Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Pedagogiczna Biblioteka Wojewódzka im. Komisji Edukacji Narodowej w Lublinie Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaPedagogiczna Biblioteka Wojewódzka im. Komisji Edukacji Narodowej w Lublinie
Zmień bibliotekę

Wyszukujesz frazę "endothelin-1" wg kryterium: Temat

  Lista filtrów
Wyrównaj
Wyświetlanie 1-10 z 18
Tytuł:
Inflammatory response to a marathon run in amateur athletes
Autorzy:
Dąbrowska-Kugacka, Alicja
Kalinowski, Leszek
Lewicka-Potocka, Zuzanna
Woźniak, Marcin
Siekierzycka, Anna
Raczak, Grzegorz
Lewicka, Ewa Katarzyna
Kaleta-Duss, Anna Maria
Wydawca:
Medical University of Gdańsk
Cytata wydawnicza:
Kaleta-Duss AM, Lewicka-Potocka Z, Dąbrowska-Kugacka A, Raczak G, Siekierzycka A, Woźniak M, Kalinowski L, Lewicka EK. Eur J Transl Clin Med. 2021;4(1):43-49. DOI: 10.31373/ejtcm/136659
Opis:
Background: While moderate physical exercise has positive effects on the cardiovascular system, the data regarding intensive endurance sports is biased with studies suggesting that the inflammatory response to strenuous exercise may act proarrhythmogenic. In amateurs, the effects of intensive endurance exercise on the cardiovascular system have not been studied. Analysis of the effects of a marathon on the kinetics of inflammatory biomarkers may bring new insights into this issue. Material and methods: We studied the effect of a marathon on the kinetics of inflammatory biomarkers: Endothelin-1 (ET-1), Pentraxin-3 (PTX-3), Neopterin and Interleukin-6 (IL-6) in the population of 35 amateur male marathoners. The study was divided into 3 stages: two weeks prior to the marathon (S1), at the finish line (S2) and two weeks after (S3). Blood analyses for biomarkers were performed at each stage. Results: The concentrations of ET-1 (3.20 ± 0.90 vs. 1.30 ±0.34 pg/ml, p <0,001), PTX-3 (441.09 ± 295.64 vs. 279.99 ± 125.68 pg/ml, p < 0,001), Neopterin (9.97 ± 2.17 vs. 8.36 ± 2.68 nmol/l, p < 0,05) and IL-6 (32.5 ± 13.90 vs. 0.97 ± 0.77 pg/ml, p < 0,001) were significantly higher at S2 compared to S1. Conclusions: Running a marathon causes an acute rise in concentrations of inflammatory biomarkers. Further research is needed on the long-term effects of intensive endurance exercise on the cardiovascular system.
Dostawca treści:
Repozytorium Centrum Otwartej Nauki
Artykuł
Tytuł:
Inflammatory response to a marathon run in amateur athletes
Autorzy:
Kaleta-Duss, Anna Maria
Lewicka-Potocka, Zuzanna
Dąbrowska-Kugacka, Alicja
Raczak, Grzegorz
Siekierzycka, Anna
Woźniak, Marcin
Kalinowski, Leszek
Lewicka, Ewa Katarzyna
Tematy:
neopterin
endothelin-1
pentraxin-3
marathon
amateur runners
Pokaż więcej
Wydawca:
Gdański Uniwersytet Medyczny
Powiązania:
https://bibliotekanauki.pl/articles/1197575.pdf  Link otwiera się w nowym oknie
Opis:
Background: While moderate physical exercise has positive effects on the cardiovascular system, the data regarding intensive endurance sports is biased with studies suggesting that the inflammatory response to strenuous exercise may act proarrhythmogenic. In amateurs, the effects of intensive endurance exercise on the cardiovascular system have not been studied. Analysis of the effects of a marathon on the kinetics of inflammatory biomarkers may bring new insights into this issue. Material and methods: We studied the effect of a marathon on the kinetics of inflammatory biomarkers: Endothelin-1 (ET-1), Pentraxin-3 (PTX-3), Neopterin and Interleukin-6 (IL-6) in the population of 35 amateur male marathoners. The study was divided into 3 stages: two weeks prior to the marathon (S1), at the finish line (S2) and two weeks after (S3). Blood analyses for biomarkers were performed at each stage. Results: The concentrations of ET-1 (3.20 ± 0.90 vs. 1.30 ±0.34 pg/ml, p <0,001), PTX-3 (441.09 ± 295.64 vs. 279.99 ± 125.68 pg/ml, p < 0,001), Neopterin (9.97 ± 2.17 vs. 8.36 ± 2.68 nmol/l, p < 0,05) and IL-6 (32.5 ± 13.90 vs. 0.97 ± 0.77 pg/ml, p < 0,001) were significantly higher at S2 compared to S1. Conclusions: Running a marathon causes an acute rise in concentrations of inflammatory biomarkers. Further research is needed on the long-term effects of intensive endurance exercise on the cardiovascular system.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Endothelial dysfunction in obstructive sleep apnea patients
Autorzy:
Płazak, Wojciech
Harańczyk, Michał
Konieczyńska, Małgorzata
Opis:
Purpose: Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for cardiovascular diseases. The aim of the study was to assess the influence of OSAS on endothelial dysfunction and thrombosis biomarkers and to evaluate the effect of treatment with continuous positive airway pressure (CPAP) on biomarker levels. Methods: NT-proBNP, sICAM-1, endothelin-1, von Willebrand factor, D-dimers, and thrombin-antithrombin complex (TAT) were measured in 50 patients diagnosed with moderate-to-severe OSAS. All patients underwent transthoracic echocardiography, and 38 months after the inclusion, 16 CPAP users and 22 non-CPAP users were reassessed. Results: Sleep-related indices of apnea-hypopnea index (AHI) and mean SpO$_{2}$ were associated with higher sICAM-1 levels (AHI < 30: 7.3 ± 4.7 vs. AHI ≥ 30: 19.5 ± 19.4 mg/ml, p = 0.04; SpO2 ≥ 90%: 11.9 ± 9.3 vs. SpO2 < 90%: 23.6 ± 25.8, p = 0.04). sICAM-1 levels were significantly higher in obese patients, particularly with BMI ≥ 40. Plasma levels of TAT were significantly correlated with the increased right ventricular size (right ventricular diameter ≤ 37 mm: 0.86 ± 0.70 vs. > 37 mm: 1.96 ± 1.20 ng/ml, p = 0.04). Endothelin-1 levels were higher in patients with decreased right ventricular function (right ventricle TDI-derived S′ ≥ 12 cm/s: 11.5 ± 10.9 vs. < 12 cm/s: 26.0 ± 13.2 pg/ml, p = 0.04). An increase in NT-proBNP was related to impaired parameters of the right ventricular contractile function. There were no correlations between long-term CPAP therapy and the levels of biomarkers. Conclusion: Severe OSAS influences endothelial damage as manifested by an increase in sICAM-1 levels. Changes in right ventricular structure and function, observed mainly in patients with higher TAT and endothelin-1 levels, are also manifested by an increase in NT-proBNP levels. Long-term CPAP treatment does not seem to influence biomarkers in patients with moderate-to-severe OSAS, which may help to explain the lack of influence of CPAP on cardiovascular risk reduction.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Changes in inflammatory markers in patients with chronic thromboembolic pulmonary hypertension treated with balloon pulmonary angioplasty
Autorzy:
Podolec, Piotr
Przybylski, Roman
Jonas, Kamil
Waligóra, Marcin
Magoń, Wojciech
Stępniewski, Jakub
Kopeć, Grzegorz
Opis:
Background: Inflammatory response and endothelial dysfunction contribute to the progression of chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to assess changes in biomarkers involved in those processes in inoperable CTEPH patients treated with balloon pulmonary angioplasty (BPA). Methods: We enrolled 20 patients with inoperable CTEPH qualified for BPA and a control group. Interleukin 6, 8, 10 (IL-6, IL-8, IL-10), monocyte chemoattractant protein-1 (MCP-1), and C-reactive protein (hsCRP) constituted the markers of systemic inflammation. Endothelin 1 (ET-1) served as a marker of endothelial dysfunction. Selected markers were assessed before the BPA treatment, 24 h after the first BPA, and six months after completion of the BPA treatment. Results: At baseline, the CTEPH patients had increased serum concentrations of IL-6, IL-8 and ET-1. Twenty-four hours after a BPA session, we observed an increase in concentrations of IL-6 (∆ = 3.67 (1.41; 7.16); p < 0.001), of IL-10 (∆ = 0.25 (0; 0.47); p = 0.003), of MCP-1 (∆ = 111 (60.1; 202.8); p = 0.002), and of hsCRP (∆ = 4.81 (3.46; 8.47); p < 0.001). Six months after completion of the BPA treatment, there was a decrease in concentrations of IL-6 (∆ = −1.61 (−3.11; −0.20); p = 0.03), of IL8 (∆ = −3.24 (−7.72; 0.82); p = 0.01), and of ET-1 (∆ = −0.47 (−0.96; 0.05); p = 0.005). Conclusions: Patients with inoperable CTEPH exhibit increased systemic inflammation and endothelial dysfunction, which improves after completion of the BPA treatment. A single BPA session evokes an acute inflammatory response.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Stężenia TNF$\alpha$ i rozpuszczalnej formy VCAM w czasie standardowego testu wysiłkowego są wyższe u pacjentek po menopauzie z hipercholesterolemią
TNF$\alpha$ and sVCAM plasma levels during standard exercise test are higher in postrmenopausal women with hypercholesterolemia
Autorzy:
Rajtar-Salwa, Renata
Fedak, Danuta
Kolasińska-Kloch, Władysława
Thor, Piotr
Milewicz, Tomasz
Krzysiek, Józef
Banach, Tomasz
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Wyświetlanie 1-10 z 18

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies