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Wyszukujesz frazę "inhalation" wg kryterium: Temat


Tytuł:
Analysis of the content of leaflets attached to inhaled drug forms in terms of the most common mistakes during inhalation
Analiza treści ulotek dołączonych do wziewnych postaci leków w aspekcie najczęściej popełnianych błędów podczas inhalacji
Autorzy:
Gołuchowska, Weronika
Opis:
Stosowanie leków wziewnych niesie ze sobą wiele korzyści i pomaga pominąć trudności związane z podaniem ich inną drogą, ale też jest bardzo wymagającą formą terapii. Obsługa inhalatorów suchego proszku stwarza pacjentom trudności i generuje dużą liczbę popełnianych przez nich błędów. Celem pracy jest ocena ulotek dołączonych do inhalatorów suchego proszku, których analiza pozwoli stwierdzić, czy są one dobrym źródłem wiedzy dla pacjenta, z którego może czerpać informacje konieczne do prawidłowego przeprowadzenia procesu inhalacji.Przeprowadzono przegląd literaturowy i na jego podstawie sporządzono spis błędów popełnianych przez pacjentów stosujących inhalatory suchego proszku. W oparciu o niego stworzono formularz oceny ulotek. W formularzu znalazły się zarówno informacje niespecyficzne, które dotyczyły wszystkich inhalatorów, jak i specyficzne odnoszące się tylko do konkretnej grupy urządzeń.Żadna z analizowanych ulotek nie uzyskała maksymalnej liczby punktów. Najlepiej oceniono, biorąc pod uwagę łączną ocenę informacji specyficznych i niespecyficznych, ulotki inhalatorów Breezhaler (Onbrez, Seebri i Ultibro) oraz Handihaler (Spiriva) - otrzymały równo po 41 punktów (77,36%). Najsłabszy wynik w ogólnej punktacji uzyskała ulotka inhalatora Turbuhaler (Oxis).Przeprowadzone badanie ukazuje, że ulotki nie są idealnym źródłem wiedzy, gdyż żadna z nich nie otrzymała maksymalnej liczby punktów. Pomimo pewnych braków w informacjach, stanowią łatwo dostępną formę wiedzy dla pacjenta, a także mogą być oparciem dla farmaceutów podczas indywidualnego edukowania pacjenta. Połączenie edukacji prowadzonej przez farmaceutę wraz ze znajomością treści ulotki przez pacjenta daje największą szansę na zminimalizowanie błędów popełnianych podczas inhalacji.
Inhalation therapy has many benefits and helps to avoid the difficulties associated with administering them in another way, but it is also a very demanding form of therapy. Using a dry powder inhalers correctly is difficult for patients and generates a large number of errors.The aim of the study is to evaluate the leaflets attached to dry powder inhalers, the analysis of which will allow to determine whether they are a good source of knowledge for the patient, from which he can obtain information necessary for the proper conduct of the inhalation process.After a literature review there was prepared a list of errors made by patients while using dry powder inhalers. The leaflet evaluation form was created based on this list. The form included both non-specific information, which was related to all inhalers, and specific information, related only to a specific group of devices. None of the analyzed leaflets obtained the maximum number of points. The Breezhaler (Onbrez, Seebri and Ultibro) and Handihaler (Spiriva) inhaler leaflets were best rated. They have received 41 points (77.36%). The lowest result in the total puncture was obtained by the Turbuhaler (Oxis) inhaler leaflet.The conducted research shows that the leaflets are not an ideal source of knowledge, as none of them received the maximum number of points. Despite this they are easily accessible form of knowledge for the patient, and can also be a support for pharmacists in the individual patient education.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Inne
Tytuł:
Thiram - toxic inhalational lung injury
Autorzy:
Siwiec, J.
Siek, E.
Grzywa-Celińska, A.
Mackiewicz, B.
Czekajska-Chehab, E.
Tematy:
thiram
lung injury
inhalation
Pokaż więcej
Wydawca:
Instytut Medycyny Wsi
Powiązania:
https://bibliotekanauki.pl/articles/2085136.pdf  Link otwiera się w nowym oknie
Opis:
Introduction. Thiram, a fungicides, is widely used on seeds and as foliar agent on turf, vegetables and fruit. It is also used in the rubber industry as a vulcanization accelerator. When absorbed through the respiratory system, it is rapidly metabolised to dimethylthiocarbamate and carbon disulphide, causing noxious effects. A brief review is presented of the literature, centering on the interesting case of a 45-year-old woman admitted to the hospital suffering from acute respiratory failure. Results. Computer tomography in angiographic option (angio-CT) showed an extensive, irregular area of ground glass in both upper lobes and apical segments of the lower lobes of the lungs. A significant enlargement of both atria was also described. There was no improvement after cardiac treatment and patient was transferred to the pulmonary department where she was succesfully treated with systemic glucocortycosteroids. The patient remains under the supervision of the pulmonary out-patient department.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chicken bone in the bronchus masquerading as bronchopneumonia in an asthmatic boy
Kość kurczaka w oskrzelu dająca objawy odoskrzelowego zapalenia płuc u chłopca z astmą
Autorzy:
Farahiyah Abdullah, Nurul
Saramoses, Shamina
Gazali, Norzi
Mohamad, Irfan
Tematy:
bronchopneumonia
bronchus
foreign body inhalation
Pokaż więcej
Wydawca:
Medical Communications
Powiązania:
https://bibliotekanauki.pl/articles/1030862.pdf  Link otwiera się w nowym oknie
Opis:
Aim of the study: To emphasise the importance of a thorough history to exclude foreign body inhalation in children presenting with respiratory symptoms. Case study: We report a case of a 2-year-old boy with underlying bronchial asthma, who presented with cough and difficulty breathing of two-day duration, with no stridor. He was treated for acute exacerbation of bronchial asthma and bronchopneumonia. However, the symptoms persisted despite treatment. A detailed history revealed a choking episode while eating chicken curry prior admission. Bronchoscopy confirmed the presence of a piece of chicken bone in the left main bronchus, which was removed. The child was in good overall condition after the operation. Chest radiograph showed resolved lung collapse. Conclusion: A thorough history to exclude foreign body ingestion is necessary to avoid delayed complications of foreign body aspiration.
Cel badania: Podkreślenie znaczenia wywiadu chorobowego dla wykluczenia aspiracji ciała obcego u dzieci z objawami ze strony układu oddechowego. Opis przypadku: W pracy przedstawiono przypadek 2-letniego chłopca z astmą oskrzelową, u którego od dwóch dni utrzymywały się kaszel i trudności w oddychaniu bez obecności świstu krtaniowego. Pacjenta poddano leczeniu z powodu ostrego zaostrzenia astmy oskrzelowej i odoskrzelowego zapalenia płuc, jednak nie dało ono oczekiwanych rezultatów. Szczegółowy wywiad chorobowy ujawnił epizod zakrztuszenia potrawą curry z kurczaka przed przyjęciem do szpitala. Bronchoskopia potwierdziła obecność kości kurczaka w lewym głównym oskrzelu, którą następnie usunięto. Stan dziecka po zabiegu oceniono jako dobry. W badaniu radiologicznym klatki piersiowej stwierdzono ustąpienie objawów zapaści płuca. Wniosek: Dokładny wywiad w celu wykluczenia obecności ciała obcego jest niezbędny, aby uniknąć powikłań.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hemimellitene (1,2,3-trimethylbenzene) in the liver, lung, kidney, and blood, and dimethylbenzoic acid isomers in the liver, lung, kidney and urine of rats after single and repeated inhalation exposure to hemimellitene
Autorzy:
Świercz, Radosław
Majcherek, Wanda
Wąsowicz, Wojciech
Tematy:
rats
hemimellitene
pseudocumene
mesitylene
inhalation
toxicokinetic
Pokaż więcej
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Powiązania:
https://bibliotekanauki.pl/articles/2177094.pdf  Link otwiera się w nowym oknie
Opis:
Objectives The aim of the study has been to explore hemimellitene distribution in blood, liver, lung and kidney as well as toxicokinetics of its elimination from blood of rats after single and repeated inhalation exposure to this compound. Tissue distribution and excretion with urine of 2-dimethylbenzoic acids (2,3-DMBA and 2,6-DMBA) were also evaluated. Material and Methods Male outbred IMP:WIST rats were used in the experiment. The animals were exposed to hemimellitene vapors at the nominal concentration of 25 ppm, 100 ppm, and 250 ppm in the dynamic inhalation chambers for 6 h for single exposure purpose and for 4 weeks (6 h/day for 5 day/week) for repeated exposure purposes. Results Significantly lower concentrations of hemimellitene were detected in the blood and tissues of animals after repeated inhalation exposure of animals to hemimellitene vapors, which points to reduced retention of the chemical in the lungs of the experimental rats. The trend of hemimellitene elimination from the blood depended solely on exposure intensity, irrespective of exposure time, both after single and repeated exposure. As regards the 2 determined hemimellitene metabolites, the major trend of the metabolic transformation involved formation of 2,3-DMBA. Conclusions The significantly higher urinary 2,3-DMBA concentration after repeated exposure shows that hemimellitene induces enzymatic processes in the rat.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
4-Week inhalation toxicity of 2-methylnaphthalene in experimental animals
Autorzy:
Świercz, Radosław
Wąsowicz, Wojciech
Stetkiewicz, Jan
Gromadzińska, Jolanta
Majcherek, Wanda
Tematy:
2-Methylnaphthalene
rats
inhalation
NOAEL
LOAEL
Pokaż więcej
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Powiązania:
https://bibliotekanauki.pl/articles/2185378.pdf  Link otwiera się w nowym oknie
Opis:
Objectives: This paper presents toxic effects of 2-MN in laboratory animals under conditions of 4-week inhalation exposure to 2-methylnaphthalene (2-MN) vapors. Materials and Methods: Male Wistar rats were exposed to 2-MN vapors at a nominal concentration of 0, 2, 10 or 50 mg/m³ in dynamic inhalation chambers for 4 weeks (6 h/day, 5 days/week). After 4 weeks of inhalation exposure the animals were necropsied. Blood samples were collected and selected organs were weighted and prepared for histological examinations. Results: The effects of the increased levels of exposure to 2-MN experienced by the experimental rats were as follows: a) increasing γ-glutamylotransferase activity, b) stimulation of the hematopoietic system, c) lower cholesterol concentrations, d) higher number of goblet cells in lobar bronchi, e) hyperplasia of hepatic bile ducts. Conclusion: Four-week exposure of the animals to 2-MN at 2 mg/m³ proved to be the no-observed-adverse-effect-level (NOAEL), while 10 mg/m³ appeared to represent the lowest-observed-adverseeffect- level (LOAEL).
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The distribution and excretion of 1-methylnaphthalene in rats exposed to 1-methylnaphthalene by inhalation
Autorzy:
Świercz, Radosław
Wąsowicz, Wojciech
Tematy:
rats
distribution
inhalation
toxicokinetic
excretion
1-Methylonaphthalene
Pokaż więcej
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Powiązania:
https://bibliotekanauki.pl/articles/2162034.pdf  Link otwiera się w nowym oknie
Opis:
Objectives 1-Methylnaphthalene (1-MN) is a constituent of polycyclic aromatic hydrocarbons, the chemicals that have become ubiquitous in the environment as result of natural and industrial process. This paper reports a study on the distribution and excretion of 1-MN in rats after single and repeated inhalation exposure to 1-MN vapor. Material and Methods Male Wistar rats were exposed to 1-MN vapor at nominal concentrations of 50 mg/m³ or 200 mg/m³ in the dynamic inhalation chambers (TSE Systems Head Nose Only Exposure) for 6 h (single exposure) or 5 days (6 h/day, repeated exposure). Blood, urine and tissue samples were collected during and after the exposure. Blood, urine and tissue concentrations of 1-MN were estimated by gas chromatography using the headspace technique. Results The elimination of 1-MN from blood followed an open 2-compartment model. The concentration in rat tissues was dependent on the magnitude and time of exposure. After repeated exposure, the concentration 1-MN in tissue decreased in comparison to single exposure. The elimination of 1-MN with urine after single and repeated exposure to 1-MN occurred mainly in the samples collected during the first day of collection. Conclusions 1-Methylnaphthalene was rapidly eliminated from the blood and tissues of animals exposed by inhalation to 1-MN. In repeated exposure, there was probably a significant increase of 1-MN metabolism in rats exposed to low and high 1-MN doses. Under conditions of repeated 1-MN exposure, no significant systemic 1-MN accumulation could be observed. Int J Occup Med Environ Health 2018;31(6):763–770
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A systematic review of the health impacts of occupational exposure to wildland fires
Autorzy:
Groot, Emily
Caturay, Alexa
Khan, Yasmin
Copes, Ray
Tematy:
firefighter
inhalation
smoke
burns
wildfires
stress disorders
Pokaż więcej
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Powiązania:
https://bibliotekanauki.pl/articles/2162002.pdf  Link otwiera się w nowym oknie
Opis:
The aim of the paper is to summarize the evidence of health impacts of occupational exposure to wildland fires. The authors searched 3 databases for relevant articles and screened the results. After full-text review, articles were included based on pre-determined criteria. The authors identified 32 relevant articles. Occupational exposure to wildland fires affects lung function in the short term and may increase the risk of hypertension in the long term. Exposure to wildland fires is also associated with post-traumatic stress symptoms. There was insufficient evidence to comment on most longer-term risks, and in particular on respiratory disease or cancer risks. Further research is required to understand whether occupational exposure to wildland fires results in clinically significant impacts on respiratory function, and to further clarify the relationship between occupational exposure and blood pressure, mental health, and cancer outcomes. Int J Occup Med Environ Health. 2019;32(2):121–40
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Toxic effect in the lungs of rats after inhalation exposure to benzalkonium chloride
Autorzy:
Świercz, Radosław
Hałatek, Tadeusz
Stetkiewicz, Jan
Wąsowicz, Wojciech
Kur, Barbara
Grzelińska, Zofia
Majcherek, Wanda
Tematy:
benzalkonium chloride
rats
inhalation
lungs
biomarkers
histopathological examinations
Pokaż więcej
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Powiązania:
https://bibliotekanauki.pl/articles/2179138.pdf  Link otwiera się w nowym oknie
Opis:
Background: Benzalkonium chloride (BAC) is a quaternary ammonium compound (QAC) toxic to microorganisms. Inhalation is one of the major possible routes of human exposure to BAC. Materials and Methods: Experiments were performed on female Wistar rats. The rats were exposed to aerosol of BAC water solution at the target concentration of 0 (control group) and 35 mg/m³ for 5 days (6 h/day) and, after a 2-week interval, the animals were challenged (day 21) with BAC aerosol at the target concentration of 0 (control group) and 35 mg/m³ for 6 h. Results: Compared to the controls, the animals exposed to BAC aerosol were characterized by lower food intake and their body weight was significantly smaller. As regards BAC-exposed group, a significant increase was noted in relative lung mass, total protein concentration, and MIP-2 in BALF both directly after the termination of the exposure and 18 h afterwards. Significantly higher IL-6 and IgE concentrations in BALF and a decrease in the CC16 concentration in BALF were found in the exposed group immediately after the exposure. The leukocyte count in BALF was significantly higher in the animals exposed to BAC aerosol compared to the controls. In the lungs of rats exposed to BAC the following effects were observed: minimal perivascular, interstitial edema, focal aggregates of alveolar macrophages, interstitial mononuclear cell infiltrations, thickened alveolar septa and marginal lipoproteinosis. Conclusion: Inhalation of BAC induced a strong inflammatory response and a damage to the blood-air barrier. Reduced concentrations of CC16, which is an immunosuppressive and anti-inflammatory protein, in combination with increased IgE concentrations in BALF may be indicative of the immuno-inflammatory response in the animals exposed to BAC aerosol by inhalation. Histopathological examinations of tissue samples from the BAC-exposed rats revealed a number of pathological changes found only in the lungs.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pulse Nebulization in Pneumatic Devices
Autorzy:
Gradoń, L.
Sosnowski, T. R.
Podolec, Z.
Tematy:
inhalation
nebulizers
flow pulsation
inhalacja
atomizator
aerozol fizjologiczny
Pokaż więcej
Wydawca:
Centralny Instytut Ochrony Pracy
Powiązania:
https://bibliotekanauki.pl/articles/90984.pdf  Link otwiera się w nowym oknie
Opis:
Aerosols of a physiological salt solution and aqueous solutions of salbutamol, sodium cromoglicate, and dornase aifa were generated in a pneumatic nebulizer and analyzed in a system with controlled humidity of air as a carrier gas. Mass distribution of aerosol particles and yield of generation for pulse nebulization were measured. Pulsation of generation was realized with an attachment maintained by a computer program. Opening times of the valve were in the range 50-800 ms. The results indicate the possibility of improving aerosol particle delivery to the lung using a pulse generation system.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Physicochemical mechanisms of mineral nanoparticles effects on pulmonary gas/liquid interface studied in model systems
Autorzy:
Kondej, D.
Sosnowski, T. R.
Tematy:
inhalation
nanoparticles
gas-liquid interface
dynamic surface tension
Pokaż więcej
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Powiązania:
https://bibliotekanauki.pl/articles/110409.pdf  Link otwiera się w nowym oknie
Opis:
Inhaled mineral nanoparticles which are deposited on the lung surface may influence the gas/liquid barrier and the pulmonary surfactant (PS) which constitutes the vital element of the respiratory system. This research is focused on the physicochemical effects caused by selected clay nanoparticles (bentonite, halloysite, montmorillonites) interacting with PS and changing its original surface activity. Using three measuring methods (pulsating bubble technique, Langmuir balance and drop shape analysis), we demonstrated the influence of different mineral nanoparticles on the dynamic surface tension of animal-derived PS material (Survanta®) and main surfactant phospholipid (DPPC). The results which are dependent on material properties and concentration allow to hypothesize possible pathways of health effects from inhalation of mineral nanoparticles. This may help to set the guidelines in defining occupational safety standards and methods of protection of the respiratory system against inhaled mineral dusts.
Dostawca treści:
Biblioteka Nauki
Artykuł

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