Temat: MRS - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Evaluation of 3T proton MR spectroscopy in the spinal cord : preliminary results
Autorzy:: Bobek-Billewicz, Barbara
Heinze, Sylwia
Hebda, Anna
Wawrzyniak, Pawel
Opis:: Purpose: 1H-magnetic resonance spectroscopy (1H-MRS) is a non-invasive technique that provides information on tissue metabolism and biochemistry. Because of technical difficulties, this method is rarely used in spinal cord examination. The main goal of this study was to develop a routine protocol for MRS of intramedullary lesions. Material and methods: A 1H-MRS protocol was set on a group of healthy volunteers. Forty-eight spectra were acquired in total. Thirty of them were acquired in cervical spinal cord, and the remaining 18 spectra were acquired in the thoracic spinal cord. Results: In 1H-MRS of the spinal cord one of the most important problems is small voxel size. Mean voxel size in this study was 7 × 9 × 29 mm, which is much smaller than in brain examinations. Finally, almost 60% of spectra were of acceptable quality in volunteer examinations, which enabled the subsequent examinations. Conclusions: Challenges of spinal cord spectroscopy were discussed, and the ability of providing additional diagnostic information was proven.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 2.

Tytuł:: Olivopontocerebellar artrophy in MRI spectroscopy : case report
Autorzy:: Szatkowski, Maciej
Modzelewski, Marek
Ochrynik, Tomasz
Bulski, Tomasz
Opis:: Background: Olivopontocerebellar atrophy (OPCA) is an adult-onset disorder. It may occur in a sporadic or familial form. Case report: We present the case of a 62-year-old man with clinical symptoms of progressive cerebellar ataxia. Conclusions: Radiography presented atrophy of the pons and cerebellum. Clinically the syndrome results in progressive ataxia and bulbar dysfunction. Spectroscopy MR shows decrease in NAA/Cr ratio in cerebellum and pons - typical patterns of atrophy.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 3.

Tytuł:: The influence of leg positioning on the appearance and quantification of 1H magnetic resonance muscle spectra obtained from calf muscle
Autorzy:: Tungjai, Montree
Kothan, Suchart
Pasanta, Duanghathai
Opis:: Purpose: To study proton magnetic resonance spectra (1H-MRS) of the muscle metabolite of a leg muscle in neutral (NEU), internal rotation (INT), and external rotation (EXT) leg positioning. Material and methods: The volunteers were selected for this study. The tibialis anterior (TA), soleus (SOL), and gastrocnemius (GAS) muscles of a non-dominate leg were determined by using single-voxel spectroscopy 8 × 8 × 20 mm3 in size. 1H-MRS measurements were performed on a 1.5-Tesla magnetic resonance imaging (MRI) scanner. Results: The results showed that metabolite spectrum of muscle in each NEU, INT, and EXT of leg positioning were not similar. Additionally, the quantification of IMCL (CH3) and EMCL (CH3) is significantly different in SOL. Conclusions: Our study showed that leg positioning influences the appearance and quantification of 1H-MRS in the calf muscle. Hence, it is necessary to pay close attention to positioning because it interferes with spectral fitting and quantification.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 4.

Tytuł:: Układ relacyjny bohaterów w powieści Pani Dalloway Virginii Woolf
The Narrative Schemata in Virginia Woolf’s Mrs Dalloway
Autorzy:: Szeremeta-Kołodzińska, Katarzyna
Tematy:: Mrs Dalloway
narrative schemata
reflector(s)
Virginia Woolf; Pokaż więcej
Wydawca:: Uniwersytet Warmińsko-Mazurski w Olsztynie
Powiązania:: https://bibliotekanauki.pl/articles/444162.pdf Link otwiera się w nowym oknie
Opis:: In Virginia Woolf’s ample literary oeuvre the 1925 Mrs Dalloway continues to invite most interest among literary scholars. This article closely examines Woolfian narrative strategies and schemata that pertain to the image of Clarissa Dalloway, the novel’s eponymous character. The subject of analysis is the relation between Clarissa and Peter Walsh (former suitor and confidant) which shapes this portrait. Although he belongs to Clarissa’s “entourage” (Woolf called upon a group of other characters in protagonists’ support), his role as the main observer is most pronounced in the novel. Peter Walsh, who acts as a “reflector” − narrator’s agency − helps to reconstruct for the reader otherwise fragmented and elusive image of Clarissa. His contribution is realised by means of narrative functions he fulfils: legitimising her accounts, accompanying her (as a construct of protagonist’s imagination though) in London strolls and mediating between the realm of imagery and empirical world.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: This moment in June : afterword to Mrs Dalloway
Ta chwila w czerwcu : posłowie do Pani Dalloway
Autorzy:: Heydel, Magdalena
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 6.

Tytuł:: Differentiation between radionecrosis and malignant brain tumor recurrence in patients treated by Ir192 HDR brachytherapy : H1-MRS analysis of the brain metabolic spectrum
Różnicowanie popromiennej martwicy i wznowy złośliwego guza mózgu u pacjentów leczonych przy pomocy brachyterapii Ir 192 metodą HDR w oparciu o analizę spektroskopową widma metabolitów z użyciem H1-MRS
Autorzy:: Maksymowicz, Wojciech
Walecki, Jerzy
Łyczek, Jarosław
Beta, Jarosław
Bulski, Tomasz
Barczewska, Monika
Opis:: Background: Computerized tomography (CT) with contrast infusion and Magnetic Resonance Imaging (MRI) do not differentiate radionecrosis and malignant tumor recurrence. Proton Magnetic Resonance Spectroscopy seems to be a new radiological method that could solve this problem. The aim of the study was to evaluate the usability of H1-MRS in patients after brachytherapy. Material/Methods: Sixty patients were treated by Ir 192 HDR brachytherapy because of malignant brain tumors (gliomas and brain metastases). Prospectively, 4 months after brachytherapy, 24 patients underwent MRI and H1-MRS examinations. All patients qualified for the prospective study were in good general condition before and after the brachytherapy (Karnofsky Performance Score (KPS) > 60%). Results: Combined assessment of MRI and H1-MRS gave us the possibility to differentiate the observed pathological changes. In 18 cases (75%) there was a decrease in tumor volume. The tumor infiltration area was larger than the necrotic area in 5 cases. An isolated recurrence mass was observed in only one case. Neurosurgical brain decompression with pathological mass resection was needed in 6 patients with increased intracranial pressure and enhanced neurological deficits. Histopathological examination confirmed the diagnosis revealed in the H1-MRS examination in each case. Conclusions: Proton Magnetic Resonance Spectroscopy is helpful in evaluating the influence of radiation on the tumor and the surrounding brain tissue. Moreover, it solves the problem of differentiating between radionecrosis and tumor recurrence.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 7.

Tytuł:: Hankel Singular Value Decomposition as a method of preprocessing the Magnetic Resonance Spectroscopy
Rozkład macierzy Hankela według wartości osobliwych jako metoda do przetwarzania wstępnego spektroskopii rezonansu magnetycznego
Autorzy:: Staniszewski, M.
Polański, A.
Tematy:: HSVD
Hankel matrix
singular value decomposition
MRS preprocessing techniques
macierz Hankela
rozkład macierzy według wartości osobliwych
przetwarzanie wstępne sygnału MRS; Pokaż więcej
Wydawca:: Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Powiązania:: https://bibliotekanauki.pl/articles/158472.pdf Link otwiera się w nowym oknie
Opis:: The signal resulting from magnetic resonance spectroscopy is occupied by noises and irregularities so in the further analysis preprocessing techniques have to be introduced. The main idea of the paper is to develop a model of a signal as a sum of harmonics and to find its parameters. Such an approach is based on singular value decomposition applied to the data arranged in the Hankel matrix (HSVD) and can be used in each step of preprocessing techniques. For that purpose a method has was tested on real phantom data.
Sygnał pochodzący z badania spektroskopii rezonansu magnetycznego zawiera również liczne szumy oraz nieprawidłości, stąd aby zastosować wyniki jako narzędzie diagnostyczne należy wprowadzić kilka usprawnień. W tym celu stosuje się filtrowanie, korekcję linii bazowej, korekcję fazy, korekcję prądów wirowych oraz usuwanie niechcianych komponentów, które nazywa się przetwarzaniem wstępnym. W dalszej analizie bardzo ważna jest identyfikacja poszczególnych metabolitów, którą można otrzymać poprzez zamodelowanie sygnału. Głównym pomysłem przedstawionym w artykule jest rozwinięcie modelu sygnału jako sumy harmonicznych. Metoda polega na znalezieniu parametrów opisujących sygnał takich jak amplituda, przesunięcie fazowe, częstotliwości i współczynnik tłumienia. Takie podejście bazuje na rozkładzie według wartości osobliwych (SVD) zastosowanym na danych zawartych w macierzy Hankela (HSVD), który dekomponuje sygnał na sumę harmonicznych oraz wylicza potrzebne parametry. Autor zaproponował zastosowanie HSVD w technikach przetwarzania wstępnego. Artykuł opisuje główne kroki przetwarzania i rozwiązanie każdej części oparte na HSVD. Podsumowując można stwierdzić, iż HSVD stosuje się w dekompozycji sygnału ale może być również skutecznym narzędziem w przetwarzaniu wstępnym. Artykuł składa się z 6 rozdziałów, w tym wstępu, rozdziału opisującego HSVD, metody przetwarzania wstępnego i główne wyniki, wniosków i referencji. W artykule znajdują się 4 obrazki oraz 7 referencji.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Proton MR spectroscopy in mild traumatic brain injury
Autorzy:: Walecki, Jerzy
Kubas, Bożena
Łebkowska, Urszula
Łebkowski, Wojciech
Tarasow, Eugeniusz
Kułak, Wojciech
Opis:: Background: To assess the role of 1H MRS in the detection of changes in cerebral metabolite levels in pyramidal tracts after mild traumatic brain injury (MTBI) and to compare metabolite alterations to the clinical status (Glasgow Coma Scale). Material/Methods: Study group consisted of 25 patients after mild traumatic brain injury, with a score of 11 to 15 in GCS. The MR studies were performed with a 1.5 T scanner. The results of spectra approximation (presented as metabolite ratios: NAA/Cr, NAA/Cho, Cho/Cr, lac/Cr, lip/Cr, Glx/Cr) were subjected to statistical analysis. MR spectra were recorded from a normal-appearing brain region: internal capsules and cerebral peduncles. Spectra from traumatic patients were compared with a control group including 34 healthy volunteers recorded with the same techniques. Results: The statistical analysis revealed significant differences between the data obtained from various brain regions of the same patients after an MTBI and between the study and the control group. Proton MR spectroscopy detects changes in cerebral metabolite levels in apparently normal regions. In pyramidal tracts (internal capsules, cerebral peduncles), we noticed a significant reduction of NAA /Cho, lip/Cr, lac/Cr and Glx/Cr. Conclusions: In patients with mild brain injury, we can detect some metabolite abnormalities in normalappearing brain structures. Proton MRS is a very useful tool for evaluation of major changes in metabolite levels in pyramidal tracts after mild traumatic brain injury.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 9.

Tytuł:: Clinical and biochemical predictors of late-outcome in patients after ischemic stroke
Autorzy:: Bielewicz, J.E.
Kurzepa, J.
Kamieniak, P.
Daniluk, B.
Szczepańska-Szerej, A.
Rejdak, K.
Tematy:: CRP
outcome
Ischemic stroke
MRS
Barthel index
NIHSS; Pokaż więcej
Wydawca:: Instytut Medycyny Wsi
Powiązania:: https://bibliotekanauki.pl/articles/2085551.pdf Link otwiera się w nowym oknie
Opis:: Objective. The aim of this study is to evaluate neurological scales, as well as biochemical and radiological parameters measured on day 10 after ischemic stroke (IS), according to their value as predictors of the long-term outcome. Materials and method. 45 patients were assessed according to the Barthel Index (BI) and National Institute of Health Stroke Scale (NIHSS) on day 10, and according to Modified Rankin Scale (mRS) 3 months after the onset of IS. On day 10 of IS, the serum level of C-reactive protein (CRP), albumin, D-dimers (DD), S100BB and Tau proteins was measured and the volume of ischemic focus assessed with the use of Computed Tomography (CT). The patients were divided into groups with good outcome (GO) and mRS 0–2, and with bad outcome (BO) and mRS 3–6. Results. NIHSS and BI scores (p<0.001), the volume of ischemic focus (p<0.01), CRP (p<0.01) and albumin level (p<0.05), but not DD, S100BB and Tau protein levels evaluated on day 10, correlated with mRS after 3 months since IS onset. Patients from the BO group were observed to have lower BI (p=0.001), higher NIHSS (p<0.01) and CRP levels (p<0.05), and bigger volume of ischemic focus (p<0.05) measured on day 10 of IS. In the GO group, there were more patients with atherosclerotic etiology (p=0.02 x2=7.856). Regression analysis showed that only the BI score assessed on day 10 of IS can predict the outcome after 3 months assessed by mRS (OR=1.102, 95%, CI:1.01–1.203; p=0.001). Conclusions. BI assessed on day 10 has a predictive value for the outcome evaluated by mRS 3 months after the onset of IS.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Ischaemic background of brain fog in long-haul COVID-19 : a nuclear magnetic resonance spectroscopy-based metabonomic analysis : preliminary results
Autorzy:: Dorobek, Małgorzata
Walecki, Jerzy
Modrzyńska, Aneta
Sklinda, Katarzyna
Górecki, Andrzej
Mruk, Bartosz
Opis:: Purpose: Long-haul COVID-19 is a condition of unknown background occurring in COVID-19 survivors regardless of the severity of the SARS-CoV-2 infection itself. The aim of the study was to evaluate brain changes in patients suffering from variable symptoms of brain fog after COVID-19. Material and methods: Eleven patients hospitalized due to symptoms of severe brain fog, i.e. insomnia, sudden impairment of cognitive function, headache, and depression, and 14 healthy volunteers underwent brain imaging including MR spectroscopy. Results: Routine MR imaging revealed no specific macroscopic changes in keeping with brain fog. Considering that the clinical manifestation of brain fog is transient, the evaluation of the metabolic status of the brain remained the method of choice. The concentration of the major cerebral metabolites, i.e. NAA, Cho, and Cr, remained stable. However, changes in Glx and Lac concentration were observed in MR spectroscopy. Conclusions: Following results along with clinical course of the brain for imply probable ischaemic background of symptoms.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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