent abdominal surgeries blood concentration of C-reactive protein was determined prior to the surgery (measurement '0'), and then on postoperative days 1, 2, 3, 5 and 7.Results. The test for two variables (C-reactive protein on postoperative days five and seven) showed statistically significant difference, and for one variable (C-reactive protein on day three) - difference at the limit of significance. Thus, it was found that in the postoperative SIRS group the level of C-reactive protein is higher than in the non-SIRS group.Conclusions. Serial measurements of C-reactive protein are useful in the first week after surgery, as they can be prognostic of postoperative septic complications. Such complications can be anticipated if CRP on postoperative day 5 is higher than 1/2 of the maximum CRP concentration on day 2 or day 3, or CRP > 150 mg/L as of postoperative day 3. Unfortunately, the severity of the disease cannot be projected based on C-reactive protein level.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association of serum albumin and serum high-sensitivity C-reactive protein levels with acute ischemic stroke severity
Autorzy:
Yadav, Rupesh
Choudhary, Mohit
Kumar, Shailesh
Wydawca:
Towarzystwo Pomocy Doraźnej
Cytata wydawnicza:
Choudhary M, Kumar S, Yadav R. Association of serum albumin and serum high-sensitivity C-reactive protein levels with acute ischemic stroke severity. Crit. Care Innov. 2024; 7(3): 25-34.
Opis:
INTRODUCTION: Acute ischemic stroke, a type of cerebrovascular disease, is one of the most common causes of mortality and morbidity around the world. Albumin-induced neuroprotection can be attributed to properties such as reversal of thrombosis, improvement in microvascular blood perfusion, reduction in brain swelling. The increase in high-sensitivity C-reactive protein levels (hs-CRP) after an ischemic stroke suggests a systemic inflammatory response and reveals the degree of brain damage. The purpose of the study was to assess the association of serum albumin and serum high-sensitivity C-reactive protein levels with acute ischemic stroke severity. MATERIALS AND METHODS: Prospective cross-sectional observational study involving 90 patients admitted to the emergency department that met the inclusion and exclusion criteria. At the time of admission blood samples were taken for measurement of serum albumin level (normal albumin level ≥3.5 g/dl and hypoalbuminemia <3.5 g/dl), hs-CRP (low risk <1.0 mg/L; average risk 1.0-3.0 mg/L; high risk >3.0 mg/L). The severity of stroke was assessed using the National Institutes of health stroke scale (NIHSS) score. RESULTS: 60% of the cases had a normal albumin level, while 40% of the cases had hypoalbuminemia. 82.22% of the cases had a high risk level of hs-CRP, while only 1.11% of the cases had a low risk level of hs-CRP. The association of hypoalbuminemia and hs-CRP with stroke severity on the NIHSS score measured at the time of admission. It was observed that there was a statistically significant correlation between hypoalbuminemia with stroke severity (p-value <0.002) and between hs-CRP levels with stroke severity (p-value <0.013). CONCLUSIONS: The study concluded that the association between low serum albumin level and elevated hs-CRP levels with the severity of acute ischemic stroke was statistically significant.
Dostawca treści:
Repozytorium Centrum Otwartej Nauki
Artykuł
Tytuł:
Prognostic significance of C-reactive protein/albumin and neutrophil/lymphocyte ratios in patients with COVID-19
Autorzy:
Beyazal Polat, Hatice
Arpa, Medeni
Polat, Zehra
Beyazal, Mehmet
Beyazal Çeliker, Fatma
Ayaz, Teslime
Ertürk, Ayşe
Tematy:
COVID-19
C-reactive protein/albumin
neutrophil/lymphocyte
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Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Powiązania:
https://bibliotekanauki.pl/articles/40570858.pdf  Link otwiera się w nowym oknie
Opis:
Introduction and aim. COVID-19 causes an uncontrolled and generalized inflammatory response of the host immune system. Early recognition of the disease and early prediction of the clinical course are of great importance. The aim of this study was to evaluate the predictive role of the C-reactive protein/albumin ratio (CAR) and the neutrophil/lymphocyte ratio (NLR) for mortality in patients hospitalized with the diagnosis of COVID-19. Material and methods. The patients, who were hospitalized for COVID-19 and whose CRP, albumin, neutrophil, and lymphocyte levels were documented within the first 24 hours after admission, were analyzed retrospectively. Patients were divided into survivors and non-survivors; the groups were compared. Univariate and multivariate Cox regression models were developed to evaluate the CAR and the NLR as risk factors for mortality in COVID-19 patients. Results. One hundred and thirty patients were included in this study. The mean age of the survivor group (n=114) was 60±16 and 52% were male. The mean age of the non-survivor group (n=16) was 75±13 and 56% were male. In the non-survivor group, the CAR detected at the time of admission to the hospital was significantly higher compared to patients in the survivor group (p=0.026). Conclusion. As a result, the CAR, the NLR and LDH are independent risk factor indicators of mortality in hospitalized patients.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association of serum albumin and serum high-sensitivity C-reactive protein levels with acute ischemic stroke severity
Autorzy:
Choudhary, Mohit
Kumar, Shailesh
Yadav, Rupesh
Tematy:
Acute ischemic stroke
albumin
C-reactive protein
mortality
Pokaż więcej
Wydawca:
Towarzystwo Pomocy Doraźnej
Powiązania:
https://bibliotekanauki.pl/articles/55780730.pdf  Link otwiera się w nowym oknie
Opis:
INTRODUCTION: Acute ischemic stroke, a type of cerebrovascular disease, is one of the most common causes of mortality and morbidity around the world. Albumin-induced neuroprotection can be attributed to properties such as reversal of thrombosis, improvement in microvascular blood perfusion, reduction in brain swelling. The increase in high-sensitivity C-reactive protein levels (hs-CRP) after an ischemic stroke suggests a systemic inflammatory response and reveals the degree of brain damage. The purpose of the study was to assess the association of serum albumin and serum high-sensitivity C-reactive protein levels with acute ischemic stroke severity. MATERIALS AND METHODS: Prospective cross-sectional observational study involving 90 patients admitted to the emergency department that met the inclusion and exclusion criteria. At the time of admission blood samples were taken for measurement of serum albumin level (normal albumin level ≥3.5 g/dl and hypoalbuminemia <3.5 g/dl), hs-CRP (low risk <1.0 mg/L; average risk 1.0-3.0 mg/L; high risk >3.0 mg/L). The severity of stroke was assessed using the National Institutes of health stroke scale (NIHSS) score. RESULTS: 60% of the cases had a normal albumin level, while 40% of the cases had hypoalbuminemia. 82.22% of the cases had a high risk level of hs-CRP, while only 1.11% of the cases had a low risk level of hs-CRP. The association of hypoalbuminemia and hs-CRP with stroke severity on the NIHSS score measured at the time of admission. It was observed that there was a statistically significant correlation between hypoalbuminemia with stroke severity (p-value <0.002) and between hs-CRP levels with stroke severity (p-value <0.013). CONCLUSIONS: The study concluded that the association between low serum albumin level and elevated hs-CRP levels with the severity of acute ischemic stroke was statistically significant.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of risk factors for surgical site infection and other postoperative complications in patients following loop ileostomy reversal
Autorzy:
Borejsza-Wysocki, Maciej
Szmyt, Krzysztof
Jeske, Pamela
Bobkiewicz, Adam
Ledwosiński, Witold
Banasiewicz, Tomasz
Krokowicz, Łukasz
Tematy:
C-reactive protein
loop ileostomy
surgical site infections
Pokaż więcej
Wydawca:
Index Copernicus International
Powiązania:
https://bibliotekanauki.pl/articles/58714069.pdf  Link otwiera się w nowym oknie
Opis:
Introduction: Loop ileostomy reversal (LIR) procedure is still associated with a relatively high risk of complications. Surgical site infection (SSI) is the most common complication in this group of patients. SSI leads to prolonged hospital stays, delays the adjuvant therapy, and increases hospital costs. Aim: The aim of the study was to analyze the risk factors for SSI in patients following loop ileostomy reversal procedure. Material and methods: A single-center retrospective analysis was conducted in a tertiary reference center. Finally, 65 patients following loop ileostomy reversal procedure performed between 2018 and 2022 were enrolled in the study. Data were collected retrospectively based on the available medical charts. The study group comprised 23 women (35%) and 42 men (65%) with a mean age of 48.9 ±14.5 years and a mean body mass index of 24.3 ±4.9 kg/m2 . The most common indication for index surgery was ulcerative colitis (33%) and colorectal cancer (29%). Preferably, handsewn anastomosis was performed (n = 42; 64.6%). Results: The most important parameter evaluated in the above study was the diagnosis of surgical site infection, which influenced e.g. hospitalization after surgery, the need for antibiotic therapy, or C-reactive protein (CRP) values. Nine patients (13.8%) were diagnosed with SSI during their hospital stay (more than 86% without SSI). In the group with SSI, hospital stay exceeded 13 days compared to almost 6 days in the group without SSI (P = 0.00009). The time of the procedure had a statistically significant correlation with antibiotic therapy introduction (P = 0.01). The type of intestinal anastomosis had a significant impact on the operative time (P = 0.0011) and the time of hospital stay after surgery (P = 0.04). Conclusions: Most of the analyzed clinical factors were directly related to the impact on the duration of postoperative hospitalization. The duration of hospitalization is an independent and undeniable factor increasing the risk of other postoperative complications and significantly increasing the cost of hospitalization. Another factor that has a large clinical impact on postoperative treatment is the presence of comorbidities which make patients more likely to develop SSI, CRP increase, or the need for antibiotic therapy. An important factor was the level of CRP, the elevated value of which may be a predictor of many negative aspects in postoperative treatment.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparison of the Effectiveness of the Treatment Using Standard Methods and Negative Pressure Wound Therapy (NPWT) in Patients Treated with Open Abdomen Technique
Autorzy:
Szmyt, Krzysztof
Krokowicz, Łukasz
Bobkiewicz, Adam
Cybułka, Bartosz
Ledwosiński, Witold
Gordon, Maciej
Alammari, Ahmed
Banasiewicz, Tomasz
Drews, Michał
Tematy:
C-reactive protein
negative pressure wound therapy
open abdomen
Pokaż więcej
Wydawca:
Index Copernicus International
Powiązania:
https://bibliotekanauki.pl/articles/1395206.pdf  Link otwiera się w nowym oknie
Opis:
Open abdomen technique is a surgical treatment in which the fascia and skin are left open in order to reduce the value of the intra-abdominal pressure. According to the World Society of the Abdominal Compartment Syndrome (WSACS) normal values of the intra-abdominal pressure are between 5 and 7 mm Hg. Intra-abdominal hypertension occurs when the pressure value is equal to or exceeds 12 mm Hg. The aim of the study was to compare the results of the open abdomen treatment using standard methods and negative pressure wound therapy. Material and methods. The study was in the form of a retrospective analysis of the documentation of the patients treated with open abdomen technique. The study included 37 patients treated in the Department of General and Endocrine Surgery and Gastroenterological Oncology and in the Department of Anesthesiology and Intensive Care of the Medical Sciences since 2009-2012. Patients were divided into two groups: group 1 (n = 20) was treated with standard surgical procedures (laparostomy, repeated peritoneal cavity lavage) and group 2 (n =17) was treated using negative pressure wound therapy (NPWT). The analysed clinical data included the period of hospitalization and clinical outcome (survival vs death), the occurrence of enteroatmospheric fistulae, cyclical determination of the quantitative C-reactive protein levels. Results. The number of deaths during hospitalization in the group treated with NPWT was lower than in the group treated with standard methods (3 vs 9). The number of fistulae during hospitalization in the group treated with NPWT dropped as compared to the group treated using standard procedures (18% vs 70%). The decrease in the CRP levels was recorded in the group treated with NPWT and its increase - in the group treated with standard methods. Conclusions. The use of NPWT in patients requiring open abdomen treatment is reasonable due to the positive results with respect to survival rates and the decrease in the number of gastrointestinal fistulae. It is necessary to train the physicians in using this type of therapy in the form of workshops and in the clinical setting.
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 51

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