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Wyszukujesz frazę "immunoglobulin" wg kryterium: Temat


Tytuł:
Antibody - Biological warfare agents
Autorzy:
Mayrolle, Pierre
Kuillon, Jean Michel
Kuéry, Sareleï
Aulin, Vincent
Kirondot, Marc
Tematy:
Immunoglobulin A (IgA)
Immunoglobulin G (IgG)
Polyclonal antibodies (PAb)
antibody production
antibody (Ab)
immunoglobulin M (IgM)
Pokaż więcej
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Powiązania:
https://bibliotekanauki.pl/articles/1119235.pdf  Link otwiera się w nowym oknie
Opis:
An antibody (Ab), also known as immunoglobulin (Ig), is a large Y-shape protein consisting of two heavy chains and two light chains (Figure 1) which form a functionally bivalent monomer that is produced by B cells receptor used by the immune system to identify and neutralize foreign objects such as bacteria and viruses. Current widely used rapid detection systems exploit antibodies for recognition, identification and quantification of target analytes [68]. Abs played an important role in the advancement of diagnostic assays, making these indispensable in diagnostic tests that are commonly used routinely in clinics in classical immunological methods such as ELISA, dot blot immunobinding assays, electro-chemiluminescence, flow cytometry and several microscopic techniques like fluorescence, as well as in the construction of numerous immunosensors. Immunoglobulin M (IgM) usually exists as a pentamer in mammals that predominates in primary immune responses to most antigens, and is the most efficient complement fixing immunoglobulin. It comprises approximately 10% of all normal human serum Ig content. IgM is mainly produced by the immune system for protection against numerous viral, bacterial, fungal and parasitic infections.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunohistochemical study of expression of immunoglobulins in canine B-cell lymphomas
Autorzy:
Sokolowska, J.
Micun, J.
Zabielska, K.
Malicka, E.
Lechowski, R.
Tematy:
immunohistochemistry
expression
immunoglobulin
dog
B cell
lymphoma
tumour
neoplastic cell
immunoglobulin light chain
cancer
Pokaż więcej
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Powiązania:
https://bibliotekanauki.pl/articles/31685.pdf  Link otwiera się w nowym oknie
Opis:
Nineteen canine lymphomas were included in this study. Tumors were classified according to the updated Kiel classification adapted for canine lymphomas by Fournel-Fleury et al. Immunoglobulin light chains (κ and λ) and IgM and IgG expression were determined by immunohistochemical method. In all examined cases neoplastic cells were positive for one of the immunoglobulin light chains. Expression of λ light chains and κ light chains was observed in 18/19 and 1/19 tumors, respectively. In the majority of neoplastic cells in each examined specimen this reaction had a membranous pattern (sκ/sλ). In all examined cases the presence of immunoglobulin light chains was also observed in the cytoplasm of some neoplastic cells (cκ/cλ). These cells were usally rare and never constituted a dominant population. The expression of immunoglobulin was found in 13/19 cases. Most lymphomas were sIgM positive (11/13 cases). In one case expression of IgG was found, and in another lymphoma two populations of neoplastic cells with different expression of examined immunoglobulins (cells with IgM+ and IgG+ phenotypes) were observed. The reaction also had a membranous pattern. The cells containing cytoplasmic immunoglobulins were rare, and in most cases were of the same type as the surface immunoglobulins. Our study has confirmed that canine lymphomas are a monoclonal proliferation of B-cells usually expressing immunoglobulin λ light chains and that the vast majority of tumors deriving from B-cells express IgM. Our study also indicates a possibility of occurence of biclonal lymphomas in canine species.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of different diets on hematological parameters and immunoglobulin levels in Norduz sheep
Autorzy:
Tuncer, Selçuk Seçkin
Tematy:
sheep
diets
hematological parameters
immunoglobulin concentrations
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Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Powiązania:
https://bibliotekanauki.pl/articles/55795852.pdf  Link otwiera się w nowym oknie
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of the immune system parameters in children with autism spectrum disorders.
Badanie parametrów układu odporności u dzieci ze schorzeniami ze spektrum autyzmu.
Autorzy:
Michalska, Magdalena
Opis:
Choroby ze spektrum autyzmu (ASD) stanowią jedne z częstszych zaburzeń neurorozwojowych występujących w populacji. Wiążą się one z problemami rozwojowymi i upośledzeniem relacji społecznych. Pomimo ciągle nieznanej etiopatogenezy, częstość diagnozy ASD wzrosła, co przyczyniło się do badań nad chorobami towarzyszącymi. Jednym z obiektów zainteresowań badaczy stały się współistniejące zaburzenia układu odporności w tej grupie pacjentów. Celem pracy była ocena współwystępowania zaburzeń ze strony układu odporności u dzieci z ASD. Grupę badaną stanowiło 22 pacjentów z ASD skierowanych do Poradni lub Oddziału Immunologii Uniwersyteckiego Szpitala Dziecięcego w Krakowie. Badania przeprowadzono na podstawie retrospektywnej analizy wyników diagnostycznych oceniających parametry odporności wrodzonej i nabytej. Wykazały one nieprawidłowości w liczbie limfocytów T CD3+, CD3+/CD4+, CD3+/CD8+, CD19+ i komórek NK, a także w poziomie immunoglobulin poszczególnych klas. Zaobserwowano również niedobory białek układu dopełniacza i zaburzenia w produkcji przeciwciał poszczepiennych. U części pacjentów rozpoznano zdefiniowane formy pierwotnych niedoborów odporności, wymagające terapii substytucyjnej, która u większości przyniosła również złagodzenie objawów ASD. Obserwacje te były poczynione na małej grupie pacjentów, co wymaga ich dalszej weryfikacji.
Autism spectrum disorders (ASD) are one of the most common neurodevelopmental disorders in the population. They are related to development problems and impairment of social relations. Despite the unknown etiopathogenesis, the frequency of ASD diagnosis has increased, which contributed to research into comorbidities. One of the subjects of the researchers' interest was the comorbid disorders of the immune system in this group of patients. The aim of the study was to assess the coexistence of disorders of the immune system in children with ASD. The study group consisted of 22 patients with ASD referred to the Outpatient Clinic or the Ward of Immunology of the University Children's Hospital in Cracow. The study was based on a retrospective analysis of diagnostic results assessing the parameters of innate and acquired immunity. They showed abnormalities in the number of CD3 +, CD3 + / CD4 +, CD3 + / CD8 +, CD19 + and NK cells, as well as in the level of immunoglobulins of particular classes. Complement protein deficiencies and disturbances in the production of post-vaccination antibodies have also been observed. Some patients were diagnosed with defined forms of primary immunodeficiencies, requiring immunoglobulin administration, which also resulted with relief of ASD symptoms in the majority of patients. These observations were made on a small group of patients, which requires further verification.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Inne
Tytuł:
Consensus Committee of experts on Kawasaki Disease and Chinese Journal of Contemporary Pediatrics – the expert consensuses on intravenous immunoglobulin, aspirin, and glucocorticoid
Autorzy:
Shuying, Ren
Fangming, Deng
Zhongdong, Du
Xiaodong, Yang
Lijian, Xie
Hong, Wang
Fuyong, Jiao
Tematy:
aspirin
children
glucocorticoid
intravenous immunoglobulin
Kawasaki disease
Pokaż więcej
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Powiązania:
https://bibliotekanauki.pl/articles/40519598.pdf  Link otwiera się w nowym oknie
Opis:
Introduction and aim. Kawasaki disease (KD) is an acute vasculitis with unknown etiology, usually occurring in children under 5 years old. This article will summarize the three consensuses formulated in China about KD. Material and methods. English databases for consensus search include UpToDate, BMJ Clinical Evidence, National Guideline Clearinghouse, Joanna Briggs Institute Library, Cochrane Library, and PubMed, etc.; Chinese databases include China Biomedical Literature Service, China Knowledge Network, Wanfang database, etc. All literature searches ended on February 28, 2022. Analysis of the literature. KD is a common acquired heart disease in children and can lead to severe complications such as coronary injury. However, intravenous immunoglobulin (IVIG) combined with oral aspirin (Asp) is currently recognized as the most effective treatment in KD acute stage and the first-line treatment to prevent cardiovascular complications. Glucocorticoid (GC) is mainly used for KD patients with a high risk of coronary artery aneurysm (CAA), no immunoglobulin response, and confirmed CAA. There are already consensus guidelines on diagnosing and treating KD in different countries. This article summarizes the relevant expert consensus on aspirin, glucocorticoids and IVIG for the treatment of Kawasaki disease in China. Conclusion. Still, there are inconsistent opinions in the literature on the mechanism, optimal timing, and dosage of medication for KD.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hydrophobic core in domains of immunoglobulin-like fold
Autorzy:
Chomilier, J.
Prudhomme, N.
Banach, Mateusz
Roterman-Konieczna, Irena
Opis:
This work analyzes proteins which contain an immunoglobulin fold, focusing on their hydrophobic core structure. The "fuzzy oil drop" model was used to measure the regularity of hydrophobicity distribution in globular domains belonging to proteins which exhibit the above-mentioned fold. Light-chain IgG domains are found to frequently contain regular hydrophobic cores, unlike the corresponding heavy-chain domains. Enzymes and DNA binding proteins present in the data-set are found to exhibit poor accordance with the hydrophobic core model.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł

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