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    Wyświetlanie 1-7 z 7
    Tytuł:
    Effect of diosgenin, a steroidal sapogenin, on the rat skeletal system
    Autorzy:
    Folwarczna, Joanna
    Zych, Maria
    Nowińska, Barbara
    Pytlik, Maria
    Bialik, Magdalena
    Jagusiak, Anna
    Lipecka-Karcz, Maria
    Matysiak, Michał
    Tematy:
    diosgenin
    skeletal system
    osteoporosis
    estrogen deficiency
    rats
    Pokaż więcej
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Powiązania:
    https://bibliotekanauki.pl/articles/1038814.pdf  Link otwiera się w nowym oknie
    Opis:
    Diosgenin is a steroidal sapogenin present in fenugreek and Dioscorea spp. as glycosides (saponins). Diosgenin has already been reported to inhibit osteoclastogenesis and to stimulate osteogenic activity of osteoblastic cells in vitro, and to exert some antiosteoporotic effects in rats in vivo. The aim of the present study was to investigate the effects of diosgenin administration on the skeletal system of rats with normal estrogen level and with estrogen deficiency induced by bilateral ovariectomy. The experiments were carried out on 3-month-old non-ovariectomized and ovariectomized Wistar rats, divided into control rats and rats receiving diosgenin (50 mg/kg p.o. daily) for 4 weeks. Serum bone turnover markers, bone mass and mineralization, histomorphometric parameters and mechanical properties were studied. Diosgenin improved some investigated parameters in both non-ovariectomized and ovariectomized rats, in which estrogen deficiency induced osteoporotic changes. Diosgenin increased compact bone formation and probably inhibited cancellous bone resorption, which led to improvement of mechanical properties of compact and cancellous bone. In conclusion, this in vivo study demonstrated that diosgenin may be one of sparse compounds increasing bone formation.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    ANTI-INFLAMMATORY ACTIVITY AND CYTOTOXICITY OF DIOSGENIN ON LIPOPOLYSACCHARIDES INDUCED RAW 264.7 CELLS
    Autorzy:
    ning, jing
    chang, yu
    wang, ruxia
    lan, zhiwei
    ru, qing
    liu, mingchun
    tian, chunlian
    Tematy:
    Diosgenin
    Anti-inflammatory
    lipopolysaccharides
    cytotoxicity
    phagocytosis ability  
    Pokaż więcej
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Powiązania:
    https://bibliotekanauki.pl/articles/895615.pdf  Link otwiera się w nowym oknie
    Opis:
    Diosgenin is a steroidal sapogenin compound, and possesses multiple biological activities including anti-inflammatory, anticancer, immunological regulation, and anti-aging. The current study focused on its anti-inflammatory activities and cytotoxicity by analysis of NO production, phagocytosis activity, secretion of TNF-α and IL-6 and cell viability in LPS-induced RAW 264.7 cells. An IC50 value of diosgenin of 2.8 μM was calculated for diosgenin by regression of cell viability from concentrations ranging from 0.01 to 25 μM; this indicated that 0.01, 0.02, 0.04 μM diosgenin could reduce phagocytic activity very significantly (p<0.01) in a dose-dependent manner with no cytotoxic effect on the LPS-induced RAW 264.7 cells. However, there was no significant effect on NO content and secretion of TNF-α and IL-6 after diosgenin treatment. The research revealed that low concentrations diosgenin can directly inhibit cells phagocytosis, with no effect on the release of inflammatory mediators and cytokines. This lays a foundation for screening for a safe dose in research and developent of derivatives and new formulation of diosgenin for its anti-inflammatory effect.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Preparation of diosgenin-functionalized gold nanoparticles : from synthesis to antitumor activities
    Autorzy:
    Trzcińska, Kinga
    Witkowska, Anna B.
    Kubiszewski, Marek
    Muszyńska, Magdalena
    Stolarczyk, Elżbieta U.
    Stolarczyk, Krzysztof
    Strzempek, Weronika
    Wojdasiewicz, Piotr
    Opis:
    Cancer ranks among the top causes of illness and death globally. Nanotechnology holds considerable promise for enhancing the effectiveness of therapeutic and diagnostic approaches in cancer treatment. Our study presents a promising strategy for applying thiocompound nanomedicine in cancer therapy. Our first study aimed to investigate the biological properties of a new compound thiodiosgenin (TDG)—a new derivative of diosgenin—a natural compound with known antioxidant and anticancer properties. Our current second study aimed to compare the therapeutic efficacy of a new diosgenin—functionalized gold nanoparticles—with its precursor on prostate cancer (DU-145) cell lines. Moreover, the safety of the new thio-derivative and new conjugates was tested against the human epithelial line PNT-2. New advanced analytical techniques were developed for the characterization of nanomaterials using methods such as SP-ICP-MS, UV-Vis, TEM, NMR, FT-IR ELS, and TGA. Our synthetic approach was based, on the one hand, on the ligand exchange of citrates to thiodiosgenin (TDG) on gold nanoparticles, and on the other hand, on the attachment of DG through an ester bond to the linker, which was 3-mercaptopropionic acid (MPA) on gold nanoparticles. Initial in vitro studies indicate that TDG shows greater cytotoxic effects on cancer cells but poses risks to normal prostate epithelial cells (PNT-2). It was demonstrated that all the conjugates produced exhibited significant cytotoxic effects against cancer cells while being less harmful to normal prostate epithelial cells (PNT-2) compared to TDG itself. All the obtained conjugates showed antitumor properties; however, for targeted transport, the system referred to as AuNPs-MPAm1-DG is promising, due to the size of the nanoparticles of 53 nm, zeta potential of -30 mV, and loading content of 27.6%. New methods for synthesizing conjugates with diosgenin were developed and optimized for medical applications. Advanced new analytical methodologies were developed to characterize new conjugates, particularly the use of SP-ICP-MS, to solve existing differences in the shape and morphology of the surface of new conjugates.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
      Wyświetlanie 1-7 z 7

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