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Wyświetlanie 1-10 z 41
Tytuł:
Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetes
Autorzy:
Łuczyński, Włodzimierz
Wawrusiewicz-Kurylonek, Natalia
Stasiak-Barmuta, Anna
Urban, Remigiusz
Iłendo, Elżbieta
Urban, Mirosława
Hryszko, Marek
Krętowski, Adam
Górska, Maria
Tematy:
immunotherapy
T-lymphocytes
autoimmunity
FoxP3
Pokaż więcej
Wydawca:
Polskie Towarzystwo Biochemiczne
Powiązania:
https://bibliotekanauki.pl/articles/1040597.pdf  Link otwiera się w nowym oknie
Opis:
Diabetes mellitus is one of the most common chronic diseases in children. T regulatory cells (Tregs) modulate response to autoantigens and probably play a role in pathogenesis of type 1 diabetes (T1DM). The aim of the present study was the assessment of T regulatory cells including their percentages and expression of critical genes in these cells in children with newly diagnosed type 1 diabetes. The examined group consisted of 50 children with T1DM. A flow cytometric analysis of T-cell subpopulations was performed using the following markers: anti-CD4, anti-CD25 and anti-CD127 (=IL-7R). Additionally, T regulatory cells were isolated for assessment of mRNA levels for chosen genes with the real-time RT-PCR technique. The percentages of CD4+CD25highCD127dim/- were very low and did not differ between T1DM and control children. We did not observe any statistically significant differences between healthy and diabetic children in mRNA expression for FoxP3, IL-7R (CD127), IL-8RA, IL-10RA, IL-12A, IL-2RA (CD25), IL-21, STAT1, STAT3, SOCS2, SOCS3, TGF-β1-R1, TGF-β-R2 and TBX-21 genes. Interestingly the mRNA level for CTLA-4, ICOS1, IL-23, IL-27, SMAD3 and GITR were lower in Treg cells of children with diabetes compared to the control patients. No disturbances in the percentages of T regulatory cells in patients with diabetes but diminished expression of some elements important in Treg function could be the result of an immunologic imbalance accompanying the onset of the diabetes. The results of our study should be used in future research in the field of immunotherapy in pediatric diabetes.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of ingredients contained in fish and fish products in hashimoto disease®
Rola składników zawartych w rybach i produktach rybnych w chorobie Hashimoto®
Autorzy:
Lachowicz, Katarzyna
Stachoń, Małgorzata
Kołota, Aleksandra
Tematy:
fish
thyroid
autoimmunity
ryby
tarczyca
autoimmunizacja
Pokaż więcej
Wydawca:
Wyższa Szkoła Menedżerska w Warszawie
Powiązania:
https://bibliotekanauki.pl/articles/229002.pdf  Link otwiera się w nowym oknie
Opis:
Hashimoto disease is one of the most commonly recognized autoimmune and endocrine diseases. The development and the course of the ailment depends on a variety of factors, nutritional among other things. Fish and fish-based products contain nutrients regulating the homeostasis of thyroid hormones and the immune system functions. The paper provides up-to-date knowledge on the mechanisms of effects exerted by nutrients contained in fish on the thyroid functions and thyroid-released hormones, and on the course of inflammation in this gland. Familiarity with these issues is necessary for a proper planning of nutrition in Hashimoto-affected patients.
Choroba Hashimoto jest jedną z najczęściej rozpoznawa-nych chorób autoimmunologicznych i endokrynnych. Rozwój i przebieg schorzenia zależy od wielu czynników, w tym żywie-niowych. Ryby i ich przetwory są produktami zawierającymi składniki regulujące homeostazę hormonów tarczycy i funk-cjonowanie układu odpornościowego. W artykule scharakte-ryzowano aktualną wiedzę na temat mechanizmów wpływu składników zawartych w rybach na działanie tarczycy i wy-dzielanych przez nią hormonów oraz przebieg procesu zapal-nego w gruczole. Ich znajomość jest niezbędna do prawidło-wego planowania żywienia dla osób z chorobą Hashimoto.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anti-thyroidal peroxidase antibodies are associated with thyrotropin levels in hypothyroid patients and in euthyroid individuals
Autorzy:
Bromińska, Barbara
Bromiński, Gabriel
Owecki, Maciej
Michalak, Michał
Czarnywojtek, Agata
Waśko, Ryszard
Ruchała, Marek
Tematy:
anti-tpo
autoimmunity
hypothyroidism
euthyroidism
tsh
thyreoperoxidase
Pokaż więcej
Wydawca:
Instytut Medycyny Wsi
Powiązania:
https://bibliotekanauki.pl/articles/989550.pdf  Link otwiera się w nowym oknie
Opis:
Objective. The study was designed to evaluate the relationship between thyroid antibodies and gland dysfunction, with the aim of finding a clinically useful threshold value of thyreoperoxidase antibodies, which could prove to be predictive for thyroid failure. Materials and method. The study was conducted on 99 women, ages ranging from 18–91 years (mean age: 45.5 ±17.0), were treated as outpatients in the Department of Endocrinology, Metabolism and Internal Medicine. Analysis of serum samples for TSH concentration and anti-TPO titers was conducted. Results. The most common disorder was hypothyroidism. Anti-TPO titers above reference range values were observed in 35 patients (35.4%): 21 (60%) were hypothyroid and 11 (31.4 %) were euthyroid. The anti-TPO and TSH serum levels correlated both in patients with high thyroid antibody titers, and in the anti-TPO negative groups. To find the threshold value of anti-TPO that would help predict hypothyroidism, receiver operating curves were used. With this approach, TPO antibody titers over 17 IU/ml indicated hypothyroidism with a 90% sensitivity and 75% sensibility. Conclusion. It can be postulated that the cutoff values of anti-TPO in the general population should be decreased in order to improve autoimmune thyroid disorder screening. Obviously, using that margin may lead initially to the detection of some false positive subjects. However, with lower cut-off values, more patients can be enrolled into thyroid follow-up groups. In this way, many people could avoid complications of undiagnosed, insidious thyroid failure.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation
Autorzy:
Dobosz, Ewelina
Fu, Mingui
Potempa, Jan
Lorenz, Georg
Wadowska, Marta
Kozieł, Joanna
Lech, Maciej
Schmaderer, Christoph
Würf, Vivian
Kotlinowski, Jerzy
Ribeiro, Andrea
Opis:
Myeloid-derived cells, in particular macrophages, are increasingly recognized as critical regulators of the balance of immunity and tolerance. However, whether they initiate autoimmune disease or perpetuate disease progression in terms of epiphenomena remains undefined. Here, we show that depletion of MCPIP1 in macrophages and granulocytes ($Mcpip1^{fl/fl}-LysM^{cre+}$ C57BL/6 mice) is sufficient to trigger severe autoimmune disease. This was evidenced by the expansion of B cells and plasma cells and spontaneous production of autoantibodies, including anti-dsDNA, anti-Smith and anti-histone antibodies. Consequently, we document evidence of severe skin inflammation, pneumonitis and histopathologic evidence of glomerular IgG deposits alongside mesangioproliferative nephritis in 6-month-old mice. These phenomena are related to systemic autoinflammation, which secondarily induces a set of cytokines such as Baff, Il5, Il9 and Cd40L, affecting adaptive immune responses. Therefore, abnormal macrophage activation is a key factor involved in the loss of immune tolerance. Overall, we demonstrate that deficiency of MCPIP1 solely in myeloid cells triggers systemic lupus-like autoimmunity and that the control of myeloid cell activation is a crucial checkpoint in the development of systemic autoimmunity.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Is thyroid autoimmunity associated with subclinical atherosclerosis in young women with type 1 diabetes mellitus?
Autorzy:
Łukawska-Tatarczuk, Magdalena Maria
Franek, Edward
Czupryniak, Leszek
Zieliński, Jakub
Mrozikiewicz-Rakowska, Beata
Wydawca:
VM Media Group sp. z o.o., Grupa Via Medica
Cytata wydawnicza:
Łukawska-Tatarczuk, M. M., Zieliński, J., Franek, E., Czupryniak, L., Mrozikiewicz-Rakowska, B. (2022). Is thyroid autoimmunity associated with subclinical atherosclerosis in young women with type 1 diabetes mellitus? Endokrynologia Polska, 73(2), 301-308. https://doi.org/10.5603/ep.a2022.0018
Opis:
This research was funded by a Diabetes Poland Scientific Grant (27.08.2020).
Introduction: It has been hypothesized that autoimmunity may contribute to cardiovascular complications and may be an important trig- ger for processes leading to atherosclerosis, especially in type 1 diabetes mellitus (T1DM). This pilot study aimed to answer the question of whether markers of thyroid autoimmunity are associated with increased carotid intima-media thickness (cIMT) in young, asymptomatic T1DM women. Material and methods: The study population consisted of 102 women, including 72 with T1DM and 30 healthy controls. All patients had thyroid hormones within the normal range. According to the antiperoxidase antibodies (aTPO) titre, the T1DM women were divided into an aTPO-positive (T1DM aTPO+) (n = 41) and an aTPO-negative (T1DM aTPO–) (n = 31) group. In all patients, aTPO, thyroglobulin antibody (aTG) titres, thyroid-stimulating hormone (TSH), free thyroxine (FT3), free triiodothyronine (FT4), lipid parameters, glycated haemoglobin, thyroid ultrasonography, and cIMT assessment were evaluated. The association of cIMT with different risk factors related to thyroid autoimmunity was determined. Results: Carotid intima-media thickness was significantly greater in T1DM aTPO+ females (0.66 ± 0.10 mm) than in T1DM aTPO– (0.59 ± 0.11 mm) and healthy controls (0.58 ± 0.10 mm) (p = 0.007, p = 0.001, respectively). In all women cIMT was significantly, positively correlated with aTPO (p = 0.005, r = 0.273), Hashimoto’s thyroiditis (HT) duration (p = 0.00015, r = 0.367), levothyroxine dose per week (p = 0.006, r = 0.269), and ultrasound features of HT (p = 0.004, r = 0.281) and inversely with fT3 concentration (p = 0.014, r = –0.243) and FT3/FT4 ratio (p = 0.042, r = –0.201). A logistic regression analysis showed that HT duration (OR: 1.102, 95% CI: 1.008–1.206, p = 0.032) and a positive history family of HT (OR: 3.909, 95%CI: 1.014–15.071, p = 0.045) were risk factors for increased cIMT. However, multivariate regression analysis showed that the studied parameters related to thyroid autoimmunity are not independent risk factors for increased cIMT. Conclusions: We expanded the data on cIMT in young women with T1DM and showed that thyroid autoimmunity, and in particular the duration of exposure to anti-thyroid antibodies, despite adequate levothyroxine substitution, is associated with subclinical atherosclerosis in young women with T1DM. However, thyroid-related parameters are not independent risk factors for increased cIMT in euthyroid women.
Dostawca treści:
Repozytorium Centrum Otwartej Nauki
Artykuł
Wyświetlanie 1-10 z 41

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