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Wyświetlanie 1-10 z 43
Tytuł:
Feeding state and age dependent changes in melanin-concentrating hormone expression in the hypothalamus of broiler chickens
Autorzy:
Simon, Ádám
Németh, József
Jávor, András
Komlósi, István
Bai, Péter
Oláh, János
Juhász, Béla
Kiss, Rita
Szilvássy, Zoltán
Czeglédi, Levente
Tematy:
chicken
feeding states
hypothalamus
MCH
qPCR
RIA
Pokaż więcej
Wydawca:
Polskie Towarzystwo Biochemiczne
Powiązania:
https://bibliotekanauki.pl/articles/1038398.pdf  Link otwiera się w nowym oknie
Opis:
We aimed to quantify the gene expression changes of the potent orexigenic melanin-concentrating hormone (MCH) in chicken (Gallus gallus) hypothalamus with quantitative real-time polymerase chain reaction (qPCR), and for the first time determine peptide concentrations with a novel radioimmunoassay (RIA) under different feeding status. Three different experimental conditions, namely ad libitum feeding; fasting for 24 h; fasting for 24 h and then refeeding for 2 h, were applied to study changes of the aforementioned target and its receptor (MCHR4) gene expression under different nutritional status. The relative changes of MCH and MCHR4 were also studied from 7 to 35 days of age. Expression of PMCH and MCHR4 along the gastrointestinal tract (GIT) was also investigated. We found that expression of both targets was significant in the hypothalamus, while only weak expression was detected along the GIT. Different nutritional states did not affect the PMCH and MCHR4 mRNA levels. However, fasting for 24 h had significantly increased the MCH-like immunoreactivity by 25.65%. Fasting for 24 h and then refeeding for 2 h had further significantly increased the MCH peptide concentration by 32.51%, as compared to the ad libitum state. A decreasing trend with age was observable for both, the PMCH and MCHR4 mRNA levels, and also for the MCH-like immunoreactivity. Correlation analysis did not result in a significant correlation between MCH peptide concentration and abdominal fat mass in ad libitum fed birds. In conclusion, MCH peptide concentration altered in response to 24 h fasting, which indicated that this peptide may take part in feed intake regulation of broiler chickens.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Development of an educational research software with advisory role in the clinicobiochemical evaluation of amenorrhea
Autorzy:
Delimaris, I.
Delimaris, K.
Tematy:
digital learning
biomedical informatics
hypothalamus
ovary
uterus
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Wydawca:
Uniwersytet Medyczny w Białymstoku
Powiązania:
https://bibliotekanauki.pl/articles/1916337.pdf  Link otwiera się w nowym oknie
Opis:
Introduction: Amenorrhea is a symptom of a variety of disorders and dysfunctions. Historically, there have been many practical difficulties associated with the diagnosis of amenorrhea due to the complex nature of the ovaries, pituitary gland and hypothalamus. Purpose: To develop a free, simple stand alone educational research software (ERS) to assist the education of clinicians and laboratorians (or undergraduate students) with regard to the clinicobiochemical evaluation of amenorrhea. Μaterials and methods: The software was designed using: a) Microsoft Windows as operating system, b) C# .NET (4.0) as software component (plug-in), and c) C# (C Sharp) as (object-oriented) programming language. It can be distributed on Compact Disk (CD) and be run on any Personal Computer (PC) on Windows. Results: The developed (ERS) -which we have called ERSA v.1.0 - does not require comprehensive skills and expertise in computers. Its educational benefits (common reasons for use) include activating motivation, stimulating recall of the prerequisite material, providing learning guidance and feedback (interactivity), usability outside timetabled course, and competency assessment. Conclusions: The free ERSA v.1.0 could be a practical digital teaching tool for supporting the clinicobiochemical education. Future research should continue so as to evaluate and improve its accuracy, appropriateness, and usability by healthcare students or professionals.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
L’histopathologie de l’hypothalamus et du lobe neural de l’hypophyse des personnes suicidées
Histopatologia podwzgórza i tylnego płata przysadki w przypadku śmierci samobójczej
Histopathology of the hypothalamus and the neural lobe of hypophysis in suicide victims
Gistopatologičeskoe issledovanie gipotalamusa i nervnoj doli gipofiza mozga pri samoubijstvennoj smerti
Histopathologie von Hypothalamus und des hinteren Hypophysenlappens im Suizid
Гистопатологическое исследование гипоталамуса и нервной доли гипофиза мозга при самоубийственной смерти
Autorzy:
Wiliński, Bogdan
Dziobek, Konrad
Srebro, Zbigniew
Opis:
Summary: Histologic studies of the hypothalamus and neurohypophysis revealed that in young (17-35 y. o. ) suicide victims, there are degenetative changes in the supraoptic and paraventricular nuclei and partial destruction by inflammation of the neurohypophysis. Simultaneously foci of micromalaic and the gatu- ering of azurophilic material in neuronal perikarya around the cerebral blood res- sel and the laptomeninges. The degenerated neurones contain great vaculoes, often filled with lipofuscin. The probable pathogenic mechanism of the observed changes is discussed with its influence on mood-lowering leading to suicide.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
No alterations in diurnal cortisol profiles before and during the treatment in patients with stress-related exhaustion
Autorzy:
Sjörs, Anna
Jonsdottir, Ingibjörg H.
Tematy:
burnout
follow-up
hypothalamus-pitutiary-adrenal axis
longitudinal study
salivary cortisol
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Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Powiązania:
https://bibliotekanauki.pl/articles/2177034.pdf  Link otwiera się w nowym oknie
Opis:
Introduction Several theories have emerged in recent years suggesting that neuroendocrinological alterations, mainly changes in cortisol, could be of importance with respect to the link between chronic stress and disease. This study investigated possible deviations in the diurnal cortisol profiles of patients with clinically diagnosed stress-related exhaustion (exhaustion disorder – ED) compared with healthy controls. Material and methods: Salivary cortisol samples taken at home in the morning directly after waking up, 30 min later, and in the evening were compared between ED patients (N = 122; 25% men) and healthy controls (N = 98; 44% men). Follow-up measurements were performed after 6 months (79 patients) and 12 months (68 patients) of the treatment. Results: There were no clear differences in diurnal salivary cortisol profiles between the patients and healthy controls. Moreover, salivary cortisol levels and diurnal profiles did not change significantly during the treatment in the patient group. There was some indication of a smaller cortisol awakening response in the male patients compared to the male controls, but the difference appeared to be mainly related to the antidepressant use. Conclusions: Diurnal salivary cortisol profiles, at least as measured in this study, give a rather poor reflection of the prolonged stress exposure experienced by patients with ED. Such basal salivary cortisol measurements do not seem suitable as biomarkers for stress-related conditions such as ED or burnout, or as an aid to assess the effects of prolonged stress load in a routine clinical practice.
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 43

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