Temat: folate - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Cellular aspects of folate and antifolate membrane transport.
Autorzy:: Brzezińska, Agnieszka
Wińska, Patrycja
Balińska, Małgorzata
Tematy:: antifolates
folate receptor
chemotherapy
folate carrier
folates; Pokaż więcej
Wydawca:: Polskie Towarzystwo Biochemiczne
Powiązania:: https://bibliotekanauki.pl/articles/1044317.pdf Link otwiera się w nowym oknie
Opis:: Folates - one carbon carriers - take part in the metabolism of purine, thymidylate and some amino acids. Internalization of these compounds employs several mechanisms of transport systems. Reduced folate carriers and folate receptors play the most important role in this process. The physiological role of these molecules in normal and neoplastic cells is described regarding changes in transport activity and connection of transport systems with resistance to antifolates and cancer development.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Plasma homocysteine affects fibrin clot permeability and resistance to lysis in human subjects
Autorzy:: Undas, Anetta
Siudak, Zbigniew
Szczeklik, Andrzej
Brożek, Jan
Jankowski, Miłosz
Jakubowski, Hieronim
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 3.

Tytuł:: Sources of folates in human diet
Źródła folianów w diecie człowieka
Autorzy:: Bielecka, M.M.
Cichosz, G.
Nowak, K.
Tematy:: human nutrition
human diet
diet
folate source
food product
folate
bioavailability
stability; Pokaż więcej
Wydawca:: Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Powiązania:: https://bibliotekanauki.pl/articles/82772.pdf Link otwiera się w nowym oknie
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: How is the process of setting micronutrients recommendations reflected in nutrition policies in Poland? The case study of folate
Autorzy:: Sicińska, E.
Jeruszka-Bielak, M.
Roszkowski, W.
Brzozowska, A.
Jarosz, M.
Raats, M.M.
Tematy:: micronutrients
nutrition policy
public health
folate; Pokaż więcej
Wydawca:: Instytut Medycyny Wsi
Powiązania:: https://bibliotekanauki.pl/articles/2081566.pdf Link otwiera się w nowym oknie
Opis:: Introduction and objective. Ensuring the adequate intake of micronutrients by populations is an important aspect of public health. This study aims to elucidate the process of setting nutrition recommendations and the development of subsequent policies associated with micronutrients in Poland by using the case study of folate. Materials and method. The study was based on 13 interviews conducted between October 2010 – February 2011, and desk research comprising a review of the associated scientific literature and relevant documents, such as scientific opinions and reports of the meetings of scientific committees. The interviews were conducted within the EURRECA (EURopean micronutrient RECommendations Aligned) Network of Excellence in the frame of the European Union’s 6th Framework Programme. Results. Since 1997, the Experts Group of the Ministry of Health recommended that all women of childbearing age should consume folic acid as a supplement to prevent neural tube defects in their offspring. The fortification of foodstuffs with folic acid is not obligatory. This study describes the revision of the folate nutrient recommendation and the process by which strategies to increase the intake of this vitamin by the Polish population were identified. The institution responsible for the choice and implementation of folate policy is the Ministry of Health and the National Food and Nutrition Institute is responsible for setting/updating the nutrient recommendations. Conclusions. The current Polish nutrition recommendations for folate are consistent with the levels set by most other countries. The constant improvement of nutritional knowledge on folate among consumers, especially young women, is necessary.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Hyperhomocysteinemia among Omani autistic children: a case-control study
Autorzy:: Ali, Amanat
Waly, Mostafa
Al-Farsi, Yahya
Essa, Musthafa
Al-Sharbati, Marwan
Deth, Richard
Tematy:: autistic children
vitamin B12
Oman
folate
serum homocysteine; Pokaż więcej
Wydawca:: Polskie Towarzystwo Biochemiczne
Powiązania:: https://bibliotekanauki.pl/articles/1039850.pdf Link otwiera się w nowym oknie
Opis:: High serum homocysteine (Hcy) level is regarded as an indicator for impairment of folate-dependent methionine cycle and is associated with oxidative stress. In a case control study, we evaluated eighty 3-5 years old Omani children (40 diagnosed with Autism Spectrum Disorder and 40 their age and gender matched controls) for their fasting serum homocysteine levels as a biomarker of Autism Spectrum Disorder (ASD). Serum folate and vitamin B12 status were also evaluated. The serum homocysteine was measured using an enzyme immunoassay (EIA) technique whereas folate and vitamin B12 were measured using an automated random access immune-assay system. The results indicated that mean serum Hcy levels were significantly (P < 0.05) higher in autistic children (20.1 ± 3.3 µmol/L) as compared to controls (9.64 ± 2.1 µmol/L). Significantly (P < 0.05) lower serum folate (1.8 ± 0.4 µg/L) and vitamin B12 (191.1 ± 0.9 pg/mL) levels were observed in autistic children as compared to controls (6.1 ± 0.6 µg/L and 288.9 ± 1.3 pg/mL, respectively). The levels of homocysteine in autistic children were also much higher as compared to normal reference values (5-15 µmol/L). The results suggest that high fasting serum homocysteine and low folate and vitamin B12 levels could be used as clinical biomarkers for an early diagnosis and management of ASD.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Methylenetetrahydrofolate reductase gene polymorphisms in Egyptian Turner Syndrome patients
Autorzy:: Ismail, Manal
Zarouk, Waheba
Ruby, Mona
Mahmoud, Wael
Gad, Randa
Tematy:: chromosomal nondisjunction
DNA methylation
folate
MTHFR gene
Turner Syndrome; Pokaż więcej
Wydawca:: Polskie Towarzystwo Biochemiczne
Powiązania:: https://bibliotekanauki.pl/articles/1038999.pdf Link otwiera się w nowym oknie
Opis:: Background: Folate metabolism dysfunctions can result in DNA hypomethylation and abnormal chromosome segregation. Two common polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) encoding gene (C677T and A1298C) reduce MTHFR activity, but when associated with aneuploidy, the results are conflicting. Turner Syndrome (TS) is an interesting model for investigating the association between MTHFR gene polymorphisms and nondisjunction because of the high frequency of chromosomal mosaicism in this syndrome. Objective: To investigate the association of MTHFR gene C677T and A1298C polymorphisms in TS patients and their mothers and to correlate these polymorphisms with maternal risk of TS offspring. Subjects and Methods: MTHFR C677T and A1298C polymorphisms were genotyped in 33 TS patients, their mothers and 15 healthy females with their mothers as controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and sequencing technique. Results: Genotype and allele frequencies of both C677T and A1298C were not significantly different between TS cases and controls. There were no significant differences in C677T genotype distribution between the TS mothers and controls (p=1). The MTHFR 1298AA and 1298AC genotypes were significantly increased in TS mothers Vs. control mothers (p=0.002). The C allele frequency of the A1298C polymorphism was significantly different between the TS mothers and controls (p=0.02). The association of A1298C gene polymorphism in TS patients was found to increase with increasing age of both mothers (p=0.026) and fathers (p=0.044) of TS cases. Conclusion: Our findings suggest a strong association between maternal MTHFR A1298C and risk of TS in Egypt.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Determinants of plasma homocysteine in coal miners
Autorzy:: Mungan, A
Can, Murat
Kıran, Sibel
Açıkgöz, Şerefden
Güven, Berrak
Tematy:: coal miners
homocysteine
cystatin C
vitamin B12
folate; Pokaż więcej
Wydawca:: Polskie Towarzystwo Biochemiczne
Powiązania:: https://bibliotekanauki.pl/articles/1039548.pdf Link otwiera się w nowym oknie
Opis:: Aim: Several studies suggest that coal miners are under risk of severe health problems such as cardiovascular, pulmonary, neurological, renal, hematological and musculoskeletal disorders. However, there are limited data on biochemical changes in underground workers. In our study we aimed to evaluate the association between serum homocysteine (Hcy), vitamin B12, cystatin C and folate levels in the blood of underground coal miners. Materials and Methods: Eighty one coal miners who work as underground or surface workers were recruited into our study. The study population was divided into two groups: the surface worker group (control group, n=33) and the underground worker group (n=48). The folate, vitamin B12, Hcy, cystatin C levels and body mass indexes (BMI) of both groups were measured and compared. Serum folate, Hcy and vitamin B12 levels were measured with a competitive chemiluminescence immunassay. Serum levels of cystatin C were determined by the latex particle-enhanced turbidimetric method using a cystatin C kit. Urea values were measured with a kinetic method on an automated analyzer. Results: There were no statistically significant differences between the underground workers and surface workers in the urea, cystatin C and vitamin B12 levels. High serum Hcy levels and low folate levels were found in underground workers compared with those in surface workers. The correlation between Hcy and folate levels was also statistically significant. Similarly, there was also a significant correlation between Hcy and vitamin B12, and between Hcy and cystatin C levels. Conclusions: Elevated Hcy levels may be associated with underground working but further research is necessary to understand the relation between elevated Hcy and increased prevalence of health problems in coal miners.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Correlation of serum vitamin B12, folate, and magnesium levels with severity of fibrosis in non-alcoholic fatty liver disease in the medical ICU
Autorzy:: Yadav, Rupesh
Kumar, Shailesh
Goel, Kartik
Wydawca:: Towarzystwo Pomocy Doraźnej
Cytata wydawnicza:: Crit. Care Innov. 2025; 8(2): 34-45
Opis:: INTRODUCTION: Non-Alcoholic Fatty Liver Disease (NAFLD) has emerged as a major public health concern worldwide. Characterised by the accumulation of fat in liver cells in the absence of significant alcohol consumption, NAFLD spans a spectrum of conditions, from simple steatosis to more severe forms such as non-alcoholic steatohepatitis (NASH), which can progress to cirrhosis and liver cancer. Recent research has also highlighted the critical role of micronutrients in the development and management of NAFLD, suggesting that deficiencies or imbalances in essential vitamins and minerals may influence disease progression and response to treatment. Therefore, the objective of the study was to evaluate the correlation of serum vitamin B12, folate, and magnesium levels with the severity of fibrosis in non-alcoholic fatty liver disease in the medical ICU. MATERIALS AND METHODS: A prospective cross-sectional observational study was evaluated involving 70 patients with NAFLD diagnosis based on history, ultrasound abdomen and fulfilling inclusion criteria during the study period. The severity of liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD) was evaluated using the NAFLD Fibrosis Score. RESULTS: Patients with low vitamin B12 had a mean fibrosis score of 0.46 (SD 1.59), compared to -1.05 (SD 1.43) for those with normal Vitamin B12 levels, with a p-value of 0.009, indicating a significant difference. Patients with low folate levels had a mean fibrosis score of -0.36 (SD 1.63), while those with normal folate levels had a mean score of -1.19 (SD 1.40), with a p-value of 1x10-6. Patients with low magnesium levels had a mean fibrosis score of -0.3 (SD 1.6), while those with normal levels had a score of -1.28 (SD 1.38) (p = 0.001), suggesting a significant difference. CONCLUSIONS: The study concluded that serum levels of Vitamin B12, folate, and magnesium are all correlated with the severity of fibrosis in patients with NAFLD, with folate showing the strongest association. Folate had a significant negative correlation of -0.45 with fibrosis scores, compared to -0.34 for Vitamin B12 and -0.31 for magnesium.
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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Skocz do pozycji: 9.

Tytuł:: Androgen receptor and c-Myc transcription factors as putative partners in the in vivo cross-talk between androgen receptor-mediated and c-Met-mediated signalling pathways
Autorzy:: Dudkowska, Magdalena
Jaworski, Tomasz
Grzelakowska-Sztabert, Barbara
Manteuffel-Cymborowska, Małgorzata
Tematy:: HGF/c-Met; c-Myc
cross-talk
androgen receptor
antifolate/folate-injured kidney; Pokaż więcej
Wydawca:: Polskie Towarzystwo Biochemiczne
Powiązania:: https://bibliotekanauki.pl/articles/1041070.pdf Link otwiera się w nowym oknie
Opis:: Cross-talk between two signal transduction pathways leads to a negative regulation of androgen-induced ornithine decarboxylase (ODC) gene expression in the mouse kidney. One pathway is triggered by testosterone via the intracellular androgen receptor, AR, and the other is induced by antifolate CB 3717 or folate via hepatocyte growth factor and its cell membrane receptor c-Met. Here we report the studies of the expression of AR and c-Myc transcription factors involved in ODC transactivation. Administration of CB 3717 or folate decreased the expression of AR. In contrast, testosterone did not modify AR mRNA content but augmented the AR protein. Furthermore, we demonstrate that administration of folate, but not testosterone, increases c-Myc transcript and protein level. We also document that activation of both examined pathways does not decrease the testosterone-induced AR protein level, but markedly increases c-Myc protein which is nearly 2-fold up-regulated compared to its level evoked solely by testosterone. We suspect that this pronounced increase of c-Myc protein might have functional consequences mirrored by down-regulated expression of AR target genes, among them ODC.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Chicken egg riboflavin-binding protein : protein structure and ligand-binding mechanism
Białko wiążące ryboflawinę z jaj kurzych : struktura białka i mechanizm wiązania ligandu
Autorzy:: Kozik, Andrzej
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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