Temat: coumarin - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: A coumarin-based fluorescent probe for specific and rapid detection of fluoride ions
Autorzy:: Xin, Z.-H.
Meng, Y.-L.
Wu, Y.-H.
Feng, Z.-K.
Kang, Y.-F.
Tematy:: Fluorion
Fluorescence
Coumarin
Probe
Bioimaging; Pokaż więcej
Wydawca:: Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Powiązania:: https://bibliotekanauki.pl/articles/778907.pdf Link otwiera się w nowym oknie
Opis:: A simple and coumarin-based fluorescence probe has been designed and synthesized with silyl group as recognition group of fluoride ions (F−) in this study. The results showed that the fluorescence intensity of the probe displayed prominent enhancement with addition of F− at 445 nm with incubation of 1 min. There was an excellent linear relationship between fluorescence intensity and fluoride concentration from 0 to 30 μM (0~0.57 ppm), which offered the important condition for the quantitative analysis. In addition, the highly selective response to fluorion, the low detection limit with 28 nM (0.532 ppb), low toxicity and bioimaging afforded an advantage for practical application and detecting fluoride in biological systerms.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: SYNTHESIS, AND EVALUATION OF COUMARIN HYBRIDS AS ANTIMYCOBACTERIAL AGENTS
Autorzy:: Hassan, Mohd Z.
ALSAYARI, ABDULRHMAN
OSMAN, HASNAH
ALI, MOHAMED A.
MUHSINAH, ABDULLATIF B.
AHSAN, MOHAMED J.
Tematy:: cytotoxicity
Coumarin
TB
Thiazolopyrimidine
HTS
antimycobacterial; Pokaż więcej
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Powiązania:: https://bibliotekanauki.pl/articles/895509.pdf Link otwiera się w nowym oknie
Opis:: A series of twelve hybrid coumarin analogues were synthesized and screened through HTS for their antimycobacterial activity against Mtb H37Rv. The hybrid molecules were efficiently synthesized by the reactions of 3-(bromoacetyl)coumarin with Biginelli products 2-mercapto-6-oxo-4-aryl-1,6-dihydropyrimidine-5-carbonitriles. Of the resulting twelve hybrids, the two compounds 7-(2,4-dichlorophenyl)-5-oxo-3-(2-oxo-2H-chromen-3-yl)-5H-thiazolo[3,2-a] pyrimidine-6-carbonitrile (3d) and 7-(4-nitrophenyl)-5-oxo-3-(2-oxo-2H-chromen-3-yl)-5H-thiazolo[3,2-a]pyrimidine-6-carbonitrile (3f) showed excellent antimycobacterial activity against Mtb (EC50 3.19 & 7.91 µM, respectively) and low cytotoxicity against the VERO cell line (IC50 > 62.5 µg/mL).
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Influence of phosphorohydrazone derivatives of benzopyrones on polymerization and viscosity of fibrin
Autorzy:: Michalska, Marta
Pająk, Wojciech
Kołodziejska, Justyna
Łazarenkow, Andrzej
Nawrot-Modranka, Jolanta
Tematy:: fibrin
chromone
coumarin
polymerization
viscosity
phosphorohydrazone; Pokaż więcej
Wydawca:: Polskie Towarzystwo Biochemiczne
Powiązania:: https://bibliotekanauki.pl/articles/1040726.pdf Link otwiera się w nowym oknie
Opis:: The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Synthesis of 1,2,3-triazole derivative at 3rd position of coumarin via copper(I) catalyzed click chemistry using ternary solvent system (DMF + t-BuOH + water)
Autorzy:: Safi, Shahrukhkhan
Dhamsaniya, Ashish
Christian, Wilson
Trivedi, Prachi
Chhatbar, Pratiksha
Shah, Anamik
Tematy:: Click Chemistry
Coumarin
Triazole
heterocyclic hybrids; Pokaż więcej
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Powiązania:: https://bibliotekanauki.pl/articles/1059512.pdf Link otwiera się w nowym oknie
Opis:: Coumarin-based triazoles were synthesized from 2-azido-N-phenylacetamide and terminal acetylenic compound by click chemistry. Whereas the CuSO4 used catalyts and sodium ascorbate used as a reducant affords only the favourable 1,4-regioisomer of triazole. Here DMF + t-BuOH + water used as a solvent.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Administration of warfarin inhibits the development of cerulein-induced edematous acute pancreatitis in rats
Autorzy:: Ginter, Grzegorz
Stempniewicz, Agnieszka Ewa
Gałązka, Krystyna
Konarska-Bajda, Katarzyna
Bonior, Joanna
Ceranowicz, Piotr
Warzecha, Zygmunt
Kuśnierz-Cabala, Beata
Dumnicka, Paulina
Cieszkowski, Jakub
Opis:: Acute pancreatitis (AP) is a severe disease with high morbidity and mortality in which inflammation and coagulation play crucial roles. The development of inflammation leads to vascular injury, endothelium and leukocytes stimulation, and an increased level of tissue factor, which results in the activation of the coagulation process. For this reason, anticoagulants may be considered as a therapeutic option in AP. Previous studies have shown that pretreatment with heparin, low-molecular-weight heparin (LMWH), or acenocoumarol inhibits the development of AP. The aim of the present study was to check if pretreatment with warfarin affects the development of edematous pancreatitis evoked by cerulein. Warfarin (90, 180, or 270 µg/kg/dose) or saline were administered intragastrically once a day for 7 days consecutively before the induction of AP. AP was evoked by the intraperitoneal administration of cerulein. The pre-administration of warfarin at doses of 90 or 180 µg/kg/dose reduced the histological signs of pancreatic damage in animals with the induction of AP. Additionally, other parameters of AP, such as an increase in the serum activity of lipase and amylase, the plasma concentration of D-dimer, and interleukin-1β, were decreased. In addition, pretreatment with warfarin administered at doses of 90 or 180 µg/kg/dose reversed the limitation of pancreatic blood flow evoked by AP development. Warfarin administered at a dose of 270 µg/kg/dose did not exhibit a preventive effect in cerulein-induced AP. Conclusion: Pretreatment with low doses of warfarin inhibits the development of AP evoked by the intraperitoneal administration of cerulein.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 6.

Tytuł:: A convergent approach for the synthesis of new pyrazolyl bipyridinyl substituted coumarin derivatives as antimicrobials
Autorzy:: Bhila, V. G.
Chovatiya, Y. L.
Patel, C. V.
Giri, R. R.
Brahmbhatt, D. I.
Tematy:: Coumarin
Bipyridine
Pyrazole
Kröhnke’s reaction
antimicrobial activity; Pokaż więcej
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Powiązania:: https://bibliotekanauki.pl/articles/411982.pdf Link otwiera się w nowym oknie
Opis:: Some new 3-[3-(1-phenyl-3-aryl-1H-pyrazol-4-yl)acryloyl]coumarins 3a-f were synthesized (coumarin chalcones) by the condensation of various 3-acetyl coumarins 1 and appropriate 1-phenyl-3-aryl-1H-pyrazole-4-carbaldehyde 2. These coumarin chalcones 3a-f were then employed for the synthesis of pyrazolyl bipyridinyl substituted coumarins 7a-f, 8a-f, and 9a-f under Krohnke’s reaction condition. The characterization of all the synthesized compounds was carried out by elemental analysis, IR, ¹H-NMR, ¹³C-NMR, DEPT-135 and mass spectral analysis. In addition to that, in vitro antimicrobial competency of the title compounds was assessed against selected pathogens. Compounds 3b, 3e, 7b, 8b, 8c and 9b exhibited excellent antimicrobial activity and said to be the most proficient members of the series.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: PEG mediated eco-friendly one pot sunthesis of benzylamine coumarin derivatives using multicomponent reactant
Autorzy:: Viradiya, D. J.
Kotadiya, V. C
Khunt, M. D.
Baria, B. H.
Bhoya, U. C.
Tematy:: one pot reaction
benzylamine coumarin derivative
green synthesis
PEG-400; Pokaż więcej
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Powiązania:: https://bibliotekanauki.pl/articles/412545.pdf Link otwiera się w nowym oknie
Opis:: A green resourceful, eco-friendly and facile protocol was developed for the synthesis of benzylamine coumarin derivatives by the reaction of 4-hydroxy coumarin, secondary amine and aromatic aldehyde in the presence of PEG400 as a solvent as well as catalyst at room temperature. A wide range of functional groups were tolerated in the developed protocol. The structures of all the synthesized compounds were confirmed by 1H NMR, IR, MASS and Elemental Analysis. The target molecules were obtained in good to excellent yield applying this method.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Design, Efficient Synthesis, Mechanism of Reaction and Antiproliferative Activity Against Cancer And Normal Cell Lines of A Novel Class of Fused Pyrimidine Derivatives
Autorzy:: roaiah, hanaa F.
Rashdan, Huda R.
soliman, abdelmohsen
Muhammed, Zeinab
Wietrzyk, Joanna
Milczarek, Magdalena
Tematy:: anticancer activity
antiproliferative activity
Coumarin
Fused pyrimidines
3-triazole; Pokaż więcej
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Powiązania:: https://bibliotekanauki.pl/articles/895705.pdf Link otwiera się w nowym oknie
Opis:: This work concentrated on the utility of hydrazonoyl halides in synthesis of bioactive heterocycles like triazoles, pyrazoles, pyrimidines and their fused derivatives which have a wide spectrum of pharmaceutical value. Herein we discussed the synthesis of new heterocyclic compounds containing fused pyrimidine rings derived from hydrazonoyl halides and their significant pharmaceutical importance as anticancer agents. New fused pyrimidine derivatives bearing 1,2,3-triazole moiety were prepared via reaction of enaminone 2 with and 6-amino-2-thioxo-pyrimidin-4-one and then with hydrazonoyl chlorides 6a-h. In addition 3-amino-6-(2-oxo-2H-chromen-3-yl)pyridine-2-carbonitrile (12) was submitted to react with carbon dioxide to afford 3-(1,2,3,4-tetrahydro-2,4-dithioxopyrido[2,3-d]pyrimidin-7-yl)-2H-chromen-2-one (15), which act as key molecule for synthesis of new series of fused prymidinethione derivatives containing coumarine moiety via its reaction with different selected derivatives of hydrazonoyl halides 6a-h. Structures of the newly synthesized compounds were confirmed using spectral data (IR, H1NMR and Mass spectrometry) and microanalytical methods. Also, they screened for their anticancer activity.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Synthesis and antimicrobial activity of coumarinyl Schiff base derivatives
Autorzy:: Mishra, A.
Rathod, J.
Namera, D.
Thakrar, S.
Shah, A.
Tematy:: gram positive bacterial
gram negative bacterial
derivatives of coumarin; Pokaż więcej
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Powiązania:: https://bibliotekanauki.pl/articles/411623.pdf Link otwiera się w nowym oknie
Opis:: We have reported some novel N’-[(1)-ethylidene]-2-(6-methyl-2-oxo-2H-chromen-4-yl) acetohydrazide synthesized by conventional method. The reaction of 2-(6-methyl-2-oxo-2H-chromen-4-yl)acetohydrazide with substituted benzaldehyde in methanol as a solvent yielded a series of (7a-l). The structures of all synthesized compounds are well characterized by Mass, FT-IR, 1H NMR, 13C NMR and elemental analysis. Moreover, all synthesized compounds were screened for in vitro antimicrobial activity against the gram positive (Staphylococcus aureus, Bacilluas subtilis) and gram negative (Escherichia coli, P. aeruginosa, K. pneunonae, Enterobacter) bacterial strain. In which some the compounds show potential inhibition against the test organisms.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Advanced research on biological properties : a study on the activity of the Apis mellifera antioxidant system and the crystallographic and spectroscopic properties of 7-diethylamino-4-hydroxycoumarin
Autorzy:: Matwijczuk, Arkadiusz Paweł
Gryboś, Anna
Nowak, Maurycy E.
Figiel, Małgorzata
Hoser, Anna A.
Strachecka, Aneta
Rząd, Klaudia
Starzak, Karolina
Staniszewska, Patrycja
Okoń, Sylwia
Matwijczuk, Alicja
Budziak-Wieczorek, Iwona
Gładyszewska, Bożena
Staniszewski, Adam
Opis:: The search for substances that increase the immunity of bees is becoming a necessity in the era of various environmental threats and the declining immunocompetence of these insects. Therefore, we tested the biological and physicochemical properties of 7-diethylamino-4-hydroxycoumarin (7DOC). In a cage test, two groups of bees were created: a control group fed with sugar syrup and an experimental group fed with sugar syrup with the addition of 7DOC. In each group, the longevity of the bees was determined and the protein concentrations and antioxidant activities in the bees’ hemolymph were determined. The bees fed with 7DOC lived 2.7 times longer than those in the control group. The protein concentrations and activities of SOD, CAT, GPx and GST, as well as the TAC levels, were significantly higher in the hemolymph of the supplemented workers. To confirm these potent biological properties of 7DOC, the UV-Vis spectra, emission and excitation of fluorescence, synchronous spectra and finally the fluorescence lifetimes of this compound were measured using the time-correlated single photon counting method, in various environments differing in polarity and in the environment applied in bee research. This compound was shown to be sensitive to changes in solvent polarity. The spectroscopic assays were complemented with crystallographic tests of the obtained monocrystals of the aforementioned compounds, which attested to the aggregation effects observed in the spectra measurements for the selected coumarin. The research results confirm that this compound has the potential to be implemented in apiary management, which will be our application goal, but further research into apiary conditions is required.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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