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Wyświetlanie 1-10 z 95
Tytuł:
Differential effects of low and high molecular weight chitosan administered intraperitoneally to mice infected with heligmosomoides polygyrus
Autorzy:
Brodaczewska, Klaudia
Doligalska, Maria
Tematy:
chitosan
immune response
parasite
Pokaż więcej
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Powiązania:
https://bibliotekanauki.pl/articles/1035329.pdf  Link otwiera się w nowym oknie
Opis:
Aim of the study was to compare the effect of different molecular weight chitosan on activity of peritoneal cells of mice during immunosupression caused by adult stages of Heligmosomoides polygyrus. We observed that intraperitoneal injections of chitosan induce cell infiltration, but the activity of recruited cells differed depending on the type of polysaccharide used. Low molecular weight chitosan activated cells with inflammatory characteristics, while high molecular weight polysaccharide reduced cell responsiveness to stimulation. Although IgA titers in the peritoneal fluid were elevated, chitosan treatments had no effect on the level of infection.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Notes about telocytes and immunity
Autorzy:
Aleksandrovych, Veronika
Gil, Anna
Poniatowski, Adrian
Tematy:
immune response
telocytes
interleukins
cytokines
macrophages
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Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Powiązania:
https://bibliotekanauki.pl/articles/57065134.pdf  Link otwiera się w nowym oknie
Opis:
The interstitial cells known as telocytes have been described in various organs. Their role in the normal physiology and pathogenesis of numerous diseases is well known. They have been described in the context of various diseases (gallstone disease, endometriosis, uterine myoma, hydronephrosis, myocardial infraction, psoriasis, etc.), while their impact on inflammation, involvement in angiogenesis, and repair highlights their part in local homeostasis. What is known about their relationship with the immune system? Their secretomes, genome, immune profiles, contacts with surrounding cells, and specific localization allow us to give a possible explanation for their involvement in pathological pathways. This review aims to present the roles and features of telocytes in the context of intestinal immunity (the largest in our body), in the spleen, their interactions with immunocytes, and their place in stem cell niches.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Relationship between Gut-Microbiota and Sport Activity
Autorzy:
Mokarrami, Alì
Capacci, Annunziata
Trio, Beatrice
Della Morte Canosci, David
Merra, Giuseppe
Tematy:
endurance
exercise
immune response
microbiota
nutrition
probiotics
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Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Powiązania:
https://bibliotekanauki.pl/articles/32443960.pdf  Link otwiera się w nowym oknie
Opis:
Aim: The purpose of this umbrella review is to bring together the most recent reviews concerning the relationship between gut-microbiota and sport activity. Materials and Methods: A literature search was conducted through PubMed and focused on reviews and systematic reviews published between 2015 and June 2021 that dealt with the topic of microbiota and physical activity. Only articles written in English and published in peer-reviewed journals were considered. Key words related to the term microbiota alone or in conjunction with other terms such as "supplements", "diet", "probiotics", "prebiotics", "health", "physical activity", and "pathogens" were analyzed. The selection process was done first by analyzing the titles, then the abstracts, and finally the full text. Results: After screening the title and abstract, 29 articles were excluded. Therefore, 20 studies were included in the present umbrella review. The figure shows the steps of the selection process (Figure 1). The specifications of the presented articles are listed in Table 2. Conclusions: Exercise appears to be an environmental factor that can determine changes in the gut microbial composition with possible benefits for the host. Increased microbiota diversity improves metabolic profile and immunological responses and may provide a possible biomarker for health improvement. Exercise altered microbiota could be used to look for new approaches in the treatment of metabolic and inflammatory diseases.
Dostawca treści:
Biblioteka Nauki
Artykuł
Autorzy:
Płonczyńska, Alicja
Potempa, Jan
Sochalska, Maja
Prucsi, Zsombor
Opis:
Periodontitis (PD) is a chronic inflammatory disease that affects a significant portion of the global population. In susceptible individuals, the disease is driven by dysbiotic microbiota on the tooth surface below the gum line, progressively eroding the tooth-supporting structures of the periodontium, including the alveolar bone. Clinically, PD manifests as attachment loss and periodontal pocket formation. Influenced by environmental factors, it can ultimately lead to tooth loss and is associated with an increased risk of systemic conditions. Host cells, including oral keratinocytes, gingival fibroblasts, and monocytes/macrophages, regulate the immune response that drives chronic inflammation and tissue damage in PD. Programmed cell death pathways - apoptosis, pyroptosis, and necroptosis - are key regulators of the immune response. These pathways orchestrate the elimination of infected, activated, and/or damaged cells, which is essential for either fuelling or resolving local inflammation. However, periodontal pathogens, particularly Porphyromonas gingivalis, can manipulate these pathways, supporting the maintenance of highly inflammatory environment. Prolonged exposition to proinflammatory agents may induce cellular senescence. This process contributes to chronic inflammation and tissue breakdown, further exacerbating the progression of PD. In this review, we discuss the key factors contributing to the onset and progression of PD, the virulence factors of P. gingivalis, and their effects on immune responses and cell death in keratinocytes, gingival fibroblasts, and macrophages.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Personalized vaccination? II. The role of natural microbiota in a vaccine-induced immunity
Szczepienia spersonalizowane? II. Rola naturalnej mikrobioty w indukowanej odporności poszczepiennej
Autorzy:
Dlugonska, H.
Grzybowski, M.
Tematy:
vaccination
vaccine
immunity
Microbiotidae
microorganism
immune response
probiotic
prebiotic
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Wydawca:
Polskie Towarzystwo Parazytologiczne
Powiązania:
https://bibliotekanauki.pl/articles/836484.pdf  Link otwiera się w nowym oknie
Opis:
Inter-individual variation in immune response to widely used prophylactic vaccines against infectious diseases is strongly influenced by sex, MHC (Major Histocompatibility Complex), age and current hormones status of vaccinated individuals. Numerous findings showed that microorganisms residing at different sites of human or animal body (natural microbiota), especially in the gastrointestinal tract, appear to contribute to nearly every element of the host’s physiology. Recently, the microbiota is also supposed to be an underappreciated yet, but very important factor responsible for diverse vaccine efficacy observed in humans from developing vs. developed countries. In the article, selected aspects of the microbiota – host relation are presented: importance of the gut microbiota in the development of both the intestinal mucosal and systemic immune responses, bacteria of a predominant role for the immunity (e.g., SFB, Segmented Filamentous Bacteria), and several clinical observations on the varied immunogenicity of the same vaccines in different human populations. In the light of our current knowledge, manipulation of the microbiota by probiotics and/or prebiotics is becoming a realistic therapeutic and prophylactic strategy for many infectious, inflammatory and even neoplastic diseases within the gut but it may be also used for improving vaccine efficacy.
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 95

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