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Wyszukujesz frazę "atopic dermatitis" wg kryterium: Temat


Tytuł:
The study of canine atopic dermatitis involving the isolation of dogs
Autorzy:
Fujimura, M.
Tematy:
dog
animal disease
atopic dermatitis
dermatitis
isolation
atopic-like dermatitis
Pokaż więcej
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Powiązania:
https://bibliotekanauki.pl/articles/30142.pdf  Link otwiera się w nowym oknie
Opis:
Twenty-seven pruritic dogs were used in this study. When a hypoallergenic diet was fed to these 27 dogs for six weeks, none of the dogs showed improvement of the pruritus. These dogs had a history and clinical signs of atopic dermatitis (AD) as defined by Prelaud’s diagnostic criteria. Subsequently, the 27 dogs were isolated for observation for two weeks in the hospital. In the isolation room in the veterinary clinic, cages and tableware were all stainless steel, and carpet was not used. A hypoallergenic diet was continuously fed to the 27 dogs for two weeks, during which time they were kept in the isolation room. PVAS (Pruritus Visual Analog Scale) was performed prior to starting the isolation, at the start of the study and 2 weeks after starting the isolation. In 17dogs (63%) the pruritus improved in the isolation room. A statistically significant reduction (p<0.01) of PLS (Pruritus liners score) was recorded 2 weeks after isolation. It was hypothesized that the 17 dogs whose pruritus improved in the isolation room had AD caused by an environmental antigen that was not present in the isolation room. Pruritus of the remaining 10 dogs (37%) did not improve. For 6/10 dogs, the intradermal allergy testing was positive for an environmental antigen. For4/10 dogs, the intradermal allergy testing was negative for all environmental antigens. Dogs for which sensitivity to an environmental antigen was not identified were thought to have atopic-like dermatitis.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Coexistence of halo nevi, atopic dermatitis and hypothyroidism - a case study
Autorzy:
Drąg-Zalesińska, Małgorzata
Rembiałkowska, Nina
Borska, Sylwia
Tematy:
atopic dermatitis
halo nevus
hypothyroidism
Pokaż więcej
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Powiązania:
https://bibliotekanauki.pl/articles/1075602.pdf  Link otwiera się w nowym oknie
Opis:
Coexistence of autoimmune diseases is increasingly observed. The relationship between type 1 diabetes and Hashimoto's disease and celiac disease is well documented. Reports from recent years also indicate a more frequent occurrence of Hashimoto's disease in patients with atopic dermatitis. In the presented case, we describe the occurrence of hypothyroidism in a girl with atopic dermatitis. Another symptom of the development of the immune process was formation of halo nevi from congenital and acquired nevus.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The evaluation of canine atopic dermatitis extent and severity index (CADESI) test in dogs with atopic dermatitis (AD) treated with cyclosporine or prednisone
Autorzy:
Taszkun, I.
Tematy:
canine atopic dermatitis extent and severity index test
dog
atopic dermatitis
dermatitis
treatment
prednisone
cyclosporin
animal disease
Pokaż więcej
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Powiązania:
https://bibliotekanauki.pl/articles/32356.pdf  Link otwiera się w nowym oknie
Opis:
The purpose of this study was to assess the clinical state of dogs with atopic dermatitis (AD) by use of CADESI test in own modification during the first visit in the Dermatology Consult Room as well as during the treatment. The study was performed in two groups (I-E and II-C) of 20 dogs in each group. In dogs which were qualified to the I-E group, as antiallergic, anti-inflammatory and antipruritic treatment, prednisone (oral preparation Encorton – Polfa Pabianice) at dose 0.5 mg/kg b.w./day was administered, while in dogs qualified to the II-C group – cyclosporine (oral preparation Sandimmun Neoral – Novartis Pharma) at a dose of 5 mg/kg b.w./day; the treatment was continued for 6 weeks in both groups. During the study, skin lesions were assessed in 15 specified body areas using 4 parameters and 5-point scale. In group I-E and II-C the amount of received points in CADESI test was decreased by 82.26% and by 83% respectively, after the treatment. Statistical analyses of the results obtained revealed no statistically significant (P=0.05) differences between means of I-E and II-C groups in consecutive examinations, which indicates comparable clinical efficacy of both drugs. Statistically significant differences (P=0.05) of the parameters assessed were found after secondary dermatoses treatment, and after every two weeks of antipruritic and anti-inflammatory treatment.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Distribution of Malassezia species in patients with atopic dermatitis : quality assessment
Autorzy:
Skóra, Magdalena
Macura, Anna
Krzyściak, Paweł
Rup, Elżbieta
Opis:
The fungi Malassezia are a constituent of the skin microbiota in humans and some animals. The fungi may cause skin diseases or even organ and/or generalized infections in the presence of appropriate predisposing factors. To evaluate the occurrence of Malassezia fungi on the skin in patients with psoriasis and search for a relationship between the occurrence of Malassezia and the severity of skin lesions, age and sex of the patients. The materials comprised smears sampled from four sites: scalp, face, chest and back. Malassezia spp. were isolated in cultures on modified Dixon medium and identified on the basis of morphological and biochemical features. Malassezia spp. were isolated in 55.1% of the patients. The fungi were most prevalent on the back (33.3%) and least on the scalp (17.5%) and face (19%). The prevalence on the chest was 30.2%. In the group of patients with AD localized to the head and neck Malassezia spp. were cultured in 71.4% of patients. No statistically significant differences were found between Malassezia prevalence in males vs. females. No relationship with the patients' age was found. Higher values of the atopic dermatitis severity index (SCORAD) were found in the patients in whom Malassezia spp. were isolated. Malassezia spp. were particularly common in the group of patients with AD localized to the head and neck.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Autorzy:
Jaworek, Andrzej
Hałubiec, Przemysław
Wojas-Pelc, Anna
Szepietowski, Jacek Cezary
Jaworek, Jolanta
Opis:
Atopic dermatitis (AD) is common inflammatory dermatosis, typically with chronic and recurrent course, which significantly reduces the quality of life. Sleep disturbances are considered to be remarkably burdensome ailments in patients with AD, and are routinely included during assessment of disease severity. Therefore, endogenous substances engaged in the control of circadian rhythms might be important in pathogenesis of AD and, possibly, be used as biomarkers of disease severity or even in development of novel therapies. Melatonin (MT), the indoleamine produced by pineal gland (but also by multiple other tissues, including skin), plays a pivotal role in maintaining the sleep/wake homeostasis. Additionally, it possesses strong antioxidant and anti-inflammatory properties, which might directly link chronic skin inflammation and sleep abnormalities characteristic of AD. The objective of this work is to systematically present and summarize the results of studies (both experimental and clinical) that investigated the role of MT in the AD, with a focus on the antioxidant and immunomodulatory effects of MT.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
The prevalence of atopic dermatitis and food allergy in children living in an urban agglomeration - is there a current relationship?
Autorzy:
Czarnobilska, Ewa
Dyga, Wojciech
Mazur, Marcel
Opis:
Atopic dermatitis (AD) prevalence in Poland is more frequent in individuals who live in a city. There are more studies demonstrating that long-term exposure to air pollutants is an independent risk factor for developing AD. The aim of the study was to assess the epidemiology of AD and food allergy (FA) in school children and adolescents living in Krakow, and to find a potential relationship between the incidence of atopic dermatitis with exposure to polluted air. In this paper, we presented the incidence of AD and FA between 2014 and 2018. We analyzed data collected from nearly 30,000 children aged 7–8 and adolescents aged 16–17 from the population of children and youth in Krakow. We correlated it with annual mean concentrations of PM10 and PM2.5, which indicated a gradual improvement in the air quality in Krakow. As our research results show that the prevalence of atopic dermatitis decreased with food allergy prevalence depending on the age group. We can suspect that this is the result of children growing out of a food allergy. It may be also influenced by more consequential eating habits in a group of adolescents and the elimination of allergenic foods from the diet. The decreasing incidence of atopic dermatitis appears to be also related to improvement in air quality.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Severe atopic dermatitis in children: therapeutic dilemmas
Atopowe zapalenie skóry o ciężkim przebiegu u dzieci: dylematy terapeutyczne
Autorzy:
Lis-Święty, Anna
Milewska-Wróbel, Dorota
Tematy:
adherence
atopic dermatitis
immunosuppressive drugs
therapy
Pokaż więcej
Wydawca:
Medical Communications
Powiązania:
https://bibliotekanauki.pl/articles/1034806.pdf  Link otwiera się w nowym oknie
Opis:
Atopic dermatitis is the most common skin disorder diagnosed in early childhood. Some children do not experience a relief of symptoms as they get older, and severe atopic dermatitis may develop, with manifestations including widespread skin lesions and unremitting itching. The disease is both physically and emotionally disabling, and significantly compromises the patient’s quality of life. Indications to intensify therapy include resistance to topical treatment and multidrug resistance. However, in many cases non-adherence to the treatment regimen, including inadequate skin care techniques, contribute to the development of severe or refractory atopic dermatitis. Persistent eczematous lesions may be a result of exacerbating environmental factors, secondary infection, and hypersensitivity reactions to topical treatments or other allergens. Wet-wrap treatment with topical corticosteroids, narrow-band UVB phototherapy and systemic immunosuppressive drugs, such as cyclosporine A, methotrexate, mycophenolate mofetil and azathioprine, are recommended for the treatment of severe atopic dermatitis in children. However, there are no evidence-based guidelines for using these agents. Systemic corticosteroids should be avoided, but they can be used for a short period of time for the immediate relief of acute flares before introducing other therapies. Patients need a holistic approach including education and modern biopsychosocial techniques. Paediatric studies are currently under way to test the safety and tolerability of dupilumab which was approved by the US Food and Drug Administration in 2017 for the treatment of adults with moderate-to-severe atopic dermatitis.
Atopowe zapalenie skóry jest najczęstszym schorzeniem skóry rozpoznawanym we wczesnym dzieciństwie. U części dzieci objawy nie łagodnieją w miarę dorastania, lecz rozwija się atopowe zapalenie skóry o ciężkim przebiegu z uogólnionymi zmianami skórnymi, uporczywym świądem; choroba przyczynia się do cierpienia fizycznego i psychicznego, znacząco pogarszając jakość życia. Sygnałem do intensyfikacji terapii powinna być oporność na leczenie zewnętrzne i wielolekowość. Jednak w wielu przypadkach przyczyną ciężkiego i opornego na terapię atopowego zapalenia skóry jest niedostosowanie się do zaleceń terapeutycznych (non-adherence), w tym nieprawidłowa pielęgnacja skóry. Uporczywość zmian wypryskowych może być także skutkiem narażenia na środowiskowe czynniki drażniące, wtórnej infekcji, reakcji nadwrażliwości na leki zewnętrzne czy inne alergeny. W ciężkim atopowym zapaleniu skóry u dzieci zaleca się stosowanie mokrych opatrunków z kortykosteroidami miejscowymi, fototerapii światłem wąskopasmowym UVB, ogólnoustrojowych leków immunosupresyjnych, takich jak cyklosporyna A, metotreksat, mykofenolan mofetylu i azatiopryna. Brak jest wytycznych opartych na dowodach naukowych dotyczących leczenia tymi lekami. Należy unikać kortykosteroidów ogólnych, ale można zastosować krótkotrwałą terapię w celu szybkiego opanowania dużych zaostrzeń przed wdrożeniem innych form leczenia. Pacjenci wymagają podejścia holistycznego, obejmującego edukację i stosowanie nowoczesnych technik biopsychospołecznych. W populacji pediatrycznej obecnie prowadzone są badania kliniczne oceniające bezpieczeństwo i tolerancję dupilumabu, leku biologicznego zaaprobowanego w 2017 roku przez amerykańską Agencję ds. Żywności i Leków w leczeniu umiarkowanego i ciężkiego atopowego zapalenia skóry u dorosłych.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Melatonin and sleep disorders in patients with severe atopic dermatitis
Autorzy:
Szepietowski, Jacek C.
Jaworek, Magdalena
Wojas-Pelc, Anna
Jaworek, Andrzej
Szafraniec, Krystyna
Opis:
Introduction: Many atopic dermatitis (AD) patients suffer from insomnia. Out of numerous factors associated with sleep disorders, melatonin seems to play a significant role. Aim: To assess the relation between melatonin concentration and sleep disorders in adult patients with severe and very severe AD. Material and methods: The study included 36 adult patients with severe and very severe AD and 20 healthy Caucasian volunteers. The severity of skin lesions was assessed by the EASI scale. Skin itch was evaluated by a visual-analogue scale (VAS), and sleep disorders were assessed by the Polish version of the Athens Insomnia Scale (AIS). Serum melatonin concentration of patients and controls was determined by ELISA. Results: Melatonin concentration in patients with very severe AD was significantly (p < 0.001) lower than in patients with severe AD, however, melatonin concentration in the group of AD patients did not differ significantly (p = 0.33) from that observed in the control group. There was a significant negative correlation between the concentration of melatonin in the study group and the severity of itching (R = –0.54, p < 0.001). The intensity of sleep disorders was significantly higher (p < 0.001) in patients with a very severe form of AD compared to patients with severe AD. Moreover, there was a significant negative correlation between melatonin concentration and sleep disorders (R = –0.67, p < 0.001). Conclusions: Our results clearly showed that sleep disturbances are more expressed in very severe AD patients compared to subjects suffering from severe disease. We also suggest that melatonin serum concentration could play a role in the pathogenesis of sleep disturbances in AD patients.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł

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