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Wyświetlanie 1-10 z 521
Tytuł:
Analysis of the transcriptome of Potentilla sericea under cadmium stress conditions
Autorzy:
Wu, J.
Fan, W.
Gao, P.
Yang, Q.
Zhang, J.
Wang, L.
Tematy:
glutathione metabolism
sulfur metabolism
Pokaż więcej
Wydawca:
Polskie Towarzystwo Botaniczne
Powiązania:
https://bibliotekanauki.pl/articles/2130579.pdf  Link otwiera się w nowym oknie
Opis:
Cadmium (Cd) stress significantly affects plant growth and development. Potentilla sericea is typically grown in gardens or as ground cover. In this study, the Cd response of P. sericea was analyzed based on physiological examinations and transcriptome analyses that uncovered the gene expression changes in P. sericea roots induced by a 7-day treatment with 90 μmol/L Cd2+. A total of 53,225 unigenes were identified, including 11,684 differentially expressed genes (DEGs; 8,083 upregulated and 3,601 downregulated). Additionally, 44 gene ontology terms and 127 Kyoto Encyclopedia of Genes and Genomes pathways were significantly enriched among these DEGs. Genes related to glutathione metabolism, plant hormone signal transduction, peroxisome processes, sulfur metabolism, and flavonoid biosynthesis pathways were confirmed as relevant to the Cd response of P. sericea. The molecular biology-related data described here may be useful for the future breeding of transgenic P. sericea plants with increased resistance to heavy metal stresses.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Potential of L-Arginine in Prevention and Treatment of Disturbed Carbohydrate and Lipid Metabolism - A Review
Autorzy:
Kurek, Jakub Michał
Krejpcio, Zbigniew
Szlas, Aleksanda
Wydawca:
MDPI
Cytata wydawnicza:
Szlas A, Kurek JM, Krejpcio Z. The Potential of L-Arginine in Prevention and Treatment of Disturbed Carbohydrate and Lipid Metabolism—A Review. Nutrients. 2022; 14(5):961. https://doi.org/10.3390/nu14050961 ; (https://www.mdpi.com/2072-6643/14/5/961)
Opis:
L-arginine, an endogenous amino acid, is a safe substance that can be found in food. The compound is involved in synthesis of various products responsible for regulatory functions in the body. Particularly noteworthy is, among others, nitric oxide, a signaling molecule regulating carbohydrate and lipid metabolism. The increasing experimental and clinical data indicate that L-arginine supplementation may be helpful in managing disturbed metabolism in obesity, regulate arterial blood pressure or alleviate type 2 diabetes symptoms, but the mechanisms underlying these effects have not been sufficiently elucidated. This review aims to present the up-to-date information regarding the current uses and health-promoting potential of L-arginine, its effects on nitric oxide, carbohydrate and lipid metabolisms, based on the results of in vivo, in vitro studies, and clinical human trials. Available literature suggests that L-arginine may have beneficial effects on human health. However, some studies found that higher dietary L-arginine is associated with worsening of an existing disease or may be potential risk factor for development of some diseases. The mechanisms of regulatory effects of L-arginine on carbohydrate and lipid metabolism have not been fully understood and are currently under investigation.
Dostawca treści:
Repozytorium Centrum Otwartej Nauki
Artykuł
Tytuł:
An equipment for effort metabolism recording in laboratory animals
Autorzy:
Faget, G.
Burlacu, G.
Powiązania:
Acta Theriologica
Opis:
Skonstruowano i opisano specjalne urządzenie do badania przemiany energii zwierząt laboratoryjnych w czasie wysiłku, uzyskanego bez stosowania bodźców elektrycznych. Zwierzęta umieszczone są w obracającej się komorze. Powietrze doprowadzane jest do niej przez system rur. Powietrze wydychane przez zwierzęta w czasie eksperymentu, zasysane jest przez pompę i kierowane do interferometru, gdzie odczytywany jest procent CO2 i zużycie O2.
Dostawca treści:
RCIN - Repozytorium Cyfrowe Instytutów Naukowych
Książka
Tytuł:
Modeling of the Reaction Mechanism of Enzymatic Radical C–C Coupling by Benzylsuccinate Synthase
Autorzy:
Heider, Johann
Szaleniec, Maciej
Wydawca:
MDPI
Cytata wydawnicza:
Szaleniec, Maciej, and Johann Heider. “Modeling of the Reaction Mechanism of Enzymatic Radical C-C Coupling by Benzylsuccinate Synthase.” International journal of molecular sciences vol. 17,4 514. 7 Apr. 2016, doi:10.3390/ijms17040514
Opis:
MNiSW/SGI4700/PAN/038/2007, MNiSW/IBM_BC_HS21/PAN/038/2007 the Deutsche Forschungsgemeinschaft (He2190/7-2) the state of Hessen via the LOEWE Center for Synthetic Microbiology, Marburg
Molecular modeling techniques and density functional theory calculations were performed to study the mechanism of enzymatic radical C–C coupling catalyzed by benzylsuccinate synthase (BSS). BSS has been identified as a glycyl radical enzyme that catalyzes the enantiospecific fumarate addition to toluene initiating its anaerobic metabolism in the denitrifying bacterium Thauera aromatica, and this reaction represents the general mechanism of toluene degradation in all known anaerobic degraders. In this work docking calculations, classical molecular dynamics (MD) simulations, and DFT+D2 cluster modeling was employed to address the following questions: (i) What mechanistic details of the BSS reaction yield the most probable molecular model? (ii) What is the molecular basis of enantiospecificity of BSS? (iii) Is the proposed mechanism consistent with experimental observations, such as an inversion of the stereochemistry of the benzylic protons, syn addition of toluene to fumarate, exclusive production of (R)-benzylsuccinate as a product and a kinetic isotope effect (KIE) ranging between 2 and 4? The quantum mechanics (QM) modeling confirms that the previously proposed hypothetical mechanism is the most probable among several variants considered, although C–H activation and not C–C coupling turns out to be the rate limiting step. The enantiospecificity of the enzyme seems to be enforced by a thermodynamic preference for binding of fumarate in the pro(R) orientation and reverse preference of benzyl radical attack on fumarate in pro(S) pathway which results with prohibitively high energy barrier of the radical quenching. Finally, the proposed mechanism agrees with most of the experimental observations, although the calculated intrinsic KIE from the model (6.5) is still higher than the experimentally observed values (4.0) which suggests that both C–H activation and radical quenching may jointly be involved in the kinetic control of the reaction
Maciej Szaleniec
Dostawca treści:
Repozytorium Centrum Otwartej Nauki
Artykuł
Tytuł:
Features of nitrogen metabolism in fishes
Autorzy:
Zukow, Walery
Dolomatov, Sergey
Shekk, P. V.
Kryukova, M. I.
Wydawca:
Springer
Opis:
Walery Zukow
Presence in water is easily metabolized nitrogen-containing substances is a vital condition for the existence of food organisms in ponds used for fish reproduction. At the same time, the end products of nitrogen metabolism—ammonia, nitrites and nitrates are always displayed the body of fish into the environment, adding to the total number of these compounds dissolved in water. Ammonia, nitrite and nitrate anions are formed during biological processes, as well as man-made origin, have toxic properties and are considered as environmental factors that may limit fish productivity of reservoirs. The results of a brief review of the literature showed that the features of nitrogen metabolism in fish are actual direction of research, both theoretical science and in practical fish farming. Published the results of studies of amino acid metabolism in fish suggest that, firstly, the processes responsible for the neutralization and the release of ammonia from the body of fish, as well as ontogenetic aspects of the dynamics of formation and emission of ammonia is not fully understood. Meanwhile, several authors stressed the importance of this area of interest for the formation of science-based ways to improve the efficiency of plant breeding in fish culture. Secondly, endogenous nitrite, being the product of oxidation of the molecule nitric oxide and its transport form, the norm are always present in fish. However, the mechanisms responsible for maintaining the stability of the concentration of nitrite in the internal environment of fish, not well understood. Also, in our opinion, of interest to determine the physiological rules of nitrites and nitrates in the body of various species, depending on the seasons and stages of ontogeny. Thirdly, the literature pays much attention to the toxic properties of nitrite in water biocenosis. Certainly, the analysis of the manifestation in fish tissue-specific toxic effects of nitrites and their derivatives—an important area of research. Nevertheless, we can not exclude that it may be quite promising analysis of the incorporation of exogenous nitrite as a substrate exist in fish of the physiological mechanisms re-synthesis of nitric oxide. This kind of “interference” of endogenous and exogenous nitrite-anions are not causing serious structural damage to organs and tissues, however, can cause substantial damage to the practical fish farming, causing changes in the level of regulatory mechanisms of fish at the most critical stages: when working with manufacturers, the incubation of eggs, and larvae rearing and wintering fish.
Dostawca treści:
Repozytorium Centrum Otwartej Nauki
Artykuł
Wyświetlanie 1-10 z 521

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