Temat: genetic variant - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Distribution and diversity of Nosema bombi (Microsporidia : Nosematidae) in the natural populations of bumblebees (Bombus spp.) from West Siberia
Autorzy:: Sormacheva, Irina
Blinov, Alexander
Eremeeva, Natalia
Fet, Victor
Strachecka, Aneta
Bayborodin, Sergey I.
Vavilova, Valeriya
Woyciechowski, Michał
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Tytuł:: Identification of Polish RHDVa subtype strains based on the analysis of a highly variable part VP60 gene
Autorzy:: Fitzner, A.
Niedbalski, W.
Paprocka, G.
Kesy, A.
Tematy:: identification
RHD virus
genetic variability
Polska
virus subtype strain
genetic variant
sequence analysis
VP60 gene
rabbit
nucleotide sequence
phylogenetic analysis
hemorrhagic disease
virus strain; Pokaż więcej
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Powiązania:: https://bibliotekanauki.pl/articles/31138.pdf Link otwiera się w nowym oknie
Opis:: In order to determine the genetic variability of Polish RHD virus strains and to confirm the presence of genetic variant (RHDVa) subtype the partial nucleotide sequences of capsid protein gene, including two highly variable regions C and E, were examined. Phylogenetic analyses of 15 viral strains obtained over 18 years revealed the presence of three genetic groups. The oldest RHDV strains exhibit very close amino acid sequence similarity (98-99%) to the German FRG89 reference strain and most of European strains of the same period, as well as Chinese isolate from 1984. The HA-negative strains and isolates with variable reactivity in the HA test belong to the second subgroup and exhibit an intermediate level of variability (about 3%) in the analysed VP60 gene fragment. The most genetically variable strains (6-7%) clustered to RHDVa subtype. The analysis of nucleotides and amino acid sequences demonstrated three pairs of well conserved RHDV strains, isolated over 3, 6 and 10-year period.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Identification of a new genetic variant (G231N, E232T, N235D) of peptidylarginine deiminase from P. gingivalis in advanced periodontitis
Autorzy:: Kaczmarzyk, Tomasz
Strzelec, Karolina
Potempa, Jan
Łazarz-Bartyzel, Katarzyna
Chomyszyn-Gajewska, Maria
Grabiec, Aleksander
Bielecka, Ewa
Kantyka, Tomasz
Bereta, Grzegorz
Gawron, Katarzyna
Dziedzic-Kowalska, Agata
Nowakowska, Zuzanna
Krutyhołowa, Anna
Opis:: Chronic periodontitis (CP), an inflammatory disease of periodontal tissues driven by a dysbiotic subgingival bacterial biofilm, is also associated with several systemic diseases, including rheumatoid arthritis (RA). Porphyromonas gingivalis, one of the bacterial species implicated in CP as a keystone pathogen produces peptidyl arginine deiminase (PPAD) that citrullinates C-terminal arginine residues in proteins and peptides. Autoimmunity to citrullinated epitopes is crucial in RA, hence PPAD activity is considered a possible mechanistic link between CP and RA. Here we determined the PPAD enzymatic activity produced by clinical isolates of P. gingivalis, sequenced the ppad gene, and correlated the results with clinical determinants of CP in patients from whom the bacteria were isolated. The analysis revealed variations in PPAD activity and genetic diversity of the ppad gene in clinical P. gingivalis isolates. Interestingly, the severity of CP was correlated with a higher level of PPAD activity that was associated with the presence of a triple mutation (G231N, E232T, N235D) in PPAD in comparison to W83 and ATCC 33277 type strains. The relation between mutations and enhanced activity was verified by directed mutagenesis which showed that all three amino acid residue substitutions must be introduced into PPAD expressed by the type strains to obtain the super-active enzyme. Cumulatively, these results may lead to the development of novel prognostic tools to assess the progress of CP in the context of associated RA by analyzing the ppad genotype in CP patients infected with P. gingivalis.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 4.

Tytuł:: Wariant
The Variant
Autorzy:: Wołczuk, Nikodem
Tematy:: Pierre-Marc de Biasi
variant
manuscripts
variations
genetic criticism
text genetics
rękopisy
wariant
krytyka genetyczna
genetyka tekstów
odmiany; Pokaż więcej
Wydawca:: Uniwersytet im. Adama Mickiewicza w Poznaniu
Powiązania:: https://bibliotekanauki.pl/articles/1335706.pdf Link otwiera się w nowym oknie
Opis:: Artykuł dotyczy głęboko zakorzenionego w pracach edytorskich i literaturoznawczych terminu „wariant”. Głównym celem jest przedstawienie pojęcia w rozumieniu klasycznej tekstologii oraz francuskiej krytyki genetycznej i skonfrontowanie ze sobą tych różnych sposobów jego wykorzystania.
The paper focuses on the concept of a “variant”, which is deeply rooted in the fields of editing practices and literary criticism. The main goal is to show the concept the way it is understood by the classical textology and French Genetic Criticism, as well as to confront different ways of using it.
Dostawca treści:: Biblioteka Nauki

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