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Wyświetlanie 1-10 z 73
Tytuł:
Inflammatory bowel disease: the function of metalloproteinases
Autorzy:
Pasternak, Grzegorz
Aebisher, David
Filip, Rafał
Bartusik-Aebisher, Dorota
Tematy:
inflammatory bowel disease
matrix metalloproteinases extracellular matrix
Pokaż więcej
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Powiązania:
https://bibliotekanauki.pl/articles/454718.pdf  Link otwiera się w nowym oknie
Opis:
Introduction. Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. Aim. The aim of this work was to review the current literature regarding matrix metalloproteinases. The databases such as PubMed, ScienceDirect and Springer were utilized to search the literature for relevant articles. Materials and methods. An analysis of literature. We collected information, data, and examples of the function of metalloproteinases. Results. Herein we show that metalloproteinases play a role in such processes as the immune response, angiogenesis, the epithelial barrier function, fibrosis induced by the inflammatory process, and in the process of carcinogenesis. Conclusions. Further studies on the role of metalloproteinases in the process of carcinogenesis associated with inflammatory bowel diseases are required.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Artificial extracellular matrices of collagen fibrils and lactoferrin as coatings to enhance osteoblast behavior
Autorzy:
Vandorovcova, M.
Bacakova, L.
Dubruel, P.
Douglas, T. E. L.
Tematy:
coating
collagen
osteoblasts
proliferation
extracellular matrix
lactoferrin
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Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Powiązania:
https://bibliotekanauki.pl/articles/284321.pdf  Link otwiera się w nowym oknie
Opis:
Lactoferrin, a glycoprotein found in milk, has stimulated osteoblast proliferation and differentiation, but has remained relatively unexplored as a biomaterial component. In this study, artificial extracellular matrices consisting of fibrils of collagen type I containing lactoferrin were used as coatings for the biocompatible polymer poly(lactic-co-glycolic acid) (PLGA). The numbers of cells, their viability and proliferation rate were evaluated in various time intervals. Additionally, cell initial spreading area on day 1 was measured. The results show that lactoferrin accelerates fibril-logenesis, leads to increased osteoblast cell numbers 1 and 3 days post-seeding, and encourages their proliferation in each of the tested time intervals.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fibrosis of extracellular matrix is related to the duration of the disease but is unrelated to the dynamics of collagen metabolism in dilated cardiomyopathy
Autorzy:
Podolec, Piotr
Rudnicka-Sosin, Lucyna
Karabinowska, Aleksandra
Wypasek, Ewa
Matusik, Patrycja S.
Wiśniowska-Śmiałek, Sylwia
Rubiś, Paweł
Dziewięcka, Ewa
Kozanecki, Artur
Khachatryana, Lusine
Tomkiewicz-Pająk, Lidia
Biernacka-Fijałkowska, Barbara
Opis:
Background Fibrosis of extracellular matrix (ECM) in dilated cardiomyopathy (DCM) corresponds to the myocardial over-production of various types of collagens. However, mechanism of this process is poorly understood. Objective To investigate whether enhanced metabolism of ECM occur in DCM. Methods Seventy consecutive DCM patients (pts) (48 ± 12.1 years, EF 24.4 ± 7.4 %) and 20 healthy volunteers were studied. Based on symptoms duration, pts were divided into new-onset (n = 35, 6 months) and chronic DCM (n = 35, >6 months). Markers of collagen type I and III synthesis-procollagen type I carboxy- and amino-terminal peptides (PICP and PINP) and procollagen type III carboxy- and amino-terminal peptides (PIIICP and PIIINP), collagen 1 (col-1), ECM metabolism controlling factors-tumor growth factor beta-1 (TGF1-b), connective tissue growth factor (CTGF), and ECM degradation enzymes-matrix metalloproteinases (MMP-2, MMP-9) and their tissue inhibitor (TIMP-1) were measured in serum. All pts underwent right ventricular endomyocardial biopsy to study ECM fibrosis. Results The presence of fibrosis was detected in 24 (34.3 %) pts and was more prevalent in chronic DCM [17 (48.6 %) vs. 7 (20 %), p\0.01]. The levels of PIIINP [4.41 (2.17-6.08) vs. 3.32 (1.69-5.02) ng/ml, p\0.001], CTGF [3.82 (0.48-23.87) vs. 2.37 (0.51-25.32) ng/ml, p\0.01], MMP-2 [6.06 (2.72-14.8) vs. 4.43 (2.27=7.4) ng/ml, p\0.001], MMP-9 [1.98 (0.28-9.25) vs. 1.01 (0.29-3.59) ng/ml, p\0.002)], and TIMP-1 [15.29 (1.8-36.17) vs. 2.61 (1.65-24.09) ng/ml, p\0.004] were significantly higher in DCM, whereas levels of col-1 [57.7 (23.1-233.4) vs. 159.4 (31.2-512.9) pg/ml, p\0.001] were significantly lower in DCM compared to controls. There were no differences in all measured serum markers of ECM metabolism between newonset and chronic DCM and as well as fibrosis positive and negative pts. Fibrosis was weakly correlated only with the duration of DCM (r = 0.23, p\0.05), however, not a single serum marker of fibrosis correlated with fibrosis. Neither unadjusted nor adjusted models, constructed from serum markers of ECM metabolism, predicted the probability of myocardial fibrosis. Conclusions Dynamics of ECM turnover in DCM is high, which is reflected by the increased levels CTGF and degradation enzymes. Synthesis of collagen type III prevailed over collagen type I. ECM metabolism was not different in DCM regardless of the duration of the disease and status of myocardial fibrosis. Serum markers of ECM metabolism were found not to be useful for the prediction of myocardial fibrosis in DCM.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Synthetic extracellular matrix as a substrate for regenerative medicine
Autorzy:
Stodolak-Zych, Ewa
Menaszek, Elżbieta
Twardy, Aleksandra
Ścisłowska-Czarnecka, Anna
Boguń, Maciej
Kolesińska, Beata
Tematy:
synthetic extracellular matrix
biomimetic
peptide
polysaccharides
laboratory model
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Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Powiązania:
https://bibliotekanauki.pl/articles/285740.pdf  Link otwiera się w nowym oknie
Opis:
The work presents materials characteristics of fibrous polysaccharide substrates (calcium alginate, CA) modified with short peptides. Three types of synthesized peptides (hexapeptides) were composed of: cysteine (C) and tryptophan (W) named - (WWC)2or cysteine (C) and tyrosine (Y) named (YYC)2 or phenyloalanine (F) named 6F. The peptides size distribution (DLS method) showed that they agglomerated in an alcohol medium. These results were used to select a modification method of the fibrous substrates i.e. the peptides were deposited on the fibrous alginate substrate by the electrospraying technique. Using this method three kinds of polysaccharide- peptides systems were obtained i.e.: CA/(WWC)2, CA/(YYC)2CA/6F. As a reference material, the pure calcium alginate fibrous substrate was used. The results of modification with short peptides were evaluated via scanning electron microscopy (SEM): small aggregates were observed (40-100 nm) on the surface of fibers, and the fibers size remained the same after modification (11-12 μm). The size of aggregates depended on the kind of short peptide; the smaller (40 nm) aggregates were observed when the peptide had only aromatic chain (6F), the bigger (<100 nm) ones were observed when the peptide had heterocyclic rings in the chain (WWC and YYC). All materials were contacted with osteoblast-like cells (MG-63) to test biocompatibility (cells viability after 3 and 7 days) and the results proved showed higher viability in the polysaccharide-peptide system which increased with the time of observation. The durability of polysaccharide-peptide systems was tested using the enzymatic assay: collagenase confirmed the stability of materials. The progress of degradation rate was observed using infrared spectroscopy (FTIR-ATR) - the ratio on bands with C-O and C-OH increased after degradation under in vitro conditions.Results of the investigations on the fibrous substrates have confirmed that the system is a good model of an extracellular matrix (ECM) due to its chemical composition and microstructure which both have biomimetic characteristics. Thus, it may be used as a filling of bone defects supporting the regeneration of the damaged tissue. Additionally, it may also serve as the model research system of ECM.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chemical and physical modifications of electrospun fibers as a method to stimulate tissue regeneration – minireview
Autorzy:
Kurpanik, Roksana
Stodolak-Zych, Ewa
Tematy:
electrospun fibers
fibrous scaffold
surface modification
extracellular matrix
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Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Powiązania:
https://bibliotekanauki.pl/articles/1844869.pdf  Link otwiera się w nowym oknie
Opis:
Fibrous scaffolds based on (bio)polymers are ob¬served as mimicking the microstructure of the extracel¬lular matrix. Thus, they are considered as an example of a utilitarian scaffold, useful for the regeneration of various types of tissues. The techniques described in the literature are well known to obtain submicrometric and nanometric fibers that, when randomly arranged, mimic the ECM. The biomimetic scaffold criterion might be even better reflected if the cell adhesion sites are present on the surface of such fibers. They promote the formation of the focal adhesion contact or facilitate the formation of a protein film on the fiber surface. Such a process is enhanced by an appropriate physical or chemical modification that activates the protein adsorption and the subsequent cell adhesion. The aim of this paper is to present different methods of physical and/or chemi¬cal modifications of fibrous materials: which can serve as scaffolds to support the regeneration processes of various tissues. In terms of physical methods, only weak interactions between the surface and the modi¬fier were observed. This technique is simple but not durable. Chemisorption used as a second method of fiber modification is possible if a covalent or ionic bond is formed between the fiber and the modifier. Therefo¬re, the chemical adsorption may not be fully reversible and requires a sequence of chemical actions to form a chemical bond. The most commonly used methods are the combined methods where the first step is the physical activation of the fiber surface, which facilitates the chemical modification step.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Genetic Variation as a Possible Explanation for the Heterogeneity of Pain in Tendinopathy: What can we learn from other pain syndromes?
Autorzy:
Mkumbuzi, Nonhlanhla S.
Posthumus, Michael
September, Alison V.
Collins, Malcolm
Tematy:
tendon pain
genetics
extracellular matrix genes
inflammation genes
COMT
Pokaż więcej
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Powiązania:
https://bibliotekanauki.pl/articles/1942934.pdf  Link otwiera się w nowym oknie
Opis:
The mechanisms of pain in tendinopathy are unclear. Current theories implicate tendon structural changes, neovascularisation, inflammation or changes in central pain processing. As with other types of musculoskeletal pain, tendon pain has high interindividual variability and, as with other types of pain, this could be attributed to genetic variation. Notably, the association between certain genetic polymorphisms and susceptibility to tendinopathy is well established in the literature. Therefore, the investigation of the mechanisms of tendon pain should also extend to include genetic variation as a possible explanation for the clinical features of tendon pain. This review summarises the current knowledge on genetic contributors to chronic pain and highlights findings that are relevant to chronic tendon pain. In particular, based on the current hypotheses on the possible sources of tendon pain, it focuses on findings that relate to genes that encode structural connective tissue components, inflammatory markers, ion channels and catecholamines and how they may relate to chronic tendon pain. In the absence of a definitive mechanism of tendon pain, an a priori genetic approach that is guided by these current hypotheses may help elucidate the mechanisms of tendon pain which may allow a more rational approach to research and treatment.
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 73

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