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Wyświetlanie 1-2 z 2
Tytuł:
Surface water and groundwater quality assessment using the WQI method and human health risk assessment (HHR) in the lower seybouse (Annaba Plain), northeast Algeria
Autorzy:
Fenazi, Bilal
Boucenna, Fatih
Zeddouri, Aziez
Tematy:
WQI
water quality index
HHRA
non-carcinogenic
HI
carcinogenic
Lower Seybouse
zdrowie ludzi
ocena ryzyka
wskaźnik jakości wody
rakotwórczość
dorzecze Seybouse
Pokaż więcej
Wydawca:
Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie
Powiązania:
https://bibliotekanauki.pl/articles/59123669.pdf  Link otwiera się w nowym oknie
Opis:
This study was carried out to investigate the current status of surface water and groundwater quality in Lower Seybouse and Annaba Plain, NE Algeria. 36 surface water and groundwater samples were collected in this area, and various physicochemical parameters were analysed. The quality of surface water and groundwater for drinking and the associated health risks were assessed using a Water Quality Index (WQI) and a Human Health Risk Assessment (HHRA) model. The results show that all samples are alkaline with the EC values ranging from 1139 to 5555 μS/cm. The ionic dominance pattern was in the order of Na+ > Mg2+ > Ca2+ > K+ for cations and Cl– > HCO3 – > SO4 2 – > NO3 – for anions, respectively. The dominant water types are SO4-Cl-Ca-Mg and SO4-Cl-Na, formed by dissolution of evaporative and carbonate-rich material. All samples are unsuitable for drinking, with 1 sample classified as poor (rank = 4) and 35 samples as extremely poor (rank = 5). These samples are mainly located near the Seybouse Wadi, which is a natural outlet for wastewater from human activities. The assessment of non-carcinogenic risk showed that the Hazard Index (HI) for males ranged from 0.12 to 1.01 with a mean of 0.30 and only one sample exceeded value 1. For females, the HI was between 0.16 and 1.28 for females, with a mean of 0.39. The risk for children was even higher, ranging from 0.41 to 3.28, with a mean of 1.03, suggesting that children are more vulnerable to water contamination. The Carcinogenic Risk (CR) values for Pb ranged from 10–3 to 8.6 · 10–3, with a mean of 2.6 · 10–3 for males, and between 1.4 · 10–3 to 10–2, with a mean of 3.3 · 10–3 for females, while for children the CR values ranged from 3.5 · 10–3 to 2.7 · 10–3, with a mean of 8.4 · 10–3, indicating that no possible CR from water drinking
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The human health risk assessment of heavy metals impurities (Cd and Pb) in herbal medicinal products as Menthae piperitae tinctura ( Mentha piperita L., folium) available in pharmacies from Poland
Autorzy:
Jurowski, Kamil
Krośniak, Mirosław
Opis:
Appropriate human health risk assessment (HHRA) is desire in modern regulatory toxicology, especially for elemental impurity studies. The aim of this article is the comprehensive HHRA of two heavy metals impurities—Cd and Pb in herbal medicinal products (HMP) as Menthae piperitae tinctura (Mentha × piperita L., folium) available in Polish pharmacies. These phytopharmaceuticals registered in EU are very common and usually applied OTC products by adults and also children/adolescents. For this purpose, we applied double regulatory approach, including: (1) requirements of ICH Q3D R1 guideline about elemental impurities and (2) additionally margin of exposure (MoE)-based concept to cover also specific population groups. Raw results shows that Cd and Pb were present in all analyzed HMP with Mentha × piperita L., folium (PTM1–PTM10) available in Polish pharmacies. In all samples, Cd impurities (in the range: 0.305–0.506 µg/L) were greatly lower than Pb impurities (in the range: 1.122–4.4921 µg/L). The HHRA of Cd and Pb impurities considering ICH Q3D R1 guideline-based approach made it possible to conclude that all results were below the permissible limit set by FAO/WHO for medicinal herbs and plants in different countries (300 µg/kg for Cd and 10,000 µg/kg for Pb). Additionally, the estimated daily intake of investigated elemental impurities compared to the PDE value confirm all samples safety. The second approach, an MoE-based strategy, indicated that the obtained values of MoE for Cd and Pb in daily dose for each samples were above 10,000; hence, exposure to these elemental impurities would not cause a health risk for all investigated population groups (children, adolescents, and adults). To the best our knowledge, this article is the first study about heavy metals impurities level in final HMPs as Menthae piperitae tinctura (Mentha × piperita L., folium) available in Polish pharmacies.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
    Wyświetlanie 1-2 z 2

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