Temat: antitumor - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Tyrfostiny : drobnocząsteczkowe inhibitory kinaz tyrozynowych
Tyrphostins small-molecular inhibitors of tyrosine kinases
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 2.

Tytuł:: In vitro effects of the antitumor drug miltefosine on human erythrocytes and molecular models of its membrane
Autorzy:: Strzałka, Kazimierz
Aguilar, Luis F.
Jemioła-Rzemińska, Małgorzata
Petit, Karla
Colina, José R.
Suwalsky, Mario
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 3.

Tytuł:: PHYTOCHEMICAL ANALYSIS AND BIOLOGICAL EVALUATION OF FORSSKAOLEA VIRIDIS AERIAL PARTS
Autorzy:: El-Bassossy, Taha A.
Ahmed, Fatma A.
El-Mesallamy, Amani M.
Tematy:: antimicrobial
flavonoids
phenolics
antitumor
Forsskaolea viridis; Pokaż więcej
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Powiązania:: https://bibliotekanauki.pl/articles/895657.pdf Link otwiera się w nowym oknie
Opis:: The chemical investigation of the chloroform and ethyl acetate extracts of the aerial parts of Forsskaolea viridis Ehrenb. ex Webb (Family: Urticaceae) led to isolation eight compounds for the first time from this plant, while two phenolic compounds, identified as p-coumaric and caffeic acids as well as six flavonoid compounds identified as 5-hydroxy-6,7,3',4'-tetramethoxy flavone, chrysoeriol, acacetin, chrysoeriol-7-O-β-D-glucoside, kaempferol-3-O-(2"-O-E--p-coumaroyl)-β-D-glucoside and isovetixin. The chemical structure of the isolated compounds was established by spectroscopic methods including UV, MS, 1H-NMR, and 13C-NMR. Antimicrobial, antioxidant and cytotoxic activities of the ethyl acetate and chloroform extracts were evaluated. The ethyl acetate extract exhibited strong antimicrobial activity (12-30 mm) against the tested strains. The ethyl acetate and chloroform extracts showed fair antioxidant and cytotoxicity.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Anticancer properties of Viburnum
Autorzy:: Stępień, Agnieszka
Aebisher, David
Bartusik-Aebisher, Dorota
Tematy:: antitumor activity
Viburnum species
cytotoxic activity; Pokaż więcej
Wydawca:: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Powiązania:: https://bibliotekanauki.pl/articles/454949.pdf Link otwiera się w nowym oknie
Opis:: Aim. The aim of this paper is to provide an overview of the anticancer properties of different species of Viburnum. Materials and methods. Forty nine papers that discuss the medicinal history and current research of Viburnum species as phytotherapeutic agent were used for this discussion. Literature analysis. The results of scientific research conducted in vitro indicate that the compounds present in the extracts of Viburnum significantly affect the development of cancer cells such as leukemia, cervical cancer, breast, colon, lung, skin and stomach. This indicates that they may be used as a therapeutic agent to support oncological therapies.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Grzyby nadrewnowe z rodzaju Ganoderma źródłem biologicznie aktywnych triterpenów
Wood Decay Mushrooms of The Genus Ganoderma as A Source of Biologically Active Triterpenes
Autorzy:: Sułkowska-Ziaja, Katarzyna
Piechaczek, Małgorzata
Pacławska, Aneta
Muszyńska, Bożena
Tematy:: Ganoderma sp.
anti-inflammatory
antitumor
terpenoids; Pokaż więcej
Wydawca:: Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Powiązania:: https://bibliotekanauki.pl/articles/1033575.pdf Link otwiera się w nowym oknie
Opis:: Species of the genus Ganoderma are an example of some of the most thoroughly studied representatives of Basidiomycota both in terms of chemical composition and biological activity. Among the compounds found in this kind, the therapeutic effect is primarily associated with the polysaccharides that are heteroglycans or β-D-glucans and terpenoids represented mainly by triterpenes. Triterpene compounds have a structure composed of 30 carbon atoms, usually forming a system of five six-membered rings. Characteristic of these structures are functional groups (hydroxyl, carboxyl or ketone) and double bonds. Mycochemical studies have led to the isolation of numerous triterpenes of the lanostane type (ganoderic acids, aldehydes, alcohols, esters), lucidenic acids and others from various species of the Ganoderma genus. The broad spectrum of biological activity determined by triterpene compounds includes anti- tumor, anti-inflammatory, antioxidant, hepatoprotective, antidiabetic, and antiviral effects. This work describes biologically active triterpenes in selected species of the genus Ganoderma: Ganoderma lucidum, Ganoderma applanatum, Ganoderma adspersum, Ganoderma pfeifferi, Ganoderma colossum and others. These species are sources of natural compounds valued for thousands of years in the traditional medicine of the Far East, while ongoing research has confirmed their medicinal properties nowadays.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Strategies for overcoming ABC-transporters-mediated multidrug resistance (MDR) of tumor cells
Autorzy:: Borowski, Edward
Bontemps-Gracz, Maria
Piwkowska, Agnieszka
Tematy:: antitumor cytostatics
antimetabolites
multidrug resistance
modulators; Pokaż więcej
Wydawca:: Polskie Towarzystwo Biochemiczne
Powiązania:: https://bibliotekanauki.pl/articles/1041364.pdf Link otwiera się w nowym oknie
Opis:: The development of multidrug resistance (MDR) of tumors is a major cause of failure in antitumor chemotherapy. This type of crossresistance is due to the expression of ABC transporter glycoproteins actively effluxing the drug from the cells against the concentration gradient at the expense of metabolic energy, thus preventing the accumulation in cells of therapeutic concentration of active agents. In this review strategies for overcoming this adverse phenomenon are discussed. They comprise the control of expression of MDR glycoprotein transporters and control of the functioning of the expressed transporter proteins. The latter approach is discussed in more detail, comprising the following general strategies: (i) development of compounds that are not substrates of efflux pump(s), (ii) use of agents that inactivate (inhibit) MDR proteins, (iii) design of cytostatics characterized by fast cellular uptake, surpassing their mediated efflux, (iv) use of compounds competing with the drug for the MDR protein-mediated efflux. Positive and negative aspects of these strategies are analysed, with special attention put on strategy based on the use of MDR modulators in combination therapy, allowing the restoration of cytotoxic activity of clinical cytostatics towards resistant tumor cells.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Medicinal properties of macrofungi
Autorzy:: Hilszczańska, Dorota
Wydawca:: Instytut Badawczy Leśnictwa (Forest Research Institute)
Opis:: This review highlights the importance to people of some types of wild fungi considered in the context of non-wood forest products. Macrofungi are used both for food and medicine proposes. Substances isolated from the higher Basidiomycetes and Ascomycetes mushrooms express promising immune modulating, antitumor, antiviral, antibacterial and antidiabetic properties. They have been, and are presently, used against cancer in some countries in Far East as well as in the United States of America and Canada. Their useful properties are mainly conferred by biologically-active polysaccharides present in the fruiting bodies and cultured mycelium. A few dozen different polysaccharide antitumor agents have been developed from such species as: Ganoderma lucidum, Lentinus edodes, Schizophylum commune, Trametes versicolor and Inonotus obliquus. In the review some other fungi and their properties are also described. The information is provided to widen our knowledge of the importance of the organisms that live in forest ecosystems.
Przemysław Szmit
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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Skocz do pozycji: 8.

Tytuł:: Photochemistry of trans- and cis-[$RuCl_{2}(dmso)_{4}$] in aqueous and nonaqueous solutions
Autorzy:: Stochel, Grażyna
Sostero, Silvana
Bertolasi, Valerio
Brindell, Małgorzata
Boaretto, Rita
Opis:: The photochemical behavior of the trans- and cis-[$RuCl_{2}(dmso)_{4}$] complexes has been investigated in organic coordinating solvents (dmso, $CH_{3}CN$) and aqueous solutions by means of electronic and $^{1}\textrm{H}$ NMR spectroscopy as well as chloride-selective electrode measurements. Excitation in the UVA and visible region of the cis-[$RuCl_{2}(dmso)_{4}$] complex in dmso leads to geometric isomerization with quantum yields $\phi_{313} = 0.41$ and $\phi_{365} = 0.49$ to give the photostable trans complex, whereas in acetonitrile and aqueous solutions, both isomerization and substitution processes occur. Moreover, in the latter two solvents, the trans isomer is photoactive and undergoes substitution reactions. In acetonitrile, for both trans- and cis-[$RuCl_{2}(dmso)_{4}$] isomers, selective photolabilization of the dimethylsulfoxide ligands results in the formation of the trans-[$RuC_{2}(CH_{3}CN)_{4}$] complex. In aqueous solutions, the dmso and $Cl^{-}$ ligands are gradually substituted by water molecules to give as a final product a mixture of(aqua)ruthenium(II) and (aqua)(chlorido)ruthenium(II) complexes. These species may prove to be useful in the binding of cellular components.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 9.

Tytuł:: THE INFLUENCE OF POLYETHER SUBSTITUENTS ON BIOLOGICAL ACTIVITY OF CURCUMIN DERIVATIVES
Autorzy:: Gruber, Beata M.
Tomasz, Deptuła
Adam, Krówczyński
Irena, Bubko
Tematy:: Chemical synthesis
cytotoxic activity
curcumin derivatives
antitumor drugs; Pokaż więcej
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Powiązania:: https://bibliotekanauki.pl/articles/895397.pdf Link otwiera się w nowym oknie
Opis:: Curcumin is reported as an anti proliferative and chemopreventive compound. However, it shows poor water solubility, low bioavailability, and rapid metabolism.. To address these problems, curcumin derivatives substituted with polyether chain were synthesised to improve the hydrophilicity of curcumin and thus its bioavailability. The biological activity of modified curcumin molecules were studied with human normal B-lymphocytes GM 14667 and human leukemia cells HL60 and covered: the denotation of IC50 values for each new compound with use of MTT test and the studies on apoptosis induction observed as morphological changes and the expression of apoptotic proteins, BAX, BCL-2 and survivin with use of Western Blot analysis. All effects were referenced to native curcumin. The derivatives with modified polyether chains number and the position of methoxy- groups were selected for further studies. As was shown, the solubility of the compound does not directly correlate with its cytotoxicity. The maintenance of the methoxy group in the meta position as well as the introduction of hydrophilic polyether chains but not the number of polyether chains may affect the cytotoxic activity of curcumin derivatives against cancer cells. Modifications of the curcumin molecule structure can determine its impact on the profile of pro or anti apoptotic proteins.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: The ability to overcome multidrug resistance of tumor cell lines by novel acridine cytostatics with condensed heterocyclic rings.
Autorzy:: Bontemps-Gracz, Maria
Kupiec, Agnieszka
Antonini, Ippolito
Borowski, Edward
Tematy:: acridine cytostatics
cytotoxic activity
multidrug resistance
antitumor compounds; Pokaż więcej
Wydawca:: Polskie Towarzystwo Biochemiczne
Powiązania:: https://bibliotekanauki.pl/articles/1043812.pdf Link otwiera się w nowym oknie
Opis:: Two recently synthesized groups of acridine cytostatics containing fused heterocyclic ring(s): pyrazoloacridines (PAC) and pyrazolopyrimidoacridines (PPAC) were tested in regard to their in vitro cytotoxic activity towards a panel of sensitive and resistant human tumor cell lines. The obtained results corroborate our earlier hypothesis on the essential role of heterocyclic ring fused to the acridine moiety in the ability of acridine cytostatics to overcome multidrug resistance of tumor cells. The presence, location and kind of substituents considerably influenced both the cytotoxic activity of the derivatives and their ability to overcome multidrug resistance. The same factors also affected the cytostatics ability to differentiate between tumor cell lines with various types of drug exporting pumps.
Dostawca treści:: Biblioteka Nauki

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